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THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results

Identifieur interne : 003A78 ( Ncbi/Curation ); précédent : 003A77; suivant : 003A79

THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results

Auteurs : Zachary D. Taylor ; James Garritano ; Shijun Sung ; Neha Bajwa ; David B. Bennett ; Bryan Nowroozi ; Priyamvada Tewari ; James W. Sayre ; Jean-Pierre Hubschman ; Sophie X. Deng ; Elliott R. Brown ; Warren S. Grundfest

Source :

IEEE transactions on terahertz science and technology [ 2156-342X ] ; 2015.

RBID : PMC:4493917

Abstract

A pulsed terahertz (THz) imaging system and millimeter-wave reflectometer were used to acquire images and point measurements, respectively, of five rabbit cornea in vivo. These imaging results are the first ever produced of in vivo cornea. A modified version of a standard protocol using a gentle stream of air and a Mylar window was employed to slightly dehydrate healthy cornea. The sensor data and companion central corneal thickness (CCT) measurements were acquired every 10–15 min over the course of two hours using ultrasound pachymmetry.. Statistically significant positive correlations were established between CCT measurements and millimeter wave reflectivity. Local shifts in reflectivity contrast were observed in the THz imagery; however, the THz reflectivity did not display a significant correlation with thickness in the region probed by the 100 GHz and CCT measurements. This is explained in part by a thickness sensitivity at least 10× higher in the mm-wave than the THz systems. Stratified media and effective media modeling suggest that the protocol perturbed the thickness and not the corneal tissue water content (CTWC). To further explore possible etalon effects, an additional rabbit was euthanized and millimeter wave measurements were obtained during death induced edema. These observations represent the first time that the uncoupled sensing of CTWC and CCT have been achieved in vivo.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493917

DOI: 10.1109/TTHZ.2015.2392628
PubMed: 26161292
PubMed Central: 4493917

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PMC:4493917

Le document en format XML

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 Sensing and Imaging Results</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">A pulsed terahertz (THz) imaging system and millimeter-wave reflectometer were used to acquire images and point measurements, respectively, of five rabbit cornea <italic>in vivo</italic>
. These imaging results are the first ever produced of <italic>in vivo</italic>
 cornea. A modified version of a standard protocol using a gentle stream of air and a Mylar window was employed to slightly dehydrate healthy cornea. The sensor data and companion central corneal thickness (CCT) measurements were acquired every 10–15 min over the course of two hours using ultrasound pachymmetry.. Statistically significant positive correlations were established between CCT measurements and millimeter wave reflectivity. Local shifts in reflectivity contrast were observed in the THz imagery; however, the THz reflectivity did not display a significant correlation with thickness in the region probed by the 100 GHz and CCT measurements. This is explained in part by a thickness sensitivity at least 10× higher in the mm-wave than the THz systems. Stratified media and effective media modeling suggest that the protocol perturbed the thickness and not the corneal tissue water content (CTWC). To further explore possible etalon effects, an additional rabbit was euthanized and millimeter wave measurements were obtained during death induced edema. These observations represent the first time that the uncoupled sensing of CTWC and CCT have been achieved <italic>in vivo</italic>
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THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results

THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results

Source :

Abstract

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