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Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach

Identifieur interne : 000471 ( PascalFrancis/Corpus ); précédent : 000470; suivant : 000472

Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach

Auteurs : Peter J. Ness ; Liliana Werner ; Surekha Maddula ; Don Davis ; Brian Zaugg ; Jack Stringham ; Michael Burrow ; Oliver Yeh

Source :

RBID : Pascal:11-0327851

Descripteurs français

English descriptors

Abstract

PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule opacification (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Eyes were immersed in 10% formalin after enucleation and had anterior segment scanning with very-high-frequency ultrasound (Artemis). After the eyes were sectioned at the equator, gross examination of the anterior segment was performed from the posterior aspect to assess capsular bag opacification, anterior capsule coverage of the IOL edge, and IOL fixation. Selected eyes had histopathologic examination. RESULTS: One hundred nineteen eyes with 1-piece IOLs and 100 with 3-piece IOLs were included in the analyses of capsular bag opacification. There was no difference in central (P=.29) or peripheral (P=.76) PCO. In 63 of 84 eyes with a 1-piece IOL and peripheral PCO, the optic-haptic junction was the site of initiation. In eyes with a 3-piece IOL, initial peripheral PCO was observed at nearly the same rate whether there was full 360-degree anterior capsulorhexis overlap of the optic or no overlap (P=.13). In the latter, the site of PCO initiation was in areas lacking capsulorhexis coverage in 46% of eyes. CONCLUSIONS: There was no difference in central or peripheral PCO between 1-piece and 3-piece hydrophobic acrylic IOLs. With 1-piece IOLs, PCO tended to start at the optic-haptic junctions. With 3-piece IOLs, full anterior capsule coverage did not produce a statistically significant benefit with respect to PCO prevention.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0886-3350
A02 01      @0 JCSUEV
A03   1    @0 J. cataract refractive surg.
A05       @2 37
A06       @2 5
A08 01  1  ENG  @1 Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach
A11 01  1    @1 NESS (Peter J.)
A11 02  1    @1 WERNER (Liliana)
A11 03  1    @1 MADDULA (Surekha)
A11 04  1    @1 DAVIS (Don)
A11 05  1    @1 ZAUGG (Brian)
A11 06  1    @1 STRINGHAM (Jack)
A11 07  1    @1 BURROW (Michael)
A11 08  1    @1 YEH (Oliver)
A14 01      @1 John A. Moran Eye Center, University of Utah @2 Salt Lake City, Utah @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.
A20       @1 923-930
A21       @1 2011
A23 01      @0 ENG
A43 01      @1 INIST @2 20937 @5 354000190458490190
A44       @0 0000 @1 © 2011 INIST-CNRS. All rights reserved.
A45       @0 28 ref.
A47 01  1    @0 11-0327851
A60       @1 P
A61       @0 A
A64 01  1    @0 Journal of cataract and refractive surgery
A66 01      @0 USA
C01 01    ENG  @0 PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule opacification (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Eyes were immersed in 10% formalin after enucleation and had anterior segment scanning with very-high-frequency ultrasound (Artemis). After the eyes were sectioned at the equator, gross examination of the anterior segment was performed from the posterior aspect to assess capsular bag opacification, anterior capsule coverage of the IOL edge, and IOL fixation. Selected eyes had histopathologic examination. RESULTS: One hundred nineteen eyes with 1-piece IOLs and 100 with 3-piece IOLs were included in the analyses of capsular bag opacification. There was no difference in central (P=.29) or peripheral (P=.76) PCO. In 63 of 84 eyes with a 1-piece IOL and peripheral PCO, the optic-haptic junction was the site of initiation. In eyes with a 3-piece IOL, initial peripheral PCO was observed at nearly the same rate whether there was full 360-degree anterior capsulorhexis overlap of the optic or no overlap (P=.13). In the latter, the site of PCO initiation was in areas lacking capsulorhexis coverage in 46% of eyes. CONCLUSIONS: There was no difference in central or peripheral PCO between 1-piece and 3-piece hydrophobic acrylic IOLs. With 1-piece IOLs, PCO tended to start at the optic-haptic junctions. With 3-piece IOLs, full anterior capsule coverage did not produce a statistically significant benefit with respect to PCO prevention.
C02 01  X    @0 002B09
C02 02  X    @0 002B25B
C03 01  X  FRE  @0 Anatomopathologie @5 09
C03 01  X  ENG  @0 Anatomic pathology @5 09
C03 01  X  SPA  @0 Anatomía patológica @5 09
C03 02  X  FRE  @0 Homme @5 10
C03 02  X  ENG  @0 Human @5 10
C03 02  X  SPA  @0 Hombre @5 10
C03 03  X  FRE  @0 Cadavre @5 11
C03 03  X  ENG  @0 Cadaver @5 11
C03 03  X  SPA  @0 Cadáver @5 11
C03 04  X  FRE  @0 Oeil @5 12
C03 04  X  ENG  @0 Eye @5 12
C03 04  X  SPA  @0 Ojo @5 12
C03 05  X  FRE  @0 Ophtalmologie @5 13
C03 05  X  ENG  @0 Ophthalmology @5 13
C03 05  X  SPA  @0 Oftalmología @5 13
C03 06  X  FRE  @0 Lentille intraoculaire @5 14
C03 06  X  ENG  @0 Intraocular lens @5 14
C03 06  X  SPA  @0 Lente intraocular @5 14
C03 07  X  FRE  @0 Opacification @5 15
C03 07  X  ENG  @0 Opacification @5 15
C03 07  X  SPA  @0 Opacificación @5 15
C03 08  X  FRE  @0 Chirurgie @5 16
C03 08  X  ENG  @0 Surgery @5 16
C03 08  X  SPA  @0 Cirugía @5 16
C03 09  X  FRE  @0 Traitement @5 78
C03 09  X  ENG  @0 Treatment @5 78
C03 09  X  SPA  @0 Tratamiento @5 78
N21       @1 227
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 11-0327851 INIST
ET : Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach
AU : NESS (Peter J.); WERNER (Liliana); MADDULA (Surekha); DAVIS (Don); ZAUGG (Brian); STRINGHAM (Jack); BURROW (Michael); YEH (Oliver)
AF : John A. Moran Eye Center, University of Utah/Salt Lake City, Utah/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.)
DT : Publication en série; Niveau analytique
SO : Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2011; Vol. 37; No. 5; Pp. 923-930; Bibl. 28 ref.
LA : Anglais
EA : PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule opacification (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Eyes were immersed in 10% formalin after enucleation and had anterior segment scanning with very-high-frequency ultrasound (Artemis). After the eyes were sectioned at the equator, gross examination of the anterior segment was performed from the posterior aspect to assess capsular bag opacification, anterior capsule coverage of the IOL edge, and IOL fixation. Selected eyes had histopathologic examination. RESULTS: One hundred nineteen eyes with 1-piece IOLs and 100 with 3-piece IOLs were included in the analyses of capsular bag opacification. There was no difference in central (P=.29) or peripheral (P=.76) PCO. In 63 of 84 eyes with a 1-piece IOL and peripheral PCO, the optic-haptic junction was the site of initiation. In eyes with a 3-piece IOL, initial peripheral PCO was observed at nearly the same rate whether there was full 360-degree anterior capsulorhexis overlap of the optic or no overlap (P=.13). In the latter, the site of PCO initiation was in areas lacking capsulorhexis coverage in 46% of eyes. CONCLUSIONS: There was no difference in central or peripheral PCO between 1-piece and 3-piece hydrophobic acrylic IOLs. With 1-piece IOLs, PCO tended to start at the optic-haptic junctions. With 3-piece IOLs, full anterior capsule coverage did not produce a statistically significant benefit with respect to PCO prevention.
CC : 002B09; 002B25B
FD : Anatomopathologie; Homme; Cadavre; Oeil; Ophtalmologie; Lentille intraoculaire; Opacification; Chirurgie; Traitement
ED : Anatomic pathology; Human; Cadaver; Eye; Ophthalmology; Intraocular lens; Opacification; Surgery; Treatment
SD : Anatomía patológica; Hombre; Cadáver; Ojo; Oftalmología; Lente intraocular; Opacificación; Cirugía; Tratamiento
LO : INIST-20937.354000190458490190
ID : 11-0327851

Links to Exploration step

Pascal:11-0327851

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<div type="abstract" xml:lang="en">PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule opacification (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Eyes were immersed in 10% formalin after enucleation and had anterior segment scanning with very-high-frequency ultrasound (Artemis). After the eyes were sectioned at the equator, gross examination of the anterior segment was performed from the posterior aspect to assess capsular bag opacification, anterior capsule coverage of the IOL edge, and IOL fixation. Selected eyes had histopathologic examination. RESULTS: One hundred nineteen eyes with 1-piece IOLs and 100 with 3-piece IOLs were included in the analyses of capsular bag opacification. There was no difference in central (P=.29) or peripheral (P=.76) PCO. In 63 of 84 eyes with a 1-piece IOL and peripheral PCO, the optic-haptic junction was the site of initiation. In eyes with a 3-piece IOL, initial peripheral PCO was observed at nearly the same rate whether there was full 360-degree anterior capsulorhexis overlap of the optic or no overlap (P=.
<sub>13</sub>
). In the latter, the site of PCO initiation was in areas lacking capsulorhexis coverage in 46% of eyes. CONCLUSIONS: There was no difference in central or peripheral PCO between 1-piece and 3-piece hydrophobic acrylic IOLs. With 1-piece IOLs, PCO tended to start at the optic-haptic junctions. With 3-piece IOLs, full anterior capsule coverage did not produce a statistically significant benefit with respect to PCO prevention.</div>
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<s2>37</s2>
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<fA06>
<s2>5</s2>
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<fA08 i1="01" i2="1" l="ENG">
<s1>Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach</s1>
</fA08>
<fA11 i1="01" i2="1">
<s1>NESS (Peter J.)</s1>
</fA11>
<fA11 i1="02" i2="1">
<s1>WERNER (Liliana)</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>MADDULA (Surekha)</s1>
</fA11>
<fA11 i1="04" i2="1">
<s1>DAVIS (Don)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>ZAUGG (Brian)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>STRINGHAM (Jack)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>BURROW (Michael)</s1>
</fA11>
<fA11 i1="08" i2="1">
<s1>YEH (Oliver)</s1>
</fA11>
<fA14 i1="01">
<s1>John A. Moran Eye Center, University of Utah</s1>
<s2>Salt Lake City, Utah</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA20>
<s1>923-930</s1>
</fA20>
<fA21>
<s1>2011</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>20937</s2>
<s5>354000190458490190</s5>
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<s1>© 2011 INIST-CNRS. All rights reserved.</s1>
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<s0>11-0327851</s0>
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<s1>P</s1>
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<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Journal of cataract and refractive surgery</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule opacification (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Eyes were immersed in 10% formalin after enucleation and had anterior segment scanning with very-high-frequency ultrasound (Artemis). After the eyes were sectioned at the equator, gross examination of the anterior segment was performed from the posterior aspect to assess capsular bag opacification, anterior capsule coverage of the IOL edge, and IOL fixation. Selected eyes had histopathologic examination. RESULTS: One hundred nineteen eyes with 1-piece IOLs and 100 with 3-piece IOLs were included in the analyses of capsular bag opacification. There was no difference in central (P=.29) or peripheral (P=.76) PCO. In 63 of 84 eyes with a 1-piece IOL and peripheral PCO, the optic-haptic junction was the site of initiation. In eyes with a 3-piece IOL, initial peripheral PCO was observed at nearly the same rate whether there was full 360-degree anterior capsulorhexis overlap of the optic or no overlap (P=.
<sub>13</sub>
). In the latter, the site of PCO initiation was in areas lacking capsulorhexis coverage in 46% of eyes. CONCLUSIONS: There was no difference in central or peripheral PCO between 1-piece and 3-piece hydrophobic acrylic IOLs. With 1-piece IOLs, PCO tended to start at the optic-haptic junctions. With 3-piece IOLs, full anterior capsule coverage did not produce a statistically significant benefit with respect to PCO prevention.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B09</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B25B</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Anatomopathologie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Anatomic pathology</s0>
<s5>09</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Anatomía patológica</s0>
<s5>09</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Homme</s0>
<s5>10</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Human</s0>
<s5>10</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Cadavre</s0>
<s5>11</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Cadaver</s0>
<s5>11</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Cadáver</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Oeil</s0>
<s5>12</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Eye</s0>
<s5>12</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Ojo</s0>
<s5>12</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Ophtalmologie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Ophthalmology</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Oftalmología</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Lentille intraoculaire</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Intraocular lens</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Lente intraocular</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Opacification</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Opacification</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Opacificación</s0>
<s5>15</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Chirurgie</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Surgery</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Cirugía</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Traitement</s0>
<s5>78</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Treatment</s0>
<s5>78</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Tratamiento</s0>
<s5>78</s5>
</fC03>
<fN21>
<s1>227</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
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<server>
<NO>PASCAL 11-0327851 INIST</NO>
<ET>Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach</ET>
<AU>NESS (Peter J.); WERNER (Liliana); MADDULA (Surekha); DAVIS (Don); ZAUGG (Brian); STRINGHAM (Jack); BURROW (Michael); YEH (Oliver)</AU>
<AF>John A. Moran Eye Center, University of Utah/Salt Lake City, Utah/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2011; Vol. 37; No. 5; Pp. 923-930; Bibl. 28 ref.</SO>
<LA>Anglais</LA>
<EA>PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule opacification (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Eyes were immersed in 10% formalin after enucleation and had anterior segment scanning with very-high-frequency ultrasound (Artemis). After the eyes were sectioned at the equator, gross examination of the anterior segment was performed from the posterior aspect to assess capsular bag opacification, anterior capsule coverage of the IOL edge, and IOL fixation. Selected eyes had histopathologic examination. RESULTS: One hundred nineteen eyes with 1-piece IOLs and 100 with 3-piece IOLs were included in the analyses of capsular bag opacification. There was no difference in central (P=.29) or peripheral (P=.76) PCO. In 63 of 84 eyes with a 1-piece IOL and peripheral PCO, the optic-haptic junction was the site of initiation. In eyes with a 3-piece IOL, initial peripheral PCO was observed at nearly the same rate whether there was full 360-degree anterior capsulorhexis overlap of the optic or no overlap (P=.
<sub>13</sub>
). In the latter, the site of PCO initiation was in areas lacking capsulorhexis coverage in 46% of eyes. CONCLUSIONS: There was no difference in central or peripheral PCO between 1-piece and 3-piece hydrophobic acrylic IOLs. With 1-piece IOLs, PCO tended to start at the optic-haptic junctions. With 3-piece IOLs, full anterior capsule coverage did not produce a statistically significant benefit with respect to PCO prevention.</EA>
<CC>002B09; 002B25B</CC>
<FD>Anatomopathologie; Homme; Cadavre; Oeil; Ophtalmologie; Lentille intraoculaire; Opacification; Chirurgie; Traitement</FD>
<ED>Anatomic pathology; Human; Cadaver; Eye; Ophthalmology; Intraocular lens; Opacification; Surgery; Treatment</ED>
<SD>Anatomía patológica; Hombre; Cadáver; Ojo; Oftalmología; Lente intraocular; Opacificación; Cirugía; Tratamiento</SD>
<LO>INIST-20937.354000190458490190</LO>
<ID>11-0327851</ID>
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