A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡
Identifieur interne : 000C24 ( Main/Merge ); précédent : 000C23; suivant : 000C25A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡
Auteurs : Nicole C. Ammerman ; Joseph J. Gillespie ; Andrew F. Neuwald ; Bruno W. Sobral ; Abdu F. AzadSource :
- Journal of Bacteriology [ 0021-9193 ] ; 2009.
Abstract
Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (
Url:
DOI: 10.1128/JB.01077-09
PubMed: 19820087
PubMed Central: 2786609
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PMC:2786609Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae <xref ref-type="fn" rid="fn3">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> <xref ref-type="fn" rid="fn4">‡</xref> </title><author><name sortKey="Ammerman, Nicole C" sort="Ammerman, Nicole C" uniqKey="Ammerman N" first="Nicole C." last="Ammerman">Nicole C. Ammerman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gillespie, Joseph J" sort="Gillespie, Joseph J" uniqKey="Gillespie J" first="Joseph J." last="Gillespie">Joseph J. Gillespie</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Neuwald, Andrew F" sort="Neuwald, Andrew F" uniqKey="Neuwald A" first="Andrew F." last="Neuwald">Andrew F. Neuwald</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sobral, Bruno W" sort="Sobral, Bruno W" uniqKey="Sobral B" first="Bruno W." last="Sobral">Bruno W. Sobral</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Azad, Abdu F" sort="Azad, Abdu F" uniqKey="Azad A" first="Abdu F." last="Azad">Abdu F. Azad</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19820087</idno><idno type="pmc">2786609</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786609</idno><idno type="RBID">PMC:2786609</idno><idno type="doi">10.1128/JB.01077-09</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000366</idno><idno type="wicri:Area/Pmc/Curation">000366</idno><idno type="wicri:Area/Pmc/Checkpoint">000652</idno><idno type="wicri:Area/Ncbi/Merge">000112</idno><idno type="wicri:Area/Ncbi/Curation">000112</idno><idno type="wicri:Area/Ncbi/Checkpoint">000112</idno><idno type="wicri:doubleKey">0021-9193:2009:Ammerman N:a:typhus:group</idno><idno type="wicri:Area/Main/Merge">000C24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae <xref ref-type="fn" rid="fn3">▿</xref> <xref ref-type="fn" rid="fn1">†</xref> <xref ref-type="fn" rid="fn4">‡</xref> </title><author><name sortKey="Ammerman, Nicole C" sort="Ammerman, Nicole C" uniqKey="Ammerman N" first="Nicole C." last="Ammerman">Nicole C. Ammerman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gillespie, Joseph J" sort="Gillespie, Joseph J" uniqKey="Gillespie J" first="Joseph J." last="Gillespie">Joseph J. Gillespie</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Neuwald, Andrew F" sort="Neuwald, Andrew F" uniqKey="Neuwald A" first="Andrew F." last="Neuwald">Andrew F. Neuwald</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sobral, Bruno W" sort="Sobral, Bruno W" uniqKey="Sobral B" first="Bruno W." last="Sobral">Bruno W. Sobral</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Azad, Abdu F" sort="Azad, Abdu F" uniqKey="Azad A" first="Abdu F." last="Azad">Abdu F. Azad</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Bacteriology</title><idno type="ISSN">0021-9193</idno><idno type="eISSN">1098-5530</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (<italic>ppcE</italic>) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, <italic>ppcE</italic> warrants consideration in the development of therapeutics against epidemic and murine typhus.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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