OcrV1, Main, Merge, bibRecord, 002D66

Evidence for genetic influences on smoking in adult women twins

Identifieur interne : 002D66 ( Main/Merge ); précédent : 002D65; suivant : 002D67

Evidence for genetic influences on smoking in adult women twins

Auteurs : K. L. Edwards [États-Unis] ; M. A. Austin [États-Unis] ; G. P. Jarvik

Source :

Clinical genetics [ 0009-9163 ] ; 1995.

RBID : Pascal:95-0344319

Descripteurs français

Pascal (Inist)
- Tabagisme, Déterminisme génétique, Homme, Jumeau, Femelle, Adulte.
Wicri :
- topic : Tabagisme, Homme, Adulte.

English descriptors

KwdEn :
- Adult, Female, Genetic inheritance, Human, Tobacco smoking, Twin.

Abstract

The purpose of the present study was to examine genetic influences on smoking behavior in women twins, and to compare the results before and after adjusting for environmental covariates. Subjects were participants in the Kaiser Permanente Women Twins Study in Oakland, California. Exam 1 (1978-1979) included 434 pairs of women, and exam 2 (1989-1990) included 352 pairs of women. For comparison with a previous study in male twins, pairwise concordance ratios (OCR) for smoking status between monozygotic (MZ) and dizygotic (DZ) twins were calculated. Multivariate logistic regression analysis was also used to assess the association of smoking behaviors between co-twins, adjusting for age, education, and frequency of contact. At exam 1, OCR's were consistent with previous results in male twins, and supported genetic influences on smoking initiation (OCR=1.6; 95% Confidence Interval (95% CI)=1.0, 2.3) and maintenance (OCR=1.8; 95% CI=1.3, 2.4). In contrast to the males, however, no clear evidence for genetic influences on smoking intensity or never smoking were present. The adjusted logistic regression models appeared to confirm the findings from the pairwise comparisons. The results were similar for exam 2. These results are consistent with modest genetic influences on smoking initiation and maintenance. Differences between these results and those for the male twins suggest possible genetic-environmental interactions

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Pascal:95-0344319

Le document en format XML

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<author><name sortKey="Edwards, K L" sort="Edwards, K L" uniqKey="Edwards K" first="K. L." last="Edwards">K. L. Edwards</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Washington, school public health community medicine, dep. epidemiology</s1>
<s2>Seattle WA 98195</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Seattle WA 98195</wicri:noRegion>
</affiliation>
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<author><name sortKey="Austin, M A" sort="Austin, M A" uniqKey="Austin M" first="M. A." last="Austin">M. A. Austin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Washington, school public health community medicine, dep. epidemiology</s1>
<s2>Seattle WA 98195</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Seattle WA 98195</wicri:noRegion>
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<author><name sortKey="Jarvik, G P" sort="Jarvik, G P" uniqKey="Jarvik G" first="G. P." last="Jarvik">G. P. Jarvik</name>
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<idno type="inist">95-0344319</idno>
<date when="1995">1995</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evidence for genetic influences on smoking in adult women twins</title>
<author><name sortKey="Edwards, K L" sort="Edwards, K L" uniqKey="Edwards K" first="K. L." last="Edwards">K. L. Edwards</name>
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<s2>Seattle WA 98195</s2>
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<author><name sortKey="Austin, M A" sort="Austin, M A" uniqKey="Austin M" first="M. A." last="Austin">M. A. Austin</name>
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<series><title level="j" type="main">Clinical genetics</title>
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<imprint><date when="1995">1995</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Genetic inheritance</term>
<term>Human</term>
<term>Tobacco smoking</term>
<term>Twin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tabagisme</term>
<term>Déterminisme génétique</term>
<term>Homme</term>
<term>Jumeau</term>
<term>Femelle</term>
<term>Adulte</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Tabagisme</term>
<term>Homme</term>
<term>Adulte</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">The purpose of the present study was to examine genetic influences on smoking behavior in women twins, and to compare the results before and after adjusting for environmental covariates. Subjects were participants in the Kaiser Permanente Women Twins Study in Oakland, California. Exam 1 (1978-1979) included 434 pairs of women, and exam 2 (1989-1990) included 352 pairs of women. For comparison with a previous study in male twins, pairwise concordance ratios (OCR) for smoking status between monozygotic (MZ) and dizygotic (DZ) twins were calculated. Multivariate logistic regression analysis was also used to assess the association of smoking behaviors between co-twins, adjusting for age, education, and frequency of contact. At exam 1, OCR's were consistent with previous results in male twins, and supported genetic influences on smoking initiation (OCR=1.6; 95% Confidence Interval (95% CI)=1.0, 2.3) and maintenance (OCR=1.8; 95% CI=1.3, 2.4). In contrast to the males, however, no clear evidence for genetic influences on smoking intensity or never smoking were present. The adjusted logistic regression models appeared to confirm the findings from the pairwise comparisons. The results were similar for exam 2. These results are consistent with modest genetic influences on smoking initiation and maintenance. Differences between these results and those for the male twins suggest possible genetic-environmental interactions</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<tree><noCountry><name sortKey="Jarvik, G P" sort="Jarvik, G P" uniqKey="Jarvik G" first="G. P." last="Jarvik">G. P. Jarvik</name>
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<country name="États-Unis"><noRegion><name sortKey="Edwards, K L" sort="Edwards, K L" uniqKey="Edwards K" first="K. L." last="Edwards">K. L. Edwards</name>
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<name sortKey="Austin, M A" sort="Austin, M A" uniqKey="Austin M" first="M. A." last="Austin">M. A. Austin</name>
</country>
</tree>
</affiliations>
</record>

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Evidence for genetic influences on smoking in adult women twins

Evidence for genetic influences on smoking in adult women twins

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri