Distribution of TmDOTP5- in rat tissues: TmDOTP5- vs. CoEDTA- as markers of extracellular tissue space.
Identifieur interne : 000743 ( PubMed/Corpus ); précédent : 000742; suivant : 000744Distribution of TmDOTP5- in rat tissues: TmDOTP5- vs. CoEDTA- as markers of extracellular tissue space.
Auteurs : J D Makos ; C R Malloy ; A D SherrySource :
- Journal of applied physiology (Bethesda, Md. : 1985) [ 8750-7587 ] ; 1998.
English descriptors
- KwdEn :
- Animals, Calcium (blood), Chelating Agents (pharmacokinetics), Edetic Acid (pharmacokinetics), Edetic Acid (urine), Extracellular Space (metabolism), Liver (metabolism), Magnesium (blood), Male, Models, Biological, Myocardium (metabolism), Organometallic Compounds (pharmacokinetics), Organometallic Compounds (urine), Organophosphorus Compounds (pharmacokinetics), Organophosphorus Compounds (urine), Rats, Rats, Sprague-Dawley, Spectrophotometry, Atomic, Thulium (blood), Thulium (pharmacokinetics), Thulium (urine), Tissue Distribution.
- MESH :
- chemical , blood : Calcium, Magnesium, Thulium.
- chemical , pharmacokinetics : Chelating Agents, Edetic Acid, Organometallic Compounds, Organophosphorus Compounds, Thulium.
- chemical , urine : Edetic Acid, Organometallic Compounds, Organophosphorus Compounds, Thulium.
- metabolism : Extracellular Space, Liver, Myocardium.
- Animals, Male, Models, Biological, Rats, Rats, Sprague-Dawley, Spectrophotometry, Atomic, Tissue Distribution.
Abstract
The distribution of TmDOTP5- in rat tissue was compared with CoEDTA-, an anionic complex previously used as a marker of extracellular space. Heart, liver, muscle, blood, and urine were collected from rats after infusion of either complex and were quantitatively analyzed by atomic absorption spectroscopy. Although total TmDOTP5- in blood and tissue was consistently lower (0.88 +/- 0.04; n = 6) than CoEDTA- after an identical infusion protocol (presumably because of some association of the phosphonate complex with bone), a comparison of blood and tissue contents indicated that the two anionic complexes distributed into identical extracellular spaces. Relative extracellular space in the in vivo liver, as determined by TmDOTP5- and CoEDTA-, was 0.18 +/- 0.02 and 0.15 +/- 0.01, respectively. The corresponding relative extracellular space values for the in vivo heart reported by the two agents were identical (0. 11 +/- 0.02). Experiments were also performed to evaluate the washout kinetics of TmDOTP5- from anesthesized rats. In rats given a total dose of 0.16 mmol TmDOTP5-, 81% appeared in urine by 180 min, <2% was found in all remaining soft tissue, leaving approximately 18% undetected. The rate of Tm appearance in urine was fit to a standard pharmacokinetic model that included four tissue compartments: plasma, one fast equilbrating space, one slow equilibrating space, and one very slow equilibrating space (presumably bone). The best fit result suggests that the highly charged TmDOTP5- complex is cleared from plasma more rapidly than is the typical lower charged Gd-based contrast agents and that release from bone is slow compared with renal clearance.
PubMed: 9804584
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distribution of TmDOTP5- in rat tissues: TmDOTP5- vs. CoEDTA- as markers of extracellular tissue space.</title><author><name sortKey="Makos, J D" sort="Makos, J D" uniqKey="Makos J" first="J D" last="Makos">J D Makos</name><affiliation><nlm:affiliation>Department of Chemistry, University of Texas at Dallas, Richardson, 75083-0688, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C R" last="Malloy">C R Malloy</name></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9804584</idno><idno type="pmid">9804584</idno><idno type="wicri:Area/PubMed/Corpus">000743</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000743</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Distribution of TmDOTP5- in rat tissues: TmDOTP5- vs. CoEDTA- as markers of extracellular tissue space.</title><author><name sortKey="Makos, J D" sort="Makos, J D" uniqKey="Makos J" first="J D" last="Makos">J D Makos</name><affiliation><nlm:affiliation>Department of Chemistry, University of Texas at Dallas, Richardson, 75083-0688, Texas, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C R" last="Malloy">C R Malloy</name></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name></author></analytic><series><title level="j">Journal of applied physiology (Bethesda, Md. : 1985)</title><idno type="ISSN">8750-7587</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcium (blood)</term><term>Chelating Agents (pharmacokinetics)</term><term>Edetic Acid (pharmacokinetics)</term><term>Edetic Acid (urine)</term><term>Extracellular Space (metabolism)</term><term>Liver (metabolism)</term><term>Magnesium (blood)</term><term>Male</term><term>Models, Biological</term><term>Myocardium (metabolism)</term><term>Organometallic Compounds (pharmacokinetics)</term><term>Organometallic Compounds (urine)</term><term>Organophosphorus Compounds (pharmacokinetics)</term><term>Organophosphorus Compounds (urine)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Spectrophotometry, Atomic</term><term>Thulium (blood)</term><term>Thulium (pharmacokinetics)</term><term>Thulium (urine)</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Calcium</term><term>Magnesium</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Chelating Agents</term><term>Edetic Acid</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Edetic Acid</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Thulium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Extracellular Space</term><term>Liver</term><term>Myocardium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Models, Biological</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Spectrophotometry, Atomic</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The distribution of TmDOTP5- in rat tissue was compared with CoEDTA-, an anionic complex previously used as a marker of extracellular space. Heart, liver, muscle, blood, and urine were collected from rats after infusion of either complex and were quantitatively analyzed by atomic absorption spectroscopy. Although total TmDOTP5- in blood and tissue was consistently lower (0.88 +/- 0.04; n = 6) than CoEDTA- after an identical infusion protocol (presumably because of some association of the phosphonate complex with bone), a comparison of blood and tissue contents indicated that the two anionic complexes distributed into identical extracellular spaces. Relative extracellular space in the in vivo liver, as determined by TmDOTP5- and CoEDTA-, was 0.18 +/- 0.02 and 0.15 +/- 0.01, respectively. The corresponding relative extracellular space values for the in vivo heart reported by the two agents were identical (0. 11 +/- 0.02). Experiments were also performed to evaluate the washout kinetics of TmDOTP5- from anesthesized rats. In rats given a total dose of 0.16 mmol TmDOTP5-, 81% appeared in urine by 180 min, <2% was found in all remaining soft tissue, leaving approximately 18% undetected. The rate of Tm appearance in urine was fit to a standard pharmacokinetic model that included four tissue compartments: plasma, one fast equilbrating space, one slow equilibrating space, and one very slow equilibrating space (presumably bone). The best fit result suggests that the highly charged TmDOTP5- complex is cleared from plasma more rapidly than is the typical lower charged Gd-based contrast agents and that release from bone is slow compared with renal clearance.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9804584</PMID><DateCreated><Year>1998</Year><Month>12</Month><Day>29</Day></DateCreated><DateCompleted><Year>1998</Year><Month>12</Month><Day>29</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">8750-7587</ISSN><JournalIssue CitedMedium="Print"><Volume>85</Volume><Issue>5</Issue><PubDate><Year>1998</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of applied physiology (Bethesda, Md. : 1985)</Title><ISOAbbreviation>J. Appl. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Distribution of TmDOTP5- in rat tissues: TmDOTP5- vs. CoEDTA- as markers of extracellular tissue space.</ArticleTitle><Pagination><MedlinePgn>1800-5</MedlinePgn></Pagination><Abstract><AbstractText>The distribution of TmDOTP5- in rat tissue was compared with CoEDTA-, an anionic complex previously used as a marker of extracellular space. Heart, liver, muscle, blood, and urine were collected from rats after infusion of either complex and were quantitatively analyzed by atomic absorption spectroscopy. Although total TmDOTP5- in blood and tissue was consistently lower (0.88 +/- 0.04; n = 6) than CoEDTA- after an identical infusion protocol (presumably because of some association of the phosphonate complex with bone), a comparison of blood and tissue contents indicated that the two anionic complexes distributed into identical extracellular spaces. Relative extracellular space in the in vivo liver, as determined by TmDOTP5- and CoEDTA-, was 0.18 +/- 0.02 and 0.15 +/- 0.01, respectively. The corresponding relative extracellular space values for the in vivo heart reported by the two agents were identical (0. 11 +/- 0.02). Experiments were also performed to evaluate the washout kinetics of TmDOTP5- from anesthesized rats. In rats given a total dose of 0.16 mmol TmDOTP5-, 81% appeared in urine by 180 min, <2% was found in all remaining soft tissue, leaving approximately 18% undetected. The rate of Tm appearance in urine was fit to a standard pharmacokinetic model that included four tissue compartments: plasma, one fast equilbrating space, one slow equilibrating space, and one very slow equilibrating space (presumably bone). The best fit result suggests that the highly charged TmDOTP5- complex is cleared from plasma more rapidly than is the typical lower charged Gd-based contrast agents and that release from bone is slow compared with renal clearance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Makos</LastName><ForeName>J D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Chemistry, University of Texas at Dallas, Richardson, 75083-0688, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malloy</LastName><ForeName>C R</ForeName><Initials>CR</Initials></Author><Author ValidYN="Y"><LastName>Sherry</LastName><ForeName>A D</ForeName><Initials>AD</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P41-RR-02584</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>J Appl Physiol (1985)</MedlineTA><NlmUniqueID>8502536</NlmUniqueID><ISSNLinking>0161-7567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002614">Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009943">Organophosphorus Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C069929">thulium(III) 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetramethylenephosphonate</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical><Chemical><RegistryNumber>9G34HU7RV0</RegistryNumber><NameOfSubstance UI="D004492">Edetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>I38ZP9992A</RegistryNumber><NameOfSubstance UI="D008274">Magnesium</NameOfSubstance></Chemical><Chemical><RegistryNumber>SY7Q814VUP</RegistryNumber><NameOfSubstance UI="D002118">Calcium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002118">Calcium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002614">Chelating Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004492">Edetic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000652">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005110">Extracellular Space</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008099">Liver</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008274">Magnesium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008954">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009206">Myocardium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009942">Organometallic Compounds</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000652">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009943">Organophosphorus Compounds</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000652">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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