An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.
Identifieur interne : 000878 ( PubMed/Corpus ); précédent : 000877; suivant : 000879An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.
Auteurs : C R Triggle ; D J TriggleSource :
- The Journal of physiology [ 0022-3751 ] ; 1976.
English descriptors
- KwdEn :
- Animals, Calcium (metabolism), Cerium (pharmacology), Dioxolanes (antagonists & inhibitors), Extracellular Space (metabolism), Guinea Pigs, Ileum (drug effects), Ileum (metabolism), In Vitro Techniques, Lanthanum (pharmacology), Male, Metals, Rare Earth (pharmacology), Methylamines (antagonists & inhibitors), Muscle Contraction (drug effects), Muscle, Smooth (drug effects), Muscle, Smooth (metabolism), Potassium (pharmacology), Thulium (metabolism), Thulium (pharmacology).
- MESH :
- chemical , antagonists & inhibitors : Dioxolanes, Methylamines.
- chemical , metabolism : Calcium, Thulium.
- chemical , pharmacology : Cerium, Lanthanum, Metals, Rare Earth, Potassium, Thulium.
- drug effects : Ileum, Muscle Contraction, Muscle, Smooth.
- metabolism : Extracellular Space, Ileum, Muscle, Smooth.
- Animals, Guinea Pigs, In Vitro Techniques, Male.
Abstract
1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.
PubMed: 1249741
Links to Exploration step
pubmed:1249741Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</title><author><name sortKey="Triggle, C R" sort="Triggle, C R" uniqKey="Triggle C" first="C R" last="Triggle">C R Triggle</name></author><author><name sortKey="Triggle, D J" sort="Triggle, D J" uniqKey="Triggle D" first="D J" last="Triggle">D J Triggle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1976">1976</date><idno type="RBID">pubmed:1249741</idno><idno type="pmid">1249741</idno><idno type="wicri:Area/PubMed/Corpus">000878</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000878</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</title><author><name sortKey="Triggle, C R" sort="Triggle, C R" uniqKey="Triggle C" first="C R" last="Triggle">C R Triggle</name></author><author><name sortKey="Triggle, D J" sort="Triggle, D J" uniqKey="Triggle D" first="D J" last="Triggle">D J Triggle</name></author></analytic><series><title level="j">The Journal of physiology</title><idno type="ISSN">0022-3751</idno><imprint><date when="1976" type="published">1976</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcium (metabolism)</term><term>Cerium (pharmacology)</term><term>Dioxolanes (antagonists & inhibitors)</term><term>Extracellular Space (metabolism)</term><term>Guinea Pigs</term><term>Ileum (drug effects)</term><term>Ileum (metabolism)</term><term>In Vitro Techniques</term><term>Lanthanum (pharmacology)</term><term>Male</term><term>Metals, Rare Earth (pharmacology)</term><term>Methylamines (antagonists & inhibitors)</term><term>Muscle Contraction (drug effects)</term><term>Muscle, Smooth (drug effects)</term><term>Muscle, Smooth (metabolism)</term><term>Potassium (pharmacology)</term><term>Thulium (metabolism)</term><term>Thulium (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Dioxolanes</term><term>Methylamines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cerium</term><term>Lanthanum</term><term>Metals, Rare Earth</term><term>Potassium</term><term>Thulium</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Ileum</term><term>Muscle Contraction</term><term>Muscle, Smooth</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Extracellular Space</term><term>Ileum</term><term>Muscle, Smooth</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Guinea Pigs</term><term>In Vitro Techniques</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1249741</PMID><DateCreated><Year>1976</Year><Month>04</Month><Day>15</Day></DateCreated><DateCompleted><Year>1976</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3751</ISSN><JournalIssue CitedMedium="Print"><Volume>254</Volume><Issue>1</Issue><PubDate><Year>1976</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Journal of physiology</Title><ISOAbbreviation>J. Physiol. (Lond.)</ISOAbbreviation></Journal><ArticleTitle>An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</ArticleTitle><Pagination><MedlinePgn>39-54</MedlinePgn></Pagination><Abstract><AbstractText>1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Triggle</LastName><ForeName>C R</ForeName><Initials>CR</Initials></Author><Author ValidYN="Y"><LastName>Triggle</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ENGLAND</Country><MedlineTA>J Physiol</MedlineTA><NlmUniqueID>0266262</NlmUniqueID><ISSNLinking>0022-3751</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004148">Dioxolanes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008674">Metals, Rare Earth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008744">Methylamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>30K4522N6T</RegistryNumber><NameOfSubstance UI="D002563">Cerium</NameOfSubstance></Chemical><Chemical><RegistryNumber>6I3K30563S</RegistryNumber><NameOfSubstance UI="D007811">Lanthanum</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical><Chemical><RegistryNumber>RWP5GA015D</RegistryNumber><NameOfSubstance UI="D011188">Potassium</NameOfSubstance></Chemical><Chemical><RegistryNumber>SY7Q814VUP</RegistryNumber><NameOfSubstance UI="D002118">Calcium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):57-71</RefSource><PMID Version="1">4144699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Physiol. 1951 Oct;38(2):245-70</RefSource><PMID Version="1">14897863</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arzneimittelforschung. 1972 Dec;22(12):2019-28</RefSource><PMID Version="1">4196671</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 1972 May 26;47(4):808-13</RefSource><PMID Version="1">4260315</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1974 Feb;138(2):239-52</RefSource><PMID Version="1">4362742</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pflugers Arch. 1972;335(4):309-22</RefSource><PMID Version="1">4673213</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Theor Biol. 1973 Jul;40(1):125-54</RefSource><PMID Version="1">4723547</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Can J Physiol Pharmacol. 1973 Dec;51(12):900-13</RefSource><PMID Version="1">4777241</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Cell Cardiol. 1974 Apr;6(2):149-61</RefSource><PMID Version="1">4828688</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 1969 Sep;169(1):46-55</RefSource><PMID Version="1">4979682</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 1972 Jan;30(1):44-54</RefSource><PMID Version="1">5007527</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1972 Sep;54(3):441-55</RefSource><PMID Version="1">5044754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1970 May 23;226(5247):760-1</RefSource><PMID Version="1">5443255</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1968 Jul 25;243(14):3884-90</RefSource><PMID Version="1">5661713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 1968 Sep 30;32(6):977-83</RefSource><PMID Version="1">5723329</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacol Rev. 1964 Mar;16:85-127</RefSource><PMID Version="1">14164045</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc R Soc Lond B Biol Sci. 1965 Aug 24;163:1-44</RefSource><PMID Version="1">14338492</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Microsc. 1972 Jun;95(3):413-9</RefSource><PMID Version="1">4114957</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 1971 Jan 22;42(2):298-305</RefSource><PMID Version="1">4250976</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pharmacol. 1972;12:185-96</RefSource><PMID Version="1">4339015</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pharmacol. 1971;11:303-26</RefSource><PMID Version="1">4402440</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pflugers Arch. 1972;337(4):333-50</RefSource><PMID Version="1">4674882</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Cell Cardiol. 1974 Apr;6(2):137-47</RefSource><PMID Version="1">4828687</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Physiol. 1969;31:581-646</RefSource><PMID Version="1">4885777</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol. 1971 Mar;220(3):759-66</RefSource><PMID Version="1">4993569</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Can J Physiol Pharmacol. 1972 Jul;50(7):730-3</RefSource><PMID Version="1">5050609</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Biochem Biophys. 1971 Apr;143(2):506-15</RefSource><PMID Version="1">5558134</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 1967 Sep;192(1):145-57</RefSource><PMID Version="1">6051800</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Pharmacol Chemother. 1964 Apr;22:356-65</RefSource><PMID Version="1">14190470</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Int Physiol Biochim. 1969 Oct;77(4):710-6</RefSource><PMID Version="1">4188409</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002118">Calcium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002563">Cerium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004148">Dioxolanes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000037">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005110">Extracellular Space</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006168">Guinea Pigs</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007082">Ileum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D066298">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007811">Lanthanum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008674">Metals, Rare Earth</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008744">Methylamines</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000037">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009119">Muscle Contraction</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009130">Muscle, Smooth</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011188">Potassium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1309178</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1976</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1976</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1976</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1249741</ArticleId><ArticleId IdType="pmc">PMC1309178</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000878 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000878 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:1249741
|texte= An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:1249741" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ThuliumV1
| This area was generated with Dilib version V0.6.21. |  |