Experimental studies of capsular equator rings of soft latex
Identifieur interne : 003535 ( Istex/Corpus ); précédent : 003534; suivant : 003536Experimental studies of capsular equator rings of soft latex
Auteurs : Ehud I. Assia ; Michal Shelach ; Henry M. Israel ; Mordechai Rosner ; Michael Blumenthal ; Michael BelkinSource :
- Journal of Cataract & Refractive Surgery [ 0886-3350 ] ; 2000.
Abstract
Purpose To determine the efficacy of wide equatorial rings of various materials in reducing posterior capsule opacification (PCO) and maintaining the circular contour of the capsular equator in a rabbit model.Setting Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.Methods Closed rings made of poly(methyl methacrylate), Teflon®, polyurethane, and latex were introduced into the capsular bags of rabbit eyes after removal of the lens material. The soft latex rings were deemed the only practical rings for atraumatic implantation through a small incision. Latex rings of 2 dimensions with rectangular edges were implanted in 8 rabbits. One eye served as a control after lens removal and no ring implantation. The eyes were followed for up to 5 months and then evaluated by light microscopy.Results Posterior capsule opacification was minimal or absent in all animals implanted with the latex rings. Mild to moderate inflammatory reaction was noted in most eyes. It was caused by the ring material or secondary to long-standing pressure on the ciliary tissue. The rings also maintained well the circular contour of the capsular bags.Conclusions Equatorial rings of soft latex with sharp rectangular edges were effective in minimizing PCO and maintaining the shape of the capsule after lens removal in rabbits. Soft rings made of a biocompatible material may be effective in humans.
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DOI: 10.1016/S0886-3350(00)00606-4
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Experimental studies of capsular equator rings of soft latex</title><author><name sortKey="Assia, Ehud I" sort="Assia, Ehud I" uniqKey="Assia E" first="Ehud I" last="Assia">Ehud I. Assia</name><affiliation><mods:affiliation>Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba (Assia) Israel</mods:affiliation></affiliation></author><author><name sortKey="Shelach, Michal" sort="Shelach, Michal" uniqKey="Shelach M" first="Michal" last="Shelach">Michal Shelach</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author><author><name sortKey="Israel, Henry M" sort="Israel, Henry M" uniqKey="Israel H" first="Henry M" last="Israel">Henry M. Israel</name><affiliation><mods:affiliation>Acuity (Israel) Ltd., Bnei Brak (Israel), Israel</mods:affiliation></affiliation></author><author><name sortKey="Rosner, Mordechai" sort="Rosner, Mordechai" uniqKey="Rosner M" first="Mordechai" last="Rosner">Mordechai Rosner</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author><author><name sortKey="Blumenthal, Michael" sort="Blumenthal, Michael" uniqKey="Blumenthal M" first="Michael" last="Blumenthal">Michael Blumenthal</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author><author><name sortKey="Belkin, Michael" sort="Belkin, Michael" uniqKey="Belkin M" first="Michael" last="Belkin">Michael Belkin</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8669089507851846C1C34F8EC0CEF3F3866756FD</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0886-3350(00)00606-4</idno><idno type="url">https://api.istex.fr/document/8669089507851846C1C34F8EC0CEF3F3866756FD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003535</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Experimental studies of capsular equator rings of soft latex</title><author><name sortKey="Assia, Ehud I" sort="Assia, Ehud I" uniqKey="Assia E" first="Ehud I" last="Assia">Ehud I. Assia</name><affiliation><mods:affiliation>Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba (Assia) Israel</mods:affiliation></affiliation></author><author><name sortKey="Shelach, Michal" sort="Shelach, Michal" uniqKey="Shelach M" first="Michal" last="Shelach">Michal Shelach</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author><author><name sortKey="Israel, Henry M" sort="Israel, Henry M" uniqKey="Israel H" first="Henry M" last="Israel">Henry M. Israel</name><affiliation><mods:affiliation>Acuity (Israel) Ltd., Bnei Brak (Israel), Israel</mods:affiliation></affiliation></author><author><name sortKey="Rosner, Mordechai" sort="Rosner, Mordechai" uniqKey="Rosner M" first="Mordechai" last="Rosner">Mordechai Rosner</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author><author><name sortKey="Blumenthal, Michael" sort="Blumenthal, Michael" uniqKey="Blumenthal M" first="Michael" last="Blumenthal">Michael Blumenthal</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author><author><name sortKey="Belkin, Michael" sort="Belkin, Michael" uniqKey="Belkin M" first="Michael" last="Belkin">Michael Belkin</name><affiliation><mods:affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Cataract & Refractive Surgery</title><title level="j" type="abbrev">JCRS</title><idno type="ISSN">0886-3350</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="457">457</biblScope><biblScope unit="page" to="462">462</biblScope></imprint><idno type="ISSN">0886-3350</idno></series><idno type="istex">8669089507851846C1C34F8EC0CEF3F3866756FD</idno><idno type="DOI">10.1016/S0886-3350(00)00606-4</idno><idno type="PII">S0886-3350(00)00606-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0886-3350</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose To determine the efficacy of wide equatorial rings of various materials in reducing posterior capsule opacification (PCO) and maintaining the circular contour of the capsular equator in a rabbit model.Setting Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.Methods Closed rings made of poly(methyl methacrylate), Teflon®, polyurethane, and latex were introduced into the capsular bags of rabbit eyes after removal of the lens material. The soft latex rings were deemed the only practical rings for atraumatic implantation through a small incision. Latex rings of 2 dimensions with rectangular edges were implanted in 8 rabbits. One eye served as a control after lens removal and no ring implantation. The eyes were followed for up to 5 months and then evaluated by light microscopy.Results Posterior capsule opacification was minimal or absent in all animals implanted with the latex rings. Mild to moderate inflammatory reaction was noted in most eyes. It was caused by the ring material or secondary to long-standing pressure on the ciliary tissue. The rings also maintained well the circular contour of the capsular bags.Conclusions Equatorial rings of soft latex with sharp rectangular edges were effective in minimizing PCO and maintaining the shape of the capsule after lens removal in rabbits. Soft rings made of a biocompatible material may be effective in humans.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Ehud I Assia MD</name><affiliations><json:string>Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba (Assia) Israel</json:string></affiliations></json:item><json:item><name>Michal Shelach MD</name><affiliations><json:string>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</json:string></affiliations></json:item><json:item><name>Henry M Israel</name><affiliations><json:string>Acuity (Israel) Ltd., Bnei Brak (Israel), Israel</json:string></affiliations></json:item><json:item><name>Mordechai Rosner MD</name><affiliations><json:string>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</json:string></affiliations></json:item><json:item><name>Michael Blumenthal MD</name><affiliations><json:string>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</json:string></affiliations></json:item><json:item><name>Michael Belkin MD</name><affiliations><json:string>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Laboratory science</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Purpose To determine the efficacy of wide equatorial rings of various materials in reducing posterior capsule opacification (PCO) and maintaining the circular contour of the capsular equator in a rabbit model.Setting Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.Methods Closed rings made of poly(methyl methacrylate), Teflon®, polyurethane, and latex were introduced into the capsular bags of rabbit eyes after removal of the lens material. The soft latex rings were deemed the only practical rings for atraumatic implantation through a small incision. Latex rings of 2 dimensions with rectangular edges were implanted in 8 rabbits. One eye served as a control after lens removal and no ring implantation. The eyes were followed for up to 5 months and then evaluated by light microscopy.Results Posterior capsule opacification was minimal or absent in all animals implanted with the latex rings. Mild to moderate inflammatory reaction was noted in most eyes. It was caused by the ring material or secondary to long-standing pressure on the ciliary tissue. The rings also maintained well the circular contour of the capsular bags.Conclusions Equatorial rings of soft latex with sharp rectangular edges were effective in minimizing PCO and maintaining the shape of the capsule after lens removal in rabbits. Soft rings made of a biocompatible material may be effective in humans.</abstract><qualityIndicators><score>5.378</score><pdfVersion>1.2</pdfVersion><pdfPageSize>586 x 785 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>1487</abstractCharCount><pdfWordCount>2714</pdfWordCount><pdfCharCount>16654</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>222</abstractWordCount></qualityIndicators><title>Experimental studies of capsular equator rings of soft latex</title><pii><json:string>S0886-3350(00)00606-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>27</volume><pii><json:string>S0886-3350(00)X0023-5</json:string></pii><pages><last>462</last><first>457</first></pages><issn><json:string>0886-3350</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Journal of Cataract & Refractive Surgery</title><publicationDate>2001</publicationDate></host><categories><wos><json:string>OPHTHALMOLOGY</json:string><json:string>SURGERY</json:string></wos></categories><publicationDate>2000</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1016/S0886-3350(00)00606-4</json:string></doi><id>8669089507851846C1C34F8EC0CEF3F3866756FD</id><score>1</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8669089507851846C1C34F8EC0CEF3F3866756FD/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8669089507851846C1C34F8EC0CEF3F3866756FD/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8669089507851846C1C34F8EC0CEF3F3866756FD/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8669089507851846C1C34F8EC0CEF3F3866756FD/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Experimental studies of capsular equator rings of soft latex</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2001</date></publicationStmt><notesStmt><note>Supported in part by funding from Acuity (Israel) Ltd.</note><note type="content">Section title: Laboratory science</note><note type="content">Figure 1: (Assia) The 4 rings used in the study: polyurethane (U), Teflon (T), PMMA (P), and latex (L).</note><note type="content">Figure 2: (Assia) Side view of a latex ring in the capsular bag of a rabbit eye 5 months after implantation. Note the ring’s sharp rectangular edges.</note><note type="content">Figure 3: (Assia) The capsular equator of a rabbit eye 5 months after implantation of a latex ring. There are no cells over the anterior, equatorial, or posterior capsule. Mild inflammatory reaction is seen in the adjacent tissues.</note><note type="content">Figure 4: (Assia) The capsular equator of the control eye (no ring). The proliferation and migration of remaining LECs is limited by adhesions between the anterior and posterior capsules, creating a typical Soemmering’s ring.</note><note type="content">Figure 5: (Assia) The capsular bag of a rabbit after long-term implantation of a small latex ring. The rectangular shape of the equator corresponds to the shape of the ring (arrow heads), causing forward bowing of the iris and slight lateral compression of the ciliary body. Inflammatory reaction is minimal, and a few cells are adhered to the external surface of the capsule (arrow). The inner capsule is clear of lens epithelial or inflammatory cells.</note><note type="content">Table 1: Dimensions of the tested closed rings.legend</note><note type="content">Table 2: Long-term clinicopathological findings after implantation of latex rings.legend</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Experimental studies of capsular equator rings of soft latex</title><author><persName><forename type="first">Ehud I</forename><surname>Assia</surname></persName><roleName type="degree">MD</roleName><note type="biography">Reprint requests to Ehud I. Assia, MD, Director, Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba, 44281, Israel</note><affiliation>Reprint requests to Ehud I. Assia, MD, Director, Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba, 44281, Israel</affiliation><affiliation>Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba (Assia) Israel</affiliation></author><author><persName><forename type="first">Michal</forename><surname>Shelach</surname></persName><roleName type="degree">MD</roleName><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation></author><author><persName><forename type="first">Henry M</forename><surname>Israel</surname></persName><affiliation>Acuity (Israel) Ltd., Bnei Brak (Israel), Israel</affiliation></author><author><persName><forename type="first">Mordechai</forename><surname>Rosner</surname></persName><roleName type="degree">MD</roleName><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Blumenthal</surname></persName><roleName type="degree">MD</roleName><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Belkin</surname></persName><roleName type="degree">MD</roleName><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation></author></analytic><monogr><title level="j">Journal of Cataract & Refractive Surgery</title><title level="j" type="abbrev">JCRS</title><idno type="pISSN">0886-3350</idno><idno type="PII">S0886-3350(00)X0023-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">27</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="457">457</biblScope><biblScope unit="page" to="462">462</biblScope></imprint></monogr><idno type="istex">8669089507851846C1C34F8EC0CEF3F3866756FD</idno><idno type="DOI">10.1016/S0886-3350(00)00606-4</idno><idno type="PII">S0886-3350(00)00606-4</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Purpose To determine the efficacy of wide equatorial rings of various materials in reducing posterior capsule opacification (PCO) and maintaining the circular contour of the capsular equator in a rabbit model.Setting Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.Methods Closed rings made of poly(methyl methacrylate), Teflon®, polyurethane, and latex were introduced into the capsular bags of rabbit eyes after removal of the lens material. The soft latex rings were deemed the only practical rings for atraumatic implantation through a small incision. Latex rings of 2 dimensions with rectangular edges were implanted in 8 rabbits. One eye served as a control after lens removal and no ring implantation. The eyes were followed for up to 5 months and then evaluated by light microscopy.Results Posterior capsule opacification was minimal or absent in all animals implanted with the latex rings. Mild to moderate inflammatory reaction was noted in most eyes. It was caused by the ring material or secondary to long-standing pressure on the ciliary tissue. The rings also maintained well the circular contour of the capsular bags.Conclusions Equatorial rings of soft latex with sharp rectangular edges were effective in minimizing PCO and maintaining the shape of the capsule after lens removal in rabbits. Soft rings made of a biocompatible material may be effective in humans.</p></abstract><textClass><keywords scheme="keyword"><list><head>Article category</head><item><term>Laboratory science</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000-06-23">Registration</change><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="GR1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="GR2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="GR3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="GR4"></istex:entity><istex:entity SYSTEM="gr5" NDATA="IMAGE" name="GR5"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>JCRS</jid><aid>779</aid><ce:pii>S0886-3350(00)00606-4</ce:pii><ce:doi>10.1016/S0886-3350(00)00606-4</ce:doi><ce:copyright type="society" year="2001">ASCRS and ESCRS</ce:copyright><ce:doctopics><ce:doctopic><ce:text>Laboratory science</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Supported in part by funding from Acuity (Israel) Ltd.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Laboratory science</ce:textfn></ce:dochead><ce:title>Experimental studies of capsular equator rings of soft latex</ce:title><ce:presented>Presented at the XVIth Congress of the European Society of Cataract & Refractive Surgeons, Nice, France, September 1998, and as a poster at the annual meeting of the Association for Research in Vision and Ophthalmology, Ft. Lauderdale, Florida, USA, May 1998.</ce:presented><ce:author-group><ce:author><ce:given-name>Ehud I</ce:given-name><ce:surname>Assia</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>Michal</ce:given-name><ce:surname>Shelach</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Henry M</ce:given-name><ce:surname>Israel</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Mordechai</ce:given-name><ce:surname>Rosner</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Michael</ce:given-name><ce:surname>Blumenthal</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Michael</ce:given-name><ce:surname>Belkin</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba (Assia) Israel</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Acuity (Israel) Ltd., Bnei Brak (Israel), Israel</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Reprint requests to Ehud I. Assia, MD, Director, Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba, 44281, Israel</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="23" month="6" year="2000"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:section-title>Purpose</ce:section-title><ce:simple-para>To determine the efficacy of wide equatorial rings of various materials in reducing posterior capsule opacification (PCO) and maintaining the circular contour of the capsular equator in a rabbit model.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Setting</ce:section-title><ce:simple-para>Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Methods</ce:section-title><ce:simple-para>Closed rings made of poly(methyl methacrylate), Teflon®, polyurethane, and latex were introduced into the capsular bags of rabbit eyes after removal of the lens material. The soft latex rings were deemed the only practical rings for atraumatic implantation through a small incision. Latex rings of 2 dimensions with rectangular edges were implanted in 8 rabbits. One eye served as a control after lens removal and no ring implantation. The eyes were followed for up to 5 months and then evaluated by light microscopy.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Results</ce:section-title><ce:simple-para>Posterior capsule opacification was minimal or absent in all animals implanted with the latex rings. Mild to moderate inflammatory reaction was noted in most eyes. It was caused by the ring material or secondary to long-standing pressure on the ciliary tissue. The rings also maintained well the circular contour of the capsular bags.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Conclusions</ce:section-title><ce:simple-para>Equatorial rings of soft latex with sharp rectangular edges were effective in minimizing PCO and maintaining the shape of the capsule after lens removal in rabbits. Soft rings made of a biocompatible material may be effective in humans.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Experimental studies of capsular equator rings of soft latex</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Experimental studies of capsular equator rings of soft latex</title></titleInfo><name type="personal"><namePart type="given">Ehud I</namePart><namePart type="family">Assia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba (Assia) Israel</affiliation><description>Reprint requests to Ehud I. Assia, MD, Director, Department of Ophthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba, 44281, Israel</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michal</namePart><namePart type="family">Shelach</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henry M</namePart><namePart type="family">Israel</namePart><affiliation>Acuity (Israel) Ltd., Bnei Brak (Israel), Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mordechai</namePart><namePart type="family">Rosner</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Blumenthal</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Belkin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Goldschleger Eye Research Institute, Sackler School of Medicine, Tel-Aviv University and Sheba Medical Center, Tel-Hashomer (Assia, Shelach, Rosner, Blumenthal, Belkin) Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><dateValid encoding="w3cdtf">2000-06-23</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Purpose To determine the efficacy of wide equatorial rings of various materials in reducing posterior capsule opacification (PCO) and maintaining the circular contour of the capsular equator in a rabbit model.Setting Laboratory for Intraocular Microsurgery and Implants, Goldschleger Eye Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.Methods Closed rings made of poly(methyl methacrylate), Teflon®, polyurethane, and latex were introduced into the capsular bags of rabbit eyes after removal of the lens material. The soft latex rings were deemed the only practical rings for atraumatic implantation through a small incision. Latex rings of 2 dimensions with rectangular edges were implanted in 8 rabbits. One eye served as a control after lens removal and no ring implantation. The eyes were followed for up to 5 months and then evaluated by light microscopy.Results Posterior capsule opacification was minimal or absent in all animals implanted with the latex rings. Mild to moderate inflammatory reaction was noted in most eyes. It was caused by the ring material or secondary to long-standing pressure on the ciliary tissue. The rings also maintained well the circular contour of the capsular bags.Conclusions Equatorial rings of soft latex with sharp rectangular edges were effective in minimizing PCO and maintaining the shape of the capsule after lens removal in rabbits. Soft rings made of a biocompatible material may be effective in humans.</abstract><note>Supported in part by funding from Acuity (Israel) Ltd.</note><note type="content">Section title: Laboratory science</note><note type="content">Figure 1: (Assia) The 4 rings used in the study: polyurethane (U), Teflon (T), PMMA (P), and latex (L).</note><note type="content">Figure 2: (Assia) Side view of a latex ring in the capsular bag of a rabbit eye 5 months after implantation. Note the ring’s sharp rectangular edges.</note><note type="content">Figure 3: (Assia) The capsular equator of a rabbit eye 5 months after implantation of a latex ring. There are no cells over the anterior, equatorial, or posterior capsule. Mild inflammatory reaction is seen in the adjacent tissues.</note><note type="content">Figure 4: (Assia) The capsular equator of the control eye (no ring). The proliferation and migration of remaining LECs is limited by adhesions between the anterior and posterior capsules, creating a typical Soemmering’s ring.</note><note type="content">Figure 5: (Assia) The capsular bag of a rabbit after long-term implantation of a small latex ring. The rectangular shape of the equator corresponds to the shape of the ring (arrow heads), causing forward bowing of the iris and slight lateral compression of the ciliary body. Inflammatory reaction is minimal, and a few cells are adhered to the external surface of the capsule (arrow). The inner capsule is clear of lens epithelial or inflammatory cells.</note><note type="content">Table 1: Dimensions of the tested closed rings.legend</note><note type="content">Table 2: Long-term clinicopathological findings after implantation of latex rings.legend</note><subject><genre>Article category</genre><topic>Laboratory science</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Cataract & Refractive Surgery</title></titleInfo><titleInfo type="abbreviated"><title>JCRS</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">200103</dateIssued></originInfo><identifier type="ISSN">0886-3350</identifier><identifier type="PII">S0886-3350(00)X0023-5</identifier><part><date>200103</date><detail type="volume"><number>27</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>339</start><end>484</end></extent><extent unit="pages"><start>457</start><end>462</end></extent></part></relatedItem><identifier type="istex">8669089507851846C1C34F8EC0CEF3F3866756FD</identifier><identifier type="DOI">10.1016/S0886-3350(00)00606-4</identifier><identifier type="PII">S0886-3350(00)00606-4</identifier><accessCondition type="use and reproduction" contentType="">© 2001ASCRS and ESCRS</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>ASCRS and ESCRS, ©2001</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/8669089507851846C1C34F8EC0CEF3F3866756FD/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">OPHTHALMOLOGY</classCode><classCode scheme="WOS">SURGERY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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