Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.
Identifieur interne : 000009 ( PubMed/Corpus ); précédent : 000008; suivant : 000010Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.
Auteurs : G. Landmann ; C. Lustenberger ; W. Schleinzer ; M. Schmelz ; L. Stockinger ; R. RukwiedSource :
- European journal of pain (London, England) [ 1532-2149 ] ; 2016.
Abstract
At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.
DOI: 10.1002/ejp.867
PubMed: 26988467
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pubmed:26988467Le document en format XML
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<author><name sortKey="Landmann, G" sort="Landmann, G" uniqKey="Landmann G" first="G" last="Landmann">G. Landmann</name>
<affiliation><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation>
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<author><name sortKey="Lustenberger, C" sort="Lustenberger, C" uniqKey="Lustenberger C" first="C" last="Lustenberger">C. Lustenberger</name>
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<author><name sortKey="Schleinzer, W" sort="Schleinzer, W" uniqKey="Schleinzer W" first="W" last="Schleinzer">W. Schleinzer</name>
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<author><name sortKey="Schmelz, M" sort="Schmelz, M" uniqKey="Schmelz M" first="M" last="Schmelz">M. Schmelz</name>
<affiliation><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation>
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<author><name sortKey="Stockinger, L" sort="Stockinger, L" uniqKey="Stockinger L" first="L" last="Stockinger">L. Stockinger</name>
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<author><name sortKey="Rukwied, R" sort="Rukwied, R" uniqKey="Rukwied R" first="R" last="Rukwied">R. Rukwied</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.</title>
<author><name sortKey="Landmann, G" sort="Landmann, G" uniqKey="Landmann G" first="G" last="Landmann">G. Landmann</name>
<affiliation><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation>
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<author><name sortKey="Lustenberger, C" sort="Lustenberger, C" uniqKey="Lustenberger C" first="C" last="Lustenberger">C. Lustenberger</name>
<affiliation><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation>
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<author><name sortKey="Schleinzer, W" sort="Schleinzer, W" uniqKey="Schleinzer W" first="W" last="Schleinzer">W. Schleinzer</name>
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<author><name sortKey="Schmelz, M" sort="Schmelz, M" uniqKey="Schmelz M" first="M" last="Schmelz">M. Schmelz</name>
<affiliation><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation>
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<author><name sortKey="Stockinger, L" sort="Stockinger, L" uniqKey="Stockinger L" first="L" last="Stockinger">L. Stockinger</name>
<affiliation><nlm:affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</nlm:affiliation>
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<author><name sortKey="Rukwied, R" sort="Rukwied, R" uniqKey="Rukwied R" first="R" last="Rukwied">R. Rukwied</name>
<affiliation><nlm:affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</nlm:affiliation>
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<series><title level="j">European journal of pain (London, England)</title>
<idno type="eISSN">1532-2149</idno>
<imprint><date when="2016" type="published">2016</date>
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<front><div type="abstract" xml:lang="en">At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.</div>
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<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26988467</PMID>
<DateCreated><Year>2016</Year>
<Month>3</Month>
<Day>18</Day>
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<DateRevised><Year>2016</Year>
<Month>3</Month>
<Day>19</Day>
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<Month>Mar</Month>
<Day>14</Day>
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<Title>European journal of pain (London, England)</Title>
<ISOAbbreviation>Eur J Pain</ISOAbbreviation>
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<ArticleTitle>Short lasting transient effects of a capsaicin 8% patch on nociceptor activation in humans.</ArticleTitle>
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<ELocationID EIdType="doi">10.1002/ejp.867</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We investigated the effects of a 5 × 10 cm capsaicin 8% patch on C- and A-delta-nociceptor activation in ten healthy subjects before and at days 1-3-7-21 after patch application. Thermal thresholds, infrared thulium-YAG laser-evoked potentials (LEP) and heat pain (numeric rating scale, NRS, 0-10), electrically induced pain (10 pulses, 1.5-fold pain threshold intensity, five randomized series of 5-10-20-50-100 Hz), and axon-reflex flare (laser Doppler imaging) were recorded.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Thermal hypoesthesia developed upon capsaicin 8% treatment. Warmth detection thresholds increased at day 1-3, heat pain thresholds were increased by about 2.6 °C after day 3, and laser-evoked heat pain remained significantly reduced for 7 days. Axon-reflex flare responses (days 1-3), but not supra-threshold electrically induced pain were significantly reduced by the capsaicin patch.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Axonal nociceptor function assessed by electrical excitability tests supplements threshold tests of nociceptive endings. The differential analgesic effects of 8% capsaicin patches may be attributed to the kinetics of capsaicin and the different depth of nociceptive nerve fibres, yet, the time course does not match the long-lasting analgesia observed in neuropathic pain patients treated with the same patch. WHAT DOES THIS STUDY ADD?: Axonal nociceptor function assessed by supra-threshold electrical excitability tests did not coincide with capsaicin-induced transduction changes supplementing threshold measures of terminal nociceptor endings. Threshold measurements do not reflect the sustained effect of pain relief seen in neuropathic pain patients. Capsaicin-sensitive nociceptors responsible for spontaneous pain are either not specifically tested with currently available sensory stimulation protocols or have higher capsaicin sensitivity or slower recovery under neuropathic conditions.</AbstractText>
<CopyrightInformation>© 2016 European Pain Federation - EFIC®</CopyrightInformation>
</Abstract>
<AuthorList><Author><LastName>Landmann</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Lustenberger</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Schleinzer</LastName>
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<AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation>
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<Author><LastName>Schmelz</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Stockinger</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre for Pain Medicine, Swiss Paraplegic Centre, Nottwil, Switzerland.</Affiliation>
</AffiliationInfo>
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<Author><LastName>Rukwied</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>University Medicine Mannheim, Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.</Affiliation>
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<Language>ENG</Language>
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<Month>3</Month>
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<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year>
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