THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results
Identifieur interne : 003A78 ( Ncbi/Merge ); précédent : 003A77; suivant : 003A79THz and mm-Wave Sensing of Corneal Tissue Water Content: In Vivo Sensing and Imaging Results
Auteurs : Zachary D. Taylor ; James Garritano ; Shijun Sung ; Neha Bajwa ; David B. Bennett ; Bryan Nowroozi ; Priyamvada Tewari ; James W. Sayre ; Jean-Pierre Hubschman ; Sophie X. Deng ; Elliott R. Brown ; Warren S. GrundfestSource :
- IEEE transactions on terahertz science and technology [ 2156-342X ] ; 2015.
Abstract
A pulsed terahertz (THz) imaging system and millimeter-wave reflectometer were used to acquire images and point measurements, respectively, of five rabbit cornea
Url:
DOI: 10.1109/TTHZ.2015.2392628
PubMed: 26161292
PubMed Central: 4493917
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Sensing and Imaging Results</title>
<author><name sortKey="Taylor, Zachary D" sort="Taylor, Zachary D" uniqKey="Taylor Z" first="Zachary D." last="Taylor">Zachary D. Taylor</name>
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<author><name sortKey="Garritano, James" sort="Garritano, James" uniqKey="Garritano J" first="James" last="Garritano">James Garritano</name>
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<author><name sortKey="Sung, Shijun" sort="Sung, Shijun" uniqKey="Sung S" first="Shijun" last="Sung">Shijun Sung</name>
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<author><name sortKey="Bajwa, Neha" sort="Bajwa, Neha" uniqKey="Bajwa N" first="Neha" last="Bajwa">Neha Bajwa</name>
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<author><name sortKey="Bennett, David B" sort="Bennett, David B" uniqKey="Bennett D" first="David B." last="Bennett">David B. Bennett</name>
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<author><name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
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<author><name sortKey="Sayre, James W" sort="Sayre, James W" uniqKey="Sayre J" first="James W." last="Sayre">James W. Sayre</name>
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<author><name sortKey="Hubschman, Jean Pierre" sort="Hubschman, Jean Pierre" uniqKey="Hubschman J" first="Jean-Pierre" last="Hubschman">Jean-Pierre Hubschman</name>
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<author><name sortKey="Deng, Sophie X" sort="Deng, Sophie X" uniqKey="Deng S" first="Sophie X." last="Deng">Sophie X. Deng</name>
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<author><name sortKey="Brown, Elliott R" sort="Brown, Elliott R" uniqKey="Brown E" first="Elliott R." last="Brown">Elliott R. Brown</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">THz and mm-Wave Sensing of Corneal Tissue Water Content: <italic>In Vivo</italic>
Sensing and Imaging Results</title>
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<author><name sortKey="Garritano, James" sort="Garritano, James" uniqKey="Garritano J" first="James" last="Garritano">James Garritano</name>
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<author><name sortKey="Sung, Shijun" sort="Sung, Shijun" uniqKey="Sung S" first="Shijun" last="Sung">Shijun Sung</name>
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<author><name sortKey="Bajwa, Neha" sort="Bajwa, Neha" uniqKey="Bajwa N" first="Neha" last="Bajwa">Neha Bajwa</name>
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<author><name sortKey="Bennett, David B" sort="Bennett, David B" uniqKey="Bennett D" first="David B." last="Bennett">David B. Bennett</name>
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<author><name sortKey="Nowroozi, Bryan" sort="Nowroozi, Bryan" uniqKey="Nowroozi B" first="Bryan" last="Nowroozi">Bryan Nowroozi</name>
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<author><name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
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<author><name sortKey="Sayre, James W" sort="Sayre, James W" uniqKey="Sayre J" first="James W." last="Sayre">James W. Sayre</name>
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<author><name sortKey="Hubschman, Jean Pierre" sort="Hubschman, Jean Pierre" uniqKey="Hubschman J" first="Jean-Pierre" last="Hubschman">Jean-Pierre Hubschman</name>
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<author><name sortKey="Deng, Sophie X" sort="Deng, Sophie X" uniqKey="Deng S" first="Sophie X." last="Deng">Sophie X. Deng</name>
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<author><name sortKey="Brown, Elliott R" sort="Brown, Elliott R" uniqKey="Brown E" first="Elliott R." last="Brown">Elliott R. Brown</name>
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<author><name sortKey="Grundfest, Warren S" sort="Grundfest, Warren S" uniqKey="Grundfest W" first="Warren S." last="Grundfest">Warren S. Grundfest</name>
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<series><title level="j">IEEE transactions on terahertz science and technology</title>
<idno type="ISSN">2156-342X</idno>
<idno type="eISSN">2156-3446</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">A pulsed terahertz (THz) imaging system and millimeter-wave reflectometer were used to acquire images and point measurements, respectively, of five rabbit cornea <italic>in vivo</italic>
. These imaging results are the first ever produced of <italic>in vivo</italic>
cornea. A modified version of a standard protocol using a gentle stream of air and a Mylar window was employed to slightly dehydrate healthy cornea. The sensor data and companion central corneal thickness (CCT) measurements were acquired every 10–15 min over the course of two hours using ultrasound pachymmetry.. Statistically significant positive correlations were established between CCT measurements and millimeter wave reflectivity. Local shifts in reflectivity contrast were observed in the THz imagery; however, the THz reflectivity did not display a significant correlation with thickness in the region probed by the 100 GHz and CCT measurements. This is explained in part by a thickness sensitivity at least 10× higher in the mm-wave than the THz systems. Stratified media and effective media modeling suggest that the protocol perturbed the thickness and not the corneal tissue water content (CTWC). To further explore possible etalon effects, an additional rabbit was euthanized and millimeter wave measurements were obtained during death induced edema. These observations represent the first time that the uncoupled sensing of CTWC and CCT have been achieved <italic>in vivo</italic>
.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101593215</journal-id>
<journal-id journal-id-type="pubmed-jr-id">40701</journal-id>
<journal-id journal-id-type="nlm-ta">IEEE Trans Terahertz Sci Technol</journal-id>
<journal-id journal-id-type="iso-abbrev">IEEE Trans Terahertz Sci Technol</journal-id>
<journal-title-group><journal-title>IEEE transactions on terahertz science and technology</journal-title>
</journal-title-group>
<issn pub-type="ppub">2156-342X</issn>
<issn pub-type="epub">2156-3446</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26161292</article-id>
<article-id pub-id-type="pmc">4493917</article-id>
<article-id pub-id-type="doi">10.1109/TTHZ.2015.2392628</article-id>
<article-id pub-id-type="manuscript">NIHMS694042</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>THz and mm-Wave Sensing of Corneal Tissue Water Content: <italic>In Vivo</italic>
Sensing and Imaging Results</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>Zachary D.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A1">Department of Bioengineering, University of California (UCLA), Los Angeles, CA 90095 USA, and also with the Center for Advanced Surgical and Interventional Technology (CASIT), University of California (UCLA), Los Angeles, CA 90095 USA</aff>
<email>zdeis@seas.ucla.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Garritano</surname>
<given-names>James</given-names>
</name>
<aff id="A2">Department of Bioengineering, University of California (UCLA), Los Angeles, CA 90095 USA, and also with the Center for Advanced Surgical and Interventional Technology (CASIT), University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Sung</surname>
<given-names>Shijun</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A3">Department of Electrical Engineering, University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Bajwa</surname>
<given-names>Neha</given-names>
</name>
<aff id="A4">Department of Bioengineering, University of California (UCLA), Los Angeles, CA 90095 USA, and also with the Center for Advanced Surgical and Interventional Technology (CASIT), University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Bennett</surname>
<given-names>David B.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A5">Department of Electrical Engineering, University of California (UCLA), Los Angeles, CA 90095 USA. He is now with Fitbit, San Francisco, CA 94105 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Nowroozi</surname>
<given-names>Bryan</given-names>
</name>
<aff id="A6">Department of Bioengineering, University of California (UCLA), Los Angeles, CA 90095 USA, and also with the Center for Advanced Surgical and Interventional Technology (CASIT), University of California (UCLA), Los Angeles, CA 90095 USA. He is now with Mimeo Labs Inc, Santa Monica, CA 90404 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Tewari</surname>
<given-names>Priyamvada</given-names>
</name>
<aff id="A7">Department of Bioengineering, University of California (UCLA), Los Angeles, CA 90095 USA, and also with the Center for Advanced Surgical and Interventional Technology (CASIT), University of California (UCLA), Los Angeles, CA 90095 USA. She is now with Elsevier Life Science solutions, San Francisco, CA 94105 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Sayre</surname>
<given-names>James W.</given-names>
</name>
<aff id="A8">Department of Biostatistics, University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Hubschman</surname>
<given-names>Jean-Pierre</given-names>
</name>
<aff id="A9">Department of Ophthalmology, University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Deng</surname>
<given-names>Sophie X.</given-names>
</name>
<aff id="A10">Department of Ophthalmology, University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>Elliott R.</given-names>
</name>
<role>Fellow, IEEE</role>
<aff id="A11">Department. of Electrical Engineering, Wright State University, Dayton, OH 45435 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Grundfest</surname>
<given-names>Warren S.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A12">Department of Bioengineering, University of California (UCLA), Los Angeles, CA 90095 USA, and also with the Center for Advanced Surgical and Interventional Technology (CASIT), University of California (UCLA), Los Angeles, CA 90095 USA</aff>
</contrib>
</contrib-group>
<pub-date pub-type="nihms-submitted"><day>28</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>07</day>
<month>7</month>
<year>2015</year>
</pub-date>
<volume>5</volume>
<issue>2</issue>
<fpage>184</fpage>
<lpage>196</lpage>
<pmc-comment>elocation-id from pubmed: 10.1109/TTHZ.2015.2392628</pmc-comment>
<permissions><copyright-statement>© 2015 IEEE.</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract><p id="P1">A pulsed terahertz (THz) imaging system and millimeter-wave reflectometer were used to acquire images and point measurements, respectively, of five rabbit cornea <italic>in vivo</italic>
. These imaging results are the first ever produced of <italic>in vivo</italic>
cornea. A modified version of a standard protocol using a gentle stream of air and a Mylar window was employed to slightly dehydrate healthy cornea. The sensor data and companion central corneal thickness (CCT) measurements were acquired every 10–15 min over the course of two hours using ultrasound pachymmetry.. Statistically significant positive correlations were established between CCT measurements and millimeter wave reflectivity. Local shifts in reflectivity contrast were observed in the THz imagery; however, the THz reflectivity did not display a significant correlation with thickness in the region probed by the 100 GHz and CCT measurements. This is explained in part by a thickness sensitivity at least 10× higher in the mm-wave than the THz systems. Stratified media and effective media modeling suggest that the protocol perturbed the thickness and not the corneal tissue water content (CTWC). To further explore possible etalon effects, an additional rabbit was euthanized and millimeter wave measurements were obtained during death induced edema. These observations represent the first time that the uncoupled sensing of CTWC and CCT have been achieved <italic>in vivo</italic>
.</p>
</abstract>
<kwd-group><title>Index Terms</title>
<kwd>Biological and medical imaging</kwd>
<kwd>clinical instruments</kwd>
<kwd>medical diagnostics</kwd>
<kwd>tissue water content interactions</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bajwa, Neha" sort="Bajwa, Neha" uniqKey="Bajwa N" first="Neha" last="Bajwa">Neha Bajwa</name>
<name sortKey="Bennett, David B" sort="Bennett, David B" uniqKey="Bennett D" first="David B." last="Bennett">David B. Bennett</name>
<name sortKey="Brown, Elliott R" sort="Brown, Elliott R" uniqKey="Brown E" first="Elliott R." last="Brown">Elliott R. Brown</name>
<name sortKey="Deng, Sophie X" sort="Deng, Sophie X" uniqKey="Deng S" first="Sophie X." last="Deng">Sophie X. Deng</name>
<name sortKey="Garritano, James" sort="Garritano, James" uniqKey="Garritano J" first="James" last="Garritano">James Garritano</name>
<name sortKey="Grundfest, Warren S" sort="Grundfest, Warren S" uniqKey="Grundfest W" first="Warren S." last="Grundfest">Warren S. Grundfest</name>
<name sortKey="Hubschman, Jean Pierre" sort="Hubschman, Jean Pierre" uniqKey="Hubschman J" first="Jean-Pierre" last="Hubschman">Jean-Pierre Hubschman</name>
<name sortKey="Nowroozi, Bryan" sort="Nowroozi, Bryan" uniqKey="Nowroozi B" first="Bryan" last="Nowroozi">Bryan Nowroozi</name>
<name sortKey="Sayre, James W" sort="Sayre, James W" uniqKey="Sayre J" first="James W." last="Sayre">James W. Sayre</name>
<name sortKey="Sung, Shijun" sort="Sung, Shijun" uniqKey="Sung S" first="Shijun" last="Sung">Shijun Sung</name>
<name sortKey="Taylor, Zachary D" sort="Taylor, Zachary D" uniqKey="Taylor Z" first="Zachary D." last="Taylor">Zachary D. Taylor</name>
<name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
</noCountry>
</tree>
</affiliations>
</record>
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