Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
Identifieur interne : 000392 ( Pmc/Curation ); précédent : 000391; suivant : 000393Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
Auteurs : Nina Schultz ; Henrietta M. Nielsen ; Lennart Minthon ; Malin WennströmSource :
- Journal of Neuropathology and Experimental Neurology [ 0022-3069 ] ; 2014.
Abstract
Supplemental digital content is available in the text.
Url:
DOI: 10.1097/NEN.0000000000000084
PubMed: 24918635
PubMed Central: 4072439
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000392
Links to Exploration step
PMC:4072439Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2</title><author><name sortKey="Schultz, Nina" sort="Schultz, Nina" uniqKey="Schultz N" first="Nina" last="Schultz">Nina Schultz</name></author><author><name sortKey="Nielsen, Henrietta M" sort="Nielsen, Henrietta M" uniqKey="Nielsen H" first="Henrietta M." last="Nielsen">Henrietta M. Nielsen</name></author><author><name sortKey="Minthon, Lennart" sort="Minthon, Lennart" uniqKey="Minthon L" first="Lennart" last="Minthon">Lennart Minthon</name></author><author><name sortKey="Wennstrom, Malin" sort="Wennstrom, Malin" uniqKey="Wennstrom M" first="Malin" last="Wennström">Malin Wennström</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24918635</idno><idno type="pmc">4072439</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072439</idno><idno type="RBID">PMC:4072439</idno><idno type="doi">10.1097/NEN.0000000000000084</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000392</idno><idno type="wicri:Area/Pmc/Curation">000392</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2</title><author><name sortKey="Schultz, Nina" sort="Schultz, Nina" uniqKey="Schultz N" first="Nina" last="Schultz">Nina Schultz</name></author><author><name sortKey="Nielsen, Henrietta M" sort="Nielsen, Henrietta M" uniqKey="Nielsen H" first="Henrietta M." last="Nielsen">Henrietta M. Nielsen</name></author><author><name sortKey="Minthon, Lennart" sort="Minthon, Lennart" uniqKey="Minthon L" first="Lennart" last="Minthon">Lennart Minthon</name></author><author><name sortKey="Wennstrom, Malin" sort="Wennstrom, Malin" uniqKey="Wennstrom M" first="Malin" last="Wennström">Malin Wennström</name></author></analytic><series><title level="j">Journal of Neuropathology and Experimental Neurology</title><idno type="ISSN">0022-3069</idno><idno type="eISSN">1554-6578</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Supplemental digital content is available in the text.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armulik, A" uniqKey="Armulik A">A Armulik</name></author><author><name sortKey="Genove, G" uniqKey="Genove G">G Genove</name></author><author><name sortKey="Mae, M" uniqKey="Mae M">M Mae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Sagare, Ap" uniqKey="Sagare A">AP Sagare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimizu, F" uniqKey="Shimizu F">F Shimizu</name></author><author><name sortKey="Sano, Y" uniqKey="Sano Y">Y Sano</name></author><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vagnucci, Ah" uniqKey="Vagnucci A">AH Vagnucci</name></author><author><name sortKey="Li, Ww" uniqKey="Li W">WW Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, We" uniqKey="Thomas W">WE Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darland, Dc" uniqKey="Darland D">DC Darland</name></author><author><name sortKey="Massingham, Lj" uniqKey="Massingham L">LJ Massingham</name></author><author><name sortKey="Smith, Sr" uniqKey="Smith S">SR Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arihiro, S" uniqKey="Arihiro S">S Arihiro</name></author><author><name sortKey="Ohtani, H" uniqKey="Ohtani H">H Ohtani</name></author><author><name sortKey="Hiwatashi, N" uniqKey="Hiwatashi N">N Hiwatashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takata, F" uniqKey="Takata F">F Takata</name></author><author><name sortKey="Dohgu, S" uniqKey="Dohgu S">S Dohgu</name></author><author><name sortKey="Matsumoto, J" uniqKey="Matsumoto J">J Matsumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Jin, M" uniqKey="Jin M">M Jin</name></author><author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sagare, Ap" uniqKey="Sagare A">AP Sagare</name></author><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blennow, K" uniqKey="Blennow K">K Blennow</name></author><author><name sortKey="De Leon, Mj" uniqKey="De Leon M">MJ de Leon</name></author><author><name sortKey="Zetterberg, H" uniqKey="Zetterberg H">H Zetterberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author><author><name sortKey="Han, Sb" uniqKey="Han S">SB Han</name></author><author><name sortKey="Nam, Sy" uniqKey="Nam S">SY Nam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brun, A" uniqKey="Brun A">A Brun</name></author><author><name sortKey="Englund, E" uniqKey="Englund E">E Englund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Englund, E" uniqKey="Englund E">E Englund</name></author><author><name sortKey="Brun, A" uniqKey="Brun A">A Brun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farkas, E" uniqKey="Farkas E">E Farkas</name></author><author><name sortKey="Luiten, Pg" uniqKey="Luiten P">PG Luiten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalaria, Rn" uniqKey="Kalaria R">RN Kalaria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchesi, Vt" uniqKey="Marchesi V">VT Marchesi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iadecola, C" uniqKey="Iadecola C">C Iadecola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sengillo, Jd" uniqKey="Sengillo J">JD Sengillo</name></author><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Walker, Ct" uniqKey="Walker C">CT Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, Mm" uniqKey="Verbeek M">MM Verbeek</name></author><author><name sortKey="De Waal, Rm" uniqKey="De Waal R">RM de Waal</name></author><author><name sortKey="Schipper, Jj" uniqKey="Schipper J">JJ Schipper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilhelmus, Mm" uniqKey="Wilhelmus M">MM Wilhelmus</name></author><author><name sortKey="Otte Holler, I" uniqKey="Otte Holler I">I Otte-Holler</name></author><author><name sortKey="Van Triel, Jj" uniqKey="Van Triel J">JJ van Triel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozerdem, U" uniqKey="Ozerdem U">U Ozerdem</name></author><author><name sortKey="Grako, Ka" uniqKey="Grako K">KA Grako</name></author><author><name sortKey="Dahlin Huppe, K" uniqKey="Dahlin Huppe K">K Dahlin-Huppe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author><author><name sortKey="Huang, Fj" uniqKey="Huang F">FJ Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozerdem, U" uniqKey="Ozerdem U">U Ozerdem</name></author><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="You, Wk" uniqKey="You W">WK You</name></author><author><name sortKey="Yotsumoto, F" uniqKey="Yotsumoto F">F Yotsumoto</name></author><author><name sortKey="Sakimura, K" uniqKey="Sakimura K">K Sakimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukushi, J" uniqKey="Fukushi J">J Fukushi</name></author><author><name sortKey="Makagiansar, It" uniqKey="Makagiansar I">IT Makagiansar</name></author><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, H" uniqKey="Nielsen H">H Nielsen</name></author><author><name sortKey="Ek, D" uniqKey="Ek D">D Ek</name></author><author><name sortKey="Avdic, U" uniqKey="Avdic U">U Avdic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, Hm" uniqKey="Nielsen H">HM Nielsen</name></author><author><name sortKey="Hall, S" uniqKey="Hall S">S Hall</name></author><author><name sortKey="Surova, Y" uniqKey="Surova Y">Y Surova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibb, Wr" uniqKey="Gibb W">WR Gibb</name></author><author><name sortKey="Luthert, Pj" uniqKey="Luthert P">PJ Luthert</name></author><author><name sortKey="Janota, I" uniqKey="Janota I">I Janota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishiyama, A" uniqKey="Nishiyama A">A Nishiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asher, Ra" uniqKey="Asher R">RA Asher</name></author><author><name sortKey="Morgenstern, Da" uniqKey="Morgenstern D">DA Morgenstern</name></author><author><name sortKey="Properzi, F" uniqKey="Properzi F">F Properzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Shubayev, Vi" uniqKey="Shubayev V">VI Shubayev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, Ph" uniqKey="Larsen P">PH Larsen</name></author><author><name sortKey="Wells, Je" uniqKey="Wells J">JE Wells</name></author><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreier, R" uniqKey="Dreier R">R Dreier</name></author><author><name sortKey="Wallace, S" uniqKey="Wallace S">S Wallace</name></author><author><name sortKey="Fuchs, S" uniqKey="Fuchs S">S Fuchs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogata, Y" uniqKey="Ogata Y">Y Ogata</name></author><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name></author><author><name sortKey="Nagase, H" uniqKey="Nagase H">H Nagase</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steenport, M" uniqKey="Steenport M">M Steenport</name></author><author><name sortKey="Khan, Km" uniqKey="Khan K">KM Khan</name></author><author><name sortKey="Du, B" uniqKey="Du B">B Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouchard, Ba" uniqKey="Bouchard B">BA Bouchard</name></author><author><name sortKey="Shatos, Ma" uniqKey="Shatos M">MA Shatos</name></author><author><name sortKey="Tracy, Pb" uniqKey="Tracy P">PB Tracy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, Mm" uniqKey="Verbeek M">MM Verbeek</name></author><author><name sortKey="Otte Holler, I" uniqKey="Otte Holler I">I Otte-Holler</name></author><author><name sortKey="Wesseling, P" uniqKey="Wesseling P">P Wesseling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tigges, U" uniqKey="Tigges U">U Tigges</name></author><author><name sortKey="Welser Alves, Jv" uniqKey="Welser Alves J">JV Welser-Alves</name></author><author><name sortKey="Boroujerdi, A" uniqKey="Boroujerdi A">A Boroujerdi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, Mm" uniqKey="Verbeek M">MM Verbeek</name></author><author><name sortKey="Otte Holler, I" uniqKey="Otte Holler I">I Otte-Holler</name></author><author><name sortKey="Wesseling, P" uniqKey="Wesseling P">P Wesseling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korzeniewski, C" uniqKey="Korzeniewski C">C Korzeniewski</name></author><author><name sortKey="Callewaert, Dm" uniqKey="Callewaert D">DM Callewaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos Desimone, N" uniqKey="Ramos Desimone N">N Ramos-DeSimone</name></author><author><name sortKey="Hahn Dantona, E" uniqKey="Hahn Dantona E">E Hahn-Dantona</name></author><author><name sortKey="Sipley, J" uniqKey="Sipley J">J Sipley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horstmann, S" uniqKey="Horstmann S">S Horstmann</name></author><author><name sortKey="Budig, L" uniqKey="Budig L">L Budig</name></author><author><name sortKey="Gardner, H" uniqKey="Gardner H">H Gardner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, Wl" uniqKey="Klein W">WL Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stefani, M" uniqKey="Stefani M">M Stefani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biron, Ke" uniqKey="Biron K">KE Biron</name></author><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Gopaul, R" uniqKey="Gopaul R">R Gopaul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ujiie, M" uniqKey="Ujiie M">M Ujiie</name></author><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Carlow, Da" uniqKey="Carlow D">DA Carlow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biron, Ke" uniqKey="Biron K">KE Biron</name></author><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Gopaul, R" uniqKey="Gopaul R">R Gopaul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Biron, Ke" uniqKey="Biron K">KE Biron</name></author><author><name sortKey="Ujiie, M" uniqKey="Ujiie M">M Ujiie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieper, C" uniqKey="Pieper C">C Pieper</name></author><author><name sortKey="Pieloch, P" uniqKey="Pieloch P">P Pieloch</name></author><author><name sortKey="Galla, Hj" uniqKey="Galla H">HJ Galla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Estrada, Ey" uniqKey="Estrada E">EY Estrada</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virgintino, D" uniqKey="Virgintino D">D Virgintino</name></author><author><name sortKey="Errede, M" uniqKey="Errede M">M Errede</name></author><author><name sortKey="Girolamo, F" uniqKey="Girolamo F">F Girolamo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrall, Aj" uniqKey="Farrall A">AJ Farrall</name></author><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Golob, Ej" uniqKey="Golob E">EJ Golob</name></author><author><name sortKey="Su, My" uniqKey="Su M">MY Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baloyannis, Sj" uniqKey="Baloyannis S">SJ Baloyannis</name></author><author><name sortKey="Baloyannis, Is" uniqKey="Baloyannis I">IS Baloyannis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buee, L" uniqKey="Buee L">L Buee</name></author><author><name sortKey="Hof, Pr" uniqKey="Hof P">PR Hof</name></author><author><name sortKey="Bouras, C" uniqKey="Bouras C">C Bouras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stomrud, E" uniqKey="Stomrud E">E Stomrud</name></author><author><name sortKey="Bjorkqvist, M" uniqKey="Bjorkqvist M">M Bjorkqvist</name></author><author><name sortKey="Janciauskiene, S" uniqKey="Janciauskiene S">S Janciauskiene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Singh, I" uniqKey="Singh I">I Singh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neuropathol Exp Neurol</journal-id><journal-id journal-id-type="iso-abbrev">J. Neuropathol. Exp. Neurol</journal-id><journal-id journal-id-type="publisher-id">NEN</journal-id><journal-title-group><journal-title>Journal of Neuropathology and Experimental Neurology</journal-title></journal-title-group><issn pub-type="ppub">0022-3069</issn><issn pub-type="epub">1554-6578</issn><publisher><publisher-name>American Association of Neuropathologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24918635</article-id><article-id pub-id-type="pmc">4072439</article-id><article-id pub-id-type="publisher-id">NEN13243</article-id><article-id pub-id-type="doi">10.1097/NEN.0000000000000084</article-id><article-id pub-id-type="art-access-id">00005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schultz</surname><given-names>Nina</given-names></name><degrees>BS</degrees></contrib><contrib contrib-type="author"><name><surname>Nielsen</surname><given-names>Henrietta M.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Minthon</surname><given-names>Lennart</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Wennström</surname><given-names>Malin</given-names></name><degrees>PhD</degrees></contrib></contrib-group><aff>From the Clinical Memory Research Unit, The Wallenberg Laboratory, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden (NS, LM, MW); and Department of Neuroscience, Mayo Clinic, Jacksonville, Florida (HMN).</aff><author-notes><corresp>Send correspondence and reprint requests to: Malin Wennström, PhD, Clinical Memory Research Unit, The Wallenberg Laboratory, Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Second Floor, Inga Marie Nilssons gata, Entrance 53, Malmö 205 02, Sweden; E-mail: <email>malin.wennstrom@med.lu.se</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>19</day><month>6</month><year>2014</year></pub-date><volume>73</volume><issue>7</issue><fpage>684</fpage><lpage>692</lpage><permissions><copyright-statement>Copyright © 2014 by the American Association of Neuropathologists, Inc.</copyright-statement><copyright-year>2014</copyright-year><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.</license-p></license></permissions><self-uri xlink:type="simple" xlink:href="nen-73-684.pdf"></self-uri><abstract abstract-type="toc"><p>Supplemental digital content is available in the text.</p></abstract><abstract><title>Abstract</title><p>Deposition of amyloid-β (Aβ) 1–42, the major component of senile plaques characteristic of Alzheimer disease, affects brain microvascular integrity and causes blood-brain barrier dysfunction, increased angiogenesis, and pericyte degeneration. To understand the cellular events underlying Aβ1–42 effects on microvascular alterations, we investigated whether different aggregation forms of Aβ1–42 affect shedding of the pericyte proteoglycan NG2 and whether they affect proteolytic cleavage mediated by matrix metalloproteinase (MMP)-9. We found decreased levels of soluble NG2, total MMP-9, and MMP-9 activity in pericyte culture supernatants in response to fibril-enriched preparations of Aβ1–42. Conversely, oligomer-enriched preparations of Aβ1–42 increased soluble NG2 levels in the supernatants. This increase was ablated by the MMP-9/MMP-2 inhibitor SB-3CT. There was also a trend toward increased MMP-9 activity observed after oligomeric Aβ1–42 exposure. Our results, demonstrating an Aβ1–42 aggregation-dependent effect on levels of NG2 and MMP-9, support previous studies showing an impact of Aβ1–42 on vascular integrity and thereby add to our understanding of mechanisms behind the microvascular changes commonly found in patients with Alzheimer disease.</p></abstract><kwd-group><title>Key Words</title><kwd>Alzheimer disease</kwd><kwd>Amyloid-β</kwd><kwd>Matrix metalloproteinase-9</kwd><kwd>NG2 proteoglycan</kwd><kwd>Pericytes</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta><custom-meta><meta-name>SDC</meta-name><meta-value>T</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000392 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000392 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4072439
|texte= Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:24918635" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a OpenAccessBelV2
| This area was generated with Dilib version V0.6.25. |  |