Folin-Ciocalteu spectrophotometric assay of ascorbic acid in pharmaceutical tablets and orange juice with pH adjustment and pre-extraction of lanthanum(III)–flavonoid complexes.
Identifieur interne : 000340 ( PubMed/Checkpoint ); précédent : 000339; suivant : 000341Folin-Ciocalteu spectrophotometric assay of ascorbic acid in pharmaceutical tablets and orange juice with pH adjustment and pre-extraction of lanthanum(III)–flavonoid complexes.
Auteurs : F Ayca Ozdemir Olgun ; Dilek Ozyurt ; Kadriye Isil Berker ; Birsen Demirata ; Resat ApakSource :
- Journal of the science of food and agriculture [ 1097-0010 ] ; 2014.
English descriptors
- KwdEn :
- Antioxidants (analysis), Ascorbic Acid (analysis), Beverages (analysis), Butanols, Chelating Agents, Citrus sinensis (chemistry), Flavonoids, Humans, Hydrogen-Ion Concentration, Hydrophobic and Hydrophilic Interactions, Ions, Lanthanum, Oxidation-Reduction, Pharmaceutical Preparations, Phenols, Reproducibility of Results, Spectrophotometry (methods), Tablets (chemistry).
- MESH :
- chemical , analysis : Antioxidants, Ascorbic Acid.
- analysis : Beverages.
- chemistry : Citrus sinensis, Tablets.
- methods : Spectrophotometry.
- chemical : Butanols, Chelating Agents, Flavonoids, Humans, Hydrogen-Ion Concentration, Hydrophobic and Hydrophilic Interactions, Ions, Lanthanum, Oxidation-Reduction, Pharmaceutical Preparations, Phenols, Reproducibility of Results.
Abstract
This study proposes modifications to the conventional Folin-Ciocalteu (FC) spectrophotometric method for individually determining ascorbic acid (AA) in complex matrices in the presence of other phenolics and potential interferents. The conventional FC assay in the aqueous phase,which normally measures total water-soluble phenolics and other antioxidants, has recently been modified by incorporating isobutanol (iso-BuOH) in the solvent mixture for the simultaneous determination of lipophilic and hydrophilic antioxidants in foods.
DOI: 10.1002/jsfa.6569
PubMed: 24415496
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Folin-Ciocalteu spectrophotometric assay of ascorbic acid in pharmaceutical tablets and orange juice with pH adjustment and pre-extraction of lanthanum(III)–flavonoid complexes.</title><author><name sortKey="Olgun, F Ayca Ozdemir" sort="Olgun, F Ayca Ozdemir" uniqKey="Olgun F" first="F Ayca Ozdemir" last="Olgun">F Ayca Ozdemir Olgun</name></author><author><name sortKey="Ozyurt, Dilek" sort="Ozyurt, Dilek" uniqKey="Ozyurt D" first="Dilek" last="Ozyurt">Dilek Ozyurt</name></author><author><name sortKey="Berker, Kadriye Isil" sort="Berker, Kadriye Isil" uniqKey="Berker K" first="Kadriye Isil" last="Berker">Kadriye Isil Berker</name></author><author><name sortKey="Demirata, Birsen" sort="Demirata, Birsen" uniqKey="Demirata B" first="Birsen" last="Demirata">Birsen Demirata</name></author><author><name sortKey="Apak, Resat" sort="Apak, Resat" uniqKey="Apak R" first="Resat" last="Apak">Resat Apak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24415496</idno><idno type="pmid">24415496</idno><idno type="doi">10.1002/jsfa.6569</idno><idno type="wicri:Area/PubMed/Corpus">000308</idno><idno type="wicri:Area/PubMed/Curation">000308</idno><idno type="wicri:Area/PubMed/Checkpoint">000308</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Folin-Ciocalteu spectrophotometric assay of ascorbic acid in pharmaceutical tablets and orange juice with pH adjustment and pre-extraction of lanthanum(III)–flavonoid complexes.</title><author><name sortKey="Olgun, F Ayca Ozdemir" sort="Olgun, F Ayca Ozdemir" uniqKey="Olgun F" first="F Ayca Ozdemir" last="Olgun">F Ayca Ozdemir Olgun</name></author><author><name sortKey="Ozyurt, Dilek" sort="Ozyurt, Dilek" uniqKey="Ozyurt D" first="Dilek" last="Ozyurt">Dilek Ozyurt</name></author><author><name sortKey="Berker, Kadriye Isil" sort="Berker, Kadriye Isil" uniqKey="Berker K" first="Kadriye Isil" last="Berker">Kadriye Isil Berker</name></author><author><name sortKey="Demirata, Birsen" sort="Demirata, Birsen" uniqKey="Demirata B" first="Birsen" last="Demirata">Birsen Demirata</name></author><author><name sortKey="Apak, Resat" sort="Apak, Resat" uniqKey="Apak R" first="Resat" last="Apak">Resat Apak</name></author></analytic><series><title level="j">Journal of the science of food and agriculture</title><idno type="eISSN">1097-0010</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (analysis)</term><term>Ascorbic Acid (analysis)</term><term>Beverages (analysis)</term><term>Butanols</term><term>Chelating Agents</term><term>Citrus sinensis (chemistry)</term><term>Flavonoids</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Ions</term><term>Lanthanum</term><term>Oxidation-Reduction</term><term>Pharmaceutical Preparations</term><term>Phenols</term><term>Reproducibility of Results</term><term>Spectrophotometry (methods)</term><term>Tablets (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antioxidants</term><term>Ascorbic Acid</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Tablets</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Spectrophotometry</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Butanols</term><term>Chelating Agents</term><term>Flavonoids</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Ions</term><term>Lanthanum</term><term>Oxidation-Reduction</term><term>Pharmaceutical Preparations</term><term>Phenols</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study proposes modifications to the conventional Folin-Ciocalteu (FC) spectrophotometric method for individually determining ascorbic acid (AA) in complex matrices in the presence of other phenolics and potential interferents. The conventional FC assay in the aqueous phase,which normally measures total water-soluble phenolics and other antioxidants, has recently been modified by incorporating isobutanol (iso-BuOH) in the solvent mixture for the simultaneous determination of lipophilic and hydrophilic antioxidants in foods.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24415496</PMID><DateCreated><Year>2014</Year><Month>8</Month><Day>27</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2014</Year><Month>8</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1097-0010</ISSN><JournalIssue CitedMedium="Internet"><Volume>94</Volume><Issue>12</Issue><PubDate><Year>2014</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of the science of food and agriculture</Title><ISOAbbreviation>J. Sci. Food Agric.</ISOAbbreviation></Journal><ArticleTitle>Folin-Ciocalteu spectrophotometric assay of ascorbic acid in pharmaceutical tablets and orange juice with pH adjustment and pre-extraction of lanthanum(III)–flavonoid complexes.</ArticleTitle><Pagination><MedlinePgn>2401-8</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study proposes modifications to the conventional Folin-Ciocalteu (FC) spectrophotometric method for individually determining ascorbic acid (AA) in complex matrices in the presence of other phenolics and potential interferents. The conventional FC assay in the aqueous phase,which normally measures total water-soluble phenolics and other antioxidants, has recently been modified by incorporating isobutanol (iso-BuOH) in the solvent mixture for the simultaneous determination of lipophilic and hydrophilic antioxidants in foods.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Interference effects of other flavonoids and phenolics to individual AA assays were overcome by preliminary extraction–removal as their La(III) chelates into ethyl acetate (EtAc). The pH of the medium was adjusted to 3.0 in order to prevent conversion of AA into over-oxidation products further beyond the dehydroascorbic acid stage, as encountered in the conventional FC assay carried out at pH 10. This pH does not permit most phenolics to ionise, rendering their oxidation difficult.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Both methods (conventional and iso-BuOH-modified FC at pH 3, with and without La(III)/EtAc pre-extraction) were applied to the determination of ascorbic acid in pharmaceutical tablets and orange juice, showing good agreement with HPLC results. The proposed spectrophotometric methods with their low cost, simplicity, reliability, versatility and accuracy offer novelty to the determination of AA in complex matrices.</AbstractText><CopyrightInformation>© 2014 Society of Chemical Industry.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Olgun</LastName><ForeName>F Ayca Ozdemir</ForeName><Initials>FA</Initials></Author><Author ValidYN="Y"><LastName>Ozyurt</LastName><ForeName>Dilek</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Berker</LastName><ForeName>Kadriye Isil</ForeName><Initials>KI</Initials></Author><Author ValidYN="Y"><LastName>Demirata</LastName><ForeName>Birsen</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Apak</LastName><ForeName>Resat</ForeName><Initials>R</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D023361">Validation Studies</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Sci Food Agric</MedlineTA><NlmUniqueID>0376334</NlmUniqueID><ISSNLinking>0022-5142</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000440">Butanols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002614">Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007477">Ions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004364">Pharmaceutical Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013607">Tablets</NameOfSubstance></Chemical><Chemical><RegistryNumber>56F9Z98TEM</RegistryNumber><NameOfSubstance UI="C040507">isobutyl alcohol</NameOfSubstance></Chemical><Chemical><RegistryNumber>6I3K30563S</RegistryNumber><NameOfSubstance UI="D007811">Lanthanum</NameOfSubstance></Chemical><Chemical><RegistryNumber>PQ6CK8PD0R</RegistryNumber><NameOfSubstance UI="D001205">Ascorbic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic Acid</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000440" MajorTopicYN="Y">Butanols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002614" MajorTopicYN="N">Chelating Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="Y">Flavonoids</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006863" MajorTopicYN="N">Hydrogen-Ion Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057927" MajorTopicYN="N">Hydrophobic and Hydrophilic Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007477" MajorTopicYN="N">Ions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007811" MajorTopicYN="Y">Lanthanum</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004364" MajorTopicYN="N">Pharmaceutical Preparations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="Y">Phenols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013053" MajorTopicYN="N">Spectrophotometry</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013607" MajorTopicYN="N">Tablets</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>12</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>1</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24415496</ArticleId><ArticleId IdType="doi">10.1002/jsfa.6569</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Apak, Resat" sort="Apak, Resat" uniqKey="Apak R" first="Resat" last="Apak">Resat Apak</name><name sortKey="Berker, Kadriye Isil" sort="Berker, Kadriye Isil" uniqKey="Berker K" first="Kadriye Isil" last="Berker">Kadriye Isil Berker</name><name sortKey="Demirata, Birsen" sort="Demirata, Birsen" uniqKey="Demirata B" first="Birsen" last="Demirata">Birsen Demirata</name><name sortKey="Olgun, F Ayca Ozdemir" sort="Olgun, F Ayca Ozdemir" uniqKey="Olgun F" first="F Ayca Ozdemir" last="Olgun">F Ayca Ozdemir Olgun</name><name sortKey="Ozyurt, Dilek" sort="Ozyurt, Dilek" uniqKey="Ozyurt D" first="Dilek" last="Ozyurt">Dilek Ozyurt</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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