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THz Medical Imaging: in vivo Hydration Sensing

Identifieur interne : 002966 ( Main/Merge ); précédent : 002965; suivant : 002967

THz Medical Imaging: in vivo Hydration Sensing

Auteurs : Zachary D. Taylor ; Rahul S. Singh ; David B. Bennett ; Priyamvada Tewari ; Colin P. Kealey ; Neha Bajwa ; Martin O. Culjat ; Alexander Stojadinovic ; Hua Lee ; Jean-Pierre Hubschman ; Elliott R. Brown ; Warren S. Grundfest

Source :

RBID : PMC:4467694

Abstract

The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.


Url:
DOI: 10.1109/TTHZ.2011.2159551
PubMed: 26085958
PubMed Central: 4467694

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PMC:4467694

Le document en format XML

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<name sortKey="Singh, Rahul S" sort="Singh, Rahul S" uniqKey="Singh R" first="Rahul S." last="Singh">Rahul S. Singh</name>
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<name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
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<p id="P1">The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models
<italic>in vivo</italic>
over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of
<italic>ex vivo</italic>
porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.</p>
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