Stem cell‐based cell therapy for Huntington disease: A review
Identifieur interne : 001D52 ( Istex/Corpus ); précédent : 001D51; suivant : 001D53Stem cell‐based cell therapy for Huntington disease: A review
Auteurs : Manho Kim ; Soon-Tae Lee ; Kon Chu ; Seung U. KimSource :
- Neuropathology [ 0919-6544 ] ; 2008-02.
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- KwdEn :
Abstract
Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell‐based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.
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DOI: 10.1111/j.1440-1789.2007.00858.x
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ISTEX:229F12C2C01674694E867419F1457EAC253121E4Le document en format XML
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Kim</name><affiliation><mods:affiliation>Institute for Regenerative Medicine, Gachon University School of Medicine, Inchon, Korea, and</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: sukim@interchange.ubc.ca</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:229F12C2C01674694E867419F1457EAC253121E4</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1440-1789.2007.00858.x</idno><idno type="url">https://api-v5.istex.fr/document/229F12C2C01674694E867419F1457EAC253121E4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001D52</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Stem cell‐based cell therapy for Huntington disease: A review</title><author><name sortKey="Kim, Manho" sort="Kim, Manho" uniqKey="Kim M" first="Manho" last="Kim">Manho Kim</name><affiliation><mods:affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</mods:affiliation></affiliation></author><author><name sortKey="Lee, Soon Ae" sort="Lee, Soon Ae" uniqKey="Lee S" first="Soon-Tae" last="Lee">Soon-Tae Lee</name><affiliation><mods:affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</mods:affiliation></affiliation></author><author><name sortKey="Chu, Kon" sort="Chu, Kon" uniqKey="Chu K" first="Kon" last="Chu">Kon Chu</name><affiliation><mods:affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</mods:affiliation></affiliation></author><author><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. 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unit="page" from="1">1</biblScope><biblScope unit="page" to="9">9</biblScope></imprint></monogr><idno type="istex">229F12C2C01674694E867419F1457EAC253121E4</idno><idno type="DOI">10.1111/j.1440-1789.2007.00858.x</idno><idno type="ArticleID">NEUP858</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell‐based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>functional recovery</term></item><item><term>Huntington disease</term></item><item><term>mesenchymal stem cell</term></item><item><term>neural stem cell</term></item><item><term>neurotrophic factors</term></item><item><term>transplantation</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/229F12C2C01674694E867419F1457EAC253121E4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Asia</publisherName><publisherLoc>Melbourne, Australia</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1440-1789</doi><issn type="print">0919-6544</issn><issn type="electronic">1440-1789</issn><idGroup><id type="product" value="NEUP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="NEUROPATHOLOGY">Neuropathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="02001"><doi origin="wiley">10.1111/neu.2007.28.issue-1</doi><numberingGroup><numbering type="journalVolume" number="28">28</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2008-02">February 2008</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="1" status="forIssue"><doi origin="wiley">10.1111/j.1440-1789.2007.00858.x</doi><idGroup><id type="unit" value="NEUP858"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">REVIEW ARTICLE</title></titleGroup><copyright>2007 Japanese Society of Neuropathology</copyright><eventGroup><event type="firstOnline" date="2007-12-07"></event><event type="publishedOnlineFinalForm" date="2007-12-07"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1">1</numbering><numbering type="pageLast" number="9">9</numbering></numberingGroup><correspondenceTo>Seung U. Kim, MD, PhD, Department of Neurology, UBC Hospital, University of British Columbia, Vancouver, BC V6T2B5, Canada. Email: <email>sukim@interchange.ubc.ca</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NEUP.NEUP858.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 11 June 2007; revised and accepted 3 August 2007.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="87"></count><count type="wordTotal" number="6563"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Stem cell‐based cell therapy for Huntington disease: A review</title><title type="shortAuthors">M Kim <i>et al.</i></title><title type="short">Stem cell‐based therapy for Huntington disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Manho</givenNames><familyName>Kim</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Soon‐Tae</givenNames><familyName>Lee</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Kon</givenNames><familyName>Chu</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2 #a3" corresponding="yes"><personName><givenNames>Seung U.</givenNames><familyName>Kim</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Institute for Regenerative Medicine, Gachon University School of Medicine, Inchon, Korea, and</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="CA"><unparsedAffiliation>Department of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">functional recovery</keyword><keyword xml:id="k2">Huntington disease</keyword><keyword xml:id="k3">mesenchymal stem cell</keyword><keyword xml:id="k4">neural stem cell</keyword><keyword xml:id="k5">neurotrophic factors</keyword><keyword xml:id="k6">transplantation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell‐based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Stem cell‐based cell therapy for Huntington disease: A review</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Stem cell‐based therapy for Huntington disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Stem cell‐based cell therapy for Huntington disease: A review</title></titleInfo><name type="personal"><namePart type="given">Manho</namePart><namePart type="family">Kim</namePart><affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Soon‐Tae</namePart><namePart type="family">Lee</namePart><affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kon</namePart><namePart type="family">Chu</namePart><affiliation>Department of Neurology, Seoul National University College of Medicine, Seoul,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Seung U.</namePart><namePart type="family">Kim</namePart><affiliation>Institute for Regenerative Medicine, Gachon University School of Medicine, Inchon, Korea, and</affiliation><affiliation>Department of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><affiliation>E-mail: sukim@interchange.ubc.ca</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle"></genre><originInfo><publisher>Blackwell Publishing Asia</publisher><place><placeTerm type="text">Melbourne, Australia</placeTerm></place><dateIssued encoding="w3cdtf">2008-02</dateIssued><edition>Received 11 June 2007; revised and accepted 3 August 2007.</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">87</extent><extent unit="words">6563</extent></physicalDescription><abstract lang="en">Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell‐based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.</abstract><subject lang="en"><genre>keywords</genre><topic>functional recovery</topic><topic>Huntington disease</topic><topic>mesenchymal stem cell</topic><topic>neural stem cell</topic><topic>neurotrophic factors</topic><topic>transplantation</topic></subject><relatedItem type="host"><titleInfo><title>Neuropathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0919-6544</identifier><identifier type="eISSN">1440-1789</identifier><identifier type="DOI">10.1111/(ISSN)1440-1789</identifier><identifier type="PublisherID">NEUP</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>1</start><end>9</end><total>9</total></extent></part></relatedItem><identifier type="istex">229F12C2C01674694E867419F1457EAC253121E4</identifier><identifier type="DOI">10.1111/j.1440-1789.2007.00858.x</identifier><identifier type="ArticleID">NEUP858</identifier><accessCondition type="use and reproduction" contentType="copyright">2007 Japanese Society of Neuropathology</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Asia</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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