Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe
Identifieur interne : 000141 ( Ncbi/Checkpoint ); précédent : 000140; suivant : 000142Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe
Auteurs : Melike Deger [Suisse] ; Wolfgang Eisterer [Autriche] ; Lucie Kutikova [Suisse] ; Sam SalekSource :
- Supportive Care in Cancer [ 0941-4355 ] ; 2012.
Abstract
Erythropoiesis-stimulating agents can reduce red blood cell transfusion rates in patients developing anemia while receiving chemotherapy. We investigated potential cost savings from reduced transfusion rates in patients starting darbepoetin alfa (DA) at higher versus lower hemoglobin (Hb) levels.
Two systematic literature reviews were performed: transfusion outcomes in patients receiving DA stratified by baseline Hb level and costs of transfusion in Europe. Potential cost savings were calculated by multiplying the difference in transfusion rates between Hb levels by the midpoint of transfusion costs.
Despite differences in baseline characteristics, treatment duration and analysis technique, the clinical studies (
Transfusion incidence increases with DA initiation at lower Hb levels. Potential cost savings depend on the number of units transfused and cost items included. DA initiation according to guidelines can reduce transfusions and potentially reduce transfusion-associated costs.
Url:
DOI: 10.1007/s00520-012-1538-0
PubMed: 22825456
PubMed Central: 3538022
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe</title><author><name sortKey="Deger, Melike" sort="Deger, Melike" uniqKey="Deger M" first="Melike" last="Deger">Melike Deger</name><affiliation><nlm:aff id="Aff1">Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB UK</nlm:aff><wicri:noCountry code="subfield">CF10 3NB UK</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Amgen Europe GmbH, Dammstrasse 23, 6300 Zug, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen Europe GmbH, Dammstrasse 23, 6300 Zug</wicri:regionArea><wicri:noRegion>6300 Zug</wicri:noRegion></affiliation></author><author><name sortKey="Eisterer, Wolfgang" sort="Eisterer, Wolfgang" uniqKey="Eisterer W" first="Wolfgang" last="Eisterer">Wolfgang Eisterer</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department for Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department for Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Kutikova, Lucie" sort="Kutikova, Lucie" uniqKey="Kutikova L" first="Lucie" last="Kutikova">Lucie Kutikova</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Amgen Europe GmbH, Dammstrasse 23, 6300 Zug, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen Europe GmbH, Dammstrasse 23, 6300 Zug</wicri:regionArea><wicri:noRegion>6300 Zug</wicri:noRegion></affiliation></author><author><name sortKey="Salek, Sam" sort="Salek, Sam" uniqKey="Salek S" first="Sam" last="Salek">Sam Salek</name><affiliation><nlm:aff id="Aff4">Centre for Socioeconomic Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB UK</nlm:aff><wicri:noCountry code="subfield">CF10 3NB UK</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22825456</idno><idno type="pmc">3538022</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538022</idno><idno type="RBID">PMC:3538022</idno><idno type="doi">10.1007/s00520-012-1538-0</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000191</idno><idno type="wicri:Area/Pmc/Curation">000191</idno><idno type="wicri:Area/Pmc/Checkpoint">000319</idno><idno type="wicri:Area/Ncbi/Merge">000141</idno><idno type="wicri:Area/Ncbi/Curation">000141</idno><idno type="wicri:Area/Ncbi/Checkpoint">000141</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe</title><author><name sortKey="Deger, Melike" sort="Deger, Melike" uniqKey="Deger M" first="Melike" last="Deger">Melike Deger</name><affiliation><nlm:aff id="Aff1">Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB UK</nlm:aff><wicri:noCountry code="subfield">CF10 3NB UK</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Amgen Europe GmbH, Dammstrasse 23, 6300 Zug, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen Europe GmbH, Dammstrasse 23, 6300 Zug</wicri:regionArea><wicri:noRegion>6300 Zug</wicri:noRegion></affiliation></author><author><name sortKey="Eisterer, Wolfgang" sort="Eisterer, Wolfgang" uniqKey="Eisterer W" first="Wolfgang" last="Eisterer">Wolfgang Eisterer</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department for Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department for Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Kutikova, Lucie" sort="Kutikova, Lucie" uniqKey="Kutikova L" first="Lucie" last="Kutikova">Lucie Kutikova</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Amgen Europe GmbH, Dammstrasse 23, 6300 Zug, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen Europe GmbH, Dammstrasse 23, 6300 Zug</wicri:regionArea><wicri:noRegion>6300 Zug</wicri:noRegion></affiliation></author><author><name sortKey="Salek, Sam" sort="Salek, Sam" uniqKey="Salek S" first="Sam" last="Salek">Sam Salek</name><affiliation><nlm:aff id="Aff4">Centre for Socioeconomic Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB UK</nlm:aff><wicri:noCountry code="subfield">CF10 3NB UK</wicri:noCountry></affiliation></author></analytic><series><title level="j">Supportive Care in Cancer</title><idno type="ISSN">0941-4355</idno><idno type="eISSN">1433-7339</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Erythropoiesis-stimulating agents can reduce red blood cell transfusion rates in patients developing anemia while receiving chemotherapy. We investigated potential cost savings from reduced transfusion rates in patients starting darbepoetin alfa (DA) at higher versus lower hemoglobin (Hb) levels.</p></sec><sec><title>Methods</title><p>Two systematic literature reviews were performed: transfusion outcomes in patients receiving DA stratified by baseline Hb level and costs of transfusion in Europe. Potential cost savings were calculated by multiplying the difference in transfusion rates between Hb levels by the midpoint of transfusion costs.</p></sec><sec><title>Results</title><p>Despite differences in baseline characteristics, treatment duration and analysis technique, the clinical studies (<italic>n</italic> = 8) showed that fewer transfusions were required when DA was initiated at higher versus lower Hb levels. The economic studies (<italic>n</italic> = 9) showed that 1 unit of transfusion ranged from €130 to €537 (2010-adjusted values). Cost savings from initiating DA at higher versus lower Hb levels were €503–2,226 (2 units transfused) and €880–3,895 (3.5 units) per ten patients.</p></sec><sec><title>Conclusions</title><p>Transfusion incidence increases with DA initiation at lower Hb levels. Potential cost savings depend on the number of units transfused and cost items included. 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F" uniqKey="Song F">F Song</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Autriche</li><li>Suisse</li></country></list><tree><noCountry><name sortKey="Salek, Sam" sort="Salek, Sam" uniqKey="Salek S" first="Sam" last="Salek">Sam Salek</name></noCountry><country name="Suisse"><noRegion><name sortKey="Deger, Melike" sort="Deger, Melike" uniqKey="Deger M" first="Melike" last="Deger">Melike Deger</name></noRegion><name sortKey="Kutikova, Lucie" sort="Kutikova, Lucie" uniqKey="Kutikova L" first="Lucie" last="Kutikova">Lucie Kutikova</name></country><country name="Autriche"><noRegion><name sortKey="Eisterer, Wolfgang" sort="Eisterer, Wolfgang" uniqKey="Eisterer W" first="Wolfgang" last="Eisterer">Wolfgang Eisterer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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