Response properties of mouse trigeminal ganglion neurons
Identifieur interne : 001029 ( Pmc/Curation ); précédent : 001028; suivant : 001030Response properties of mouse trigeminal ganglion neurons
Auteurs : Ernest E. Kwegyir-Afful ; Sashi Marella ; Daniel J. SimonsSource :
- Somatosensory & motor research [ 0899-0220 ] ; 2008.
Abstract
We used controlled whisker deflections to examine the response properties of 208 primary afferent neurons in the trigeminal ganglion of adult mice. Proportions of rapidly adapting (RA, 47%) and slowly adapting (SA, 53%) neurons were equivalent, and most cells had low or no spontaneous activity. We quantified angular tuning and sensitivity to deflection amplitude and velocity. Both RA and SA units fired more frequently to larger deflections and faster deflections, but RA units were more sensitive to differences in velocity whereas SA units were more sensitive to deflection amplitudes. Almost all neurons were tuned for deflection angle, and the average response to the maximally effective direction was more than fourfold greater than the average response in the opposite direction; SA units were more tuned than RA units. Responses of primary afferent whisker-responsive neurons are qualitatively similar to those of the rat. However, average firing rates of both RA and SA neurons in the mouse are less sensitive to differences in deflection velocity, and RA units, unlike those in the rat, display amplitude sensitivity. Subtle observed differences between mice and rats may reflect greater mechanical compliance in mice of the whisker hairs and of the tissue in which they are embedded.
Url:
DOI: 10.1080/08990220802467612
PubMed: 18989828
PubMed Central: 2597100
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<front><div type="abstract" xml:lang="en"><p id="P1">We used controlled whisker deflections to examine the response properties of 208 primary afferent neurons in the trigeminal ganglion of adult mice. Proportions of rapidly adapting (RA, 47%) and slowly adapting (SA, 53%) neurons were equivalent, and most cells had low or no spontaneous activity. We quantified angular tuning and sensitivity to deflection amplitude and velocity. Both RA and SA units fired more frequently to larger deflections and faster deflections, but RA units were more sensitive to differences in velocity whereas SA units were more sensitive to deflection amplitudes. Almost all neurons were tuned for deflection angle, and the average response to the maximally effective direction was more than fourfold greater than the average response in the opposite direction; SA units were more tuned than RA units. Responses of primary afferent whisker-responsive neurons are qualitatively similar to those of the rat. However, average firing rates of both RA and SA neurons in the mouse are less sensitive to differences in deflection velocity, and RA units, unlike those in the rat, display amplitude sensitivity. Subtle observed differences between mice and rats may reflect greater mechanical compliance in mice of the whisker hairs and of the tissue in which they are embedded.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8904127</journal-id>
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<journal-id journal-id-type="nlm-ta">Somatosens Mot Res</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Response properties of mouse trigeminal ganglion neurons</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>KWEGYIR-AFFUL</surname>
<given-names>ERNEST E.</given-names>
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<contrib contrib-type="author"><name><surname>MARELLA</surname>
<given-names>SASHI</given-names>
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<contrib contrib-type="author" corresp="yes"><name><surname>SIMONS</surname>
<given-names>DANIEL J.</given-names>
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<aff id="A1">Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff>
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<author-notes><corresp id="CR1">Correspondence: Dr D. Simons, Department of Neurobiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST E1452, Pittsburgh, PA 15261, USA. Tel: +1 412 648 9443. Fax: +1 412 648 1441. E-mail: <email>cortex@pitt.edu</email>
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<pub-date pub-type="nihms-submitted"><day>2</day>
<month>12</month>
<year>2008</year>
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<pub-date pub-type="ppub"><month>12</month>
<year>2008</year>
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<pub-date pub-type="pmc-release"><day>8</day>
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<year>2008</year>
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<volume>25</volume>
<issue>4</issue>
<fpage>209</fpage>
<lpage>221</lpage>
<abstract><p id="P1">We used controlled whisker deflections to examine the response properties of 208 primary afferent neurons in the trigeminal ganglion of adult mice. Proportions of rapidly adapting (RA, 47%) and slowly adapting (SA, 53%) neurons were equivalent, and most cells had low or no spontaneous activity. We quantified angular tuning and sensitivity to deflection amplitude and velocity. Both RA and SA units fired more frequently to larger deflections and faster deflections, but RA units were more sensitive to differences in velocity whereas SA units were more sensitive to deflection amplitudes. Almost all neurons were tuned for deflection angle, and the average response to the maximally effective direction was more than fourfold greater than the average response in the opposite direction; SA units were more tuned than RA units. Responses of primary afferent whisker-responsive neurons are qualitatively similar to those of the rat. However, average firing rates of both RA and SA neurons in the mouse are less sensitive to differences in deflection velocity, and RA units, unlike those in the rat, display amplitude sensitivity. Subtle observed differences between mice and rats may reflect greater mechanical compliance in mice of the whisker hairs and of the tissue in which they are embedded.</p>
</abstract>
<kwd-group><kwd>Mechanoreceptor</kwd>
<kwd>primary afferent neuron</kwd>
<kwd>vibrissae</kwd>
<kwd>whiskers</kwd>
<kwd>stimulus coding</kwd>
</kwd-group>
<contract-num rid="NS1">R01 NS019950-25</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
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