Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort
Identifieur interne : 000521 ( Pmc/Corpus ); précédent : 000520; suivant : 000522Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort
Auteurs : Emmanuelle Kesse-Guyot ; Valentina A. Andreeva ; Claude Jeandel ; Monique Ferry ; Mathilde Touvier ; Serge Hercberg ; Pilar GalanSource :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.
To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.
3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996
In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.
In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.
ClinicalTrials.gov
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DOI: 10.1371/journal.pone.0052311
PubMed: 23284983
PubMed Central: 3526526
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort</title><author><name sortKey="Kesse Guyot, Emmanuelle" sort="Kesse Guyot, Emmanuelle" uniqKey="Kesse Guyot E" first="Emmanuelle" last="Kesse-Guyot">Emmanuelle Kesse-Guyot</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andreeva, Valentina A" sort="Andreeva, Valentina A" uniqKey="Andreeva V" first="Valentina A." last="Andreeva">Valentina A. Andreeva</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jeandel, Claude" sort="Jeandel, Claude" uniqKey="Jeandel C" first="Claude" last="Jeandel">Claude Jeandel</name><affiliation><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ferry, Monique" sort="Ferry, Monique" uniqKey="Ferry M" first="Monique" last="Ferry">Monique Ferry</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><addr-line>Département de Santé Publique, Hôpital Avicenne, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23284983</idno><idno type="pmc">3526526</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526526</idno><idno type="RBID">PMC:3526526</idno><idno type="doi">10.1371/journal.pone.0052311</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000521</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000521</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort</title><author><name sortKey="Kesse Guyot, Emmanuelle" sort="Kesse Guyot, Emmanuelle" uniqKey="Kesse Guyot E" first="Emmanuelle" last="Kesse-Guyot">Emmanuelle Kesse-Guyot</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Andreeva, Valentina A" sort="Andreeva, Valentina A" uniqKey="Andreeva V" first="Valentina A." last="Andreeva">Valentina A. Andreeva</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Jeandel, Claude" sort="Jeandel, Claude" uniqKey="Jeandel C" first="Claude" last="Jeandel">Claude Jeandel</name><affiliation><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ferry, Monique" sort="Ferry, Monique" uniqKey="Ferry M" first="Monique" last="Ferry">Monique Ferry</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><addr-line>Département de Santé Publique, Hôpital Avicenne, Bobigny, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.</p></sec><sec><title>Objective</title><p>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.</p></sec><sec><title>Methods</title><p>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996<bold>.</bold> Cognitive performance was assessed in 2007–2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean = 50, SD = 10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).</p></sec><sec><title>Results</title><p>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.</p></sec><sec><title>Conclusion</title><p>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT00272428">NCT00272428</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Middleton, Le" uniqKey="Middleton L">LE Middleton</name></author><author><name sortKey="Yaffe, K" uniqKey="Yaffe K">K Yaffe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Coley, N" uniqKey="Coley N">N Coley</name></author><author><name sortKey="Andrieu, S" uniqKey="Andrieu S">S Andrieu</name></author><author><name sortKey="Gardette, V" uniqKey="Gardette V">V Gardette</name></author><author><name sortKey="Gillette Guyonnet, S" uniqKey="Gillette Guyonnet S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23284983</article-id><article-id pub-id-type="pmc">3526526</article-id><article-id pub-id-type="publisher-id">PONE-D-12-29046</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0052311</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Neuroscience</subject><subj-group><subject>Cognitive Neuroscience</subject><subj-group><subject>Cognition</subject></subj-group></subj-group></subj-group><subj-group><subject>Population Biology</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Epidemiology of Aging</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Clinical Research Design</subject><subj-group><subject>Epidemiology</subject><subject>Longitudinal Studies</subject></subj-group></subj-group><subj-group><subject>Epidemiology</subject><subj-group><subject>Epidemiology of Aging</subject></subj-group></subj-group><subj-group><subject>Nutrition</subject></subj-group><subj-group><subject>Public Health</subject><subj-group><subject>Alcohol</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort</article-title><alt-title alt-title-type="running-head">Alcohol and Cognition</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kesse-Guyot</surname><given-names>Emmanuelle</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Andreeva</surname><given-names>Valentina A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jeandel</surname><given-names>Claude</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ferry</surname><given-names>Monique</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Touvier</surname><given-names>Mathilde</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hercberg</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Galan</surname><given-names>Pilar</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Département de Santé Publique, Hôpital Avicenne, Bobigny, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Manzoli</surname><given-names>Lamberto</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Chieti, Italy</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>e.kesse@uren.smbh.univ-paris13.fr</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors declare that commercial funding received from Médéric, Sodexo, Ipsen, MGEN and Pierre Fabre, as mentioned in the Financial Disclosure, does not alter in any way the authors' adherence to all the PLOS ONE policies on sharing data and materials.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: SH PG EKG. Analyzed the data: EKG. Wrote the paper: EKG. Involved in interpreting results and editing the manuscript: VAA CJ MF MT SH PG.</p></fn></author-notes><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>12</month><year>2012</year></pub-date><volume>7</volume><issue>12</issue><elocation-id>e52311</elocation-id><history><date date-type="received"><day>19</day><month>9</month><year>2012</year></date><date date-type="accepted"><day>16</day><month>11</month><year>2012</year></date></history><permissions><copyright-year>2012</copyright-year><copyright-holder>Kesse-Guyot et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.</p></sec><sec><title>Objective</title><p>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.</p></sec><sec><title>Methods</title><p>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996<bold>.</bold> Cognitive performance was assessed in 2007–2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean = 50, SD = 10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).</p></sec><sec><title>Results</title><p>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.</p></sec><sec><title>Conclusion</title><p>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT00272428">NCT00272428</ext-link></p></sec></abstract><funding-group><funding-statement>This work was funded by the French National Research Agency (n°ANR-05-PNRA-010), the French Ministry of Health, Médéric, Sodexo, Ipsen, MGEN and Pierre Fabre. Mederic and MGEN are French health insurance organizations, which are complementary to the National Health Insurance System. Ipsen and Pierre Fabre are private pharmaceutical companies. Sodexo, a food catering company, supported the study by organizing meetings between researchers and study participants. Sponsors were not involved in the analysis or interpretation of findings. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="11"></page-count></counts></article-meta></front><body><sec id="s1"><title>Introduction</title><p>At present, treatments to cure or slow the progression of cognitive decline and dementia are not available, arguing for a focus on prevention through health behaviors including physical, social, and cognitive activities, and dietary intake <xref ref-type="bibr" rid="pone.0052311-Middleton1">[1]</xref>–<xref ref-type="bibr" rid="pone.0052311-Coley1">[3]</xref>. Among these modifiable factors, alcohol consumption is of major concern because it is a well-known risk factor for many chronic diseases including fetal alcohol syndrome, neuropsychiatric disorders, cancer, and also for certain risk behaviors (eg, driving under the influence) and injuries <xref ref-type="bibr" rid="pone.0052311-WHO1">[4]</xref>–<xref ref-type="bibr" rid="pone.0052311-Parry1">[6]</xref>. A more complex relationship has been reported between level of alcohol consumption and cardiovascular disease, as light-to-moderate drinking may in fact display beneficial effects <xref ref-type="bibr" rid="pone.0052311-WHO1">[4]</xref>, <xref ref-type="bibr" rid="pone.0052311-Parry1">[6]</xref>.</p><p>The association between cognitive function or risk of dementia and alcohol consumption has received a great deal of attention over the past few decades and several reviews of scientific evidence have recently become available <xref ref-type="bibr" rid="pone.0052311-Neafsey1">[7]</xref>–<xref ref-type="bibr" rid="pone.0052311-Panza1">[9]</xref>. In particular, the importance of evaluating the sex-specific associations has been highlighted because of fundamental differences between men and women in alcohol consumption patterns and their impact on health/functioning <xref ref-type="bibr" rid="pone.0052311-Panza1">[9]</xref><monospace>.</monospace></p><p>The most consistent findings across sex and age concern a somewhat higher risk of cognitive impairment or dementia among abstainers compared to low-to-moderate drinkers <xref ref-type="bibr" rid="pone.0052311-Neafsey1">[7]</xref>. In turn, firm conclusions are not yet established, in particular regarding cognitive decline, because of heterogeneous methodology and relatively low overall quality of the evidence <xref ref-type="bibr" rid="pone.0052311-Plassman1">[10]</xref>. For example, it has been emphasized that sex-specific and alcoholic beverage-specific data are insufficient, although a beneficial impact of wine intake has been suggested in a few studies <xref ref-type="bibr" rid="pone.0052311-Neafsey1">[7]</xref>, <xref ref-type="bibr" rid="pone.0052311-Panza1">[9]</xref>.</p><p>Dietary intake, assessed via holistic approaches, has been associated with cognitive outcomes <xref ref-type="bibr" rid="pone.0052311-Tangney1">[11]</xref>–<xref ref-type="bibr" rid="pone.0052311-GustawRothenberg1">[14]</xref> and epidemiologic findings suggest a positive correlation between alcohol intake and unhealthy dietary patterns (characterized by increased consumption of meat/processed food and low consumption of plant-derived foods) <xref ref-type="bibr" rid="pone.0052311-Newby1">[15]</xref>. In a context where moderate alcohol consumption may help to preserve cognitive function, it is of major interest to assess whether diet indeed accounts for the observed associations. Moderate alcohol consumers have been shown to engage in healthy lifestyles, which has been attributed to their higher educational levels <xref ref-type="bibr" rid="pone.0052311-Hansel1">[16]</xref>.</p><p>We hypothesized that midlife alcohol intake (total and by source) would be longitudinally associated with cognitive performance and that these associations would be independent of comorbidities, sociodemographic and economic factors and global quality of the diet.</p></sec><sec sec-type="materials|methods" id="s2"><title>Materials and Methods</title><sec id="s2a"><title>Population</title><p>The SU.VI.MAX study (1994–2002) included a total of 12,741 French adults (7,713 women aged 35–60 and 5,028 men aged 45–60) and was initially designed as an 8-year randomized double-blind, placebo-controlled primary prevention trial to test the potential efficacy of daily supplementation with antioxidants at nutritional doses on the incidence of cancer, ischemic heart disease and overall mortality <xref ref-type="bibr" rid="pone.0052311-Hercberg1">[17]</xref>, <xref ref-type="bibr" rid="pone.0052311-Hercberg2">[18]</xref>. During that period, participants were invited to a yearly check-up consisting of blood sampling alternating with a clinical examination. At the end of the supplementation period (2002), a total of 6,850 subjects had agreed to participate in a post-supplementation observational follow-up, the SU.VI.MAX 2 study <xref ref-type="bibr" rid="pone.0052311-KesseGuyot2">[19]</xref>. These participants attended a clinical examination during 2007–2009. The SU.VI.MAX and SU.VI.MAX 2 studies were conducted according to the guidelines laid down in the Declaration of Helsinki and were approved by the Ethics Committee for Studies with Human Subjects of Paris-Cochin Hospital (CCPPRB n° 706 and n° 2364, respectively) and the Comité National Informatique et Liberté (CNIL n° 334641 and n° 907094, respectively). Written informed consent was obtained from all subjects.</p></sec><sec id="s2b"><title>Selection Criteria for the Present Study</title><p>Among the 6,850 adults included in the SU.VI.MAX 2 study, a total of 4,447 individuals aged 45–60 y at baseline completed all cognitive tests. Among them, 3,362 participants had complete dietary intake data (i.e., at least three complete 24-h dietary records provided during the first two years of follow-up, to account for variability in alcohol intake). From that subsample, we selected a total of 3,088 participants without missing values on any of the covariables for inclusion in the present analysis.</p></sec><sec id="s2c"><title>Alcohol Consumption and Dietary Data</title><p>During the SU.VI.MAX study, subjects were invited to complete a 24 h dietary record every 2 months for a total of 6 records per year, randomly assigned across two weekend days and four weekdays per year. Thus, each day of the week and all seasons had an equal chance of being covered. In turn, that allowed taking into account individual variability in intake. Dietary data were collected using the Minitel Telematic Network. The Minitel is a small terminal that was widely used in France as an adjunct to the telephone at the beginning of the SU.VI.MAX study. At enrollment, the participants received a calendar with the assigned days for the 24-hour dietary data reporting and a small central processing unit specifically developed for the study. It contained specialized software that allowed subjects to fill out the computerized dietary record off-line and to transmit the data during brief telephone connections. Participants were assisted by an instruction manual for coding food portions, including validated photographs of more than 250 foods represented in three main portion sizes. Two intermediate and two extreme portions made up a total of seven different portion sizes <xref ref-type="bibr" rid="pone.0052311-LeMoullec1">[20]</xref>. Additional assistance was available by telephone.</p><p>Detailed information on alcoholic beverage consumption was provided with the 24-h dietary records. Participants could specify intake from a total of 46 different beverage items, including several types of wine, beer, cider and spirits. Accurate quantities were estimated through a set of 30 validated photographs showing various serving (glass) sizes.</p><p>Food, alcoholic beverage, and nutrient intakes (including alcohol) were based on the mean intakes across all selected 24-h records. Global dietary quality was calculated using a modified version of the validated <italic>Programme National Nutrition Santé</italic> - Guidelines Score (PNNS-GS), which estimates adherence to French nutrition recommendations. PNNS-GS computation, including food groupings, serving sizes, scoring, and cut-offs, has been described in detail elsewhere <xref ref-type="bibr" rid="pone.0052311-Estaquio1">[21]</xref>. Scoring and cut-off criteria are shown in Supplemental <xref ref-type="table" rid="pone-0052311-t001">Table 1</xref>. For the present analysis, we used a modified score (mPNNS-GS) after removing the alcohol intake and physical activity components.</p><table-wrap id="pone-0052311-t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0052311.t001</object-id><label>Table 1</label><caption><title>Comparison between included and excluded participants regarding baseline characteristics and neuropsychological test scores, SU.VI.MAX 2 Study, 2007–2009 (N = 6,850).</title></caption><alternatives><graphic id="pone-0052311-t001-1" xlink:href="pone.0052311.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">Variable</td><td colspan="2" align="left" rowspan="1">Excluded participants</td><td colspan="2" align="left" rowspan="1">Included participants</td><td align="left" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="nt101">a</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">mean ± sd or %</td><td align="left" rowspan="1" colspan="1">n with available data</td><td align="left" rowspan="1" colspan="1">mean ± sd or %</td><td align="left" rowspan="1" colspan="1">n with available data</td><td align="left" rowspan="1" colspan="1"></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">General characteristics</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Male</td><td align="left" rowspan="1" colspan="1">49</td><td align="left" rowspan="1" colspan="1">2495</td><td align="left" rowspan="1" colspan="1">54</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.0002</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Age at baseline (years)</td><td align="left" rowspan="1" colspan="1">51±5</td><td align="left" rowspan="1" colspan="1">2495</td><td align="left" rowspan="1" colspan="1">52±5</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">BMI (kg/m<sup>2</sup>)</td><td align="left" rowspan="1" colspan="1">24.5±3.6</td><td align="left" rowspan="1" colspan="1">2375</td><td align="left" rowspan="1" colspan="1">24.3±3.4</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.09</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Education</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">2359</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.02</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Primary</italic></td><td align="left" rowspan="1" colspan="1">23</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">21</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Secondary</italic></td><td align="left" rowspan="1" colspan="1">40</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">40</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>University or equivalent</italic></td><td align="left" rowspan="1" colspan="1">36</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">39</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Occupational status</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">2308</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Unemployed</italic></td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Manual labor</italic></td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Intermediate professions</italic></td><td align="left" rowspan="1" colspan="1">55</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">51</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Self-employed, farmer</italic></td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Managerial staff</italic></td><td align="left" rowspan="1" colspan="1">28</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">32</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Physical activity</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">2407</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.04</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Irregular</italic></td><td align="left" rowspan="1" colspan="1">25</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">23</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic><1h walking/d or equivalent</italic></td><td align="left" rowspan="1" colspan="1">30</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">30</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>≥1h walking/d or equivalent</italic></td><td align="left" rowspan="1" colspan="1">45</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">47</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Smoking status</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">2230</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.34</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Non-smoker</italic></td><td align="left" rowspan="1" colspan="1">51</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">51</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Former smoker</italic></td><td align="left" rowspan="1" colspan="1">37</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">39</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Current smoker</italic></td><td align="left" rowspan="1" colspan="1">12</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">10</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Intervention group (1994–2002)</td><td align="left" rowspan="1" colspan="1">53</td><td align="left" rowspan="1" colspan="1">2495</td><td align="left" rowspan="1" colspan="1">53</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.95</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">mPNNS-GS</td><td align="left" rowspan="1" colspan="1">6.5±1.6</td><td align="left" rowspan="1" colspan="1">950</td><td align="left" rowspan="1" colspan="1">6.6±1.6</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.32</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Alcohol intake (g/d)</td><td align="left" rowspan="1" colspan="1">19.5±21.1</td><td align="left" rowspan="1" colspan="1">1086</td><td align="left" rowspan="1" colspan="1">20.5±20.9</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic>0.10</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Alcohol categories (drinks/d)</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">1086</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Abstainers</italic></td><td align="left" rowspan="1" colspan="1">8.8</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">7.8</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>0.21</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>>0 to 2 for women/3 for men</italic></td><td align="left" rowspan="1" colspan="1">66.9</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">65.5</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>>2 for women/>3 for men</italic></td><td align="left" rowspan="1" colspan="1">24.2</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">26.7</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Number of 24-h dietary records</td><td align="left" rowspan="1" colspan="1">9.7±3.3</td><td align="left" rowspan="1" colspan="1">1086</td><td align="left" rowspan="1" colspan="1">10.1±3.1</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Energy intake b (Kcal/d)</td><td align="left" rowspan="1" colspan="1">2133±615</td><td align="left" rowspan="1" colspan="1">1086</td><td align="left" rowspan="1" colspan="1">2196±610</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Memory troubles at baseline (yes/no) c</td><td align="left" rowspan="1" colspan="1">42</td><td align="left" rowspan="1" colspan="1">1086</td><td align="left" rowspan="1" colspan="1">36</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">RI-48 cued recall task d</td><td align="left" rowspan="1" colspan="1">25.8±6.3</td><td align="left" rowspan="1" colspan="1">1410</td><td align="left" rowspan="1" colspan="1">26.4±6.0</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Semantic fluency d</td><td align="left" rowspan="1" colspan="1">28.9±8.1</td><td align="left" rowspan="1" colspan="1">1396</td><td align="left" rowspan="1" colspan="1">29.8±8.2</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Phonemic fluency d</td><td align="left" rowspan="1" colspan="1">22.1±6.8</td><td align="left" rowspan="1" colspan="1">1401</td><td align="left" rowspan="1" colspan="1">22.9±6.6</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Delis-Kaplan trail-making test e</td><td align="left" rowspan="1" colspan="1">97.5±42.2</td><td align="left" rowspan="1" colspan="1">1403</td><td align="left" rowspan="1" colspan="1">91.4±37.7</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Forward digit span f</td><td align="left" rowspan="1" colspan="1">6.8±2.0</td><td align="left" rowspan="1" colspan="1">1439</td><td align="left" rowspan="1" colspan="1">7.1±2.0</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Backward digit span f</td><td align="left" rowspan="1" colspan="1">6.1±2.1</td><td align="left" rowspan="1" colspan="1">1438</td><td align="left" rowspan="1" colspan="1">6.3±2.1</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">CES-D score g</td><td align="left" rowspan="1" colspan="1">9.8±8.2</td><td align="left" rowspan="1" colspan="1">2405</td><td align="left" rowspan="1" colspan="1">8.7±7.4</td><td align="left" rowspan="1" colspan="1">3088</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt101"><label>a</label><p>P values based on Kruskal-Wallis test or chi-squared test.</p></fn><fn id="nt102"><label>b</label><p>Without energy from alcohol.</p></fn><fn id="nt103"><label>c</label><p>Sex-adjusted %.</p></fn><fn id="nt104"><label>d</label><p>Number of words.</p></fn><fn id="nt105"><label>e</label><p>The score on the trail making test is reported as time taken to complete the task. A lower score indicates better performance.</p></fn><fn id="nt106"><label>f</label><p>Number of correct sequences was repeated until the participant failed two consecutive trials of the same digit span.</p></fn><fn id="nt107"><label>g</label><p>CES-D range between 0 and 60; lower score indicates fewer depressive symptoms.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s2d"><title>Cognitive Data</title><p>Self-reported memory troubles (yes/no) were recorded at baseline (1994).</p><p>During the SU.VI.MAX 2 phase (2007–2009), all participants were invited for a neuropsychological evaluation carried out by trained neuropsychologists. Validated tests limiting floor and ceiling effects were selected as regards cognitive domains affected during brain aging <xref ref-type="bibr" rid="pone.0052311-Amieva1">[22]</xref>, <xref ref-type="bibr" rid="pone.0052311-Lezak1">[23]</xref>. Episodic memory was evaluated using the RI-48 test, a delayed cued recall test (maximum score of 48) <xref ref-type="bibr" rid="pone.0052311-Ivanoiu1">[24]</xref>. Lexical-semantic memory was assessed by verbal fluency tasks, including a semantic fluency task (naming as many animals as possible) and a phonemic fluency task (citing words beginning with the letter P). The score was the number of correct words produced during a 2-min period for each task <xref ref-type="bibr" rid="pone.0052311-Lezak1">[23]</xref>. Working memory was assessed with the forward and backward digit span. One point was scored for each correct sequence repeated, with a maximum score of 14 points for digit span forward as well as backward <xref ref-type="bibr" rid="pone.0052311-Wechsler1">[25]</xref>. Mental flexibility was assessed through the Delis-Kaplan trail-making test (connecting numbers and letters alternating between the two series). The score was the time in seconds needed to complete the task <xref ref-type="bibr" rid="pone.0052311-Delis1">[26]</xref>.</p></sec><sec id="s2e"><title>Covariates</title><p>At baseline, information on gender, date of birth, smoking status, medication use (antihypertensives, anti-diabetic treatments), occupational category, retirement status, physical activity and education was collected. At the first clinical examination (1995–1996), anthropometric measurements and blood pressure (BP) were assessed. Weight was measured using an electronic scale, with subjects wearing indoor clothing and no shoes. Height was measured under the same conditions with a wall-mounted stadiometer. Systolic and diastolic BP were measured twice during a single visit following a 10-min rest and the two measurements were averaged.</p><p>At the SU.VI.MAX 2 phase, retirement status and medication use were self-reported. Depressive symptoms were assessed using the French version of the Center for Epidemiologic Studies Depression Scale (CES-D) <xref ref-type="bibr" rid="pone.0052311-Radloff1">[27]</xref>. BP was assessed using a semi-automatic device (Digital blood pressure monitor OMROM UA-787; OMRON Corporation, Kyoto, Japan). Systolic and diastolic BP were again measured twice during a single visit following a 10-min rest and the two measurements were averaged. Fasting blood samples were obtained at baseline and at the end of the follow-up and all biochemical measurements were centralized. Fasting blood glucose was measured using an enzymatic method (Advia 1650; Bayer Diagnostics). During the entire follow-up, in case of suspected cardiovascular disease, relevant medical data (clinical, biochemical, histological, radiological reports) were requested from participants, physicians and/or hospitals. All reported cardiovascular events were reviewed and validated by an independent expert committee.</p></sec><sec id="s2f"><title>Statistical Analyses</title><p>Individual cognitive test scores were converted into T scores (mean = 50, SD = 10) <xref ref-type="bibr" rid="pone.0052311-Rust1">[28]</xref>. Thus, a one-point difference in the test score corresponded to one-tenth of a SD difference. A composite cognitive score defined as the mean of the standardized individual test scores was first computed and then rescaled to SD = 10. Thus, a one-point difference in the test score corresponded to a one-tenth of a SD difference. Daily alcohol intakes - total and by source (wine, beer and spirits) - were computed as the mean values across all 24-h records. Total alcohol intake was converted to the number of alcoholic drinks consumed in one day, considering that 1 drink was equivalent to 11 g of alcohol. Daily alcohol use categories were defined as follows: abstainers (0 drinks/d), low-to-moderate drinkers (1 to 3 drinks/d for men and 1 to 2 drinks/d for women) and heavy drinkers (>3 drinks/d for men and >2 drinks/d for women).</p><p>In addition, sex-specific tertiles of percent alcohol from wine were computed. For percent alcohol from spirits and beer, a no-consumer category and two categories according to the median value among consumers were defined. Body mass index (BMI) was calculated as the ratio of weight to squared height (kg/m<sup>2</sup>). History of hypertension was defined as systolic BP ≥140 mm Hg or diastolic BP ≥ 90 mm Hg, or reporting of antihypertensive drug use. History of diabetes mellitus was defined as glucose concentrations ≥7 mmol/L or reporting of antidiabetic drug use. Time-dependent retirement status was computed as follows: retired at baseline, retired during follow-up, not yet retired at the end of follow-up.</p><p>Included SU.VI.MAX 2 subjects were compared to those excluded from the present study. Descriptive baseline characteristics by sex are reported as mean (SD) or percentage across alcohol consumption categories. Reported P-values refer to a linear contrast test (after a natural log or square root transformation to improve normality), non-parametric Wilcoxon rank test or to the chi<sup>2</sup> test, as appropriate. Covariance analyses were used to estimate the difference in mean cognitive scores (95% confidence interval) across alcohol intake categories using low-to-moderate drinkers as reference. P for trend was assessed using linear contrast tests across categories. A quadratic contrast was also calculated.</p><p>The first ANCOVA model was adjusted for age at the neuropsychological assessment (y) (Model 1). Model 2 was adjusted for age at the neuropsychological assessment (y), number of 24-h dietary records, education (primary, secondary, university or equivalent), supplementation group (active or placebo), baseline BMI (kg/m<sup>2</sup>), memory troubles (yes/no), occupational category (unemployed, manual workers, intermediate professions, self-employed or farmers, managerial staff), tobacco use status (never, former, current), physical activity (irregular, <1h walking/d or equivalent, ≥1h walking/d or equivalent). The third ANCOVA model was further adjusted for comorbidities (depressive symptoms at cognitive evaluation, history of hypertension (yes/no), history of diabetes (yes/no), history of cardiovascular diseases (yes/no)). The final model (Model 4) further included mPNNS-GS and energy intake without alcohol (Kcal/d). Data imputations were carried out in cases of missing mPNNS-GS values. Models focusing on percent alcohol from wine, beer or spirits were adjusted for total alcohol intake.</p><p>A secondary analysis was performed using a moredetailed categorisation of alcohol use, as previously suggested <xref ref-type="bibr" rid="pone.0052311-Hvidtfeldt1">[29]</xref>. Specifically, the following categories of daily alcohol intake in g/d were considered: 0, 0.1 to 4.9, 5.0 to 14.9, 15.0 to 29.9, 30.0 to 59.9, and ≥60.0 in women; 0, 0.1 to 4.9, 5.0 to 14.9, 15.0 to 29.9, 30.0 to 59.9, 60.0 to 89.9, and ≥90.0 in men.</p><p>Finally, in sensitivity analyses, we used inverse probability weighting to correct the estimates for potential selection bias <xref ref-type="bibr" rid="pone.0052311-Cole1">[30]</xref>–<xref ref-type="bibr" rid="pone.0052311-Hernan1">[32]</xref>. First, a logistic regression model was fitted using baseline covariates to predict the probability of inclusion in the present analysis for each participant. Then, the main analysis was rerun using the inverse of the predicted probabilities as weights. All tests of statistical significance were two-sided and the type I error was set at 5%. Statistical analyses were performed using SAS software (version 9.2, SAS Institute Inc, Cary, NC, USA).</p></sec></sec><sec id="s3"><title>Results</title><sec id="s3a"><title>Comparison of Included and Excluded Participants</title><p>Compared with included subjects, subjects in SU.VI.MAX 2 excluded from the current study were younger, with lower levels of education, less often men and less physically active. Excluded subjects also had fewer 24-h records, worse scores on the CES-D and on the neuropsychological tests, and reported more frequent memory troubles at baseline. No difference in alcohol consumption was detected (<xref ref-type="table" rid="pone-0052311-t001">Table 1</xref>).</p></sec><sec id="s3b"><title>Sample Description</title><p>At baseline, men and women were 52.4 (4.6) and 51.5 (4.5) years of age, respectively (p<0.001). Daily median alcohol intake was 28.5 g in men and 11.2 g in women (p<0.001).</p><p>Characteristics of the participants are presented by gender across alcohol intake categories (<xref ref-type="table" rid="pone-0052311-t002">Table 2</xref>). In both men and women, increasing alcohol consumption was associated with being a former or current smoker, a higher number of 24-h records, higher energy intake and higher percent energy from lipids, lower percent energy form carbohydrates as well as poorer diet quality, estimated through the mPNNS-GS. In men, increasing alcohol intake was also associated with higher percent energy from proteins. In women, heavy drinkers less frequently displayed high levels of physical activity and were more educated.</p><table-wrap id="pone-0052311-t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0052311.t002</object-id><label>Table 2</label><caption><title>Sample characteristics according to alcohol consumption, by sex<sup>1.</sup></title></caption><alternatives><graphic id="pone-0052311-t002-2" xlink:href="pone.0052311.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1"></td><td colspan="4" align="left" rowspan="1">Men</td><td colspan="4" align="left" rowspan="1">Women</td></tr><tr><td align="left" rowspan="1" colspan="1">Variable</td><td align="left" rowspan="1" colspan="1">Abstainers(0 drinks/d)</td><td align="left" rowspan="1" colspan="1">Low to moderate drinkers(>0–≤3 drinks/d)</td><td align="left" rowspan="1" colspan="1">Heavy drinkers(>3 drinks/d)</td><td align="left" rowspan="1" colspan="1"><italic>P<sup>b</sup></italic></td><td align="left" rowspan="1" colspan="1">Abstainers(0 drinks/d)</td><td align="left" rowspan="1" colspan="1">Low to* moderate drinkers(>0–≤2 drinks/d)</td><td align="left" rowspan="1" colspan="1">Heavy drinkers(>2 drinks/d)</td><td align="left" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="nt110">2</xref></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">N</td><td align="left" rowspan="1" colspan="1">58</td><td align="left" rowspan="1" colspan="1">1010</td><td align="left" rowspan="1" colspan="1">589</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">183</td><td align="left" rowspan="1" colspan="1">1014</td><td align="left" rowspan="1" colspan="1">234</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Ethanol intake<xref ref-type="table-fn" rid="nt111">3</xref> (g/d)</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">15</td><td align="left" rowspan="1" colspan="1">49</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">31</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Age at baseline (y)</td><td align="left" rowspan="1" colspan="1">51.6 (4.1)</td><td align="left" rowspan="1" colspan="1">52.3 (4.6)</td><td align="left" rowspan="1" colspan="1">52.8 (4.7)</td><td align="left" rowspan="1" colspan="1">0.07</td><td align="left" rowspan="1" colspan="1">51.4 (4.5)</td><td align="left" rowspan="1" colspan="1">51.6 (4.5)</td><td align="left" rowspan="1" colspan="1">51.5 (4.2)</td><td align="left" rowspan="1" colspan="1">0.89</td></tr><tr><td align="left" rowspan="1" colspan="1">Body mass index (kg/m<sup>2</sup>)</td><td align="left" rowspan="1" colspan="1">24.8 (3.2)</td><td align="left" rowspan="1" colspan="1">25.0 (2.9)</td><td align="left" rowspan="1" colspan="1">25.6 (2.8)</td><td align="left" rowspan="1" colspan="1">0.05</td><td align="left" rowspan="1" colspan="1">23.4 (3.7)</td><td align="left" rowspan="1" colspan="1">23.4 (3.6)</td><td align="left" rowspan="1" colspan="1">23.2 (3.2)</td><td align="left" rowspan="1" colspan="1">0.72</td></tr><tr><td align="left" rowspan="1" colspan="1">Energy intake<xref ref-type="table-fn" rid="nt112">4</xref> (Kcal/d)</td><td align="left" rowspan="1" colspan="1">2151 (551)</td><td align="left" rowspan="1" colspan="1">2288 (523)</td><td align="left" rowspan="1" colspan="1">2358 (498)</td><td align="left" rowspan="1" colspan="1">0.001</td><td align="left" rowspan="1" colspan="1">1584 (460)</td><td align="left" rowspan="1" colspan="1">1779 (429)</td><td align="left" rowspan="1" colspan="1">1801 (433)</td><td align="left" rowspan="1" colspan="1"><.0001</td></tr><tr><td align="left" rowspan="1" colspan="1">Total number of 24-h dietary records</td><td align="left" rowspan="1" colspan="1">8.1 (3.8)</td><td align="left" rowspan="1" colspan="1">10.3 (3.1)</td><td align="left" rowspan="1" colspan="1">10.6 (2.7)</td><td align="left" rowspan="1" colspan="1"><.0001</td><td align="left" rowspan="1" colspan="1">7.5 (3.6)</td><td align="left" rowspan="1" colspan="1">10.3 (3.0)</td><td align="left" rowspan="1" colspan="1">9.9 (2.9)</td><td align="left" rowspan="1" colspan="1"><.0001</td></tr><tr><td align="left" rowspan="1" colspan="1">Number of 24-h dietary records (weekday)</td><td align="left" rowspan="1" colspan="1">5.2 (2.8)</td><td align="left" rowspan="1" colspan="1">7.2 (2.6)</td><td align="left" rowspan="1" colspan="1">7.3 (2.4)</td><td align="left" rowspan="1" colspan="1"><.0001</td><td align="left" rowspan="1" colspan="1">5.1 (2.8)</td><td align="left" rowspan="1" colspan="1">7.2 (2.5)</td><td align="left" rowspan="1" colspan="1">7.0 (2.5)</td><td align="left" rowspan="1" colspan="1"><.0001</td></tr><tr><td align="left" rowspan="1" colspan="1">Number of 24-h dietary records (weekend)</td><td align="left" rowspan="1" colspan="1">2.9 (1.8)</td><td align="left" rowspan="1" colspan="1">3.2 (1.7)</td><td align="left" rowspan="1" colspan="1">3.3 (1.7)</td><td align="left" rowspan="1" colspan="1">0.03</td><td align="left" rowspan="1" colspan="1">2.4 (1.6)</td><td align="left" rowspan="1" colspan="1">3.1 (1.7)</td><td align="left" rowspan="1" colspan="1">2.9 (1.6)</td><td align="left" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" rowspan="1" colspan="1">mPNNS-GS</td><td align="left" rowspan="1" colspan="1">6.5 (1.8)</td><td align="left" rowspan="1" colspan="1">6.5 (1.5)</td><td align="left" rowspan="1" colspan="1">6.1 (1.6)</td><td align="left" rowspan="1" colspan="1">0.03</td><td align="left" rowspan="1" colspan="1">6.7 (1.5)</td><td align="left" rowspan="1" colspan="1">7.0 (1.5)</td><td align="left" rowspan="1" colspan="1">6.3 (1.5)</td><td align="left" rowspan="1" colspan="1">0.002</td></tr><tr><td align="left" rowspan="1" colspan="1">Carbohydrates<xref ref-type="table-fn" rid="nt113">5</xref></td><td align="left" rowspan="1" colspan="1">45.3 (7.6)</td><td align="left" rowspan="1" colspan="1">43.0 (6.2)</td><td align="left" rowspan="1" colspan="1">40.6 (6.1)</td><td align="left" rowspan="1" colspan="1"><.0001</td><td align="left" rowspan="1" colspan="1">42.9 (7.5)</td><td align="left" rowspan="1" colspan="1">42.2 (5.4)</td><td align="left" rowspan="1" colspan="1">39.4 (5.8)</td><td align="left" rowspan="1" colspan="1"><.0001</td></tr><tr><td align="left" rowspan="1" colspan="1">Lipids<xref ref-type="table-fn" rid="nt113">5</xref></td><td align="left" rowspan="1" colspan="1">37.6 (5.8)</td><td align="left" rowspan="1" colspan="1">39.4 (5.1)</td><td align="left" rowspan="1" colspan="1">41.1 (5.1)</td><td align="left" rowspan="1" colspan="1"><.0001</td><td align="left" rowspan="1" colspan="1">38.5 (6.2)</td><td align="left" rowspan="1" colspan="1">40.1 (4.7)</td><td align="left" rowspan="1" colspan="1">42.4 (4.7)</td><td align="left" rowspan="1" colspan="1"><.0001</td></tr><tr><td align="left" rowspan="1" colspan="1">Protein<xref ref-type="table-fn" rid="nt113">5</xref></td><td align="left" rowspan="1" colspan="1">17.1 (3.7)</td><td align="left" rowspan="1" colspan="1">17.6 (2.7)</td><td align="left" rowspan="1" colspan="1">18.3 (2.6)</td><td align="left" rowspan="1" colspan="1"><.0001</td><td align="left" rowspan="1" colspan="1">18.6 (3.7)</td><td align="left" rowspan="1" colspan="1">17.7 (2.6)</td><td align="left" rowspan="1" colspan="1">18.2 (2.5)</td><td align="left" rowspan="1" colspan="1">0.37</td></tr><tr><td align="left" rowspan="1" colspan="1">Active supplementation group (yes/no, 1994–2002)</td><td align="left" rowspan="1" colspan="1">60</td><td align="left" rowspan="1" colspan="1">53</td><td align="left" rowspan="1" colspan="1">53</td><td align="left" rowspan="1" colspan="1">0.68</td><td align="left" rowspan="1" colspan="1">57</td><td align="left" rowspan="1" colspan="1">53</td><td align="left" rowspan="1" colspan="1">49</td><td align="left" rowspan="1" colspan="1">0.08</td></tr><tr><td align="left" rowspan="1" colspan="1">Self-reported memory troubles (yes/no)</td><td align="left" rowspan="1" colspan="1">36</td><td align="left" rowspan="1" colspan="1">27</td><td align="left" rowspan="1" colspan="1">26</td><td align="left" rowspan="1" colspan="1">0.28</td><td align="left" rowspan="1" colspan="1">48</td><td align="left" rowspan="1" colspan="1">44</td><td align="left" rowspan="1" colspan="1">44</td><td align="left" rowspan="1" colspan="1">0.50</td></tr><tr><td align="left" rowspan="1" colspan="1">Occupational categories</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0.44</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0.03</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Unemployed</italic></td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1">0</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Manual labor</italic></td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">2</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Intermediate professions</italic></td><td align="left" rowspan="1" colspan="1">50</td><td align="left" rowspan="1" colspan="1">42</td><td align="left" rowspan="1" colspan="1">41</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">69</td><td align="left" rowspan="1" colspan="1">69</td><td align="left" rowspan="1" colspan="1">62</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Self-employed, farmer</italic></td><td align="left" rowspan="1" colspan="1">10</td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">6</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">8</td><td align="left" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1">3</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Managerial staff</italic></td><td align="left" rowspan="1" colspan="1">36</td><td align="left" rowspan="1" colspan="1">46</td><td align="left" rowspan="1" colspan="1">45</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1">17</td><td align="left" rowspan="1" colspan="1">23</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Education</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0.32</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0.02</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Primary</italic></td><td align="left" rowspan="1" colspan="1">19</td><td align="left" rowspan="1" colspan="1">22</td><td align="left" rowspan="1" colspan="1">22</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">25</td><td align="left" rowspan="1" colspan="1">20</td><td align="left" rowspan="1" colspan="1">18</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Secondary (high school)</italic></td><td align="left" rowspan="1" colspan="1">34</td><td align="left" rowspan="1" colspan="1">34</td><td align="left" rowspan="1" colspan="1">37</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">42</td><td align="left" rowspan="1" colspan="1">46</td><td align="left" rowspan="1" colspan="1">38</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>University or equivalent</italic></td><td align="left" rowspan="1" colspan="1">47</td><td align="left" rowspan="1" colspan="1">44</td><td align="left" rowspan="1" colspan="1">41</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">33</td><td align="left" rowspan="1" colspan="1">34</td><td align="left" rowspan="1" colspan="1">44</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Physical activity</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0.63</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">0.01</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Irregular</italic></td><td align="left" rowspan="1" colspan="1">17</td><td align="left" rowspan="1" colspan="1">22</td><td align="left" rowspan="1" colspan="1">24</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">17</td><td align="left" rowspan="1" colspan="1">24</td><td align="left" rowspan="1" colspan="1">25</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic><1h walking/d or equivalent</italic></td><td align="left" rowspan="1" colspan="1">28</td><td align="left" rowspan="1" colspan="1">24</td><td align="left" rowspan="1" colspan="1">22</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">34</td><td align="left" rowspan="1" colspan="1">36</td><td align="left" rowspan="1" colspan="1">41</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>≥1h walking/d or equivalent</italic></td><td align="left" rowspan="1" colspan="1">55</td><td align="left" rowspan="1" colspan="1">53</td><td align="left" rowspan="1" colspan="1">54</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">48</td><td align="left" rowspan="1" colspan="1">40</td><td align="left" rowspan="1" colspan="1">34</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Smoking status</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><.0001</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><.0001</td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Never</italic></td><td align="left" rowspan="1" colspan="1">43</td><td align="left" rowspan="1" colspan="1">43</td><td align="left" rowspan="1" colspan="1">27</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">71</td><td align="left" rowspan="1" colspan="1">68</td><td align="left" rowspan="1" colspan="1">51</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Former</italic></td><td align="left" rowspan="1" colspan="1">41</td><td align="left" rowspan="1" colspan="1">47</td><td align="left" rowspan="1" colspan="1">57</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">24</td><td align="left" rowspan="1" colspan="1">25</td><td align="left" rowspan="1" colspan="1">32</td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"><italic>Current</italic></td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">9</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">5</td><td align="left" rowspan="1" colspan="1">7</td><td align="left" rowspan="1" colspan="1">17</td><td align="left" rowspan="1" colspan="1"></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt108"><p>Abbreviations: mPNNS-GS: modified Programme National Nutrition Santé-Guidelines Score.</p></fn><fn id="nt109"><label>1</label><p>Values are mean (SD) or % as appropriate except when otherwise noted.</p></fn><fn id="nt110"><label>2</label><p>P is based on linear contrast (log-transformed data except for mPNNS-GS) or chi<sup>2</sup> test, as appropriate.</p></fn><fn id="nt111"><label>3</label><p>Median values.</p></fn><fn id="nt112"><label>4</label><p>Energy intake without alcohol.</p></fn><fn id="nt113"><label>5</label><p>Percent of energy intake (without alcohol).</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3c"><title>Association between Global Cognitive Function and Midlife Total Alcohol Intake</title><p>Associations between the composite cognitive score and alcohol intake are presented in <xref ref-type="table" rid="pone-0052311-t003">Table 3</xref>. In the age-adjusted model (Model 1), heavy drinking was associated with better cognitive performance. The association was slightly attenuated after adjustment for age, number of 24-h records, BMI, baseline memory troubles, education, occupational category, tobacco use status and physical activity (Models 2 and 3). This association was not modified by further adjustment for comorbidities, energy intake and mPNNS-GS (Model 4).</p><table-wrap id="pone-0052311-t003" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0052311.t003</object-id><label>Table 3</label><caption><title>ANCOVA-derived associations between alcohol intake and global cognitive function, by sex<sup>1.</sup></title></caption><alternatives><graphic id="pone-0052311-t003-3" xlink:href="pone.0052311.t003"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td colspan="3" align="left" rowspan="1">Alcohol intake</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">Abstainers</td><td align="left" rowspan="1" colspan="1">low to moderate drinkers</td><td align="left" rowspan="1" colspan="1">heavy drinkers</td><td align="left" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="nt115">2</xref></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Men</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 1<xref ref-type="table-fn" rid="nt116">3</xref></td><td align="left" rowspan="1" colspan="1">−0.28 (−2.87–2.31)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>1.06 (0.07–2.06)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.32</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 2<xref ref-type="table-fn" rid="nt117">4</xref></td><td align="left" rowspan="1" colspan="1">0.04 (−2.38–2.47)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>1.03 (0.09–1.97)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.44</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 3<xref ref-type="table-fn" rid="nt118">5</xref></td><td align="left" rowspan="1" colspan="1">−0.03 (−2.45–2.39)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>1.04 (0.10–1.98)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.40</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 4<xref ref-type="table-fn" rid="nt119">6</xref></td><td align="left" rowspan="1" colspan="1">0.04 (−2.39–2.46)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>1.05 (0.10–1.99)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.43</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Women</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 1<xref ref-type="table-fn" rid="nt116">3</xref></td><td align="left" rowspan="1" colspan="1"><bold>−2.91 (−4.46–1.36)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">1.32 (−0.08–2.72)</td><td align="left" rowspan="1" colspan="1"><italic><0.0001</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 2<xref ref-type="table-fn" rid="nt117">4</xref></td><td align="left" rowspan="1" colspan="1"><bold>−2.04 (−3.54–0.54)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.71 (−0.61–2.03)</td><td align="left" rowspan="1" colspan="1"><italic>0.003</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 3<xref ref-type="table-fn" rid="nt118">5</xref></td><td align="left" rowspan="1" colspan="1"><bold>−2.05 (−3.56–0.54)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.76 (−0.55–2.08)</td><td align="left" rowspan="1" colspan="1"><italic>0.003</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Model 4<xref ref-type="table-fn" rid="nt119">6</xref></td><td align="left" rowspan="1" colspan="1"><bold>−1.77 (−3.29–0.25)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">1.03 (−0.31–2.36)</td><td align="left" rowspan="1" colspan="1"><italic>0.003</italic></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt114"><label>1</label><p>Values are mean difference (95% confidence interval) in composite cognitive score, low to moderate drinkers as reference.</p></fn><fn id="nt115"><label>2</label><p>P for trend across categories.</p></fn><fn id="nt116"><label>3</label><p>Model 1 is adjusted for age.</p></fn><fn id="nt117"><label>4</label><p>Model 2 : model 1+ number of 24-h records, BMI, baseline memory troubles, education, occupational category, tobacco use status and physical activity.</p></fn><fn id="nt118"><label>5</label><p>Model 3: model 2+ supplementation group during the trial phase, depressive symptoms concomitant with cognitive function assessment, history of diabetes, hypertension, or cardiovascular disease.</p></fn><fn id="nt119"><label>6</label><p>Model 4: model 3+ energy intake and mPNNS-GS.</p></fn></table-wrap-foot></table-wrap><p>In women, lower cognitive performance scores were detected among abstainers compared to low-to-moderate drinkers in the age-adjusted model. Despite a substantial reduction of the extent of the association after adjustment for age, number of 24-h records, BMI, baseline memory troubles, education, occupational category, tobacco use status, physical activity comorbidities (depressive symptoms, history of diabetes, hypertension, or cardiovascular disease) as well as energy intake and mPNNS-GS (model 4), the lower cognitive performance scores among abstainers remained statistically significant. The findings of the secondary analysis are shown in <xref ref-type="fig" rid="pone-0052311-g001">Figure 1</xref>. Despite a loss of power due to the increase in the number of categories, elevated alcohol consumption (≥90 g/d ≈ 8 drinks/d) among men was associated with a lower cognitive performance compared to consumption of 15.0 to 29.9 g/d (≈1.4 to 2.7 drinks/d).</p><fig id="pone-0052311-g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0052311.g001</object-id><label>Figure 1</label><caption><title>ANCOVA-derived associations between alcohol intake categories and global cognitive function, by sex.</title><p>Association between the composite cognitive score and alcohol consumption using a detailed categorization of the exposure level. Models adjusted for age, number of 24-h records, BMI, baseline memory troubles, education, occupational category, tobacco use status, physical activity, supplementation group during the trial phase, depressive symptoms concomitant with cognitive function assessment, history of diabetes/hypertension/cardiovascular disease, energy intake and mPNNS-GS. Values are mean difference and 95% confidence interval.</p></caption><graphic xlink:href="pone.0052311.g001"></graphic></fig></sec><sec id="s3d"><title>Association between Global Cognitive Function and Midlife Alcohol Intake by Source</title><p>Median percentages of alcohol intake from beer, spirits and wine were 2.45, 6.78, 82.40 and 0.0, 6.18, 78.91 in men and women, respectively. Wine was by far the biggest contributor to alcohol intake. In turn, alcohol intake in terms of percent ethanol from each source, largely provided no significant results regarding cognition after adjustment for total intake of alcohol, except for an inverse association between ethanol intake from beer and cognitive performance in men. In particular, compared to men with low ethanol intake from beer (0 - median value among consumers = 10.4% of ethanol), those with high intake (>10.4% of ethanol) showed poorer cognitive performance (mean difference = −1.27, 95% confidence interval: −2.45, −0.09) (data not tabulated).</p></sec><sec id="s3e"><title>Association between Individual Cognitive Tests and Alcohol Intake</title><p>Associations between each individual cognitive test and alcohol intake are presented in <xref ref-type="table" rid="pone-0052311-t004">Table 4</xref>. No significant association was detected among men. Among women, a similar association as the one with the composite cognitive score was observed between alcohol intake and scores on semantic fluency and with the RI-48 cued recall task. On the opposite, compared to low-to-moderate drinkers, women who were heavy drinkers displayed better scores for phonemic fluency.</p></sec><sec id="s3f"><title>Sensitivity Analysis</title><p>Results of the additional analyses using inverse probability weighting are presented in <xref ref-type="table" rid="pone-0052311-t005">Table 5</xref>. Estimates and confidence intervals were slightly modified but similar associations were detected.</p></sec></sec><sec id="s4"><title>Discussion</title><p>In this population of French adults, alcohol abstinence was associated with somewhat decreased cognitive performance compared to low-to-moderate alcohol drinking in women. The overall association was largely driven by performance on episodic memory and semantic fluency tasks. In men, heavy drinking (>3 drinks/d) was associated with better cognitive performance, particularly on the backward digit span task. After splitting the alcohol use categories, men with alcohol intake ≥90 g/d (corresponding to about 8 drinks/d) showed lower cognitive performance compared to those consuming ∼ 1.4–2.7 drinks/d. An inverse association between ethanol intake from beer and cognitive performance was also observed.</p><sec id="s4a"><title>Alcohol intake and Cognitive Function</title><p>Our findings in women are in accordance with various previous studies investigating the relationship between alcohol intake and cognitive outcomes, and reporting a favorable association of low-to-moderate drinking with subsequent cognitive functioning <xref ref-type="bibr" rid="pone.0052311-Neafsey1">[7]</xref>, <xref ref-type="bibr" rid="pone.0052311-Panza1">[9]</xref>. The significant association detected only in women is in line with the results of several other studies <xref ref-type="bibr" rid="pone.0052311-Dufouil1">[33]</xref>–<xref ref-type="bibr" rid="pone.0052311-Elias1">[36]</xref> showing sex-specific associations. It has generally been speculated that the inconsistent testing of sex-specific models could partly account for the observed discrepancies among studies. Indeed, the very small number of abstainers, particularly among middle-aged men, and of heavy drinkers, especially among women, may have prevented the detection of a potential relationship. Further, heterogeneous findings may have resulted partly as a consequence of omitted confounders of the effects of alcohol use. Among them, diet, comorbidities involving changes in alcohol use habits or social factors could be considered. Indeed, former drinkers, who had possibly discontinued alcohol consumption as a result of vascular diseases, are usually included with abstainers. This may have led to a classification bias resulting in lower cognitive functioning in non-drinkers. A recent study focusing on the association between alcohol intake and cognitive decline did not find a beneficial effect of low-to-moderate drinking compared to abstinence when former drinkers were separately accounted for <xref ref-type="bibr" rid="pone.0052311-Lobo1">[37]</xref>. In the present study, adjustment for comorbidities occurring during the follow-up did not substantially modify the results.</p><table-wrap id="pone-0052311-t004" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0052311.t004</object-id><label>Table 4</label><caption><title>Associations between alcohol intake and specific cognitive tests, by sex<xref ref-type="table-fn" rid="nt120">1,2.</xref></title></caption><alternatives><graphic id="pone-0052311-t004-4" xlink:href="pone.0052311.t004"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td colspan="3" align="left" rowspan="1">Alcohol intake</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">abstainers</td><td align="left" rowspan="1" colspan="1">low to moderate drinkers</td><td align="left" rowspan="1" colspan="1">heavy drinkers</td><td align="left" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="nt121">2</xref></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Men</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Backward digit span</td><td align="left" rowspan="1" colspan="1">1.55 (−1.13–4.22)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">1.04 (−0.01–2.08)</td><td align="left" rowspan="1" colspan="1"><italic>0.71</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Forward digit span</td><td align="left" rowspan="1" colspan="1">0.86 (−1.81–3.53)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.88 (−0.16–1.92)</td><td align="left" rowspan="1" colspan="1"><italic>0.99</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Trail-making test</td><td align="left" rowspan="1" colspan="1">−1.17 (−3.58–1.24)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">−0.05 (−0.99–0.89)</td><td align="left" rowspan="1" colspan="1"><italic>0.38</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">RI-48 cued recall task</td><td align="left" rowspan="1" colspan="1">−1.24 (−3.83–1.35)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.72 (−0.29–1.74)</td><td align="left" rowspan="1" colspan="1"><italic>0.15</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Semantic fluency</td><td align="left" rowspan="1" colspan="1">0.61 (−1.87–3.10)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.59 (−0.38–1.56)</td><td align="left" rowspan="1" colspan="1"><italic>0.99</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Phonemic fluency</td><td align="left" rowspan="1" colspan="1">−0.47 (−3.03–2.09)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.86 (−0.14–1.86)</td><td align="left" rowspan="1" colspan="1"><italic>0.32</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Women</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Backward digit span</td><td align="left" rowspan="1" colspan="1">−0.52 (−2.08–1.03)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">1.00 (−0.37–2.36)</td><td align="left" rowspan="1" colspan="1"><italic>0.12</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Forward digit span</td><td align="left" rowspan="1" colspan="1">−0.81 (−2.40–0.78)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.41 (−0.98–1.81)</td><td align="left" rowspan="1" colspan="1"><italic>0.21</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Trail-making test</td><td align="left" rowspan="1" colspan="1">−0.46 (−2.06–1.14)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">−0.54 (−1.94–0.86)</td><td align="left" rowspan="1" colspan="1"><italic>0.93</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">RI-48 cued recall task</td><td align="left" rowspan="1" colspan="1"><bold>−2.25 (−3.88–0.62)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.07 (−1.36–1.50)</td><td align="left" rowspan="1" colspan="1"><italic>0.02</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Semantic fluency</td><td align="left" rowspan="1" colspan="1"><bold>−1.67 (−3.31–0.03)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.84 (−0.59–2.28)</td><td align="left" rowspan="1" colspan="1"><italic>0.01</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Phonemic fluency</td><td align="left" rowspan="1" colspan="1">−1.11 (−2.68–0.47)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>2.17 (0.79–3.55)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.001</italic></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt120"><label>1</label><p>Values are mean difference (95% confidence interval) in composite cognitive score, low to moderate drinkers as reference.</p></fn><fn id="nt121"><label>2</label><p>Models adjusted for age, number of 24-h records, BMI, baseline memory troubles, education, occupational category, tobacco use status, physical activity, supplementation group during the trial phase, depressive symptoms concomitant with cognitive function assessment, history of diabetes/hypertension/cardiovascular disease, energy intake and mPNNS-GS.</p></fn><fn id="nt122"><label>3</label><p>P for trend across categories.</p></fn></table-wrap-foot></table-wrap><p>Our SU.VI.MAX 2 data showed a slight reduction in the mean difference in women’s cognitive functioning between low-to-moderate drinkers and abstainers after accounting for the quality of diet, but the association remained statistically significant. Indeed, low-to-moderate drinking in women was associated with better adherence to existing nutrition recommendations in our population (data not shown). The positive association between heavy drinking and cognitive function observed in men was not substantially modified after accounting for the quality of the diet, given that the adverse effects of high alcohol intake could have been at least partly due to poor diet quality. While we are not aware of any relevant studies accounting for dietary confounders, epidemiologic data on the association between dietary behaviors and alcohol intake are plentiful <xref ref-type="bibr" rid="pone.0052311-Newby1">[15]</xref>, <xref ref-type="bibr" rid="pone.0052311-Tucker1">[38]</xref>. Likewise, a differential impact of alcohol intake on cognitive outcomes according to social position was recently reported <xref ref-type="bibr" rid="pone.0052311-Sabia1">[39]</xref>. In that study among French blue-collar workers, lower cognitive functioning was observed among heavy drinkers compared to low-to-moderate drinkers, but that association was restricted to men of low socio-economic status. We did not retrieve such an interaction in our population (data not shown).</p><p>In our study, the association between alcohol consumption and cognitive function remained even after accounting for major confounders, suggesting a true association which could be corroborated by mechanistic hypotheses. The mechanisms underlying the potential beneficial effect of alcohol intake on brain aging encompass lipoprotein level modification and improvement of cerebral blood flow <xref ref-type="bibr" rid="pone.0052311-Sinforiani1">[40]</xref>. Some experimental studies further suggest that ethanol may directly affect brain structure <xref ref-type="bibr" rid="pone.0052311-Bate1">[41]</xref>, <xref ref-type="bibr" rid="pone.0052311-Collins1">[42]</xref>. Indirect effects through the antioxidant and anti-inflammatory properties of flavonoids found in red wine (resveratrol) have also been postulated <xref ref-type="bibr" rid="pone.0052311-Collins1">[42]</xref>.</p><table-wrap id="pone-0052311-t005" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0052311.t005</object-id><label>Table 5</label><caption><title>Associations between alcohol intake and cognitive tests, by sex: inverse probability-weighted models<xref ref-type="table-fn" rid="nt123">1,2.</xref></title></caption><alternatives><graphic id="pone-0052311-t005-5" xlink:href="pone.0052311.t005"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td colspan="3" align="left" rowspan="1">Alcohol intake</td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">abstainers</td><td align="left" rowspan="1" colspan="1">low to moderate drinkers</td><td align="left" rowspan="1" colspan="1">heavy drinkers</td><td align="left" rowspan="1" colspan="1"><italic>P</italic><xref ref-type="table-fn" rid="nt124">2</xref></td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Men</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Composite cognitive score</td><td align="left" rowspan="1" colspan="1">0.41 (−1.83–2.66)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>1.03 (0.08–1.98)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.60</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Backward digit span</td><td align="left" rowspan="1" colspan="1">1.91 (−0.57–4.39)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>1.07 (0.03–2.12)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.52</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Forward digit span</td><td align="left" rowspan="1" colspan="1">1.17 (−1.32–3.65)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.83 (−0.22–1.87)</td><td align="left" rowspan="1" colspan="1"><italic>0.80</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Trail-making test</td><td align="left" rowspan="1" colspan="1">−1.09 (−3.33–1.15)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">−0.12 (−1.06–0.83)</td><td align="left" rowspan="1" colspan="1"><italic>0.41</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">RI-48 cued recall task</td><td align="left" rowspan="1" colspan="1">−0.89 (−3.29–1.52)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.73 (−0.28–1.75)</td><td align="left" rowspan="1" colspan="1"><italic>0.20</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Semantic fluency</td><td align="left" rowspan="1" colspan="1">0.66 (−1.64–2.97)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.59 (−0.38–1.56)</td><td align="left" rowspan="1" colspan="1"><italic>0.95</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Phonemic fluency</td><td align="left" rowspan="1" colspan="1">−0.16 (−2.54–2.21)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.86 (−0.14–1.86)</td><td align="left" rowspan="1" colspan="1"><italic>0.41</italic></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Women</bold></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1">Composite cognitive score</td><td align="left" rowspan="1" colspan="1"><bold>−1.81 (−3.26–0.36)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.88 (−0.46–2.22)</td><td align="left" rowspan="1" colspan="1"><italic>0.003</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Backward digit span</td><td align="left" rowspan="1" colspan="1">−0.63 (−2.11–0.84)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.99 (−0.37–2.35)</td><td align="left" rowspan="1" colspan="1"><italic>0.08</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Forward digit span</td><td align="left" rowspan="1" colspan="1">−0.82 (−2.33–0.70)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.27 (−1.13–1.66)</td><td align="left" rowspan="1" colspan="1"><italic>0.26</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Trail-making test</td><td align="left" rowspan="1" colspan="1">−0.48 (−2.01–1.05)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">−0.73 (−2.15–0.68)</td><td align="left" rowspan="1" colspan="1"><italic>0.79</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">RI-48 cued recall task</td><td align="left" rowspan="1" colspan="1"><bold>−2.19 (−3.74–0.63)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">−0.01 (−1.44–1.43)</td><td align="left" rowspan="1" colspan="1"><italic>0.03</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Semantic fluency</td><td align="left" rowspan="1" colspan="1"><bold>−1.73 (−3.29–0.17)</bold></td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1">0.79 (−0.65–2.23)</td><td align="left" rowspan="1" colspan="1"><italic>0.01</italic></td></tr><tr><td align="left" rowspan="1" colspan="1">Phonemic fluency</td><td align="left" rowspan="1" colspan="1">−1.13 (−2.63–0.38)</td><td align="left" rowspan="1" colspan="1">0 (reference)</td><td align="left" rowspan="1" colspan="1"><bold>2.09 (0.71–3.48)</bold></td><td align="left" rowspan="1" colspan="1"><italic>0.001</italic></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt123"><label>1</label><p>Values are mean difference (95% confidence interval) in composite cognitive score, low to moderate drinkers as reference.</p></fn><fn id="nt124"><label>2</label><p>Models adjusted for age, number of 24-h records, BMI, baseline memory troubles, education, occupational category, tobacco use status, physical activity, supplementation group during the trial phase, depressive symptoms concomitant with cognitive function assessment, history of diabetes/hypertension/cardiovascular disease, energy intake and mPNNS-GS.</p></fn><fn id="nt125"><label>3</label><p>P for trend across categories.</p></fn></table-wrap-foot></table-wrap><p>Some epidemiologic data support the hypothesis of a harmful effect of heavy drinking on cognitive performance but findings are not consistent <xref ref-type="bibr" rid="pone.0052311-Neafsey1">[7]</xref>. We observed a significant mean difference in cognitive function among heavy drinkers compared to low-to-moderate drinkers only in men. However, heavy drinking is a heterogeneous category including people with various levels of intake. In particular, volunteering for an active follow-up could have led to a selection bias towards including participants who are not “heavy drinkers” by common standards. Despite the low number of such drinkers in the SU.VI.MAX study, the findings of our secondary analysis showing that extreme heavy drinking could have an adverse association with cognitive function suggest that alcohol intake and cognition may exhibit an inverted U or J shape.</p><p>In the present study, specific neuropsychological tests, namely those related to episodic memory, semantic fluency and backward digit span were associated with alcohol intake. This is in line with other findings <xref ref-type="bibr" rid="pone.0052311-Elias1">[36]</xref>, <xref ref-type="bibr" rid="pone.0052311-Gross1">[43]</xref>–<xref ref-type="bibr" rid="pone.0052311-Ngandu1">[46]</xref> suggesting that alcohol may differentially affect cognitive domains.</p></sec><sec id="s4b"><title>Type of Alcoholic Beverages and Cognitive Function</title><p>In this study, no differences in cognitive function according to the type of beverage consumed were observed. One exception was the finding of lower cognitive performance scores among men with a high contribution of beer to their total alcohol intake. Nevertheless, alcohol intake was mainly provided by wine and thus highly correlated with wine consumption, preventing a clear distinction between specific alcohol sources. Some authors have focused on the association between cognitive outcomes and alcohol intake by source <xref ref-type="bibr" rid="pone.0052311-Neafsey1">[7]</xref>. To the best of our knowledge, the relative contribution of each source to total alcohol intake has not been highlighted, however, authors focusing on the type of alcoholic beverage after accounting for other sources do not report specific effects <xref ref-type="bibr" rid="pone.0052311-Stampfer1">[47]</xref>. Nonetheless, authors have distinguished between “wet” (as in France) and “dry” drinking cultures as regards quantities and patterns of drinking. Future analyses using appropriate designs and comparing associations between alcohol intake and cognitive outcomes across countries may help improve understanding of the independent impact of the particular drinking culture <xref ref-type="bibr" rid="pone.0052311-Gordon1">[48]</xref>.</p></sec><sec id="s4c"><title>Limitations</title><p>Some limitations of our study should be noted. First, cognitive evaluation was not available at baseline, thus adjustment for baseline differences in cognitive performance according to midlife alcohol consumption was not possible. Preexisting differences in cognitive performance may have led to differences in alcohol consumption. However, our sample included relatively young and healthy volunteers, arguing for the likely absence of cognitive impairment at baseline. In addition, we were also not able to focus on cognitive decline over time. Second, we were not able to firmly distinguish between abstainers and former drinkers, acknowledging that former drinkers may be an at-risk population as quitters. The impact of that limitation, however, might be small in our study since we used midlife exposure assessment and adjustment for comorbidities. In addition, abstainers were not more likely to be hypertensive and were in fact less likely to have diabetes. Third, as wine was the dominant source of alcohol in our population, we were unable to separate the effects of wine from those of alcohol. Finally, caution is advised when assessing the external validity of our results as we cannot assume that our population is representative of the general population. Indeed, these analyses were based on a subsample of the SU.VI.MAX cohort, whose participants generally had a higher educational level and occupational status, along with a healthier diet than the general French population. In particular, subjects with available cognitive and alcohol data may have been particularly health-conscious, as shown by the comparison between included and excluded participants, limiting the generalizability of the findings. Nonetheless, use of inverse probability weighting to correct for potential selection bias did not modify the findings.</p></sec><sec id="s4d"><title>Strengths</title><p>In turn, some strengths of our analysis should also be emphasized. The long follow-up allowed focusing on alcohol intake as a midlife exposure. Further, food and alcoholic beverage consumption was assessed through repeated 24h dietary records strengthening the accuracy of the collected exposure data. Finally, standardized cognitive evaluation was completed in a relatively young population and a neuropsychological battery of sensitive tests was used to limit floor or ceiling effects.</p></sec><sec id="s4e"><title>Conclusion</title><p>In conclusion, while providing evidence for sex-specific associations, our results support the hypothesis that midlife low-to-moderate drinking in women and even heavy drinking in men might be associated with better cognitive functioning, independent of diet or comorbidities. However, extreme alcohol consumption may be harmful for cognitive function at least among men. Albeit sex-specific, the definitions of low-to-moderate and heavy drinking are not clear-cut. There is substantial evidence from other health domains (e.g., cancer development) that even a single serving of alcohol might have a detrimental impact.</p></sec></sec></body><back><ack><p>We thank all scientists, dietitians, technicians and assistants who helped carry out the SU.VI.MAX 2 study. 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