CyberinfraV1, Pmc, Corpus, bibRecord, 000366

A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡

Identifieur interne : 000366 ( Pmc/Corpus ); précédent : 000365; suivant : 000367

A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡

Auteurs : Nicole C. Ammerman ; Joseph J. Gillespie ; Andrew F. Neuwald ; Bruno W. Sobral ; Abdu F. Azad

Source :

Journal of Bacteriology [ 0021-9193 ] ; 2009.

RBID : PMC:2786609

Abstract

Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786609

DOI: 10.1128/JB.01077-09
PubMed: 19820087
PubMed Central: 2786609

Links to Exploration step

PMC:2786609

Le document en format XML

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 <xref ref-type="fn" rid="fn1">†</xref>
 <xref ref-type="fn" rid="fn4">‡</xref>
 </title>
<author><name sortKey="Ammerman, Nicole C" sort="Ammerman, Nicole C" uniqKey="Ammerman N" first="Nicole C." last="Ammerman">Nicole C. Ammerman</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Gillespie, Joseph J" sort="Gillespie, Joseph J" uniqKey="Gillespie J" first="Joseph J." last="Gillespie">Joseph J. Gillespie</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Neuwald, Andrew F" sort="Neuwald, Andrew F" uniqKey="Neuwald A" first="Andrew F." last="Neuwald">Andrew F. Neuwald</name>
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<author><name sortKey="Sobral, Bruno W" sort="Sobral, Bruno W" uniqKey="Sobral B" first="Bruno W." last="Sobral">Bruno W. Sobral</name>
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<author><name sortKey="Azad, Abdu F" sort="Azad, Abdu F" uniqKey="Azad A" first="Abdu F." last="Azad">Abdu F. Azad</name>
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<idno type="pmid">19820087</idno>
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<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786609</idno>
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<idno type="doi">10.1128/JB.01077-09</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae <xref ref-type="fn" rid="fn3">▿</xref>
 <xref ref-type="fn" rid="fn1">†</xref>
 <xref ref-type="fn" rid="fn4">‡</xref>
 </title>
<author><name sortKey="Ammerman, Nicole C" sort="Ammerman, Nicole C" uniqKey="Ammerman N" first="Nicole C." last="Ammerman">Nicole C. Ammerman</name>
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<author><name sortKey="Gillespie, Joseph J" sort="Gillespie, Joseph J" uniqKey="Gillespie J" first="Joseph J." last="Gillespie">Joseph J. Gillespie</name>
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<author><name sortKey="Neuwald, Andrew F" sort="Neuwald, Andrew F" uniqKey="Neuwald A" first="Andrew F." last="Neuwald">Andrew F. Neuwald</name>
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</affiliation>
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<author><name sortKey="Sobral, Bruno W" sort="Sobral, Bruno W" uniqKey="Sobral B" first="Bruno W." last="Sobral">Bruno W. Sobral</name>
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<author><name sortKey="Azad, Abdu F" sort="Azad, Abdu F" uniqKey="Azad A" first="Abdu F." last="Azad">Abdu F. Azad</name>
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</affiliation>
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<series><title level="j">Journal of Bacteriology</title>
<idno type="ISSN">0021-9193</idno>
<idno type="eISSN">1098-5530</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><p>Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (<italic>ppcE</italic>
) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, <italic>ppcE</italic>
 warrants consideration in the development of therapeutics against epidemic and murine typhus.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Bacteriol</journal-id>
<journal-id journal-id-type="publisher-id">jbacter</journal-id>
<journal-title-group><journal-title>Journal of Bacteriology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0021-9193</issn>
<issn pub-type="epub">1098-5530</issn>
<publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19820087</article-id>
<article-id pub-id-type="pmc">2786609</article-id>
<article-id pub-id-type="publisher-id">1077-09</article-id>
<article-id pub-id-type="doi">10.1128/JB.01077-09</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Population Genetics and Evolution</subject>
</subj-group>
</article-categories>
<title-group><article-title>A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae <xref ref-type="fn" rid="fn3">▿</xref>
 <xref ref-type="fn" rid="fn1">†</xref>
 <xref ref-type="fn" rid="fn4">‡</xref>
 </article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ammerman</surname>
<given-names>Nicole C.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="fn" rid="fn2">§</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gillespie</surname>
<given-names>Joseph J.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
<xref ref-type="fn" rid="fn2">§</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neuwald</surname>
<given-names>Andrew F.</given-names>
</name>
<xref ref-type="aff" rid="aff1">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sobral</surname>
<given-names>Bruno W.</given-names>
</name>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Azad</surname>
<given-names>Abdu F.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201,<label>1</label>
 Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia 24061,<label>2</label>
 Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201<label>3</label>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Mailing address for Joseph J. Gillespie: HSF I Suite 380, 685 W. Baltimore St., University of Maryland—Baltimore, Baltimore, MD 21201. Phone: (410) 706-3337. Fax: (410) 706-0282. E-mail: <email>jgille@vbi.vt.edu</email>
. Mailing address for Abdu Azad: Department of Microbiology & Immunology, School of Medicine, University of Maryland—Baltimore, 685 West Baltimore St., Room 380C, Baltimore, MD 21201. Phone: (410) 706-7066. Fax: (410) 706-0282. E-mail: <email>aazad@umaryland.edu</email>
</corresp>
<fn id="fn2"><label>§</label>
<p>These authors contributed equally to the present study.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>9</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>9</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on 
 			/art/fm/atl/fn/p. </pmc-comment>
      <volume>191</volume>
<issue>24</issue>
<fpage>7609</fpage>
<lpage>7613</lpage>
<history><date date-type="received"><day>15</day>
<month>8</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>25</day>
<month>9</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2009, American Society for Microbiology</copyright-statement>
<copyright-year>2009</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:href="zjb02409007609.pdf"></self-uri>
<abstract><p>Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (<italic>ppcE</italic>
) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, <italic>ppcE</italic>
 warrants consideration in the development of therapeutics against epidemic and murine typhus.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡

A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae ▿ † ‡

Source :

Abstract

Links to Exploration step

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