Restoration of radiation injury in mice by two Chinese medicinal prescriptions Kuei‐Pi‐Tang and Jen‐Sheng‐Yang‐Yung‐Tang
Identifieur interne : 001320 ( Istex/Corpus ); précédent : 001319; suivant : 001321Restoration of radiation injury in mice by two Chinese medicinal prescriptions Kuei‐Pi‐Tang and Jen‐Sheng‐Yang‐Yung‐Tang
Auteurs : Hsue-Yin Hsu ; Chun-Ching Lin ; Dou-Mong HauSource :
- Phytotherapy Research [ 0951-418X ] ; 1992-11.
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Abstract
A comparison of Kuei‐Pi‐Tang and Jen‐Sheng‐Yang‐Yung‐Tang, two traditional Chinese medicines, on promoting the recovery of mice from radiation‐induced damage was studied by using the measurements of colony forming stem cells in spleen, the appearance of occult blood in feces and changes of hemograms after x‐irradiation. Different sequences of x‐irradiation were studied with or without drug administration in groups of ICR strain mice which were intraperitoneally injected at a concentration of 10 or 20 mg/20 g body weight, once a day for 7 consecutive days. Kuei‐Pi‐Tang showed no significant difference on the efficacy of recovery from hemorrhage and hemograms, as compared with that of Jen‐Sheng‐Yang‐Yung‐Tang. In contrast, the effect of Kuei‐Pi‐Tang on the recovery of CPUs was more likely induced by eliminating the radiosensitivity of bone marrow cells. However, Jen‐Sheng‐Yang‐Yung‐Tang appears to increase the radiotolerance of the cells. The recovery of thrombocyte counts which was reported to have an important influence on the survival ratio coincided with that of the recovery from hemorrhage.
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DOI: 10.1002/ptr.2650060603
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ISTEX:5636835FE7B5B87190CED34365456D2B6C32A744Le document en format XML
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Different sequences of x‐irradiation were studied with or without drug administration in groups of ICR strain mice which were intraperitoneally injected at a concentration of 10 or 20 mg/20 g body weight, once a day for 7 consecutive days. Kuei‐Pi‐Tang showed no significant difference on the efficacy of recovery from hemorrhage and hemograms, as compared with that of Jen‐Sheng‐Yang‐Yung‐Tang. In contrast, the effect of Kuei‐Pi‐Tang on the recovery of CPUs was more likely induced by eliminating the radiosensitivity of bone marrow cells. However, Jen‐Sheng‐Yang‐Yung‐Tang appears to increase the radiotolerance of the cells. The recovery of thrombocyte counts which was reported to have an important influence on the survival ratio coincided with that of the recovery from hemorrhage.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hsue‐Yin Hsu</name><affiliations><json:string>School of Technology for Medical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>Chun‐Ching Lin</name><affiliations><json:string>School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan</json:string></affiliations></json:item><json:item><name>Dou‐Mong Hau</name><affiliations><json:string>Institute of Radiation Biology, National Tsing Hua University, Hsinchu, Taiwan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Kuei‐Pi‐Tang</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Jen‐Sheng‐Yang‐Yung‐Tang</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>traditional Chinese medicine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>radiation‐induced damage in mice</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CFUs</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>haemorrhage</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>haemograms</value></json:item></subject><articleId><json:string>PTR2650060603</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>A comparison of Kuei‐Pi‐Tang and Jen‐Sheng‐Yang‐Yung‐Tang, two traditional Chinese medicines, on promoting the recovery of mice from radiation‐induced damage was studied by using the measurements of colony forming stem cells in spleen, the appearance of occult blood in feces and changes of hemograms after x‐irradiation. Different sequences of x‐irradiation were studied with or without drug administration in groups of ICR strain mice which were intraperitoneally injected at a concentration of 10 or 20 mg/20 g body weight, once a day for 7 consecutive days. Kuei‐Pi‐Tang showed no significant difference on the efficacy of recovery from hemorrhage and hemograms, as compared with that of Jen‐Sheng‐Yang‐Yung‐Tang. In contrast, the effect of Kuei‐Pi‐Tang on the recovery of CPUs was more likely induced by eliminating the radiosensitivity of bone marrow cells. However, Jen‐Sheng‐Yang‐Yung‐Tang appears to increase the radiotolerance of the cells. 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