Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates
Identifieur interne : 001418 ( Pmc/Curation ); précédent : 001417; suivant : 001419Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates
Auteurs : Dylan F. Cooke [États-Unis] ; Adam B. Goldring [États-Unis] ; Itsukyo Yamayoshi [États-Unis] ; Phillippos Tsourkas [États-Unis] ; Gregg H. Recanzone [États-Unis] ; Alex Tiriac [États-Unis] ; Tingrui Pan [États-Unis] ; Scott I. Simon [États-Unis] ; Leah Krubitzer [États-Unis]Source :
- Journal of Neurophysiology [ 0022-3077 ] ; 2012.
Abstract
We have developed a compact and lightweight microfluidic cooling device to reversibly deactivate one or more areas of the neocortex to examine its functional macrocircuitry as well as behavioral and cortical plasticity. The device, which we term the “cooling chip,” consists of thin silicone tubing (through which chilled ethanol is circulated) embedded in mechanically compliant polydimethylsiloxane (PDMS). PDMS is tailored to compact device dimensions (as small as 21 mm3) that precisely accommodate the geometry of the targeted cortical area. The biocompatible design makes it suitable for both acute preparations and chronic implantation for long-term behavioral studies. The cooling chip accommodates an in-cortex microthermocouple measuring local cortical temperature. A microelectrode may be used to record simultaneous neural responses at the same location. Cortex temperature is controlled by computer regulation of the coolant flow, which can achieve a localized cortical temperature drop from 37 to 20°C in less than 3 min and maintain target temperature to within ±0.3°C indefinitely. Here we describe cooling chip fabrication and performance in mediating cessation of neural signaling in acute preparations of rodents, ferrets, and primates.
Url:
DOI: 10.1152/jn.01101.2011
PubMed: 22402651
PubMed Central: 3378414
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Recanzone</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Neurobiology, Physiology and Behavior, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Neurobiology, Physiology and Behavior, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Tiriac, Alex" sort="Tiriac, Alex" uniqKey="Tiriac A" first="Alex" last="Tiriac">Alex Tiriac</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. Simon</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22402651</idno><idno type="pmc">3378414</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378414</idno><idno type="RBID">PMC:3378414</idno><idno type="doi">10.1152/jn.01101.2011</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001418</idno><idno type="wicri:Area/Pmc/Curation">001418</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates</title><author><name sortKey="Cooke, Dylan F" sort="Cooke, Dylan F" uniqKey="Cooke D" first="Dylan F." last="Cooke">Dylan F. Cooke</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Goldring, Adam B" sort="Goldring, Adam B" uniqKey="Goldring A" first="Adam B." last="Goldring">Adam B. Goldring</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Yamayoshi, Itsukyo" sort="Yamayoshi, Itsukyo" uniqKey="Yamayoshi I" first="Itsukyo" last="Yamayoshi">Itsukyo Yamayoshi</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Tsourkas, Phillippos" sort="Tsourkas, Phillippos" uniqKey="Tsourkas P" first="Phillippos" last="Tsourkas">Phillippos Tsourkas</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Recanzone, Gregg H" sort="Recanzone, Gregg H" uniqKey="Recanzone G" first="Gregg H." last="Recanzone">Gregg H. Recanzone</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Neurobiology, Physiology and Behavior, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Neurobiology, Physiology and Behavior, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Tiriac, Alex" sort="Tiriac, Alex" uniqKey="Tiriac A" first="Alex" last="Tiriac">Alex Tiriac</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Pan, Tingrui" sort="Pan, Tingrui" uniqKey="Pan T" first="Tingrui" last="Pan">Tingrui Pan</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Simon, Scott I" sort="Simon, Scott I" uniqKey="Simon S" first="Scott I." last="Simon">Scott I. Simon</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff3">Department of Biomedical Engineering, University of California, Davis, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, University of California, Davis</wicri:cityArea></affiliation></author><author><name sortKey="Krubitzer, Leah" sort="Krubitzer, Leah" uniqKey="Krubitzer L" first="Leah" last="Krubitzer">Leah Krubitzer</name><affiliation wicri:level="2"><nlm:aff id="aff1">Center for Neuroscience, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neuroscience, University of California, Davis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Psychology, University of California, Davis, California;</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychology, University of California, Davis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of Neurophysiology</title><idno type="ISSN">0022-3077</idno><idno type="eISSN">1522-1598</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have developed a compact and lightweight microfluidic cooling device to reversibly deactivate one or more areas of the neocortex to examine its functional macrocircuitry as well as behavioral and cortical plasticity. The device, which we term the “cooling chip,” consists of thin silicone tubing (through which chilled ethanol is circulated) embedded in mechanically compliant polydimethylsiloxane (PDMS). PDMS is tailored to compact device dimensions (as small as 21 mm<sup>3</sup>) that precisely accommodate the geometry of the targeted cortical area. The biocompatible design makes it suitable for both acute preparations and chronic implantation for long-term behavioral studies. The cooling chip accommodates an in-cortex microthermocouple measuring local cortical temperature. A microelectrode may be used to record simultaneous neural responses at the same location. Cortex temperature is controlled by computer regulation of the coolant flow, which can achieve a localized cortical temperature drop from 37 to 20°C in less than 3 min and maintain target temperature to within ±0.3°C indefinitely. Here we describe cooling chip fabrication and performance in mediating cessation of neural signaling in acute preparations of rodents, ferrets, and primates.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurophysiol</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurophysiol</journal-id><journal-id journal-id-type="hwp">jn</journal-id><journal-id journal-id-type="pmc">jn</journal-id><journal-id journal-id-type="publisher-id">JN</journal-id><journal-title-group><journal-title>Journal of Neurophysiology</journal-title></journal-title-group><issn pub-type="ppub">0022-3077</issn><issn pub-type="epub">1522-1598</issn><publisher><publisher-name>American Physiological Society</publisher-name><publisher-loc>Bethesda, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22402651</article-id><article-id pub-id-type="pmc">3378414</article-id><article-id pub-id-type="publisher-id">JN-01101-2011</article-id><article-id pub-id-type="doi">10.1152/jn.01101.2011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Innovative Methodology</subject></subj-group></article-categories><title-group><article-title>Fabrication of an inexpensive, implantable cooling device for reversible brain deactivation in animals ranging from rodents to primates</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cooke</surname><given-names>Dylan F.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Goldring</surname><given-names>Adam B.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yamayoshi</surname><given-names>Itsukyo</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tsourkas</surname><given-names>Phillippos</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Recanzone</surname><given-names>Gregg H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tiriac</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Tingrui</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Simon</surname><given-names>Scott I.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Krubitzer</surname><given-names>Leah</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><sup>1</sup>Center for Neuroscience, University of California, Davis, California;</aff><aff id="aff2"><sup>2</sup>Department of Psychology, University of California, Davis, California;</aff><aff id="aff3"><sup>3</sup>Department of Biomedical Engineering, University of California, Davis, California; and</aff><aff id="aff4"><sup>4</sup>Department of Neurobiology, Physiology and Behavior, University of California, Davis, California</aff></contrib-group><author-notes><corresp>Address for reprint requests and other correspondence: L. Krubitzer, <addr-line>Center for Neuroscience, 1544 Newton Ct., Davis, CA 95618</addr-line> (e-mail: <email>lakrubitzer@ucdavis.edu</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>7</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>6</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>107</volume><issue>12</issue><fpage>3543</fpage><lpage>3558</lpage><history><date date-type="received"><day>2</day><month>12</month><year>2011</year></date><date date-type="accepted"><day>4</day><month>3</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012 the American Physiological Society</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z9k01212003543.pdf"></self-uri><abstract><p>We have developed a compact and lightweight microfluidic cooling device to reversibly deactivate one or more areas of the neocortex to examine its functional macrocircuitry as well as behavioral and cortical plasticity. The device, which we term the “cooling chip,” consists of thin silicone tubing (through which chilled ethanol is circulated) embedded in mechanically compliant polydimethylsiloxane (PDMS). PDMS is tailored to compact device dimensions (as small as 21 mm<sup>3</sup>) that precisely accommodate the geometry of the targeted cortical area. The biocompatible design makes it suitable for both acute preparations and chronic implantation for long-term behavioral studies. The cooling chip accommodates an in-cortex microthermocouple measuring local cortical temperature. A microelectrode may be used to record simultaneous neural responses at the same location. Cortex temperature is controlled by computer regulation of the coolant flow, which can achieve a localized cortical temperature drop from 37 to 20°C in less than 3 min and maintain target temperature to within ±0.3°C indefinitely. Here we describe cooling chip fabrication and performance in mediating cessation of neural signaling in acute preparations of rodents, ferrets, and primates.</p></abstract><kwd-group><kwd>cryoloop</kwd><kwd>inactivation</kwd><kwd>plasticity</kwd><kwd>magnetic resonance compatible</kwd><kwd>cortex</kwd><kwd>biocompatible</kwd></kwd-group><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">NS35103</award-id><award-id rid="CS100">NS59262</award-id><award-id rid="CS100">AI47294</award-id><award-id rid="CS100">HL082689</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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