Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis
Identifieur interne : 000026 ( Pmc/Curation ); précédent : 000025; suivant : 000027Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis
Auteurs : Pei Lin ; Jianmei Lu ; Yanfang Wang ; Wen Gu ; Jie Yu ; Ronghua ZhaoSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4′-tetrahydroxy-stilbene-2-
Url:
DOI: 10.1371/journal.pone.0140346
PubMed: 26474417
PubMed Central: 4608713
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</title><author><name sortKey="Lin, Pei" sort="Lin, Pei" uniqKey="Lin P" first="Pei" last="Lin">Pei Lin</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Lu, Jianmei" sort="Lu, Jianmei" uniqKey="Lu J" first="Jianmei" last="Lu">Jianmei Lu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Wang, Yanfang" sort="Wang, Yanfang" uniqKey="Wang Y" first="Yanfang" last="Wang">Yanfang Wang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Gu, Wen" sort="Gu, Wen" uniqKey="Gu W" first="Wen" last="Gu">Wen Gu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Ronghua" sort="Zhao, Ronghua" uniqKey="Zhao R" first="Ronghua" last="Zhao">Ronghua Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26474417</idno><idno type="pmc">4608713</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608713</idno><idno type="RBID">PMC:4608713</idno><idno type="doi">10.1371/journal.pone.0140346</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000026</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000026</idno><idno type="wicri:Area/Pmc/Curation">000026</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000026</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</title><author><name sortKey="Lin, Pei" sort="Lin, Pei" uniqKey="Lin P" first="Pei" last="Lin">Pei Lin</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Lu, Jianmei" sort="Lu, Jianmei" uniqKey="Lu J" first="Jianmei" last="Lu">Jianmei Lu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Wang, Yanfang" sort="Wang, Yanfang" uniqKey="Wang Y" first="Yanfang" last="Wang">Yanfang Wang</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Gu, Wen" sort="Gu, Wen" uniqKey="Gu W" first="Wen" last="Gu">Wen Gu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Ronghua" sort="Zhao, Ronghua" uniqKey="Zhao R" first="Ronghua" last="Zhao">Ronghua Zhao</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4′-tetrahydroxy-stilbene-2-<italic>O</italic>-<italic>β</italic>-<sc>D</sc>-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moller, De" uniqKey="Moller D">DE Moller</name></author><author><name sortKey="Kaufman, Kd" uniqKey="Kaufman K">KD Kaufman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wattacheril, J" uniqKey="Wattacheril J">J Wattacheril</name></author><author><name sortKey="Chalasani, N" uniqKey="Chalasani N">N Chalasani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matteoni, Ca" uniqKey="Matteoni C">CA Matteoni</name></author><author><name sortKey="Younossi, Zm" uniqKey="Younossi Z">ZM Younossi</name></author><author><name sortKey="Gramlich, T" uniqKey="Gramlich T">T Gramlich</name></author><author><name sortKey="Boparai, N" uniqKey="Boparai N">N Boparai</name></author><author><name sortKey="Liu, Yc" uniqKey="Liu Y">YC Liu</name></author><author><name sortKey="Mccullough, Aj" uniqKey="Mccullough A">AJ McCullough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehal, Wz" uniqKey="Mehal W">WZ Mehal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chassaing, B" uniqKey="Chassaing B">B Chassaing</name></author><author><name sortKey="Etienne Mesmin, L" uniqKey="Etienne Mesmin L">L Etienne-Mesmin</name></author><author><name sortKey="Gewirtz, At" uniqKey="Gewirtz A">AT Gewirtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machado, Mv" uniqKey="Machado M">MV Machado</name></author><author><name sortKey="Cortez Pinto, H" uniqKey="Cortez Pinto H">H Cortez-Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miura, K" uniqKey="Miura K">K Miura</name></author><author><name sortKey="Seki, E" uniqKey="Seki E">E Seki</name></author><author><name sortKey="Ohnishi, H" uniqKey="Ohnishi H">H Ohnishi</name></author><author><name sortKey="Brenner, Da" uniqKey="Brenner D">DA Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broering, R" uniqKey="Broering R">R Broering</name></author><author><name sortKey="Lu, M" uniqKey="Lu M">M Lu</name></author><author><name sortKey="Schlaak, Jf" uniqKey="Schlaak J">JF Schlaak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heinrichsdorff, J" uniqKey="Heinrichsdorff J">J Heinrichsdorff</name></author><author><name sortKey="Olefsky, Jm" uniqKey="Olefsky J">JM Olefsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorkbacka, H" uniqKey="Bjorkbacka H">H Björkbacka</name></author><author><name sortKey="Kunjathoor, Vv" uniqKey="Kunjathoor V">VV Kunjathoor</name></author><author><name sortKey="Moore, Kj" uniqKey="Moore K">KJ Moore</name></author><author><name sortKey="Koehn, S" uniqKey="Koehn S">S Koehn</name></author><author><name sortKey="Ordija, Cm" uniqKey="Ordija C">CM Ordija</name></author><author><name sortKey="Lee, Ma" uniqKey="Lee M">MA Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seki, E" uniqKey="Seki E">E Seki</name></author><author><name sortKey="Brenner, Da" uniqKey="Brenner D">DA Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zivkovic, Am" uniqKey="Zivkovic A">AM Zivkovic</name></author><author><name sortKey="German, Jb" uniqKey="German J">JB German</name></author><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bugianesi, E" uniqKey="Bugianesi E">E Bugianesi</name></author><author><name sortKey="Gentilcore, E" uniqKey="Gentilcore E">E Gentilcore</name></author><author><name sortKey="Manini, R" uniqKey="Manini R">R Manini</name></author><author><name sortKey="Natale, S" uniqKey="Natale S">S Natale</name></author><author><name sortKey="Vanni, E" uniqKey="Vanni E">E Vanni</name></author><author><name sortKey="Villanova, N" uniqKey="Villanova N">N Villanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belfort, R" uniqKey="Belfort R">R Belfort</name></author><author><name sortKey="Harrison, Sa" uniqKey="Harrison S">SA Harrison</name></author><author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name></author><author><name sortKey="Darland, C" uniqKey="Darland C">C Darland</name></author><author><name sortKey="Finch, J" uniqKey="Finch J">J Finch</name></author><author><name sortKey="Hardies, J" uniqKey="Hardies J">J Hardies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name></author><author><name sortKey="Chalasani, N" uniqKey="Chalasani N">N Chalasani</name></author><author><name sortKey="Kowdley, Kv" uniqKey="Kowdley K">KV Kowdley</name></author><author><name sortKey="Mccullough, A" uniqKey="Mccullough A">A McCullough</name></author><author><name sortKey="Diehl, Am" uniqKey="Diehl A">AM Diehl</name></author><author><name sortKey="Bass, Nm" uniqKey="Bass N">NM Bass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chalasani, N" uniqKey="Chalasani N">N Chalasani</name></author><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Lavine, Je" uniqKey="Lavine J">JE Lavine</name></author><author><name sortKey="Diehl, Am" uniqKey="Diehl A">AM Diehl</name></author><author><name sortKey="Brunt, Em" uniqKey="Brunt E">EM Brunt</name></author><author><name sortKey="Cusi, K" uniqKey="Cusi K">K Cusi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baur, Ja" uniqKey="Baur J">JA Baur</name></author><author><name sortKey="Pearson, Kj" uniqKey="Pearson K">KJ Pearson</name></author><author><name sortKey="Price, Nl" uniqKey="Price N">NL Price</name></author><author><name sortKey="Jamieson, Ha" uniqKey="Jamieson H">HA Jamieson</name></author><author><name sortKey="Lerin, C" uniqKey="Lerin C">C Lerin</name></author><author><name sortKey="Kalra, A" uniqKey="Kalra A">A Kalra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito Nagahata, T" uniqKey="Ito Nagahata T">T Ito-Nagahata</name></author><author><name sortKey="Kurihara, C" uniqKey="Kurihara C">C Kurihara</name></author><author><name sortKey="Hasebe, M" uniqKey="Hasebe M">M Hasebe</name></author><author><name sortKey="Ishii, A" uniqKey="Ishii A">A Ishii</name></author><author><name sortKey="Yamashita, K" uniqKey="Yamashita K">K Yamashita</name></author><author><name sortKey="Iwabuchi, M" uniqKey="Iwabuchi M">M Iwabuchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Pang, X" uniqKey="Pang X">X Pang</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Kang, C" uniqKey="Kang C">C Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Wg" uniqKey="Wang W">WG Wang</name></author><author><name sortKey="He, Yr" uniqKey="He Y">YR He</name></author><author><name sortKey="Lin, P" uniqKey="Lin P">P Lin</name></author><author><name sortKey="Li, Yf" uniqKey="Li Y">YF Li</name></author><author><name sortKey="Sun, Rf" uniqKey="Sun R">RF Sun</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, F" uniqKey="Sun F">F Sun</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldsmith, Jr" uniqKey="Goldsmith J">JR Goldsmith</name></author><author><name sortKey="Sartor, Rb" uniqKey="Sartor R">RB Sartor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, L" uniqKey="Zhong L">L Zhong</name></author><author><name sortKey="Fan, Jg" uniqKey="Fan J">JG Fan</name></author><author><name sortKey="Wang, Gl" uniqKey="Wang G">GL Wang</name></author><author><name sortKey="Wu, Wq" uniqKey="Wu W">WQ Wu</name></author><author><name sortKey="Jiang, Jm" uniqKey="Jiang J">JM Jiang</name></author><author><name sortKey="Shi, Q" uniqKey="Shi Q">Q Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, Jg" uniqKey="Fan J">JG Fan</name></author><author><name sortKey="Zhong, L" uniqKey="Zhong L">L Zhong</name></author><author><name sortKey="Xu, Zj" uniqKey="Xu Z">ZJ Xu</name></author><author><name sortKey="Tia, Ly" uniqKey="Tia L">LY Tia</name></author><author><name sortKey="Ding, Xd" uniqKey="Ding X">XD Ding</name></author><author><name sortKey="Li, Ms" uniqKey="Li M">MS Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashburne, M" uniqKey="Ashburne M">M Ashburne</name></author><author><name sortKey="Ball, Ca" uniqKey="Ball C">CA Ball</name></author><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name></author><author><name sortKey="Botstein, D" uniqKey="Botstein D">D Botstein</name></author><author><name sortKey="Butler, H" uniqKey="Butler H">H Butler</name></author><author><name sortKey="Cherry, Jm" uniqKey="Cherry J">JM Cherry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caporaso, Jg" uniqKey="Caporaso J">JG Caporaso</name></author><author><name sortKey="Kuczynski, J" uniqKey="Kuczynski J">J Kuczynski</name></author><author><name sortKey="Stombaugh, J" uniqKey="Stombaugh J">J Stombaugh</name></author><author><name sortKey="Bittinger, K" uniqKey="Bittinger K">K Bittinger</name></author><author><name sortKey="Bushman, Fd" uniqKey="Bushman F">FD Bushman</name></author><author><name sortKey="Costello, Ek" uniqKey="Costello E">EK Costello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mago, T" uniqKey="Mago T">T Magoč</name></author><author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Chi, Y" uniqKey="Chi Y">Y Chi</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Jr" uniqKey="Turner J">JR Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuhashi, M" uniqKey="Furuhashi M">M Furuhashi</name></author><author><name sortKey="Hotamisligil, Gs" uniqKey="Hotamisligil G">GS Hotamisligil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stahl, A" uniqKey="Stahl A">A Stahl</name></author><author><name sortKey="Gimeno, Re" uniqKey="Gimeno R">RE Gimeno</name></author><author><name sortKey="Tartaglia, La" uniqKey="Tartaglia L">LA Tartaglia</name></author><author><name sortKey="Lodish, Hf" uniqKey="Lodish H">HF Lodish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, A" uniqKey="Feng A">A Feng</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Lin, P" uniqKey="Lin P">P Lin</name></author><author><name sortKey="Lu, Jm" uniqKey="Lu J">JM Lu</name></author><author><name sortKey="Wang, Wg" uniqKey="Wang W">WG Wang</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author><author><name sortKey="Zhao, Rh" uniqKey="Zhao R">RH Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, X" uniqKey="Dai X">X Dai</name></author><author><name sortKey="Lv, Z" uniqKey="Lv Z">Z Lv</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivera, Ca" uniqKey="Rivera C">CA Rivera</name></author><author><name sortKey="Adegboyega, P" uniqKey="Adegboyega P">P Adegboyega</name></author><author><name sortKey="Rooijen, Nv" uniqKey="Rooijen N">NV Rooijen</name></author><author><name sortKey="Tagalicud, A" uniqKey="Tagalicud A">A Tagalicud</name></author><author><name sortKey="Allman, M" uniqKey="Allman M">M Allman</name></author><author><name sortKey="Wallace, M" uniqKey="Wallace M">M Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baffy, G" uniqKey="Baffy G">G Baffy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tilg, H" uniqKey="Tilg H">H Tilg</name></author><author><name sortKey="Moschen, Ar" uniqKey="Moschen A">AR Moschen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26474417</article-id><article-id pub-id-type="pmc">4608713</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0140346</article-id><article-id pub-id-type="publisher-id">PONE-D-15-26079</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Naturally Occurring Stilbenoid TSG Reverses Non-Alcoholic Fatty Liver Diseases via Gut-Liver Axis</article-title><alt-title alt-title-type="running-head">TSG Reverses NAFLD via Gut-Liver Axis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Pei</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Jianmei</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yanfang</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Gu</surname><given-names>Wen</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Jie</given-names></name><xref rid="cor001" ref-type="corresp">*</xref><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Ronghua</given-names></name><xref rid="cor001" ref-type="corresp">*</xref><xref ref-type="aff" rid="aff001"></xref></contrib></contrib-group><aff id="aff001"><addr-line>Department of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Hribal</surname><given-names>Marta Letizia</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Catanzaro Magna Graecia, ITALY</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: PL JY RHZ. Performed the experiments: PL JML YFW. Analyzed the data: PL WG. Contributed reagents/materials/analysis tools: JML YFW. Wrote the paper: PL JY.</p></fn><corresp id="cor001">* E-mail: <email>cz.yujie@gmail.com</email> (JY); <email>kmzhaoronghua@hotmail.com</email> (RH.Z)</corresp></author-notes><pub-date pub-type="epub"><day>16</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>10</volume><issue>10</issue><elocation-id>e0140346</elocation-id><history><date date-type="received"><day>16</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>24</day><month>9</month><year>2015</year></date></history><permissions><copyright-year>2015</copyright-year><copyright-holder>Lin et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0140346.pdf"></self-uri><abstract><p>The gut-liver axis is largely involved in the development of non-alcoholic fatty liver disease (NAFLD). We investigated whether 2, 3, 5, 4′-tetrahydroxy-stilbene-2-<italic>O</italic>-<italic>β</italic>-<sc>D</sc>-glucoside (TSG) could reverse NAFLD induced by a high-fat diet (HFD) and whether it did so via the gut-liver axis. Results showed that TSG could reduce the accumulation of FFA and it did so by reducing the expression of L-FABP and FATP4. TSG regulated gut microbiota balanced and increased the protein expression of ZO-1 and occludin, which could improve the function of the intestinal mucosal barrier and reduce serum LPS content by about 25%. TSG reduced TL4 levels by 56% and NF-κB expression by 23% relative to the NAFLD model group. This suggests that prevention of NAFLD by TSG in HFD-fed rats is mediated by modulation of the gut microbiota and TLR4/NF-κB pathway, which may alleviate chronic low-grade inflammation by reducing the exogenous antigen load on the host.</p></abstract><funding-group><funding-statement>This research was financially supported by the National Natural Science Foundation of China (Grant no. 81060337, Grant no. 81260553, and Grant no. 81460623), the Natural Science Foundation of Yunnan Province (Grant no. 2014FA035 and Grant no. 2012FD043) and the Southern Medicine Collaborative And Innovation Center (30270100500). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="5"></fig-count><table-count count="1"></table-count><page-count count="14"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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