Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates
Identifieur interne : 002444 ( Main/Merge ); précédent : 002443; suivant : 002445Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates
Auteurs : Dylan F. Cooke [États-Unis] ; Adam B. Goldring [États-Unis] ; Itsukyo Yamayoshi [États-Unis] ; Phillippos Tsourkas [États-Unis] ; Gregg H. Recanzone [États-Unis] ; Alex Tiriac [États-Unis] ; Tingrui Pan [États-Unis] ; Scott I. Simon [États-Unis] ; Leah Krubitzer [États-Unis]Source :
- Journal of Neurophysiology [ 0022-3077 ] ; 2012.
Abstract
We have developed a compact and lightweight microfluidic cooling device to reversibly deactivate one or more areas of the neocortex to examine its functional macrocircuitry as well as behavioral and cortical plasticity. The device, which we term the “cooling chip,” consists of thin silicone tubing (through which chilled ethanol is circulated) embedded in mechanically compliant polydimethylsiloxane (PDMS). PDMS is tailored to compact device dimensions (as small as 21 mm3) that precisely accommodate the geometry of the targeted cortical area. The biocompatible design makes it suitable for both acute preparations and chronic implantation for long-term behavioral studies. The cooling chip accommodates an in-cortex microthermocouple measuring local cortical temperature. A microelectrode may be used to record simultaneous neural responses at the same location. Cortex temperature is controlled by computer regulation of the coolant flow, which can achieve a localized cortical temperature drop from 37 to 20°C in less than 3 min and maintain target temperature to within ±0.3°C indefinitely. Here we describe cooling chip fabrication and performance in mediating cessation of neural signaling in acute preparations of rodents, ferrets, and primates.
Url:
DOI: 10.1152/jn.01101.2011
PubMed: 22402651
PubMed Central: 3378414
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Cooke</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Yamayoshi, Itsukyo" sort="Yamayoshi, Itsukyo" uniqKey="Yamayoshi I" first="Itsukyo" last="Yamayoshi">Itsukyo Yamayoshi</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Tsourkas, Phillippos" sort="Tsourkas, Phillippos" uniqKey="Tsourkas P" first="Phillippos" last="Tsourkas">Phillippos Tsourkas</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Neurobiology, Physiology and Behavior, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Neurobiology, Physiology and Behavior, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Tiriac, Alex" sort="Tiriac, Alex" uniqKey="Tiriac A" first="Alex" last="Tiriac">Alex Tiriac</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. Simon</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of Neurophysiology</title><idno type="ISSN">0022-3077</idno><idno type="eISSN">1522-1598</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have developed a compact and lightweight microfluidic cooling device to reversibly deactivate one or more areas of the neocortex to examine its functional macrocircuitry as well as behavioral and cortical plasticity. The device, which we term the “cooling chip,” consists of thin silicone tubing (through which chilled ethanol is circulated) embedded in mechanically compliant polydimethylsiloxane (PDMS). PDMS is tailored to compact device dimensions (as small as 21 mm<sup>3</sup>) that precisely accommodate the geometry of the targeted cortical area. The biocompatible design makes it suitable for both acute preparations and chronic implantation for long-term behavioral studies. The cooling chip accommodates an in-cortex microthermocouple measuring local cortical temperature. A microelectrode may be used to record simultaneous neural responses at the same location. Cortex temperature is controlled by computer regulation of the coolant flow, which can achieve a localized cortical temperature drop from 37 to 20°C in less than 3 min and maintain target temperature to within ±0.3°C indefinitely. Here we describe cooling chip fabrication and performance in mediating cessation of neural signaling in acute preparations of rodents, ferrets, and primates.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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