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Complications, adverse events and additional intraocular surgery one year after cataract surgery in the Infant Aphakia Treatment Study

Identifieur interne : 001173 ( Pmc/Curation ); précédent : 001172; suivant : 001174

Complications, adverse events and additional intraocular surgery one year after cataract surgery in the Infant Aphakia Treatment Study

Auteurs : David A. Plager ; Michael J. Lynn ; Edward G. Buckley ; M. Edward Wilson ; Scott R. Lambert

Source :

Ophthalmology [ 0161-6420 ] ; 2011.

RBID : PMC:3230731

Abstract

Purpose

To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implant.

Design

Prospective randomized clinical trial.

Participants

The Infant Aphakia Treatment Study (IATS) is a randomized, multi-center (12) clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with unilateral congenital cataract.

Intervention

Infants underwent cataract surgery with or without placement of IOL.

Main Outcome Measures

The rate, character and severity of intraoperative complications (IC), adverse events (AE) and additional intraocular surgeries (AIS) during the first post operative year in the two groups were analyzed.

Results

There were more patients with ICs (28% vs. 11%, p=.031), AEs (77% vs 25%, p< .0001) and AIS (63% vs 12%, p< .0001) in the IOL group than the contact lens group. Iris prolapse was the most common intraoperative complication. The most common adverse event was visual axis opacification and the most common additional intraocular reoperation was a clearing of visual axis opacification.

Conclusion

The rates of intra operative complications, adverse events and additional intraocular surgeries one year postoperatively were numerically higher in the IOL group, but their functional impact does not clearly favor either treatment group.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230731

DOI: 10.1016/j.ophtha.2011.06.017
PubMed: 21925737
PubMed Central: 3230731

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PMC:3230731

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<author><name sortKey="Plager, David A" sort="Plager, David A" uniqKey="Plager D" first="David A" last="Plager">David A. Plager</name>
</author>
<author><name sortKey="Lynn, Michael J" sort="Lynn, Michael J" uniqKey="Lynn M" first="Michael J." last="Lynn">Michael J. Lynn</name>
</author>
<author><name sortKey="Buckley, Edward G" sort="Buckley, Edward G" uniqKey="Buckley E" first="Edward G." last="Buckley">Edward G. Buckley</name>
</author>
<author><name sortKey="Wilson, M Edward" sort="Wilson, M Edward" uniqKey="Wilson M" first="M. Edward" last="Wilson">M. Edward Wilson</name>
</author>
<author><name sortKey="Lambert, Scott R" sort="Lambert, Scott R" uniqKey="Lambert S" first="Scott R." last="Lambert">Scott R. Lambert</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Complications, adverse events and additional intraocular surgery one year after cataract surgery in the Infant Aphakia Treatment Study</title>
<author><name sortKey="Plager, David A" sort="Plager, David A" uniqKey="Plager D" first="David A" last="Plager">David A. Plager</name>
</author>
<author><name sortKey="Lynn, Michael J" sort="Lynn, Michael J" uniqKey="Lynn M" first="Michael J." last="Lynn">Michael J. Lynn</name>
</author>
<author><name sortKey="Buckley, Edward G" sort="Buckley, Edward G" uniqKey="Buckley E" first="Edward G." last="Buckley">Edward G. Buckley</name>
</author>
<author><name sortKey="Wilson, M Edward" sort="Wilson, M Edward" uniqKey="Wilson M" first="M. Edward" last="Wilson">M. Edward Wilson</name>
</author>
<author><name sortKey="Lambert, Scott R" sort="Lambert, Scott R" uniqKey="Lambert S" first="Scott R." last="Lambert">Scott R. Lambert</name>
</author>
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<series><title level="j">Ophthalmology</title>
<idno type="ISSN">0161-6420</idno>
<idno type="eISSN">1549-4713</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P2">To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implant.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P3">Prospective randomized clinical trial.</p>
</sec>
<sec id="S3"><title>Participants</title>
<p id="P4">The Infant Aphakia Treatment Study (IATS) is a randomized, multi-center (<xref ref-type="bibr" rid="R12">12</xref>
) clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with unilateral congenital cataract.</p>
</sec>
<sec id="S4"><title>Intervention</title>
<p id="P5">Infants underwent cataract surgery with or without placement of IOL.</p>
</sec>
<sec id="S5"><title>Main Outcome Measures</title>
<p id="P6">The rate, character and severity of intraoperative complications (IC), adverse events (AE) and additional intraocular surgeries (AIS) during the first post operative year in the two groups were analyzed.</p>
</sec>
<sec id="S6"><title>Results</title>
<p id="P7">There were more patients with ICs (28% vs. 11%, p=.031), AEs (77% vs 25%, p< .0001) and AIS (63% vs 12%, p< .0001) in the IOL group than the contact lens group. Iris prolapse was the most common intraoperative complication. The most common adverse event was visual axis opacification and the most common additional intraocular reoperation was a clearing of visual axis opacification.</p>
</sec>
<sec id="S7"><title>Conclusion</title>
<p id="P8">The rates of intra operative complications, adverse events and additional intraocular surgeries one year postoperatively were numerically higher in the IOL group, but their functional impact does not clearly favor either treatment group.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">7802443</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6266</journal-id>
<journal-id journal-id-type="nlm-ta">Ophthalmology</journal-id>
<journal-title-group><journal-title>Ophthalmology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0161-6420</issn>
<issn pub-type="epub">1549-4713</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21925737</article-id>
<article-id pub-id-type="pmc">3230731</article-id>
<article-id pub-id-type="doi">10.1016/j.ophtha.2011.06.017</article-id>
<article-id pub-id-type="manuscript">NIHMS308887</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Complications, adverse events and additional intraocular surgery one year after cataract surgery in the Infant Aphakia Treatment Study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Plager</surname>
<given-names>David A</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Lynn</surname>
<given-names>Michael J.</given-names>
</name>
<degrees>M.S.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Buckley</surname>
<given-names>Edward G.</given-names>
</name>
<degrees>M.D.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Wilson</surname>
<given-names>M. Edward</given-names>
</name>
<degrees>M.D.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Lambert</surname>
<given-names>Scott R.</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<on-behalf-of>for the Infant Aphakia Treatment Study Group</on-behalf-of>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib-group>
<author-notes><corresp id="FN1">Corresponding Author: David A. Plager MD, Indiana University Medical Center, 702 Rotary Circle, Indianapolis, IN 46202, <email>dplager@iupui.edu</email>
, ph 317 274-1214, fax 317 274-5247</corresp>
<fn id="FN2"><label>*</label>
<p>(<xref rid="SD1" ref-type="supplementary-material">Appendix 1</xref>
, available at <ext-link ext-link-type="uri" xlink:href="http://aaojournal.org">http://aaojournal.org</ext-link>
)</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>9</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>118</volume>
<issue>12</issue>
<fpage>2330</fpage>
<lpage>2334</lpage>
<permissions><copyright-statement>© 2011 American Academy of Ophthalmology, Inc. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P2">To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implant.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P3">Prospective randomized clinical trial.</p>
</sec>
<sec id="S3"><title>Participants</title>
<p id="P4">The Infant Aphakia Treatment Study (IATS) is a randomized, multi-center (<xref ref-type="bibr" rid="R12">12</xref>
) clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with unilateral congenital cataract.</p>
</sec>
<sec id="S4"><title>Intervention</title>
<p id="P5">Infants underwent cataract surgery with or without placement of IOL.</p>
</sec>
<sec id="S5"><title>Main Outcome Measures</title>
<p id="P6">The rate, character and severity of intraoperative complications (IC), adverse events (AE) and additional intraocular surgeries (AIS) during the first post operative year in the two groups were analyzed.</p>
</sec>
<sec id="S6"><title>Results</title>
<p id="P7">There were more patients with ICs (28% vs. 11%, p=.031), AEs (77% vs 25%, p< .0001) and AIS (63% vs 12%, p< .0001) in the IOL group than the contact lens group. Iris prolapse was the most common intraoperative complication. The most common adverse event was visual axis opacification and the most common additional intraocular reoperation was a clearing of visual axis opacification.</p>
</sec>
<sec id="S7"><title>Conclusion</title>
<p id="P8">The rates of intra operative complications, adverse events and additional intraocular surgeries one year postoperatively were numerically higher in the IOL group, but their functional impact does not clearly favor either treatment group.</p>
</sec>
</abstract>
<funding-group><award-group><funding-source country="United States">National Eye Institute  : NEI</funding-source>
<award-id>U10 EY013272-01A2 || EY</award-id>
</award-group>
<award-group><funding-source country="United States">National Eye Institute  : NEI</funding-source>
<award-id>R21 EY011987-01A1 || EY</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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Complications, adverse events and additional intraocular surgery one year after cataract surgery in the Infant Aphakia Treatment Study

Complications, adverse events and additional intraocular surgery one year after cataract surgery in the Infant Aphakia Treatment Study

Source :

Abstract

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