HapticV1, Pmc, Checkpoint, bibRecord, 001966

THz Medical Imaging: in vivo Hydration Sensing

Identifieur interne : 001966 ( Pmc/Checkpoint ); précédent : 001965; suivant : 001967

THz Medical Imaging: in vivo Hydration Sensing

Auteurs : Zachary D. Taylor ; Rahul S. Singh ; David B. Bennett ; Priyamvada Tewari ; Colin P. Kealey ; Neha Bajwa ; Martin O. Culjat ; Alexander Stojadinovic ; Hua Lee ; Jean-Pierre Hubschman ; Elliott R. Brown ; Warren S. Grundfest

Source :

IEEE transactions on terahertz science and technology [ 2156-342X ] ; 2011.

RBID : PMC:4467694

Abstract

The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467694

DOI: 10.1109/TTHZ.2011.2159551
PubMed: 26085958
PubMed Central: 4467694

Affiliations:

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PMC:4467694

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">THz Medical Imaging: <italic>in vivo</italic>
 Hydration Sensing</title>
<author><name sortKey="Taylor, Zachary D" sort="Taylor, Zachary D" uniqKey="Taylor Z" first="Zachary D." last="Taylor">Zachary D. Taylor</name>
</author>
<author><name sortKey="Singh, Rahul S" sort="Singh, Rahul S" uniqKey="Singh R" first="Rahul S." last="Singh">Rahul S. Singh</name>
</author>
<author><name sortKey="Bennett, David B" sort="Bennett, David B" uniqKey="Bennett D" first="David B." last="Bennett">David B. Bennett</name>
</author>
<author><name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
</author>
<author><name sortKey="Kealey, Colin P" sort="Kealey, Colin P" uniqKey="Kealey C" first="Colin P." last="Kealey">Colin P. Kealey</name>
</author>
<author><name sortKey="Bajwa, Neha" sort="Bajwa, Neha" uniqKey="Bajwa N" first="Neha" last="Bajwa">Neha Bajwa</name>
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<author><name sortKey="Culjat, Martin O" sort="Culjat, Martin O" uniqKey="Culjat M" first="Martin O." last="Culjat">Martin O. Culjat</name>
</author>
<author><name sortKey="Stojadinovic, Alexander" sort="Stojadinovic, Alexander" uniqKey="Stojadinovic A" first="Alexander" last="Stojadinovic">Alexander Stojadinovic</name>
</author>
<author><name sortKey="Lee, Hua" sort="Lee, Hua" uniqKey="Lee H" first="Hua" last="Lee">Hua Lee</name>
</author>
<author><name sortKey="Hubschman, Jean Pierre" sort="Hubschman, Jean Pierre" uniqKey="Hubschman J" first="Jean-Pierre" last="Hubschman">Jean-Pierre Hubschman</name>
</author>
<author><name sortKey="Brown, Elliott R" sort="Brown, Elliott R" uniqKey="Brown E" first="Elliott R." last="Brown">Elliott R. Brown</name>
</author>
<author><name sortKey="Grundfest, Warren S" sort="Grundfest, Warren S" uniqKey="Grundfest W" first="Warren S." last="Grundfest">Warren S. Grundfest</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">THz Medical Imaging: <italic>in vivo</italic>
 Hydration Sensing</title>
<author><name sortKey="Taylor, Zachary D" sort="Taylor, Zachary D" uniqKey="Taylor Z" first="Zachary D." last="Taylor">Zachary D. Taylor</name>
</author>
<author><name sortKey="Singh, Rahul S" sort="Singh, Rahul S" uniqKey="Singh R" first="Rahul S." last="Singh">Rahul S. Singh</name>
</author>
<author><name sortKey="Bennett, David B" sort="Bennett, David B" uniqKey="Bennett D" first="David B." last="Bennett">David B. Bennett</name>
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<author><name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
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<author><name sortKey="Kealey, Colin P" sort="Kealey, Colin P" uniqKey="Kealey C" first="Colin P." last="Kealey">Colin P. Kealey</name>
</author>
<author><name sortKey="Bajwa, Neha" sort="Bajwa, Neha" uniqKey="Bajwa N" first="Neha" last="Bajwa">Neha Bajwa</name>
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<author><name sortKey="Culjat, Martin O" sort="Culjat, Martin O" uniqKey="Culjat M" first="Martin O." last="Culjat">Martin O. Culjat</name>
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<author><name sortKey="Stojadinovic, Alexander" sort="Stojadinovic, Alexander" uniqKey="Stojadinovic A" first="Alexander" last="Stojadinovic">Alexander Stojadinovic</name>
</author>
<author><name sortKey="Lee, Hua" sort="Lee, Hua" uniqKey="Lee H" first="Hua" last="Lee">Hua Lee</name>
</author>
<author><name sortKey="Hubschman, Jean Pierre" sort="Hubschman, Jean Pierre" uniqKey="Hubschman J" first="Jean-Pierre" last="Hubschman">Jean-Pierre Hubschman</name>
</author>
<author><name sortKey="Brown, Elliott R" sort="Brown, Elliott R" uniqKey="Brown E" first="Elliott R." last="Brown">Elliott R. Brown</name>
</author>
<author><name sortKey="Grundfest, Warren S" sort="Grundfest, Warren S" uniqKey="Grundfest W" first="Warren S." last="Grundfest">Warren S. Grundfest</name>
</author>
</analytic>
<series><title level="j">IEEE transactions on terahertz science and technology</title>
<idno type="ISSN">2156-342X</idno>
<idno type="eISSN">2156-3446</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models <italic>in vivo</italic>
 over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of <italic>ex vivo</italic>
 porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101593215</journal-id>
<journal-id journal-id-type="pubmed-jr-id">40701</journal-id>
<journal-id journal-id-type="nlm-ta">IEEE Trans Terahertz Sci Technol</journal-id>
<journal-id journal-id-type="iso-abbrev">IEEE Trans Terahertz Sci Technol</journal-id>
<journal-title-group><journal-title>IEEE transactions on terahertz science and technology</journal-title>
</journal-title-group>
<issn pub-type="ppub">2156-342X</issn>
<issn pub-type="epub">2156-3446</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26085958</article-id>
<article-id pub-id-type="pmc">4467694</article-id>
<article-id pub-id-type="doi">10.1109/TTHZ.2011.2159551</article-id>
<article-id pub-id-type="manuscript">NIHMS694034</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>THz Medical Imaging: <italic>in vivo</italic>
 Hydration Sensing</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>Zachary D.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A1">Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA (<email>zdeis@seas.ucla.edu</email>
).</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Singh</surname>
<given-names>Rahul S.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A2">Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Bennett</surname>
<given-names>David B.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A3">Department of Electrical Engineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Tewari</surname>
<given-names>Priyamvada</given-names>
</name>
<aff id="A4">Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Kealey</surname>
<given-names>Colin P.</given-names>
</name>
<aff id="A5">Department of Surgery and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Bajwa</surname>
<given-names>Neha</given-names>
</name>
<aff id="A6">Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Culjat</surname>
<given-names>Martin O.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A7">Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Stojadinovic</surname>
<given-names>Alexander</given-names>
</name>
<aff id="A8">Department of Surgery, Walter Reed Army Medical Center and the Combat Wound Initiative Program, Washington, DC 20307 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Hua</given-names>
</name>
<role>Fellow, IEEE</role>
<aff id="A9">Department of Electrical and Computer Engineering, University of California at Santa Barbara, Santa Barbara, CA 93106 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Hubschman</surname>
<given-names>Jean-Pierre</given-names>
</name>
<aff id="A10">Department of Ophthalmology, University of California at Los Angeles, Los Angeles, CA 90095 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>Elliott R.</given-names>
</name>
<role>Fellow, IEEE</role>
<aff id="A11">Department of Physics, Wright State University, Dayton, OH 45435 USA.</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Grundfest</surname>
<given-names>Warren S.</given-names>
</name>
<role>Member, IEEE</role>
<aff id="A12">Department of Electrical Engineering, Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA</aff>
</contrib>
</contrib-group>
<pub-date pub-type="nihms-submitted"><day>28</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>1</volume>
<issue>1</issue>
<fpage>201</fpage>
<lpage>219</lpage>
<pmc-comment>elocation-id from pubmed: 10.1109/TTHZ.2011.2159551</pmc-comment>
      <permissions><copyright-statement>© 2011 IEEE</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models <italic>in vivo</italic>
 over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of <italic>ex vivo</italic>
 porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.</p>
</abstract>
<kwd-group><kwd>Biological and medical imaging</kwd>
<kwd>clinical instruments</kwd>
<kwd>hydration interactions</kwd>
<kwd>medical diagnostics</kwd>
<kwd>submillimeter</kwd>
<kwd>Terahertz</kwd>
<kwd>THz</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bajwa, Neha" sort="Bajwa, Neha" uniqKey="Bajwa N" first="Neha" last="Bajwa">Neha Bajwa</name>
<name sortKey="Bennett, David B" sort="Bennett, David B" uniqKey="Bennett D" first="David B." last="Bennett">David B. Bennett</name>
<name sortKey="Brown, Elliott R" sort="Brown, Elliott R" uniqKey="Brown E" first="Elliott R." last="Brown">Elliott R. Brown</name>
<name sortKey="Culjat, Martin O" sort="Culjat, Martin O" uniqKey="Culjat M" first="Martin O." last="Culjat">Martin O. Culjat</name>
<name sortKey="Grundfest, Warren S" sort="Grundfest, Warren S" uniqKey="Grundfest W" first="Warren S." last="Grundfest">Warren S. Grundfest</name>
<name sortKey="Hubschman, Jean Pierre" sort="Hubschman, Jean Pierre" uniqKey="Hubschman J" first="Jean-Pierre" last="Hubschman">Jean-Pierre Hubschman</name>
<name sortKey="Kealey, Colin P" sort="Kealey, Colin P" uniqKey="Kealey C" first="Colin P." last="Kealey">Colin P. Kealey</name>
<name sortKey="Lee, Hua" sort="Lee, Hua" uniqKey="Lee H" first="Hua" last="Lee">Hua Lee</name>
<name sortKey="Singh, Rahul S" sort="Singh, Rahul S" uniqKey="Singh R" first="Rahul S." last="Singh">Rahul S. Singh</name>
<name sortKey="Stojadinovic, Alexander" sort="Stojadinovic, Alexander" uniqKey="Stojadinovic A" first="Alexander" last="Stojadinovic">Alexander Stojadinovic</name>
<name sortKey="Taylor, Zachary D" sort="Taylor, Zachary D" uniqKey="Taylor Z" first="Zachary D." last="Taylor">Zachary D. Taylor</name>
<name sortKey="Tewari, Priyamvada" sort="Tewari, Priyamvada" uniqKey="Tewari P" first="Priyamvada" last="Tewari">Priyamvada Tewari</name>
</noCountry>
</tree>
</affiliations>
</record>

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THz Medical Imaging: in vivo Hydration Sensing

THz Medical Imaging: in vivo Hydration Sensing

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Abstract

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