Quaternized colestipol, an improved bile salt adsorbent: In vitro studies
Identifieur interne : 001508 ( Istex/Corpus ); précédent : 001507; suivant : 001509Quaternized colestipol, an improved bile salt adsorbent: In vitro studies
Auteurs : S. ClasSource :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1991-02.
Abstract
Colestipol · HCI (col‐HCI) was quaternized with methyl iodide to form col‐CH3I. The in vitro binding capacities of the quaternized and protonated resins in water and in Tris‐HCl buffer (0.0015 and 0.0025 M, pH 7.0) at ∼22 °C for sodium glycocholate (NaGC) was determined by reversed‐phase HPLC. The binding capacities were found to depend on the adsorption medium. In water, the binding capacity of col‐CH3l was 30% greater than that of its protonated form. In Tris‐HCl buffer at pH 7.0, the binding capacities of the resins were similar. When the quaternized colestipol was converted to its chloride form, the binding capacity for NaGC in Tris‐HCl increased significantly and was 30% greater than that for its protonated analogue. In Cotazym 65B‐water, a medium used to test the binding capacity of the resins in the presence of various agents (to try to simulate intestinal conditions), the binding capacity of the quaternized resin was again greater than that of its protonated form. Quaternization thus increases the in vitro binding capacity of colestipol for the glycocholate anion.
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DOI: 10.1002/jps.2600800208
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Clas</name><affiliation><mods:affiliation>Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montreal, Quebec, Canada H3A 2K6</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Paprican, 570 St. John's Blvd. Pointe‐Claire, Quebec, Canada H9R 3J9</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1D1242D7FF6F2ADE03CA47947DD82C38DC08581E</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1002/jps.2600800208</idno><idno type="url">https://api-v5.istex.fr/document/1D1242D7FF6F2ADE03CA47947DD82C38DC08581E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001508</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001508</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Quaternized colestipol, an improved bile salt adsorbent: In vitro studies</title><author><name sortKey="Clas, S" sort="Clas, S" uniqKey="Clas S" first="S." last="Clas">S. 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The in vitro binding capacities of the quaternized and protonated resins in water and in Tris‐HCl buffer (0.0015 and 0.0025 M, pH 7.0) at ∼22 °C for sodium glycocholate (NaGC) was determined by reversed‐phase HPLC. The binding capacities were found to depend on the adsorption medium. In water, the binding capacity of col‐CH3l was 30% greater than that of its protonated form. In Tris‐HCl buffer at pH 7.0, the binding capacities of the resins were similar. When the quaternized colestipol was converted to its chloride form, the binding capacity for NaGC in Tris‐HCl increased significantly and was 30% greater than that for its protonated analogue. In Cotazym 65B‐water, a medium used to test the binding capacity of the resins in the presence of various agents (to try to simulate intestinal conditions), the binding capacity of the quaternized resin was again greater than that of its protonated form. 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The binding capacities were found to depend on the adsorption medium. In water, the binding capacity of col‐CH3l was 30% greater than that of its protonated form. In Tris‐HCl buffer at pH 7.0, the binding capacities of the resins were similar. When the quaternized colestipol was converted to its chloride form, the binding capacity for NaGC in Tris‐HCl increased significantly and was 30% greater than that for its protonated analogue. In Cotazym 65B‐water, a medium used to test the binding capacity of the resins in the presence of various agents (to try to simulate intestinal conditions), the binding capacity of the quaternized resin was again greater than that of its protonated form. 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The in vitro binding capacities of the quaternized and protonated resins in water and in Tris‐HCl buffer (0.0015 and 0.0025 M, pH 7.0) at ∼22 °C for sodium glycocholate (NaGC) was determined by reversed‐phase HPLC. The binding capacities were found to depend on the adsorption medium. In water, the binding capacity of col‐CH3l was 30% greater than that of its protonated form. In Tris‐HCl buffer at pH 7.0, the binding capacities of the resins were similar. When the quaternized colestipol was converted to its chloride form, the binding capacity for NaGC in Tris‐HCl increased significantly and was 30% greater than that for its protonated analogue. In Cotazym 65B‐water, a medium used to test the binding capacity of the resins in the presence of various agents (to try to simulate intestinal conditions), the binding capacity of the quaternized resin was again greater than that of its protonated form. 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The in vitro binding capacities of the quaternized and protonated resins in water and in Tris‐HCl buffer (0.0015 and 0.0025 M, pH 7.0) at ∼22 °C for sodium glycocholate (NaGC) was determined by reversed‐phase HPLC. The binding capacities were found to depend on the adsorption medium. In water, the binding capacity of col‐CH<sub>3</sub>l was 30% greater than that of its protonated form. In Tris‐HCl buffer at pH 7.0, the binding capacities of the resins were similar. When the quaternized colestipol was converted to its chloride form, the binding capacity for NaGC in Tris‐HCl increased significantly and was 30% greater than that for its protonated analogue. In Cotazym 65B‐water, a medium used to test the binding capacity of the resins in the presence of various agents (to try to simulate intestinal conditions), the binding capacity of the quaternized resin was again greater than that of its protonated form. Quaternization thus increases the in vitro binding capacity of colestipol for the glycocholate anion.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Quaternized colestipol, an improved bile salt adsorbent: In vitro studies</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Quaternized Colestipol, an Improved Bile Salt Adsorbent</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Quaternized colestipol, an improved bile salt adsorbent: In vitro studies</title></titleInfo><name type="personal"><namePart type="given">S.‐D.</namePart><namePart type="family">Clas</namePart><affiliation>Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montreal, Quebec, Canada H3A 2K6</affiliation><affiliation>Current Address: Paprican, 570 St. John's Blvd. Pointe‐Claire, Quebec, Canada H9R 3J9</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Washington</placeTerm></place><dateIssued encoding="w3cdtf">1991-02</dateIssued><dateCaptured encoding="w3cdtf">1990-11-29</dateCaptured><dateValid encoding="w3cdtf">1990-03-27</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="references">30</extent></physicalDescription><abstract lang="en">Colestipol · HCI (col‐HCI) was quaternized with methyl iodide to form col‐CH3I. The in vitro binding capacities of the quaternized and protonated resins in water and in Tris‐HCl buffer (0.0015 and 0.0025 M, pH 7.0) at ∼22 °C for sodium glycocholate (NaGC) was determined by reversed‐phase HPLC. The binding capacities were found to depend on the adsorption medium. In water, the binding capacity of col‐CH3l was 30% greater than that of its protonated form. In Tris‐HCl buffer at pH 7.0, the binding capacities of the resins were similar. When the quaternized colestipol was converted to its chloride form, the binding capacity for NaGC in Tris‐HCl increased significantly and was 30% greater than that for its protonated analogue. In Cotazym 65B‐water, a medium used to test the binding capacity of the resins in the presence of various agents (to try to simulate intestinal conditions), the binding capacity of the quaternized resin was again greater than that of its protonated form. Quaternization thus increases the in vitro binding capacity of colestipol for the glycocholate anion.</abstract><relatedItem type="host"><titleInfo><title>Journal of Pharmaceutical Sciences</title></titleInfo><titleInfo type="abbreviated"><title>J. Pharm. 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