Image Derived Input Function for [18F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain
Identifieur interne : 000A43 ( Main/Curation ); précédent : 000A42; suivant : 000A44Image Derived Input Function for [18F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain
Auteurs : Rostom Mabrouk [Canada] ; Pablo M. Rusjan [Canada] ; Romina Mizrahi [Canada] ; Mark F. Jacobs [Canada] ; Yuko Koshimori [Canada] ; Sylvain Houle [Canada] ; Ji Hyun Ko [Canada] ; Antonio P. Strafella [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Receptors, GABA.
- metabolism : Brain, Receptors, GABA.
- methods : Positron-Emission Tomography.
- Adult, Aged, Algorithms, Female, Genotype, Humans, Kinetics, Linear Models, Male, Middle Aged, Polymorphism, Genetic, Principal Component Analysis, Software.
Abstract
In [18F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (VT) by CS-IF and ICA-IF were compared to the reference VT obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The VT values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r2 = 0.91 (
Url:
DOI: 10.1371/journal.pone.0115768
PubMed: 25549260
PubMed Central: 4280118
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PMC:4280118Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>In [<sup>18</sup>
F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V<sub>T</sub>
) by CS-IF and ICA-IF were compared to the reference V<sub>T</sub>
obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V<sub>T</sub>
values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r<sup>2</sup>
= 0.91 (<italic>p</italic>
<0.05), and r<sup>2</sup>
= 0.71 (<italic>p</italic>
<0.05) using CS-IF.</p>
</div>
</front>
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<author><name sortKey="Snow, J" uniqKey="Snow J">J Snow</name>
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</author>
<author><name sortKey="Futatsubashi, M" uniqKey="Futatsubashi M">M Futatsubashi</name>
</author>
<author><name sortKey="Kanno, T" uniqKey="Kanno T">T Kanno</name>
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</author>
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</author>
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<author><name sortKey="Kreisl, Wc" uniqKey="Kreisl W">WC Kreisl</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name>
</author>
<author><name sortKey="Dustin, I" uniqKey="Dustin I">I Dustin</name>
</author>
<author><name sortKey="Khan, O" uniqKey="Khan O">O Khan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreutzberg, Gw" uniqKey="Kreutzberg G">GW Kreutzberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turner, Mr" uniqKey="Turner M">MR Turner</name>
</author>
<author><name sortKey="Cagnin, A" uniqKey="Cagnin A">A Cagnin</name>
</author>
<author><name sortKey="Turkheimer, Fe" uniqKey="Turkheimer F">FE Turkheimer</name>
</author>
<author><name sortKey="Miller, Ccj" uniqKey="Miller C">CCJ Miller</name>
</author>
<author><name sortKey="Shaw, Ce" uniqKey="Shaw C">CE Shaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreisl, Wc" uniqKey="Kreisl W">WC Kreisl</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name>
</author>
<author><name sortKey="Fujimura, Y" uniqKey="Fujimura Y">Y Fujimura</name>
</author>
<author><name sortKey="Kimura, N" uniqKey="Kimura N">N Kimura</name>
</author>
<author><name sortKey="Jenko, Kj" uniqKey="Jenko K">KJ Jenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, Aa" uniqKey="Wilson A">AA Wilson</name>
</author>
<author><name sortKey="Garcia, A" uniqKey="Garcia A">A Garcia</name>
</author>
<author><name sortKey="Parkes, J" uniqKey="Parkes J">J Parkes</name>
</author>
<author><name sortKey="Mccormick, P" uniqKey="Mccormick P">P McCormick</name>
</author>
<author><name sortKey="Stephenson, Ka" uniqKey="Stephenson K">KA Stephenson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Briard, E" uniqKey="Briard E">E Briard</name>
</author>
<author><name sortKey="Zoghbi, Ss" uniqKey="Zoghbi S">SS Zoghbi</name>
</author>
<author><name sortKey="Imaizumi, M" uniqKey="Imaizumi M">M Imaizumi</name>
</author>
<author><name sortKey="Gourley, Jp" uniqKey="Gourley J">JP Gourley</name>
</author>
<author><name sortKey="Shetty, Hu" uniqKey="Shetty H">HU Shetty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujimura, Y" uniqKey="Fujimura Y">Y Fujimura</name>
</author>
<author><name sortKey="Zoghbi, Ss" uniqKey="Zoghbi S">SS Zoghbi</name>
</author>
<author><name sortKey="Simeon, Fg" uniqKey="Simeon F">FG Simèon</name>
</author>
<author><name sortKey="Taku, A" uniqKey="Taku A">A Taku</name>
</author>
<author><name sortKey="Pike, Vw" uniqKey="Pike V">VW Pike</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dolle, F" uniqKey="Dolle F">F Dollé</name>
</author>
<author><name sortKey="Hinnen, F" uniqKey="Hinnen F">F Hinnen</name>
</author>
<author><name sortKey="Damont, A" uniqKey="Damont A">A Damont</name>
</author>
<author><name sortKey="Kuhnast, B" uniqKey="Kuhnast B">B Kuhnast</name>
</author>
<author><name sortKey="Fookes, C" uniqKey="Fookes C">C Fookes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maeda, J" uniqKey="Maeda J">J Maeda</name>
</author>
<author><name sortKey="Suhara, T" uniqKey="Suhara T">T Suhara</name>
</author>
<author><name sortKey="Zhang, Mr" uniqKey="Zhang M">MR Zhang</name>
</author>
<author><name sortKey="Okauchi, T" uniqKey="Okauchi T">T Okauchi</name>
</author>
<author><name sortKey="Yasuno, F" uniqKey="Yasuno F">F Yasuno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boutin, H" uniqKey="Boutin H">H Boutin</name>
</author>
<author><name sortKey="Chauveau, F" uniqKey="Chauveau F">F Chauveau</name>
</author>
<author><name sortKey="Thominiaux, C" uniqKey="Thominiaux C">C Thominiaux</name>
</author>
<author><name sortKey="Gregoire, Mc" uniqKey="Gregoire M">MC Grégoire</name>
</author>
<author><name sortKey="James, Ml" uniqKey="James M">ML James</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Mr" uniqKey="Zhang M">MR Zhang</name>
</author>
<author><name sortKey="Kumata, K" uniqKey="Kumata K">K Kumata</name>
</author>
<author><name sortKey="Maeda, J" uniqKey="Maeda J">J Maeda</name>
</author>
<author><name sortKey="Yanamoto, K" uniqKey="Yanamoto K">K Yanamoto</name>
</author>
<author><name sortKey="Hatori, A" uniqKey="Hatori A">A Hatori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rusjan, P" uniqKey="Rusjan P">P Rusjan</name>
</author>
<author><name sortKey="Wilson, Aa" uniqKey="Wilson A">AA Wilson</name>
</author>
<author><name sortKey="Bloomfield, Pm" uniqKey="Bloomfield P">PM Bloomfield</name>
</author>
<author><name sortKey="Vitcu, I" uniqKey="Vitcu I">I Vitcu</name>
</author>
<author><name sortKey="Meyer, Jh" uniqKey="Meyer J">JH Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jons, Hp" uniqKey="Jons H">HP Jons</name>
</author>
<author><name sortKey="Ernst, M" uniqKey="Ernst M">M Ernst</name>
</author>
<author><name sortKey="Hankerson, J" uniqKey="Hankerson J">J Hankerson</name>
</author>
<author><name sortKey="Hardy, K" uniqKey="Hardy K">K Hardy</name>
</author>
<author><name sortKey="Zamertkin, Ja" uniqKey="Zamertkin J">JA Zamertkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mabrouk, R" uniqKey="Mabrouk R">R Mabrouk</name>
</author>
<author><name sortKey="Dubeau, F" uniqKey="Dubeau F">F Dubeau</name>
</author>
<author><name sortKey="Bentourkia, M" uniqKey="Bentourkia M">M Bentourkia</name>
</author>
<author><name sortKey="Bentabet, L" uniqKey="Bentabet L">L Bentabet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Weerdt, Ap" uniqKey="Van Der Weerdt A">AP van der Weerdt</name>
</author>
<author><name sortKey="Klein, Lj" uniqKey="Klein L">LJ Klein</name>
</author>
<author><name sortKey="Boellaard, R" uniqKey="Boellaard R">R Boellaard</name>
</author>
<author><name sortKey="Visser, Ca" uniqKey="Visser C">CA Visser</name>
</author>
<author><name sortKey="Visser, Fc" uniqKey="Visser F">FC Visser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Croteau, E" uniqKey="Croteau E">E Croteau</name>
</author>
<author><name sortKey="Lavallee, E" uniqKey="Lavallee E">E Lavallee</name>
</author>
<author><name sortKey="Labbe, Sm" uniqKey="Labbe S">SM Labbe</name>
</author>
<author><name sortKey="Hubert, L" uniqKey="Hubert L">L Hubert</name>
</author>
<author><name sortKey="Pifferi, F" uniqKey="Pifferi F">F Pifferi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Backes, H" uniqKey="Backes H">H Backes</name>
</author>
<author><name sortKey="Ullrich, R" uniqKey="Ullrich R">R Ullrich</name>
</author>
<author><name sortKey="Neumaier, B" uniqKey="Neumaier B">B Neumaier</name>
</author>
<author><name sortKey="Kracht, L" uniqKey="Kracht L">L Kracht</name>
</author>
<author><name sortKey="Wienhard, K" uniqKey="Wienhard K">K Wienhard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mourik, Emj" uniqKey="Mourik E">EMJ Mourik</name>
</author>
<author><name sortKey="Lubberink, M" uniqKey="Lubberink M">M Lubberink</name>
</author>
<author><name sortKey="Klumpers, Mhu" uniqKey="Klumpers M">MHU Klumpers</name>
</author>
<author><name sortKey="Comans, Ef" uniqKey="Comans E">EF Comans</name>
</author>
<author><name sortKey="Lammertsma, Aa" uniqKey="Lammertsma A">AA Lammertsma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zanotti Fregonara, P" uniqKey="Zanotti Fregonara P">P Zanotti-Fregonara</name>
</author>
<author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name>
</author>
<author><name sortKey="Liow, Js" uniqKey="Liow J">JS Liow</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name>
</author>
<author><name sortKey="Innis, Rb" uniqKey="Innis R">RB Innis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naganawa, M" uniqKey="Naganawa M">M Naganawa</name>
</author>
<author><name sortKey="Kimura, Y" uniqKey="Kimura Y">Y Kimura</name>
</author>
<author><name sortKey="Ishii, K" uniqKey="Ishii K">K Ishii</name>
</author>
<author><name sortKey="Oda, K" uniqKey="Oda K">K Oda</name>
</author>
<author><name sortKey="Ishiwata, K" uniqKey="Ishiwata K">K Ishiwata</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Turheimer, Ef" uniqKey="Turheimer E">EF Turheimer</name>
</author>
<author><name sortKey="Edison, P" uniqKey="Edison P">P Edison</name>
</author>
<author><name sortKey="Paves, N" uniqKey="Paves N">N Paves</name>
</author>
<author><name sortKey="Roncaroli, F" uniqKey="Roncaroli F">F Roncaroli</name>
</author>
<author><name sortKey="Anderson, Na" uniqKey="Anderson N">NA Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Keming, Y" uniqKey="Keming Y">Y Keming</name>
</author>
<author><name sortKey="Jin, Za" uniqKey="Jin Z">ZA Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Owen, Dr" uniqKey="Owen D">DR Owen</name>
</author>
<author><name sortKey="Gunn, Rn" uniqKey="Gunn R">RN Gunn</name>
</author>
<author><name sortKey="Rabiner, Ea" uniqKey="Rabiner E">EA Rabiner</name>
</author>
<author><name sortKey="Bennacef, I" uniqKey="Bennacef I">I Bennacef</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mizrahi, R" uniqKey="Mizrahi R">R Mizrahi</name>
</author>
<author><name sortKey="Rusjan, Pm" uniqKey="Rusjan P">PM Rusjan</name>
</author>
<author><name sortKey="Kennedy, J" uniqKey="Kennedy J">J Kennedy</name>
</author>
<author><name sortKey="Pollock, B" uniqKey="Pollock B">B Pollock</name>
</author>
<author><name sortKey="Mulsant, B" uniqKey="Mulsant B">B Mulsant</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sossi, V" uniqKey="Sossi V">V Sossi</name>
</author>
<author><name sortKey="De Jong, Hwam" uniqKey="De Jong H">HWAM de Jong</name>
</author>
<author><name sortKey="Barker, Wc" uniqKey="Barker W">WC Barker</name>
</author>
<author><name sortKey="Peter, B" uniqKey="Peter B">B Peter</name>
</author>
<author><name sortKey="Ziad, B" uniqKey="Ziad B">B Ziad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hong, Ik" uniqKey="Hong I">IK Hong</name>
</author>
<author><name sortKey="Chung, St" uniqKey="Chung S">ST Chung</name>
</author>
<author><name sortKey="Kim, Hk" uniqKey="Kim H">HK Kim</name>
</author>
<author><name sortKey="Kim, Yb" uniqKey="Kim Y">YB Kim</name>
</author>
<author><name sortKey="Son, Yd" uniqKey="Son Y">YD Son</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rusjan, P" uniqKey="Rusjan P">P Rusjan</name>
</author>
<author><name sortKey="Mamo, D" uniqKey="Mamo D">D Mamo</name>
</author>
<author><name sortKey="Ginovart, N" uniqKey="Ginovart N">N Ginovart</name>
</author>
<author><name sortKey="Hussey, D" uniqKey="Hussey D">D Hussey</name>
</author>
<author><name sortKey="Vitcu, I" uniqKey="Vitcu I">I Vitcu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hilton, J" uniqKey="Hilton J">J Hilton</name>
</author>
<author><name sortKey="Yokoi, F" uniqKey="Yokoi F">F Yokoi</name>
</author>
<author><name sortKey="Dannals, Rf" uniqKey="Dannals R">RF Dannals</name>
</author>
<author><name sortKey="Ravert, Ht" uniqKey="Ravert H">HT Ravert</name>
</author>
<author><name sortKey="Szabo, Z" uniqKey="Szabo Z">Z Szabo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyer, E" uniqKey="Meyer E">E Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mabrouk, R" uniqKey="Mabrouk R">R Mabrouk</name>
</author>
<author><name sortKey="Dubeau, F" uniqKey="Dubeau F">F Dubeau</name>
</author>
<author><name sortKey="Bentabet, L" uniqKey="Bentabet L">L Bentabet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amiri, Si" uniqKey="Amiri S">SI Amiri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Innis, Rb" uniqKey="Innis R">RB Innis</name>
</author>
<author><name sortKey="Cunningham, Vj" uniqKey="Cunningham V">VJ Cunningham</name>
</author>
<author><name sortKey="Delforge, J" uniqKey="Delforge J">J Delforge</name>
</author>
<author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name>
</author>
<author><name sortKey="Gjedde, A" uniqKey="Gjedde A">A Gjedde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Phelps, Me" uniqKey="Phelps M">ME Phelps</name>
</author>
<author><name sortKey="Huang, Sc" uniqKey="Huang S">SC Huang</name>
</author>
<author><name sortKey="Hoffman, Ej" uniqKey="Hoffman E">EJ Hoffman</name>
</author>
<author><name sortKey="Kuhl, De" uniqKey="Kuhl D">DE Kuhl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hyvarinen, A" uniqKey="Hyvarinen A">A Hyvarinen</name>
</author>
<author><name sortKey="Oja, E" uniqKey="Oja E">E Oja</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huhn, A" uniqKey="Huhn A">A Huhn</name>
</author>
<author><name sortKey="Nics, L" uniqKey="Nics L">L Nics</name>
</author>
<author><name sortKey="Baldinger, P" uniqKey="Baldinger P">P Baldinger</name>
</author>
<author><name sortKey="Ungersbock, J" uniqKey="Ungersbock J">J Ungersbock</name>
</author>
<author><name sortKey="Dolliner, P" uniqKey="Dolliner P">P Dolliner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hsu, Ph" uniqKey="Hsu P">PH Hsu</name>
</author>
<author><name sortKey="Hung, Ic" uniqKey="Hung I">IC Hung</name>
</author>
<author><name sortKey="Kuo, Yj" uniqKey="Kuo Y">YJ Kuo</name>
</author>
<author><name sortKey="Hsu, Cc" uniqKey="Hsu C">CC Hsu</name>
</author>
<author><name sortKey="Huang, Ye" uniqKey="Huang Y">YE Huang</name>
</author>
</analytic>
</biblStruct>
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