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Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis.

Identifieur interne : 000700 ( PubMed/Corpus ); précédent : 000699; suivant : 000701

Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis.

Auteurs : Jörg Spiegel ; Christiane Hansen ; Ulf Baumg Rtner ; Hanns Christian Hopf ; Rolf Detlef Treede

Source :

RBID : pubmed:12804667

English descriptors

Abstract

Somatosensory evoked potentials (SEPs) play a less important role in the diagnosis of multiple sclerosis (MS) than visually evoked potentials. Since standard SEPs only reflect the dorsal column function, we now investigated spinothalamic tract function in patients with MS using laser-evoked potentials (LEPs).

PubMed: 12804667

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pubmed:12804667

Le document en format XML

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<title xml:lang="en">Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis.</title>
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<name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name>
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<nlm:affiliation>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Saarstrasse 21, D-55099, Mainz, Germany.</nlm:affiliation>
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<author>
<name sortKey="Hansen, Christiane" sort="Hansen, Christiane" uniqKey="Hansen C" first="Christiane" last="Hansen">Christiane Hansen</name>
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<author>
<name sortKey="Baumg Rtner, Ulf" sort="Baumg Rtner, Ulf" uniqKey="Baumg Rtner U" first="Ulf" last="Baumg Rtner">Ulf Baumg Rtner</name>
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<name sortKey="Hopf, Hanns Christian" sort="Hopf, Hanns Christian" uniqKey="Hopf H" first="Hanns Christian" last="Hopf">Hanns Christian Hopf</name>
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<name sortKey="Treede, Rolf Detlef" sort="Treede, Rolf Detlef" uniqKey="Treede R" first="Rolf Detlef" last="Treede">Rolf Detlef Treede</name>
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<title xml:lang="en">Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis.</title>
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<name sortKey="Hansen, Christiane" sort="Hansen, Christiane" uniqKey="Hansen C" first="Christiane" last="Hansen">Christiane Hansen</name>
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<term>Adult</term>
<term>Anti-Inflammatory Agents</term>
<term>Case-Control Studies</term>
<term>Electroencephalography</term>
<term>Evoked Potentials, Somatosensory (physiology)</term>
<term>Female</term>
<term>Hand (physiopathology)</term>
<term>Humans</term>
<term>Hydrocortisone (therapeutic use)</term>
<term>Immunoglobulin G (metabolism)</term>
<term>Infrared Rays</term>
<term>Lasers</term>
<term>Leg (physiopathology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Sclerosis (drug therapy)</term>
<term>Multiple Sclerosis (pathology)</term>
<term>Multiple Sclerosis (physiopathology)</term>
<term>Reaction Time</term>
<term>Reproducibility of Results</term>
<term>Sensory Thresholds</term>
<term>Spinothalamic Tracts (physiopathology)</term>
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<term>Immunoglobulin G</term>
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<term>Hydrocortisone</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en">
<term>Anti-Inflammatory Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Multiple Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Multiple Sclerosis</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Evoked Potentials, Somatosensory</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Hand</term>
<term>Leg</term>
<term>Multiple Sclerosis</term>
<term>Spinothalamic Tracts</term>
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<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Case-Control Studies</term>
<term>Electroencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Infrared Rays</term>
<term>Lasers</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reaction Time</term>
<term>Reproducibility of Results</term>
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<div type="abstract" xml:lang="en">Somatosensory evoked potentials (SEPs) play a less important role in the diagnosis of multiple sclerosis (MS) than visually evoked potentials. Since standard SEPs only reflect the dorsal column function, we now investigated spinothalamic tract function in patients with MS using laser-evoked potentials (LEPs).</div>
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<Month>06</Month>
<Day>13</Day>
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<Year>2003</Year>
<Month>08</Month>
<Day>01</Day>
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<DateRevised>
<Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
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<ISSN IssnType="Print">1388-2457</ISSN>
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<Volume>114</Volume>
<Issue>6</Issue>
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<Year>2003</Year>
<Month>Jun</Month>
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<Title>Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology</Title>
<ISOAbbreviation>Clin Neurophysiol</ISOAbbreviation>
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<ArticleTitle>Sensitivity of laser-evoked potentials versus somatosensory evoked potentials in patients with multiple sclerosis.</ArticleTitle>
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<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Somatosensory evoked potentials (SEPs) play a less important role in the diagnosis of multiple sclerosis (MS) than visually evoked potentials. Since standard SEPs only reflect the dorsal column function, we now investigated spinothalamic tract function in patients with MS using laser-evoked potentials (LEPs).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">LEPs to thulium laser stimuli (3ms, 540 mJ, 5mm diameter) were recorded from 3 midline positions (Fz, Cz, Pz) in 20 patients with MS, and 6 patients with possible but unconfirmed MS. Peak latencies and peak-to-peak amplitude of the vertex potential negativity (N2) and positivity (P2) were evaluated and compared with normative values from 22 healthy control subjects. Median and tibial nerve SEPs were recorded with standard methods. Depending on the results of sensory testing, two skin areas (both hands, both feet, or one hand and foot of the same body side) were assessed in each patient.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In group comparisons, LEPs in patients with MS were significantly delayed and reduced in amplitude compared with healthy subjects (P<0.001) or patients with suspected but unconfirmed MS (P<0.05). In intraindividual comparisons within the patients with MS, LEP amplitude was significantly lower (P<0.01) and latencies were significantly longer (N2: P<0.01; P2: P<0.05) for a clinically hypoalgesic skin area than an unaffected control area. On a single case basis, LEPs were abnormal in 12 (60%) and SEPs in 8 (40%) of the patients with MS; combined analysis of LEPs and SEPs raised sensitivity to 75% (15 patients). LEPs were also abnormal for 7 skin areas with clinically normal nociception and thermal sensitivity, indicating subclinical lesions. Standard SEPs detected subclinical lesions in 5 areas with normal tactile sensitivity.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In patients with multiple sclerosis, spinothalamic tract function and LEPs were impaired more often than dorsal column function and SEPs. LEPs also detected subclinical lesions. Combined assessment of LEPs and SEPs can help to document dissemination of demyelinating CNS lesions and thus contribute to the diagnosis of multiple sclerosis.</AbstractText>
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