TelematiV1, Ncbi, Curation, bibRecord, 000A87

The Shigella flexneri OspB effector: an early immunomodulator.

Identifieur interne : 000A87 ( Ncbi/Curation ); précédent : 000A86; suivant : 000A88

The Shigella flexneri OspB effector: an early immunomodulator.

Auteurs : Cecilia Ambrosi [Italie] ; Monica Pompili [Italie] ; Daniela Scribano [Italie] ; Dolores Limongi [Italie] ; Andrea Petrucca [Italie] ; Sonia Cannavacciuolo [Italie] ; Serena Schippa [Italie] ; Carlo Zagaglia [Italie] ; Milena Grossi [Italie] ; Mauro Nicoletti [Italie]

Source :

International journal of medical microbiology : IJMM [ 1618-0607 ] ; 2015.

RBID : pubmed:25434600

Descripteurs français

KwdFr :
- Antigènes bactériens (métabolisme), Cellules Caco-2, Cellules HeLa, Cytokines (sécrétion), Facteurs immunologiques (métabolisme), Humains, Interactions hôte-pathogène, Protéines de la membrane externe bactérienne (métabolisme), Shigella flexneri (immunologie), Shigella flexneri (physiologie), Transduction du signal.
MESH :
- immunologie : Shigella flexneri.
- métabolisme : Antigènes bactériens, Facteurs immunologiques, Protéines de la membrane externe bactérienne.
- physiologie : Shigella flexneri.
- sécrétion : Cytokines.
- Cellules Caco-2, Cellules HeLa, Humains, Interactions hôte-pathogène, Transduction du signal.

English descriptors

KwdEn :
- Antigens, Bacterial (metabolism), Bacterial Outer Membrane Proteins (metabolism), Caco-2 Cells, Cytokines (secretion), HeLa Cells, Host-Pathogen Interactions, Humans, Immunologic Factors (metabolism), Shigella flexneri (immunology), Shigella flexneri (physiology), Signal Transduction.
MESH :
- chemical , metabolism : Antigens, Bacterial, Bacterial Outer Membrane Proteins, Immunologic Factors.
- chemical , secretion : Cytokines.
- immunology : Shigella flexneri.
- physiology : Shigella flexneri.
- Caco-2 Cells, HeLa Cells, Host-Pathogen Interactions, Humans, Signal Transduction.

Abstract

Through the action of the type three secretion system (T3SS) Shigella flexneri delivers several effectors into host cells to promote cellular invasion, multiplication and to exploit host-cell signaling pathways to modulate the host innate immune response. Although much progress has been made in the understanding of many type III effectors, the molecular and cellular mechanism of the OspB effector is still poorly characterized. In this study we present new evidence that better elucidates the role of OspB as pro-inflammatory factor at very early stages of infection. Indeed, we demonstrate that, during the first hour of infection, OspB is required for full activation of ERK1/2 and p38 MAPKs and the cytosolic phospholipase A(2) (cPLA(2)). Activation of cPLA(2) ultimately leads to the production and secretion of PMN chemoattractant metabolite(s) uncoupled with release of IL-8. Moreover, we also present evidence that OspB is required for the development of the full and promptly inflammatory reaction characteristic of S. flexneri wild-type infection in vivo. Based on OspB and OspF similarity (both effectors share similar transcription regulation, temporal secretion into host cells and nuclear localization) we hypothesized that OspB and OspF effectors may form a pair aimed at modulating the host cell response throughout the infection process, with opposite effects. A model is presented to illustrate how OspB activity would promote S. flexneri invasion and bacterial dissemination at early critical phases of infection.

DOI: 10.1016/j.ijmm.2014.11.004
PubMed: 25434600

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000150
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000150
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000150
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000A87

Links to Exploration step

pubmed:25434600

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Shigella flexneri OspB effector: an early immunomodulator.</title>
<author><name sortKey="Ambrosi, Cecilia" sort="Ambrosi, Cecilia" uniqKey="Ambrosi C" first="Cecilia" last="Ambrosi">Cecilia Ambrosi</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy. Electronic address: cecilia.ambrosi@uniroma1.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pompili, Monica" sort="Pompili, Monica" uniqKey="Pompili M" first="Monica" last="Pompili">Monica Pompili</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scribano, Daniela" sort="Scribano, Daniela" uniqKey="Scribano D" first="Daniela" last="Scribano">Daniela Scribano</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti</wicri:regionArea>
<wicri:noRegion>66100 Chieti</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Limongi, Dolores" sort="Limongi, Dolores" uniqKey="Limongi D" first="Dolores" last="Limongi">Dolores Limongi</name>
<affiliation wicri:level="1"><nlm:affiliation>San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Università Telematica San Raffaele Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Università Telematica San Raffaele Rome</wicri:regionArea>
<wicri:noRegion>Università Telematica San Raffaele Rome</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petrucca, Andrea" sort="Petrucca, Andrea" uniqKey="Petrucca A" first="Andrea" last="Petrucca">Andrea Petrucca</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratorio di Microbiologia Clinica, II Facoltà di Medicina e Chirurgia, Ospedale "Sant'Andrea", 00189 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratorio di Microbiologia Clinica, II Facoltà di Medicina e Chirurgia, Ospedale "Sant'Andrea", 00189 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cannavacciuolo, Sonia" sort="Cannavacciuolo, Sonia" uniqKey="Cannavacciuolo S" first="Sonia" last="Cannavacciuolo">Sonia Cannavacciuolo</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schippa, Serena" sort="Schippa, Serena" uniqKey="Schippa S" first="Serena" last="Schippa">Serena Schippa</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zagaglia, Carlo" sort="Zagaglia, Carlo" uniqKey="Zagaglia C" first="Carlo" last="Zagaglia">Carlo Zagaglia</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grossi, Milena" sort="Grossi, Milena" uniqKey="Grossi M" first="Milena" last="Grossi">Milena Grossi</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Biologia e Biotecnologie Charles Darwin, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Biologia e Biotecnologie Charles Darwin, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicoletti, Mauro" sort="Nicoletti, Mauro" uniqKey="Nicoletti M" first="Mauro" last="Nicoletti">Mauro Nicoletti</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti, Italy. Electronic address: mauro.nicoletti@uniroma1.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti</wicri:regionArea>
<wicri:noRegion>66100 Chieti</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25434600</idno>
<idno type="pmid">25434600</idno>
<idno type="doi">10.1016/j.ijmm.2014.11.004</idno>
<idno type="wicri:Area/PubMed/Corpus">000150</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000150</idno>
<idno type="wicri:Area/PubMed/Curation">000150</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000150</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000150</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000150</idno>
<idno type="wicri:Area/Ncbi/Merge">000A87</idno>
<idno type="wicri:Area/Ncbi/Curation">000A87</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The Shigella flexneri OspB effector: an early immunomodulator.</title>
<author><name sortKey="Ambrosi, Cecilia" sort="Ambrosi, Cecilia" uniqKey="Ambrosi C" first="Cecilia" last="Ambrosi">Cecilia Ambrosi</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy. Electronic address: cecilia.ambrosi@uniroma1.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pompili, Monica" sort="Pompili, Monica" uniqKey="Pompili M" first="Monica" last="Pompili">Monica Pompili</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scribano, Daniela" sort="Scribano, Daniela" uniqKey="Scribano D" first="Daniela" last="Scribano">Daniela Scribano</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti</wicri:regionArea>
<wicri:noRegion>66100 Chieti</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Limongi, Dolores" sort="Limongi, Dolores" uniqKey="Limongi D" first="Dolores" last="Limongi">Dolores Limongi</name>
<affiliation wicri:level="1"><nlm:affiliation>San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Università Telematica San Raffaele Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Università Telematica San Raffaele Rome</wicri:regionArea>
<wicri:noRegion>Università Telematica San Raffaele Rome</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petrucca, Andrea" sort="Petrucca, Andrea" uniqKey="Petrucca A" first="Andrea" last="Petrucca">Andrea Petrucca</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratorio di Microbiologia Clinica, II Facoltà di Medicina e Chirurgia, Ospedale "Sant'Andrea", 00189 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratorio di Microbiologia Clinica, II Facoltà di Medicina e Chirurgia, Ospedale "Sant'Andrea", 00189 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cannavacciuolo, Sonia" sort="Cannavacciuolo, Sonia" uniqKey="Cannavacciuolo S" first="Sonia" last="Cannavacciuolo">Sonia Cannavacciuolo</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schippa, Serena" sort="Schippa, Serena" uniqKey="Schippa S" first="Serena" last="Schippa">Serena Schippa</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zagaglia, Carlo" sort="Zagaglia, Carlo" uniqKey="Zagaglia C" first="Carlo" last="Zagaglia">Carlo Zagaglia</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Sanità Pubblica e Malattie Infettive, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grossi, Milena" sort="Grossi, Milena" uniqKey="Grossi M" first="Milena" last="Grossi">Milena Grossi</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Biologia e Biotecnologie Charles Darwin, "Sapienza" Università di Roma, 00185 Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Biologia e Biotecnologie Charles Darwin, "Sapienza" Università di Roma, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicoletti, Mauro" sort="Nicoletti, Mauro" uniqKey="Nicoletti M" first="Mauro" last="Nicoletti">Mauro Nicoletti</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti, Italy. Electronic address: mauro.nicoletti@uniroma1.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Sperimentali e Cliniche, Università "G. D'Annunzio", 66100 Chieti</wicri:regionArea>
<wicri:noRegion>66100 Chieti</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of medical microbiology : IJMM</title>
<idno type="eISSN">1618-0607</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, Bacterial (metabolism)</term>
<term>Bacterial Outer Membrane Proteins (metabolism)</term>
<term>Caco-2 Cells</term>
<term>Cytokines (secretion)</term>
<term>HeLa Cells</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Immunologic Factors (metabolism)</term>
<term>Shigella flexneri (immunology)</term>
<term>Shigella flexneri (physiology)</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes bactériens (métabolisme)</term>
<term>Cellules Caco-2</term>
<term>Cellules HeLa</term>
<term>Cytokines (sécrétion)</term>
<term>Facteurs immunologiques (métabolisme)</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Protéines de la membrane externe bactérienne (métabolisme)</term>
<term>Shigella flexneri (immunologie)</term>
<term>Shigella flexneri (physiologie)</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Bacterial</term>
<term>Bacterial Outer Membrane Proteins</term>
<term>Immunologic Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Shigella flexneri</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Shigella flexneri</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes bactériens</term>
<term>Facteurs immunologiques</term>
<term>Protéines de la membrane externe bactérienne</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Shigella flexneri</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Shigella flexneri</term>
</keywords>
<keywords scheme="MESH" qualifier="sécrétion" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Caco-2 Cells</term>
<term>HeLa Cells</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules Caco-2</term>
<term>Cellules HeLa</term>
<term>Humains</term>
<term>Interactions hôte-pathogène</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Through the action of the type three secretion system (T3SS) Shigella flexneri delivers several effectors into host cells to promote cellular invasion, multiplication and to exploit host-cell signaling pathways to modulate the host innate immune response. Although much progress has been made in the understanding of many type III effectors, the molecular and cellular mechanism of the OspB effector is still poorly characterized. In this study we present new evidence that better elucidates the role of OspB as pro-inflammatory factor at very early stages of infection. Indeed, we demonstrate that, during the first hour of infection, OspB is required for full activation of ERK1/2 and p38 MAPKs and the cytosolic phospholipase A(2) (cPLA(2)). Activation of cPLA(2) ultimately leads to the production and secretion of PMN chemoattractant metabolite(s) uncoupled with release of IL-8. Moreover, we also present evidence that OspB is required for the development of the full and promptly inflammatory reaction characteristic of S. flexneri wild-type infection in vivo. Based on OspB and OspF similarity (both effectors share similar transcription regulation, temporal secretion into host cells and nuclear localization) we hypothesized that OspB and OspF effectors may form a pair aimed at modulating the host cell response throughout the infection process, with opposite effects. A model is presented to illustrate how OspB activity would promote S. flexneri invasion and bacterial dissemination at early critical phases of infection.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/TelematiV1/Data/Ncbi/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A87 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000A87 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    TelematiV1
   |flux=    Ncbi
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:25434600
   |texte=   The Shigella flexneri OspB effector: an early immunomodulator.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i   -Sk "pubmed:25434600" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a TelematiV1

This area was generated with Dilib version V0.6.31.
Data generation: Thu Nov 2 16:09:04 2017. Site generation: Sun Mar 10 16:42:28 2024

	Serveur d'exploration sur la télématique
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la télématique

The Shigella flexneri OspB effector: an early immunomodulator.

The Shigella flexneri OspB effector: an early immunomodulator.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki