Image derived input function for [18F]-FEPPA: application to quantify translocator protein (18 kDa) in the human brain.
Identifieur interne : 000619 ( PubMed/Curation ); précédent : 000618; suivant : 000620Image derived input function for [18F]-FEPPA: application to quantify translocator protein (18 kDa) in the human brain.
Auteurs : Rostom Mabrouk [Canada] ; Pablo M. Rusjan [Canada] ; Romina Mizrahi [Canada] ; Mark F. Jacobs [Canada] ; Yuko Koshimori [Canada] ; Sylvain Houle [Canada] ; Ji Hyun Ko [Canada] ; Antonio P. Strafella [Canada]Source :
- PloS one [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Receptors, GABA.
- metabolism : Brain, Receptors, GABA.
- methods : Positron-Emission Tomography.
- Adult, Aged, Algorithms, Female, Genotype, Humans, Kinetics, Linear Models, Male, Middle Aged, Polymorphism, Genetic, Principal Component Analysis, Software.
Abstract
In [18F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V(T)) by CS-IF and ICA-IF were compared to the reference V(T) obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V(T) values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r² = 0.91 (p<0.05), and r² = 0.71 (p<0.05) using CS-IF.
DOI: 10.1371/journal.pone.0115768
PubMed: 25549260
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Strafella</name><affiliation wicri:level="1"><nlm:affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit, E.J. 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Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V(T)) by CS-IF and ICA-IF were compared to the reference V(T) obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V(T) values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r² = 0.91 (p<0.05), and r² = 0.71 (p<0.05) using CS-IF.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25549260</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>31</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>23</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>12</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Image derived input function for [18F]-FEPPA: application to quantify translocator protein (18 kDa) in the human brain.</ArticleTitle><Pagination><MedlinePgn>e115768</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0115768</ELocationID><Abstract><AbstractText>In [18F]-FEPPA positron emission topography (PET) imaging, automatic blood sampling system (ABSS) is currently the gold standard to obtain the blood time activity curve (TAC) required to extract the input function (IF). Here, we compare the performance of two image-based methods of IF extraction to the ABSS gold standard method for the quantification of translocator protein (TSPO) in the human brain. The IFs were obtained from a direct delineation of the internal carotid signal (CS) and a new concept of independent component analysis (ICA). PET scans were obtained from 18 healthy volunteers. The estimated total distribution volume (V(T)) by CS-IF and ICA-IF were compared to the reference V(T) obtained by ABSS-IF in the frontal and temporal cortex, cerebellum, striatum and thalamus regions. The V(T) values estimated using ICA-IF were more reliable than CS-IF for all brain regions. Specifically, the slope regression in the frontal cortex with ICA-IF was r² = 0.91 (p<0.05), and r² = 0.71 (p<0.05) using CS-IF.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mabrouk</LastName><ForeName>Rostom</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rusjan</LastName><ForeName>Pablo M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mizrahi</LastName><ForeName>Romina</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobs</LastName><ForeName>Mark F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koshimori</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houle</LastName><ForeName>Sylvain</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ko</LastName><ForeName>Ji Hyun</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strafella</LastName><ForeName>Antonio P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Toronto, Canada; Division of Brain, Imaging and Behaviour, Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>INE 117891</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018079">Receptors, GABA</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C499229">TSPO protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2007 Apr;48(4):573-81</RefSource><PMID Version="1">17401094</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2007 Jan;48(1):158-67</RefSource><PMID Version="1">17204713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9</RefSource><PMID Version="1">17519979</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2007 Nov;48(11):1853-61</RefSource><PMID Version="1">17978354</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Chem. 2008 Jan 10;51(1):17-30</RefSource><PMID Version="1">18067245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2008 Feb 1;39(3):1041-50</RefSource><PMID Version="1">18042494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucl Med Biol. 2008 Apr;35(3):305-14</RefSource><PMID Version="1">18355686</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2008 Aug;49(8):1249-56</RefSource><PMID Version="1">18632810</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2009 Jul;50(7):1047-53</RefSource><PMID Version="1">19525468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2009 Oct;66(10):1288-9</RefSource><PMID Version="1">19822787</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2010 Feb 15;49(4):2924-32</RefSource><PMID Version="1">19948230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1539-50</RefSource><PMID Version="1">20437239</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2011 Jan;52(1):24-32</RefSource><PMID Version="1">21149489</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Nucl Med Mol Imaging. 2009 Dec;36(12):1960-7</RefSource><PMID Version="1">19672593</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2011 Aug;31(8):1807-16</RefSource><PMID Version="1">21522163</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2011 Oct;31(10):1986-98</RefSource><PMID Version="1">21811289</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2012 Jan;32(1):1-5</RefSource><PMID Version="1">22008728</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2012 Feb;53(2):234-40</RefSource><PMID Version="1">22238156</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 2012 Jun;32(6):968-72</RefSource><PMID Version="1">22472607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2012 Aug 1;62(1):199-206</RefSource><PMID Version="1">22579604</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Comput Med Imaging Graph. 2012 Sep;36(6):484-91</RefSource><PMID Version="1">22658459</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Biomed Eng. 2013 Jan;60(1):63-71</RefSource><PMID Version="1">23060316</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2013 Jul;136(Pt 7):2228-38</RefSource><PMID Version="1">23775979</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neural Netw. 2000 May-Jun;13(4-5):411-30</RefSource><PMID Version="1">10946390</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucl Med Biol. 2000 Aug;27(6):627-30</RefSource><PMID Version="1">11056380</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 2001 Nov;42(11):1622-9</RefSource><PMID Version="1">11696630</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2004 Apr;15(3):601-9</RefSource><PMID Version="1">15056468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Synapse. 2004 Jun 15;52(4):283-91</RefSource><PMID Version="1">15103694</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 1979 Apr;20(4):328-34</RefSource><PMID Version="1">119833</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nucl Med. 1989 Jun;30(6):1069-78</RefSource><PMID Version="1">2786948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cereb Blood Flow Metab. 1990 Sep;10(5):740-7</RefSource><PMID Version="1">2384545</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 1991 Oct 11;19(19):5444</RefSource><PMID Version="1">1681511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 1996 Aug;19(8):312-8</RefSource><PMID Version="1">8843599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 1997;5(2):119-23</RefSource><PMID Version="1">10096416</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2005 Feb;57(2):168-75</RefSource><PMID Version="1">15668962</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Biomed Eng. 2005 Feb;52(2):201-10</RefSource><PMID Version="1">15709657</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2006 Feb;21(2):404-12</RefSource><PMID Version="1">16182554</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychiatry Res. 2006 Jun 30;147(1):79-89</RefSource><PMID Version="1">16797168</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Med Imaging. 2007 Jun;26(6):789-803</RefSource><PMID Version="1">17679330</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016014" MajorTopicYN="N">Linear Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025341" MajorTopicYN="N">Principal Component Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018079" MajorTopicYN="N">Receptors, GABA</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4280118</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25549260</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0115768</ArticleId><ArticleId IdType="pii">PONE-D-14-33268</ArticleId><ArticleId IdType="pmc">PMC4280118</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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