Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort
Identifieur interne : 000867 ( Ncbi/Merge ); précédent : 000866; suivant : 000868Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort
Auteurs : Emmanuelle Kesse-Guyot [France] ; Valentina A. Andreeva [France] ; Claude Jeandel [France] ; Monique Ferry [France] ; Mathilde Touvier [France] ; Serge Hercberg [France] ; Pilar Galan [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.
To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.
3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996
In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.
In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.
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DOI: 10.1371/journal.pone.0052311
PubMed: 23284983
PubMed Central: 3526526
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Andreeva</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Jeandel, Claude" sort="Jeandel, Claude" uniqKey="Jeandel C" first="Claude" last="Jeandel">Claude Jeandel</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ferry, Monique" sort="Ferry, Monique" uniqKey="Ferry M" first="Monique" last="Ferry">Monique Ferry</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Département de Santé Publique, Hôpital Avicenne, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Santé Publique, Hôpital Avicenne, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.</p></sec><sec><title>Objective</title><p>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.</p></sec><sec><title>Methods</title><p>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996<bold>.</bold> Cognitive performance was assessed in 2007–2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean = 50, SD = 10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).</p></sec><sec><title>Results</title><p>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.</p></sec><sec><title>Conclusion</title><p>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT00272428">NCT00272428</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Middleton, Le" uniqKey="Middleton L">LE Middleton</name></author><author><name sortKey="Yaffe, K" uniqKey="Yaffe K">K Yaffe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Coley, N" uniqKey="Coley N">N Coley</name></author><author><name sortKey="Andrieu, S" uniqKey="Andrieu S">S Andrieu</name></author><author><name sortKey="Gardette, V" uniqKey="Gardette V">V Gardette</name></author><author><name sortKey="Gillette Guyonnet, S" uniqKey="Gillette Guyonnet S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23284983</article-id><article-id pub-id-type="pmc">3526526</article-id><article-id pub-id-type="publisher-id">PONE-D-12-29046</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0052311</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Neuroscience</subject><subj-group><subject>Cognitive Neuroscience</subject><subj-group><subject>Cognition</subject></subj-group></subj-group></subj-group><subj-group><subject>Population Biology</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Epidemiology of Aging</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Clinical Research Design</subject><subj-group><subject>Epidemiology</subject><subject>Longitudinal Studies</subject></subj-group></subj-group><subj-group><subject>Epidemiology</subject><subj-group><subject>Epidemiology of Aging</subject></subj-group></subj-group><subj-group><subject>Nutrition</subject></subj-group><subj-group><subject>Public Health</subject><subj-group><subject>Alcohol</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort</article-title><alt-title alt-title-type="running-head">Alcohol and Cognition</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kesse-Guyot</surname><given-names>Emmanuelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andreeva</surname><given-names>Valentina A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jeandel</surname><given-names>Claude</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ferry</surname><given-names>Monique</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Touvier</surname><given-names>Mathilde</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hercberg</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Galan</surname><given-names>Pilar</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Département de Santé Publique, Hôpital Avicenne, Bobigny, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Manzoli</surname><given-names>Lamberto</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Chieti, Italy</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>e.kesse@uren.smbh.univ-paris13.fr</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors declare that commercial funding received from Médéric, Sodexo, Ipsen, MGEN and Pierre Fabre, as mentioned in the Financial Disclosure, does not alter in any way the authors' adherence to all the PLOS ONE policies on sharing data and materials.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: SH PG EKG. Analyzed the data: EKG. Wrote the paper: EKG. Involved in interpreting results and editing the manuscript: VAA CJ MF MT SH PG.</p></fn></author-notes><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>12</month><year>2012</year></pub-date><volume>7</volume><issue>12</issue><elocation-id>e52311</elocation-id><history><date date-type="received"><day>19</day><month>9</month><year>2012</year></date><date date-type="accepted"><day>16</day><month>11</month><year>2012</year></date></history><permissions><copyright-year>2012</copyright-year><copyright-holder>Kesse-Guyot et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.</p></sec><sec><title>Objective</title><p>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.</p></sec><sec><title>Methods</title><p>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996<bold>.</bold> Cognitive performance was assessed in 2007–2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean = 50, SD = 10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).</p></sec><sec><title>Results</title><p>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.</p></sec><sec><title>Conclusion</title><p>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT00272428">NCT00272428</ext-link></p></sec></abstract><funding-group><funding-statement>This work was funded by the French National Research Agency (n°ANR-05-PNRA-010), the French Ministry of Health, Médéric, Sodexo, Ipsen, MGEN and Pierre Fabre. Mederic and MGEN are French health insurance organizations, which are complementary to the National Health Insurance System. Ipsen and Pierre Fabre are private pharmaceutical companies. Sodexo, a food catering company, supported the study by organizing meetings between researchers and study participants. Sponsors were not involved in the analysis or interpretation of findings. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="11"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Montpellier</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Kesse Guyot, Emmanuelle" sort="Kesse Guyot, Emmanuelle" uniqKey="Kesse Guyot E" first="Emmanuelle" last="Kesse-Guyot">Emmanuelle Kesse-Guyot</name></region><name sortKey="Andreeva, Valentina A" sort="Andreeva, Valentina A" uniqKey="Andreeva V" first="Valentina A." last="Andreeva">Valentina A. Andreeva</name><name sortKey="Ferry, Monique" sort="Ferry, Monique" uniqKey="Ferry M" first="Monique" last="Ferry">Monique Ferry</name><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><name sortKey="Jeandel, Claude" sort="Jeandel, Claude" uniqKey="Jeandel C" first="Claude" last="Jeandel">Claude Jeandel</name><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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