The effects of lanthanum and thulium on the mechanical responses of rat vas deferens.
Identifieur interne : 000877 ( PubMed/Corpus ); précédent : 000876; suivant : 000878The effects of lanthanum and thulium on the mechanical responses of rat vas deferens.
Auteurs : V C Swamy ; C R Triggle ; D J TriggleSource :
- The Journal of physiology [ 0022-3751 ] ; 1976.
English descriptors
- KwdEn :
- Animals, Binding Sites, Calcium (pharmacology), Calcium (physiology), Extracellular Space (physiology), In Vitro Techniques, Lanthanum (pharmacology), Male, Muscle Contraction (drug effects), Muscle, Smooth (drug effects), Norepinephrine (antagonists & inhibitors), Potassium (antagonists & inhibitors), Rats, Thulium (metabolism), Thulium (pharmacology), Vas Deferens (drug effects), Vas Deferens (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Norepinephrine, Potassium.
- chemical , metabolism : Thulium.
- chemical , pharmacology : Calcium, Lanthanum, Thulium.
- chemical , physiology : Calcium.
- drug effects : Muscle Contraction, Muscle, Smooth, Vas Deferens.
- metabolism : Vas Deferens.
- physiology : Extracellular Space.
- Animals, Binding Sites, In Vitro Techniques, Male, Rats.
Abstract
1. The contractile responses of rat vas deferens to noradrenaline and K+ are composed of phasic and tonic components both of which are dependent upon the concentration of extracellular Ca2+. 2. Lanthanum, La3+, and thulium ions, Tm3+, inhibited the noradrenaline and K+ induced responses, complete inhibition being obtained at approximately 10(-3) M-Ln3+. 3. La3+ and Tm3+ were equally effective in inhibiting noradrenaline and K+ responses. The phasic and tonic components of the noradrenaline response were equally sensitive to lanthanide cations, Ln3+, but the phasic component of the K+ response was more sensitive than the tonic component. 4. 170Tm binding did not show any saturable component over the concentration range in which inhibition of the pharmacological response was obtained. 5. It is suggested that the actions of Ln3+ in the rat vas deferens are mediated through some kind of membrane stabilization rather than via a specific Ca2+ binding site concerned with excitation-contraction coupling, the mechanism previously postulated for the Ln3+ action in guinea-pig ileal longitudinal muscle.
PubMed: 1249752
Links to Exploration step
pubmed:1249752Le document en format XML
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The contractile responses of rat vas deferens to noradrenaline and K+ are composed of phasic and tonic components both of which are dependent upon the concentration of extracellular Ca2+. 2. Lanthanum, La3+, and thulium ions, Tm3+, inhibited the noradrenaline and K+ induced responses, complete inhibition being obtained at approximately 10(-3) M-Ln3+. 3. La3+ and Tm3+ were equally effective in inhibiting noradrenaline and K+ responses. The phasic and tonic components of the noradrenaline response were equally sensitive to lanthanide cations, Ln3+, but the phasic component of the K+ response was more sensitive than the tonic component. 4. 170Tm binding did not show any saturable component over the concentration range in which inhibition of the pharmacological response was obtained. 5. It is suggested that the actions of Ln3+ in the rat vas deferens are mediated through some kind of membrane stabilization rather than via a specific Ca2+ binding site concerned with excitation-contraction coupling, the mechanism previously postulated for the Ln3+ action in guinea-pig ileal longitudinal muscle.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1249752</PMID><DateCreated><Year>1976</Year><Month>04</Month><Day>15</Day></DateCreated><DateCompleted><Year>1976</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3751</ISSN><JournalIssue CitedMedium="Print"><Volume>254</Volume><Issue>1</Issue><PubDate><Year>1976</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Journal of physiology</Title><ISOAbbreviation>J. Physiol. (Lond.)</ISOAbbreviation></Journal><ArticleTitle>The effects of lanthanum and thulium on the mechanical responses of rat vas deferens.</ArticleTitle><Pagination><MedlinePgn>55-62</MedlinePgn></Pagination><Abstract><AbstractText>1. The contractile responses of rat vas deferens to noradrenaline and K+ are composed of phasic and tonic components both of which are dependent upon the concentration of extracellular Ca2+. 2. Lanthanum, La3+, and thulium ions, Tm3+, inhibited the noradrenaline and K+ induced responses, complete inhibition being obtained at approximately 10(-3) M-Ln3+. 3. La3+ and Tm3+ were equally effective in inhibiting noradrenaline and K+ responses. The phasic and tonic components of the noradrenaline response were equally sensitive to lanthanide cations, Ln3+, but the phasic component of the K+ response was more sensitive than the tonic component. 4. 170Tm binding did not show any saturable component over the concentration range in which inhibition of the pharmacological response was obtained. 5. It is suggested that the actions of Ln3+ in the rat vas deferens are mediated through some kind of membrane stabilization rather than via a specific Ca2+ binding site concerned with excitation-contraction coupling, the mechanism previously postulated for the Ln3+ action in guinea-pig ileal longitudinal muscle.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Swamy</LastName><ForeName>V C</ForeName><Initials>VC</Initials></Author><Author ValidYN="Y"><LastName>Triggle</LastName><ForeName>C R</ForeName><Initials>CR</Initials></Author><Author ValidYN="Y"><LastName>Triggle</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ENGLAND</Country><MedlineTA>J Physiol</MedlineTA><NlmUniqueID>0266262</NlmUniqueID><ISSNLinking>0022-3751</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>6I3K30563S</RegistryNumber><NameOfSubstance UI="D007811">Lanthanum</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical><Chemical><RegistryNumber>RWP5GA015D</RegistryNumber><NameOfSubstance UI="D011188">Potassium</NameOfSubstance></Chemical><Chemical><RegistryNumber>SY7Q814VUP</RegistryNumber><NameOfSubstance UI="D002118">Calcium</NameOfSubstance></Chemical><Chemical><RegistryNumber>X4W3ENH1CV</RegistryNumber><NameOfSubstance UI="D009638">Norepinephrine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 1976 Jan;254(1):39-54</RefSource><PMID Version="1">1249741</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):57-71</RefSource><PMID Version="1">4144699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pharmacol. 1971;11:303-26</RefSource><PMID Version="1">4402440</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Physiol Scand. 1974 Jan;90(1):113-23</RefSource><PMID Version="1">4544399</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Gen Physiol. 1966 Nov;50(2):461-71</RefSource><PMID Version="1">11526840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pflugers Arch. 1973;345(4):281-94</RefSource><PMID Version="1">4798861</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pflugers Arch. 1974;350(1):25-39</RefSource><PMID Version="1">4859231</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 1972 Jan;30(1):44-54</RefSource><PMID Version="1">5007527</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Theor Biol. 1973 Jul;40(1):125-54</RefSource><PMID Version="1">4723547</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001665">Binding Sites</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002118">Calcium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000494">pharmacology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005110">Extracellular Space</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D066298">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007811">Lanthanum</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009119">Muscle Contraction</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009130">Muscle, Smooth</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009638">Norepinephrine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000037">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011188">Potassium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000037">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014649">Vas Deferens</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1309179</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1976</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1976</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1976</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1249752</ArticleId><ArticleId IdType="pmc">PMC1309179</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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