Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain
Identifieur interne : 000D21 ( Istex/Corpus ); précédent : 000D20; suivant : 000D22Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain
Auteurs : Edward Ryder ; Kim Wong ; Diane Gleeson ; Thomas M. Keane ; Debarati Sethi ; Sapna Vyas ; Hannah Wardle-Jones ; James N. Bussell ; Richard Houghton ; Jennifer Salisbury ; Nina Harvey ; David J. Adams ; Ramiro Ramirez-SolisSource :
- genesis [ 1526-954X ] ; 2013-07.
Abstract
We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N‐TyrcWTSI). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. © 2013 Wiley Periodicals, Inc.
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DOI: 10.1002/dvg.22398
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Bussell</name><affiliation><mods:affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Houghton, Richard" sort="Houghton, Richard" uniqKey="Houghton R" first="Richard" last="Houghton">Richard Houghton</name><affiliation><mods:affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Salisbury, Jennifer" sort="Salisbury, Jennifer" uniqKey="Salisbury J" first="Jennifer" last="Salisbury">Jennifer Salisbury</name><affiliation><mods:affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Harvey, Nina" sort="Harvey, Nina" uniqKey="Harvey N" first="Nina" last="Harvey">Nina Harvey</name><affiliation><mods:affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Adams, David J" sort="Adams, David J" uniqKey="Adams D" first="David J." last="Adams">David J. Adams</name><affiliation><mods:affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Ramirez Olis, Ramiro" sort="Ramirez Olis, Ramiro" uniqKey="Ramirez Olis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation><mods:affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">genesis</title><title level="j" type="abbrev">genesis</title><idno type="ISSN">1526-954X</idno><idno type="eISSN">1526-968X</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-07">2013-07</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="523">523</biblScope><biblScope unit="page" to="528">528</biblScope></imprint><idno type="ISSN">1526-954X</idno></series><idno type="istex">BF499502F5C6E2202EA69D67D86C1A64BA6736EF</idno><idno type="DOI">10.1002/dvg.22398</idno><idno type="ArticleID">DVG22398</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1526-954X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N‐TyrcWTSI). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. © 2013 Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Edward Ryder</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Kim Wong</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Diane Gleeson</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Thomas M. Keane</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Debarati Sethi</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Sapna Vyas</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Hannah Wardle‐Jones</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>James N. Bussell</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Richard Houghton</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Jennifer Salisbury</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Nina Harvey</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>David J. Adams</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item><json:item><name>Ramiro Ramirez‐Solis</name><affiliations><json:string>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>mouse</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genome sequencing</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>transgenics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mammalian</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genomics</value></json:item></subject><articleId><json:string>DVG22398</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N‐TyrcWTSI). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. © 2013 Wiley Periodicals, Inc.</abstract><qualityIndicators><score>3.983</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 809.972 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>528</abstractCharCount><pdfWordCount>3095</pdfWordCount><pdfCharCount>18437</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>74</abstractWordCount></qualityIndicators><title>Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain</title><corporate><json:item><name>Sanger Mouse Genetics Project</name></json:item></corporate><genre><json:string>article</json:string></genre><host><volume>51</volume><publisherId><json:string>DVG</json:string></publisherId><pages><total>6</total><last>528</last><first>523</first></pages><issn><json:string>1526-954X</json:string></issn><issue>7</issue><subject><json:item><value>Technology Report</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1526-968X</json:string></eissn><title>genesis</title><doi><json:string>10.1002/(ISSN)1526-968X</json:string></doi></host><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1002/dvg.22398</json:string></doi><id>BF499502F5C6E2202EA69D67D86C1A64BA6736EF</id><score>0.25446233</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/BF499502F5C6E2202EA69D67D86C1A64BA6736EF/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/BF499502F5C6E2202EA69D67D86C1A64BA6736EF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BF499502F5C6E2202EA69D67D86C1A64BA6736EF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><availability status="free"><p>Open Access</p></availability><date>2013-07-18</date></publicationStmt><notesStmt><note>Wellcome Trust - No. WT098051;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain</title><author><orgName>Sanger Mouse Genetics Project</orgName></author><author xml:id="author-1"><persName><forename type="first">Edward</forename><surname>Ryder</surname></persName><note type="correspondence"><p>Correspondence to: Edward Ryder, the Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom. E‐mail:</p></note><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-2"><persName><forename type="first">Kim</forename><surname>Wong</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-3"><persName><forename type="first">Diane</forename><surname>Gleeson</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-4"><persName><forename type="first">Thomas M.</forename><surname>Keane</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-5"><persName><forename type="first">Debarati</forename><surname>Sethi</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-6"><persName><forename type="first">Sapna</forename><surname>Vyas</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-7"><persName><forename type="first">Hannah</forename><surname>Wardle‐Jones</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-8"><persName><forename type="first">James N.</forename><surname>Bussell</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-9"><persName><forename type="first">Richard</forename><surname>Houghton</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-10"><persName><forename type="first">Jennifer</forename><surname>Salisbury</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-11"><persName><forename type="first">Nina</forename><surname>Harvey</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-12"><persName><forename type="first">David J.</forename><surname>Adams</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author><author xml:id="author-14"><persName><forename type="first">Ramiro</forename><surname>Ramirez‐Solis</surname></persName><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation></author></analytic><monogr><title level="j">genesis</title><title level="j" type="abbrev">genesis</title><idno type="pISSN">1526-954X</idno><idno type="eISSN">1526-968X</idno><idno type="DOI">10.1002/(ISSN)1526-968X</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-07"></date><biblScope unit="volume">51</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="523">523</biblScope><biblScope unit="page" to="528">528</biblScope></imprint></monogr><idno type="istex">BF499502F5C6E2202EA69D67D86C1A64BA6736EF</idno><idno type="DOI">10.1002/dvg.22398</idno><idno type="ArticleID">DVG22398</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-07-18</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N‐TyrcWTSI). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. © 2013 Wiley Periodicals, Inc.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>mouse</term></item><item><term>genome sequencing</term></item><item><term>genetics</term></item><item><term>transgenics</term></item><item><term>mammalian</term></item><item><term>genomics</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Technology Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2013-02-19">Received</change><change when="2013-04-17">Registration</change><change when="2013-07-18">Created</change><change when="2013-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/BF499502F5C6E2202EA69D67D86C1A64BA6736EF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="dvg22398"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1526-968X</doi><issn type="print">1526-954X</issn><issn type="electronic">1526-968X</issn><idGroup><id type="product" value="DVG"></id></idGroup><titleGroup><title type="main" sort="GENESIS">genesis</title><title type="short">genesis</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi>10.1002/dvg.v51.7</doi><copyright ownership="publisher">Copyright © 2013 The Authors. Genesis Published by Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="51">51</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2013-07">July 2013</coverDate></publicationMeta><publicationMeta level="unit" position="90" type="article" status="forIssue" accessType="open"><doi>10.1002/dvg.22398</doi><idGroup><id type="unit" value="DVG22398"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Technology Report</title><title type="tocHeading1">Technology Reports</title></titleGroup><copyright ownership="publisher">Copyright © 2013 The Authors. Genesis Published by Wiley Periodicals, Inc.</copyright><legalStatement type="creativeCommonsBy-nc"><p>This is an open access article under the terms of the <url href="http://creativecommons.org/licenses/by-nc/3.0/">Creative Commons Attribution‐NonCommercial</url> License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.</p></legalStatement><eventGroup><event type="manuscriptReceived" date="2013-02-19"></event><event type="manuscriptRevised" date="2013-04-10"></event><event type="manuscriptAccepted" date="2013-04-17"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2013-07-18"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-06-25"></event><event type="publishedOnlineAccepted" date="2013-04-26"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-05-25"></event><event type="publishedOnlineFinalForm" date="2013-07-19"></event><event type="firstOnline" date="2013-05-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-05"></event></eventGroup><numberingGroup><numbering type="pageFirst">523</numbering><numbering type="pageLast">528</numbering></numberingGroup><correspondenceTo>Correspondence to: Edward Ryder, the Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom. E‐mail: <email>er1@sanger.ac.uk</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:DVG.DVG22398.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain</title><title type="short">Genome Analysis of a New C57BL/6N Albino</title><title type="shortAuthors">Ryder et al.</title></titleGroup><creators><creator affiliationRef="#dvg22398-aff-0001" corresponding="yes" creatorRole="author" xml:id="dvg22398-cr-0001"><personName><givenNames>Edward</givenNames><familyName>Ryder</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0002"><personName><givenNames>Kim</givenNames><familyName>Wong</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0003"><personName><givenNames>Diane</givenNames><familyName>Gleeson</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0004"><personName><givenNames>Thomas M.</givenNames><familyName>Keane</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0005"><personName><givenNames>Debarati</givenNames><familyName>Sethi</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0006"><personName><givenNames>Sapna</givenNames><familyName>Vyas</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0007"><personName><givenNames>Hannah</givenNames><familyName>Wardle‐Jones</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0008"><personName><givenNames>James N.</givenNames><familyName>Bussell</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0009"><personName><givenNames>Richard</givenNames><familyName>Houghton</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0010"><personName><givenNames>Jennifer</givenNames><familyName>Salisbury</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0011"><personName><givenNames>Nina</givenNames><familyName>Harvey</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0012"><personName><givenNames>David J.</givenNames><familyName>Adams</familyName></personName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0013"><groupName>Sanger Mouse Genetics Project</groupName></creator><creator affiliationRef="#dvg22398-aff-0001" creatorRole="author" xml:id="dvg22398-cr-0014"><personName><givenNames>Ramiro</givenNames><familyName>Ramirez‐Solis</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="GB" type="organization" xml:id="dvg22398-aff-0001"><orgName>The Wellcome Trust Sanger Institute</orgName><address><city>Hinxton</city><street>Cambridgeshire CB10 1SA</street><country>United Kingdom</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="dvg22398-kwd-0001">mouse</keyword><keyword xml:id="dvg22398-kwd-0002">genome sequencing</keyword><keyword xml:id="dvg22398-kwd-0003">genetics</keyword><keyword xml:id="dvg22398-kwd-0004">transgenics</keyword><keyword xml:id="dvg22398-kwd-0005">mammalian</keyword><keyword xml:id="dvg22398-kwd-0006">genomics</keyword></keywordGroup><fundingInfo><fundingAgency>Wellcome Trust </fundingAgency><fundingNumber>WT098051 </fundingNumber></fundingInfo><supportingInformation><p>Additional Supporting Information may be found in the online version of this article.</p><supportingInfoItem><mediaResource alt="application/rtf" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0001-supptables1-2"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application/xls" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0002-supp3a"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application/xls" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0003-supp3b"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application/xls" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0004-suppinfo1"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application/xls" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0005-suppinfo2"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application/xls" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0006-suppinfo3"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="application/xls" href="urn-x:wiley:1526954X:media:dvg22398:dvg22398-sup-0007-suppinfo4"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main"><p>We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the <i>tyrosinase</i> gene (C57BL/6N‐<i>Tyr<sup>cWTSI</sup></i>). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. © 2013 Wiley Periodicals, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="dvg22398-note-0001" numbered="no"><p>Author contributions: ER, DG, DS, and SV characterized the mutation and performed molecular analysis. KW, TK, DA performed whole genome sequencing and data analysis. HWJ, JB, RH, JS, NH produced the mice and performed colony management. RRS coordinated the project. All authors contributed to writing the manuscript.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Genome Analysis of a New C57BL/6N Albino</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain</title></titleInfo><name type="personal"><namePart type="given">Edward</namePart><namePart type="family">Ryder</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><description>Correspondence to: Edward Ryder, the Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom. E‐mail: </description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kim</namePart><namePart type="family">Wong</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Diane</namePart><namePart type="family">Gleeson</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas M.</namePart><namePart type="family">Keane</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Debarati</namePart><namePart type="family">Sethi</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sapna</namePart><namePart type="family">Vyas</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hannah</namePart><namePart type="family">Wardle‐Jones</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James N.</namePart><namePart type="family">Bussell</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Houghton</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jennifer</namePart><namePart type="family">Salisbury</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nina</namePart><namePart type="family">Harvey</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David J.</namePart><namePart type="family">Adams</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>Sanger Mouse Genetics Project</namePart></name><name type="personal"><namePart type="given">Ramiro</namePart><namePart type="family">Ramirez‐Solis</namePart><affiliation>The Wellcome Trust Sanger Institute, Cambridgeshire CB10 1SA, Hinxton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-07</dateIssued><dateCreated encoding="w3cdtf">2013-07-18</dateCreated><dateCaptured encoding="w3cdtf">2013-02-19</dateCaptured><dateValid encoding="w3cdtf">2013-04-17</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N‐TyrcWTSI). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523–528. © 2013 Wiley Periodicals, Inc.</abstract><note type="funding">Wellcome Trust - No. WT098051; </note><subject><genre>keywords</genre><topic>mouse</topic><topic>genome sequencing</topic><topic>genetics</topic><topic>transgenics</topic><topic>mammalian</topic><topic>genomics</topic></subject><relatedItem type="host"><titleInfo><title>genesis</title></titleInfo><titleInfo type="abbreviated"><title>genesis</title></titleInfo><genre type="journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supplementary Information - Supplementary Information - Supplementary Information - Supplementary Information - Supplementary Information - Supplementary Information - Supplementary Information - </note><subject><genre>article-category</genre><topic>Technology Report</topic></subject><identifier type="ISSN">1526-954X</identifier><identifier type="eISSN">1526-968X</identifier><identifier type="DOI">10.1002/(ISSN)1526-968X</identifier><identifier type="PublisherID">DVG</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>523</start><end>528</end><total>6</total></extent></part></relatedItem><identifier type="istex">BF499502F5C6E2202EA69D67D86C1A64BA6736EF</identifier><identifier type="DOI">10.1002/dvg.22398</identifier><identifier type="ArticleID">DVG22398</identifier><accessCondition type="use and reproduction" contentType="creativeCommonsBy-nc">This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><enrichments><json:item><type>multicat</type><uri>https://api.istex.fr/document/BF499502F5C6E2202EA69D67D86C1A64BA6736EF/enrichments/multicat</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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