The Development of Multisensory Integration in High-Functioning Autism: High-Density Electrical Mapping and Psychophysical Measures Reveal Impairments in the Processing of Audiovisual Inputs
Identifieur interne : 001336 ( Pmc/Curation ); précédent : 001335; suivant : 001337The Development of Multisensory Integration in High-Functioning Autism: High-Density Electrical Mapping and Psychophysical Measures Reveal Impairments in the Processing of Audiovisual Inputs
Auteurs : Alice B. Brandwein [États-Unis] ; John J. Foxe [États-Unis] ; John S. Butler [États-Unis] ; Natalie N. Russo [États-Unis] ; Ted S. Altschuler [États-Unis] ; Hilary Gomes [États-Unis] ; Sophie Molholm [États-Unis]Source :
- Cerebral Cortex (New York, NY) [ 1047-3211 ] ; 2012.
Abstract
Successful integration of auditory and visual inputs is crucial for both basic perceptual functions and for higher-order processes related to social cognition. Autism spectrum disorders (ASD) are characterized by impairments in social cognition and are associated with abnormalities in sensory and perceptual processes. Several groups have reported that individuals with ASD are impaired in their ability to integrate socially relevant audiovisual (AV) information, and it has been suggested that this contributes to the higher-order social and cognitive deficits observed in ASD. However, successful integration of auditory and visual inputs also influences detection and perception of nonsocial stimuli, and integration deficits may impair earlier stages of information processing, with cascading downstream effects. To assess the integrity of basic AV integration, we recorded high-density electrophysiology from a cohort of high-functioning children with ASD (7–16 years) while they performed a simple AV reaction time task. Children with ASD showed considerably less behavioral facilitation to multisensory inputs, deficits that were paralleled by less effective neural integration. Evidence for processing differences relative to typically developing children was seen as early as 100 ms poststimulation, and topographic analysis suggested that children with ASD relied on different cortical networks during this early multisensory processing stage.
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DOI: 10.1093/cercor/bhs109
PubMed: 22628458
PubMed Central: 3643715
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Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Program in Neuropsychology, Department of Psychology</addr-line>,<institution>Queens College of the City University of New York</institution>,<addr-line>Flushing, NY 11367</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foxe, John J" sort="Foxe, John J" uniqKey="Foxe J" first="John J." last="Foxe">John J. Foxe</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. 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Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Russo, Natalie N" sort="Russo, Natalie N" uniqKey="Russo N" first="Natalie N." last="Russo">Natalie N. Russo</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Altschuler, Ted S" sort="Altschuler, Ted S" uniqKey="Altschuler T" first="Ted S." last="Altschuler">Ted S. Altschuler</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gomes, Hilary" sort="Gomes, Hilary" uniqKey="Gomes H" first="Hilary" last="Gomes">Hilary Gomes</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Program in Neuropsychology, Department of Psychology</addr-line>,<institution>Queens College of the City University of New York</institution>,<addr-line>Flushing, NY 11367</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Molholm, Sophie" sort="Molholm, Sophie" uniqKey="Molholm S" first="Sophie" last="Molholm">Sophie Molholm</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>The Cognitive Neurophysiology Laboratory</addr-line>,<institution>The Nathan S. Kline Institute for Psychiatric Research</institution>,<addr-line>140 Old Orangeburg Road, Orangeburg, NY 10962</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22628458</idno><idno type="pmc">3643715</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643715</idno><idno type="RBID">PMC:3643715</idno><idno type="doi">10.1093/cercor/bhs109</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001336</idno><idno type="wicri:Area/Pmc/Curation">001336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Development of Multisensory Integration in High-Functioning Autism: High-Density Electrical Mapping and Psychophysical Measures Reveal Impairments in the Processing of Audiovisual Inputs</title><author><name sortKey="Brandwein, Alice B" sort="Brandwein, Alice B" uniqKey="Brandwein A" first="Alice B." last="Brandwein">Alice B. Brandwein</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Program in Neuropsychology, Department of Psychology</addr-line>,<institution>Queens College of the City University of New York</institution>,<addr-line>Flushing, NY 11367</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foxe, John J" sort="Foxe, John J" uniqKey="Foxe J" first="John J." last="Foxe">John J. Foxe</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Program in Neuropsychology, Department of Psychology</addr-line>,<institution>Queens College of the City University of New York</institution>,<addr-line>Flushing, NY 11367</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>The Cognitive Neurophysiology Laboratory</addr-line>,<institution>The Nathan S. Kline Institute for Psychiatric Research</institution>,<addr-line>140 Old Orangeburg Road, Orangeburg, NY 10962</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Butler, John S" sort="Butler, John S" uniqKey="Butler J" first="John S." last="Butler">John S. Butler</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Russo, Natalie N" sort="Russo, Natalie N" uniqKey="Russo N" first="Natalie N." last="Russo">Natalie N. Russo</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Altschuler, Ted S" sort="Altschuler, Ted S" uniqKey="Altschuler T" first="Ted S." last="Altschuler">Ted S. Altschuler</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gomes, Hilary" sort="Gomes, Hilary" uniqKey="Gomes H" first="Hilary" last="Gomes">Hilary Gomes</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Program in Neuropsychology, Department of Psychology</addr-line>,<institution>Queens College of the City University of New York</institution>,<addr-line>Flushing, NY 11367</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Molholm, Sophie" sort="Molholm, Sophie" uniqKey="Molholm S" first="Sophie" last="Molholm">Sophie Molholm</name><affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af4"><addr-line>Department of Psychology</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af5"><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>The Cognitive Neurophysiology Laboratory</addr-line>,<institution>The Nathan S. Kline Institute for Psychiatric Research</institution>,<addr-line>140 Old Orangeburg Road, Orangeburg, NY 10962</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cerebral Cortex (New York, NY)</title><idno type="ISSN">1047-3211</idno><idno type="eISSN">1460-2199</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Successful integration of auditory and visual inputs is crucial for both basic perceptual functions and for higher-order processes related to social cognition. Autism spectrum disorders (ASD) are characterized by impairments in social cognition and are associated with abnormalities in sensory and perceptual processes. Several groups have reported that individuals with ASD are impaired in their ability to integrate socially relevant audiovisual (AV) information, and it has been suggested that this contributes to the higher-order social and cognitive deficits observed in ASD. However, successful integration of auditory and visual inputs also influences detection and perception of nonsocial stimuli, and integration deficits may impair earlier stages of information processing, with cascading downstream effects. To assess the integrity of basic AV integration, we recorded high-density electrophysiology from a cohort of high-functioning children with ASD (7–16 years) while they performed a simple AV reaction time task. Children with ASD showed considerably less behavioral facilitation to multisensory inputs, deficits that were paralleled by less effective neural integration. Evidence for processing differences relative to typically developing children was seen as early as 100 ms poststimulation, and topographic analysis suggested that children with ASD relied on different cortical networks during this early multisensory processing stage.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cereb Cortex</journal-id><journal-id journal-id-type="iso-abbrev">Cereb. Cortex</journal-id><journal-id journal-id-type="publisher-id">cercor</journal-id><journal-id journal-id-type="hwp">cercor</journal-id><journal-title-group><journal-title>Cerebral Cortex (New York, NY)</journal-title></journal-title-group><issn pub-type="ppub">1047-3211</issn><issn pub-type="epub">1460-2199</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22628458</article-id><article-id pub-id-type="pmc">3643715</article-id><article-id pub-id-type="doi">10.1093/cercor/bhs109</article-id><article-id pub-id-type="publisher-id">bhs109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>The Development of Multisensory Integration in High-Functioning Autism: High-Density Electrical Mapping and Psychophysical Measures Reveal Impairments in the Processing of Audiovisual Inputs</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Brandwein</surname><given-names>Alice B.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Foxe</surname><given-names>John J.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Butler</surname><given-names>John S.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Russo</surname><given-names>Natalie N.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Altschuler</surname><given-names>Ted S.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gomes</surname><given-names>Hilary</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Molholm</surname><given-names>Sophie</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref><xref ref-type="aff" rid="af6">6</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Pediatrics</addr-line> and</aff><aff id="af2"><label>2</label><addr-line>Department of Neuroscience, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory</addr-line>,<institution>Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine</institution>,<addr-line>Van Etten Building – Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461</addr-line>,<country>USA</country>,</aff><aff id="af3"><label>3</label><addr-line>Program in Neuropsychology, Department of Psychology</addr-line>,<institution>Queens College of the City University of New York</institution>,<addr-line>Flushing, NY 11367</addr-line>,<country>USA</country>,</aff><aff id="af4"><label>4</label><addr-line>Department of Psychology</addr-line> and</aff><aff id="af5"><label>5</label><addr-line>Department of Biology, The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience</addr-line>,<institution>City College of the City University of New York</institution>,<addr-line>138th Street & Convent Ave, New York, NY 10031</addr-line>,<country>USA</country> and</aff><aff id="af6"><label>6</label><addr-line>The Cognitive Neurophysiology Laboratory</addr-line>,<institution>The Nathan S. Kline Institute for Psychiatric Research</institution>,<addr-line>140 Old Orangeburg Road, Orangeburg, NY 10962</addr-line>,<country>USA</country></aff><author-notes><corresp>Address correspondence to S. Molholm. Email: <email>sophie.molholm@einstein.yu.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>24</day><month>5</month><year>2012</year></pub-date><volume>23</volume><issue>6</issue><fpage>1329</fpage><lpage>1341</lpage><permissions><copyright-statement>© The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="bhs109.pdf"></self-uri><abstract><p>Successful integration of auditory and visual inputs is crucial for both basic perceptual functions and for higher-order processes related to social cognition. Autism spectrum disorders (ASD) are characterized by impairments in social cognition and are associated with abnormalities in sensory and perceptual processes. Several groups have reported that individuals with ASD are impaired in their ability to integrate socially relevant audiovisual (AV) information, and it has been suggested that this contributes to the higher-order social and cognitive deficits observed in ASD. However, successful integration of auditory and visual inputs also influences detection and perception of nonsocial stimuli, and integration deficits may impair earlier stages of information processing, with cascading downstream effects. To assess the integrity of basic AV integration, we recorded high-density electrophysiology from a cohort of high-functioning children with ASD (7–16 years) while they performed a simple AV reaction time task. Children with ASD showed considerably less behavioral facilitation to multisensory inputs, deficits that were paralleled by less effective neural integration. Evidence for processing differences relative to typically developing children was seen as early as 100 ms poststimulation, and topographic analysis suggested that children with ASD relied on different cortical networks during this early multisensory processing stage.</p></abstract><kwd-group><kwd>auditory</kwd><kwd>electrophysiology</kwd><kwd>ERPs</kwd><kwd>multimodal</kwd><kwd>visual</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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