The significance of nitrogen cost minimization in proteomes of marine microorganisms
Identifieur interne : 000646 ( Main/Merge ); précédent : 000645; suivant : 000647The significance of nitrogen cost minimization in proteomes of marine microorganisms
Auteurs : Joseph J. Grzymski [États-Unis] ; Alex M. Dussaq [États-Unis]Source :
- The ISME Journal [ 1751-7362 ] ; 2011.
Abstract
Marine microorganisms thrive under low levels of nitrogen (N). N cost minimization is a major selective pressure imprinted on open-ocean microorganism genomes. Here we show that amino-acid sequences from the open ocean are reduced in N, but increased in average mass compared with coastal-ocean microorganisms. Nutrient limitation exerts significant pressure on organisms supporting the trade-off between N cost minimization and increased average mass of amino acids that is a function of increased A+T codon usage. N cost minimization, especially of highly expressed proteins, reduces the total cellular N budget by 2.7–10% this minimization in combination with reduction in genome size and cell size is an evolutionary adaptation to nutrient limitation. The biogeochemical and evolutionary precedent for these findings suggests that N limitation is a stronger selective force in the ocean than biosynthetic costs and is an important evolutionary strategy in resource-limited ecosystems.
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DOI: 10.1038/ismej.2011.72
PubMed: 21697958
PubMed Central: 3246230
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Grzymski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Earth and Ecosystem Sciences, Desert Research Institute</institution>, Reno, NV,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dussaq, Alex M" sort="Dussaq, Alex M" uniqKey="Dussaq A" first="Alex M" last="Dussaq">Alex M. Dussaq</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Earth and Ecosystem Sciences, Desert Research Institute</institution>, Reno, NV,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">The ISME Journal</title><idno type="ISSN">1751-7362</idno><idno type="eISSN">1751-7370</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Marine microorganisms thrive under low levels of nitrogen (N). N cost minimization is a major selective pressure imprinted on open-ocean microorganism genomes. Here we show that amino-acid sequences from the open ocean are reduced in N, but increased in average mass compared with coastal-ocean microorganisms. Nutrient limitation exerts significant pressure on organisms supporting the trade-off between N cost minimization and increased average mass of amino acids that is a function of increased A+T codon usage. N cost minimization, especially of highly expressed proteins, reduces the total cellular N budget by 2.7–10% this minimization in combination with reduction in genome size and cell size is an evolutionary adaptation to nutrient limitation. 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