Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe
Identifieur interne : 000758 ( Main/Exploration ); précédent : 000757; suivant : 000759Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe
Auteurs : Melike Deger [Suisse] ; Wolfgang Eisterer [Autriche] ; Lucie Kutikova [Suisse] ; Sam SalekSource :
- Supportive Care in Cancer [ 0941-4355 ] ; 2012.
Abstract
Erythropoiesis-stimulating agents can reduce red blood cell transfusion rates in patients developing anemia while receiving chemotherapy. We investigated potential cost savings from reduced transfusion rates in patients starting darbepoetin alfa (DA) at higher versus lower hemoglobin (Hb) levels.
Two systematic literature reviews were performed: transfusion outcomes in patients receiving DA stratified by baseline Hb level and costs of transfusion in Europe. Potential cost savings were calculated by multiplying the difference in transfusion rates between Hb levels by the midpoint of transfusion costs.
Despite differences in baseline characteristics, treatment duration and analysis technique, the clinical studies (
Transfusion incidence increases with DA initiation at lower Hb levels. Potential cost savings depend on the number of units transfused and cost items included. DA initiation according to guidelines can reduce transfusions and potentially reduce transfusion-associated costs.
Url:
DOI: 10.1007/s00520-012-1538-0
PubMed: 22825456
PubMed Central: 3538022
Affiliations:
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Le document en format XML
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<author><name sortKey="Deger, Melike" sort="Deger, Melike" uniqKey="Deger M" first="Melike" last="Deger">Melike Deger</name>
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<author><name sortKey="Eisterer, Wolfgang" sort="Eisterer, Wolfgang" uniqKey="Eisterer W" first="Wolfgang" last="Eisterer">Wolfgang Eisterer</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department for Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria</nlm:aff>
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<author><name sortKey="Kutikova, Lucie" sort="Kutikova, Lucie" uniqKey="Kutikova L" first="Lucie" last="Kutikova">Lucie Kutikova</name>
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<author><name sortKey="Salek, Sam" sort="Salek, Sam" uniqKey="Salek S" first="Sam" last="Salek">Sam Salek</name>
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<series><title level="j">Supportive Care in Cancer</title>
<idno type="ISSN">0941-4355</idno>
<idno type="eISSN">1433-7339</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>Erythropoiesis-stimulating agents can reduce red blood cell transfusion rates in patients developing anemia while receiving chemotherapy. We investigated potential cost savings from reduced transfusion rates in patients starting darbepoetin alfa (DA) at higher versus lower hemoglobin (Hb) levels.</p>
</sec>
<sec><title>Methods</title>
<p>Two systematic literature reviews were performed: transfusion outcomes in patients receiving DA stratified by baseline Hb level and costs of transfusion in Europe. Potential cost savings were calculated by multiplying the difference in transfusion rates between Hb levels by the midpoint of transfusion costs.</p>
</sec>
<sec><title>Results</title>
<p>Despite differences in baseline characteristics, treatment duration and analysis technique, the clinical studies (<italic>n</italic>
= 8) showed that fewer transfusions were required when DA was initiated at higher versus lower Hb levels. The economic studies (<italic>n</italic>
= 9) showed that 1 unit of transfusion ranged from €130 to €537 (2010-adjusted values). Cost savings from initiating DA at higher versus lower Hb levels were €503–2,226 (2 units transfused) and €880–3,895 (3.5 units) per ten patients.</p>
</sec>
<sec><title>Conclusions</title>
<p>Transfusion incidence increases with DA initiation at lower Hb levels. Potential cost savings depend on the number of units transfused and cost items included. DA initiation according to guidelines can reduce transfusions and potentially reduce transfusion-associated costs.</p>
</sec>
</div>
</front>
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<author><name sortKey="Osterborg, A" uniqKey="Osterborg A">A Osterborg</name>
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<author><name sortKey="Baud, M" uniqKey="Baud M">M Baud</name>
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<author><name sortKey="Joly, Ac" uniqKey="Joly A">AC Joly</name>
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<author><name sortKey="Daguenel, A" uniqKey="Daguenel A">A Daguenel</name>
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<author><name sortKey="Chouaid, C" uniqKey="Chouaid C">C Chouaid</name>
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<author><name sortKey="Demarteau, N" uniqKey="Demarteau N">N Demarteau</name>
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<author><name sortKey="Van Belle, S" uniqKey="Van Belle S">S Van Belle</name>
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<affiliations><list><country><li>Autriche</li>
<li>Suisse</li>
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<tree><noCountry><name sortKey="Salek, Sam" sort="Salek, Sam" uniqKey="Salek S" first="Sam" last="Salek">Sam Salek</name>
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<country name="Autriche"><noRegion><name sortKey="Eisterer, Wolfgang" sort="Eisterer, Wolfgang" uniqKey="Eisterer W" first="Wolfgang" last="Eisterer">Wolfgang Eisterer</name>
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