Image Derived Input Function for [18F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain
Identifieur interne : 000473 ( Pmc/Checkpoint ); précédent : 000472; suivant : 000474Image Derived Input Function for [18F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain
Auteurs : Rostom Mabrouk [Canada] ; Pablo M. Rusjan [Canada] ; Romina Mizrahi [Canada] ; Mark F. Jacobs [Canada] ; Yuko Koshimori [Canada] ; Sylvain Houle [Canada] ; Ji Hyun Ko [Canada] ; Antonio P. Strafella [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
In [18F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (VT) by CS-IF and ICA-IF were compared to the reference VT obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The VT values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r2 = 0.91 (
Url:
DOI: 10.1371/journal.pone.0115768
PubMed: 25549260
PubMed Central: 4280118
Affiliations:
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Strafella</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25549260</idno><idno type="pmc">4280118</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280118</idno><idno type="RBID">PMC:4280118</idno><idno type="doi">10.1371/journal.pone.0115768</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000095</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000095</idno><idno type="wicri:Area/Pmc/Curation">000095</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000095</idno><idno type="wicri:Area/Pmc/Checkpoint">000473</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000473</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Image Derived Input Function for [<sup>18</sup>F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain</title><author><name sortKey="Mabrouk, Rostom" sort="Mabrouk, Rostom" uniqKey="Mabrouk R" first="Rostom" last="Mabrouk">Rostom Mabrouk</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rusjan, Pablo M" sort="Rusjan, Pablo M" uniqKey="Rusjan P" first="Pablo M." last="Rusjan">Pablo M. Rusjan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Jacobs, Mark F" sort="Jacobs, Mark F" uniqKey="Jacobs M" first="Mark F." last="Jacobs">Mark F. Jacobs</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In [<sup>18</sup>F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V<sub>T</sub>) by CS-IF and ICA-IF were compared to the reference V<sub>T</sub> obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V<sub>T</sub> values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r<sup>2</sup> = 0.91 (<italic>p</italic><0.05), and r<sup>2</sup> = 0.71 (<italic>p</italic><0.05) using CS-IF.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kreisl, Wc" uniqKey="Kreisl W">WC Kreisl</name></author><author><name sortKey="Lyoo, Ch" uniqKey="Lyoo C">CH Lyoo</name></author><author><name sortKey="Mcgwier, M" uniqKey="Mcgwier M">M McGwier</name></author><author><name sortKey="Snow, J" uniqKey="Snow J">J Snow</name></author><author><name sortKey="Jenko, Jk" uniqKey="Jenko J">JK Jenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreisl, Wc" uniqKey="Kreisl W">WC Kreisl</name></author><author><name sortKey="Mbeo, G" uniqKey="Mbeo G">G Mbeo</name></author><author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name></author><author><name sortKey="Zoghbi, Ss" uniqKey="Zoghbi S">SS 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25549260</article-id><article-id pub-id-type="pmc">4280118</article-id><article-id pub-id-type="publisher-id">PONE-D-14-33268</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0115768</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject><subj-group><subject>Biotechnology</subject><subj-group><subject>Bioengineering</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Computer and Information Sciences</subject><subj-group><subject>Computer Modeling</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Engineering and Technology</subject><subj-group><subject>Signal Processing</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and Health Sciences</subject><subj-group><subject>Inflammatory Diseases</subject></subj-group><subj-group><subject>Neurology</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Research and Analysis Methods</subject><subj-group><subject>Imaging Techniques</subject></subj-group></subj-group></article-categories><title-group><article-title>Image Derived Input Function for [<sup>18</sup>F]-FEPPA: Application to Quantify Translocator Protein (18 kDa) in the Human Brain</article-title><alt-title alt-title-type="running-head">Image Derived Input Function for [<sup>18</sup>F]-FEPPA Quantification</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mabrouk</surname><given-names>Rostom</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rusjan</surname><given-names>Pablo M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mizrahi</surname><given-names>Romina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>Mark F.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Koshimori</surname><given-names>Yuko</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Houle</surname><given-names>Sylvain</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ko</surname><given-names>Ji Hyun</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Strafella</surname><given-names>Antonio P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Herholz</surname><given-names>Karl</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Manchester, United Kingdom</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>rostom.mabrouk@camh.ca</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: AS R. Mizrahi SH. Performed the experiments: PR YK. Analyzed the data: R. Mabrouk. Contributed reagents/materials/analysis tools: R. Mabrouk PR. Contributed to the writing of the manuscript: R. Mabrouk MJ JK.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>9</volume><issue>12</issue><elocation-id>e115768</elocation-id><history><date date-type="received"><day>24</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>27</day><month>11</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Mabrouk et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>In [<sup>18</sup>F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V<sub>T</sub>) by CS-IF and ICA-IF were compared to the reference V<sub>T</sub> obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V<sub>T</sub> values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r<sup>2</sup> = 0.91 (<italic>p</italic><0.05), and r<sup>2</sup> = 0.71 (<italic>p</italic><0.05) using CS-IF.</p></abstract><funding-group><funding-statement>This work was supported by the Canadian Institutes of Health Research (INE 117891) to AS; Canadian Institutes of Health Research to YK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="20"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li><li>Ontario</li></region><settlement><li>Toronto</li><li>Winnipeg</li></settlement><orgName><li>Université de Toronto</li><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Mabrouk, Rostom" sort="Mabrouk, Rostom" uniqKey="Mabrouk R" first="Rostom" last="Mabrouk">Rostom Mabrouk</name></noRegion><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Jacobs, Mark F" sort="Jacobs, Mark F" uniqKey="Jacobs M" first="Mark F." last="Jacobs">Mark F. Jacobs</name><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name><name sortKey="Rusjan, Pablo M" sort="Rusjan, Pablo M" uniqKey="Rusjan P" first="Pablo M." last="Rusjan">Pablo M. Rusjan</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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