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Evidence for genetic influences on smoking in adult women twins

Identifieur interne : 000940 ( PascalFrancis/Curation ); précédent : 000939; suivant : 000941

Evidence for genetic influences on smoking in adult women twins

Auteurs : K. L. Edwards [États-Unis] ; M. A. Austin [États-Unis] ; G. P. Jarvik

Source :

RBID : Pascal:95-0344319

Descripteurs français

English descriptors

Abstract

The purpose of the present study was to examine genetic influences on smoking behavior in women twins, and to compare the results before and after adjusting for environmental covariates. Subjects were participants in the Kaiser Permanente Women Twins Study in Oakland, California. Exam 1 (1978-1979) included 434 pairs of women, and exam 2 (1989-1990) included 352 pairs of women. For comparison with a previous study in male twins, pairwise concordance ratios (OCR) for smoking status between monozygotic (MZ) and dizygotic (DZ) twins were calculated. Multivariate logistic regression analysis was also used to assess the association of smoking behaviors between co-twins, adjusting for age, education, and frequency of contact. At exam 1, OCR's were consistent with previous results in male twins, and supported genetic influences on smoking initiation (OCR=1.6; 95% Confidence Interval (95% CI)=1.0, 2.3) and maintenance (OCR=1.8; 95% CI=1.3, 2.4). In contrast to the males, however, no clear evidence for genetic influences on smoking intensity or never smoking were present. The adjusted logistic regression models appeared to confirm the findings from the pairwise comparisons. The results were similar for exam 2. These results are consistent with modest genetic influences on smoking initiation and maintenance. Differences between these results and those for the male twins suggest possible genetic-environmental interactions
pA  
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A08 01  1  ENG  @1 Evidence for genetic influences on smoking in adult women twins
A11 01  1    @1 EDWARDS (K. L.)
A11 02  1    @1 AUSTIN (M. A.)
A11 03  1    @1 JARVIK (G. P.)
A14 01      @1 Univ. Washington, school public health community medicine, dep. epidemiology @2 Seattle WA 98195 @3 USA @Z 1 aut. @Z 2 aut.
A20       @1 236-244
A21       @1 1995
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C01 01    ENG  @0 The purpose of the present study was to examine genetic influences on smoking behavior in women twins, and to compare the results before and after adjusting for environmental covariates. Subjects were participants in the Kaiser Permanente Women Twins Study in Oakland, California. Exam 1 (1978-1979) included 434 pairs of women, and exam 2 (1989-1990) included 352 pairs of women. For comparison with a previous study in male twins, pairwise concordance ratios (OCR) for smoking status between monozygotic (MZ) and dizygotic (DZ) twins were calculated. Multivariate logistic regression analysis was also used to assess the association of smoking behaviors between co-twins, adjusting for age, education, and frequency of contact. At exam 1, OCR's were consistent with previous results in male twins, and supported genetic influences on smoking initiation (OCR=1.6; 95% Confidence Interval (95% CI)=1.0, 2.3) and maintenance (OCR=1.8; 95% CI=1.3, 2.4). In contrast to the males, however, no clear evidence for genetic influences on smoking intensity or never smoking were present. The adjusted logistic regression models appeared to confirm the findings from the pairwise comparisons. The results were similar for exam 2. These results are consistent with modest genetic influences on smoking initiation and maintenance. Differences between these results and those for the male twins suggest possible genetic-environmental interactions
C02 01  X    @0 002B03E
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C03 01  X  ENG  @0 Tobacco smoking @5 01
C03 01  X  SPA  @0 Tabaquismo @5 01
C03 02  X  FRE  @0 Déterminisme génétique @5 02
C03 02  X  ENG  @0 Genetic inheritance @5 02
C03 02  X  SPA  @0 Determinismo genético @5 02
C03 03  X  FRE  @0 Homme @5 03
C03 03  X  ENG  @0 Human @5 03
C03 03  X  SPA  @0 Hombre @5 03
C03 04  X  FRE  @0 Jumeau @5 04
C03 04  X  ENG  @0 Twin @5 04
C03 04  X  SPA  @0 Gemelo @5 04
C03 05  X  FRE  @0 Femelle @5 05
C03 05  X  ENG  @0 Female @5 05
C03 05  X  SPA  @0 Hembra @5 05
C03 06  X  FRE  @0 Adulte @5 06
C03 06  X  ENG  @0 Adult @5 06
C03 06  X  SPA  @0 Adulto @5 06
N21       @1 199

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Pascal:95-0344319

Le document en format XML

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