Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.
Identifieur interne : 000009 ( PubMed/Curation ); précédent : 000008; suivant : 000010Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.
Auteurs : G. Landmann [Suisse] ; C. Lustenberger [Suisse] ; W. Schleinzer [Suisse] ; M. Schmelz [Allemagne] ; L. Stockinger [Suisse] ; R. Rukwied [Allemagne]Source :
- European journal of pain (London, England) [ 1532-2149 ] ; 2016.
Abstract
At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.
DOI: 10.1002/ejp.867
PubMed: 26988467
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Lustenberger</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Schleinzer, W" sort="Schleinzer, W" uniqKey="Schleinzer W" first="W" last="Schleinzer">W. Schleinzer</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Schmelz, M" sort="Schmelz, M" uniqKey="Schmelz M" first="M" last="Schmelz">M. Schmelz</name><affiliation wicri:level="1"><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Stockinger, L" sort="Stockinger, L" uniqKey="Stockinger L" first="L" last="Stockinger">L. Stockinger</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Rukwied, R" sort="Rukwied, R" uniqKey="Rukwied R" first="R" last="Rukwied">R. Rukwied</name><affiliation wicri:level="1"><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1002/ejp.867</idno><idno type="RBID">pubmed:26988467</idno><idno type="pmid">26988467</idno><idno type="wicri:Area/PubMed/Corpus">000009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000009</idno><idno type="wicri:Area/PubMed/Curation">000009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.</title><author><name sortKey="Landmann, G" sort="Landmann, G" uniqKey="Landmann G" first="G" last="Landmann">G. Landmann</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Lustenberger, C" sort="Lustenberger, C" uniqKey="Lustenberger C" first="C" last="Lustenberger">C. Lustenberger</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Schleinzer, W" sort="Schleinzer, W" uniqKey="Schleinzer W" first="W" last="Schleinzer">W. Schleinzer</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Schmelz, M" sort="Schmelz, M" uniqKey="Schmelz M" first="M" last="Schmelz">M. Schmelz</name><affiliation wicri:level="1"><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Stockinger, L" sort="Stockinger, L" uniqKey="Stockinger L" first="L" last="Stockinger">L. Stockinger</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil</wicri:regionArea></affiliation></author><author><name sortKey="Rukwied, R" sort="Rukwied, R" uniqKey="Rukwied R" first="R" last="Rukwied">R. Rukwied</name><affiliation wicri:level="1"><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg</wicri:regionArea></affiliation></author></analytic><series><title level="j">European journal of pain (London, England)</title><idno type="eISSN">1532-2149</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26988467</PMID><DateCreated><Year>2016</Year><Month>3</Month><Day>18</Day></DateCreated><DateRevised><Year>2016</Year><Month>3</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2149</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year><Month>Mar</Month><Day>14</Day></PubDate></JournalIssue><Title>European journal of pain (London, England)</Title><ISOAbbreviation>Eur J Pain</ISOAbbreviation></Journal><ArticleTitle>Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/ejp.867</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We investigated the effects of a 5 × 10 cm capsaicin 8% patch on C- and A-delta-nociceptor activation in ten healthy subjects before and at days 1-3-7-21 after patch application. Thermal thresholds, infrared thulium-YAG laser-evoked potentials (LEP) and heat pain (numeric rating scale, NRS, 0-10), electrically induced pain (10 pulses, 1.5-fold pain threshold intensity, five randomized series of 5-10-20-50-100 Hz), and axon-reflex flare (laser Doppler imaging) were recorded.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Thermal hypoesthesia developed upon capsaicin 8% treatment. Warmth detection thresholds increased at day 1-3, heat pain thresholds were increased by about 2.6 °C after day 3, and laser-evoked heat pain remained significantly reduced for 7 days. Axon-reflex flare responses (days 1-3), but not supra-threshold electrically induced pain were significantly reduced by the capsaicin patch.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Axonal nociceptor function assessed by electrical excitability tests supplements threshold tests of nociceptive endings. The differential analgesic effects of 8% capsaicin patches may be attributed to the kinetics of capsaicin and the different depth of nociceptive nerve fibres, yet, the time course does not match the long-lasting analgesia observed in neuropathic pain patients treated with the same patch. WHAT DOES THIS STUDY ADD?: Axonal nociceptor function assessed by supra-threshold electrical excitability tests did not coincide with capsaicin-induced transduction changes supplementing threshold measures of terminal nociceptor endings. Threshold measurements do not reflect the sustained effect of pain relief seen in neuropathic pain patients. Capsaicin-sensitive nociceptors responsible for spontaneous pain are either not specifically tested with currently available sensory stimulation protocols or have higher capsaicin sensitivity or slower recovery under neuropathic conditions.</AbstractText><CopyrightInformation>© 2016 European Pain Federation - EFIC®</CopyrightInformation></Abstract><AuthorList><Author><LastName>Landmann</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation></AffiliationInfo></Author><Author><LastName>Lustenberger</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation></AffiliationInfo></Author><Author><LastName>Schleinzer</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation></AffiliationInfo></Author><Author><LastName>Schmelz</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>Stockinger</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation></AffiliationInfo></Author><Author><LastName>Rukwied</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>3</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Eur J Pain</MedlineTA><NlmUniqueID>9801774</NlmUniqueID><ISSNLinking>1090-3801</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>1</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/ejp.867</ArticleId><ArticleId IdType="pubmed">26988467</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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