A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡
Identifieur interne : 000C24 ( Main/Merge ); précédent : 000C23; suivant : 000C25A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡
Auteurs : Nicole C. Ammerman ; Joseph J. Gillespie ; Andrew F. Neuwald ; Bruno W. Sobral ; Abdu F. AzadSource :
- Journal of Bacteriology [ 0021-9193 ] ; 2009.
Abstract
Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (
Url:
DOI: 10.1128/JB.01077-09
PubMed: 19820087
PubMed Central: 2786609
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PMC:2786609Le document en format XML
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<series><title level="j">Journal of Bacteriology</title>
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<front><div type="abstract" xml:lang="en"><p>Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (<italic>ppcE</italic>
) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, <italic>ppcE</italic>
warrants consideration in the development of therapeutics against epidemic and murine typhus.</p>
</div>
</front>
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