Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals.
Identifieur interne : 000423 ( PubMed/Corpus ); précédent : 000422; suivant : 000424Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals.
Auteurs : Jia-Cai Zhou ; Zheng-Lin Yang ; Wei Dong ; Ruo-Jin Tang ; Ling-Dong Sun ; Chun-Hua YanSource :
- Biomaterials [ 1878-5905 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Caenorhabditis elegans (ultrastructure), Cell Survival, Fluorides (analysis), Fluorides (chemistry), Fluorides (toxicity), HeLa Cells, Humans, Luminescent Agents (analysis), Luminescent Agents (chemistry), Luminescent Agents (toxicity), Nanoparticles (analysis), Nanoparticles (chemistry), Nanoparticles (toxicity), Nanoparticles (ultrastructure), Spectroscopy, Near-Infrared (methods), Thulium (analysis), Thulium (chemistry), Thulium (toxicity), Ytterbium (analysis), Ytterbium (chemistry), Ytterbium (toxicity), Yttrium (analysis), Yttrium (chemistry), Yttrium (toxicity).
- MESH :
- chemical , analysis : Fluorides, Luminescent Agents, Thulium, Ytterbium, Yttrium.
- chemical , chemistry : Fluorides, Luminescent Agents, Thulium, Ytterbium, Yttrium.
- chemical , toxicity : Fluorides, Luminescent Agents, Thulium, Ytterbium, Yttrium.
- analysis : Nanoparticles.
- chemistry : Nanoparticles.
- methods : Spectroscopy, Near-Infrared.
- toxicity : Nanoparticles.
- ultrastructure : Caenorhabditis elegans, Nanoparticles.
- Animals, Cell Survival, HeLa Cells, Humans.
Abstract
In vitro or in vivo bioimaging utilizing the upconversion (UC) luminescence of rare earth fluoride nanocrystals (NCs) has attracted much attention, especially for Yb(3+)/Tm(3+) doped NCs with a near-infrared (NIR) UC emission at 800 nm. Herein, water-soluble NaYF(4):Yb,Tm NCs with strong NIR UC emission were synthesized with a solvothermal method. In vitro and in vivo bioimaging and toxicity assessments were carried out with HeLa cell and Caenorhabditis elegans (C. elegans) cases, respectively. NaYF(4):Yb,Tm NCs afforded an efficient NIR image of the HeLa cells with an incubation concentration of 10 μg mL(-1), and CCK-8 assay revealed a low cytotoxicity. Fed with Escherichia coli (E. coli) and NCs together, the C. elegans showed a NIR image in the gut from the pharynx to the anus. Further, these NCs could be excreted out when those worms were then fed with only E. coli. Toxicity studies were further addressed with protein expression, life span, egg production, egg viability, and growth rate of the worms in comparison with those of the intact ones. The feeding of rare earth fluoride NCs with a dose of 100 μg does not arise obvious toxicity effect from the growth to procreation. The in vitro and in vivo studies confirm that NaYF(4):Yb,Tm NCs could be served as an excellent NIR emission bioprobe with low toxicity.
DOI: 10.1016/j.biomaterials.2011.08.038
PubMed: 21880365
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pubmed:21880365Le document en format XML
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Ling Dong" sort="Sun, Ling Dong" uniqKey="Sun L" first="Ling-Dong" last="Sun">Ling-Dong Sun</name></author><author><name sortKey="Yan, Chun Hua" sort="Yan, Chun Hua" uniqKey="Yan C" first="Chun-Hua" last="Yan">Chun-Hua Yan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1016/j.biomaterials.2011.08.038</idno><idno type="RBID">pubmed:21880365</idno><idno type="pmid">21880365</idno><idno type="wicri:Area/PubMed/Corpus">000423</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000423</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals.</title><author><name sortKey="Zhou, Jia Cai" sort="Zhou, Jia Cai" uniqKey="Zhou J" first="Jia-Cai" last="Zhou">Jia-Cai Zhou</name><affiliation><nlm:affiliation>Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Zheng Lin" sort="Yang, Zheng Lin" uniqKey="Yang Z" first="Zheng-Lin" last="Yang">Zheng-Lin Yang</name></author><author><name sortKey="Dong, Wei" sort="Dong, Wei" uniqKey="Dong W" first="Wei" last="Dong">Wei Dong</name></author><author><name sortKey="Tang, Ruo Jin" sort="Tang, Ruo Jin" uniqKey="Tang R" first="Ruo-Jin" last="Tang">Ruo-Jin Tang</name></author><author><name sortKey="Sun, Ling Dong" sort="Sun, Ling Dong" uniqKey="Sun L" first="Ling-Dong" last="Sun">Ling-Dong Sun</name></author><author><name sortKey="Yan, Chun Hua" sort="Yan, Chun Hua" uniqKey="Yan C" first="Chun-Hua" last="Yan">Chun-Hua Yan</name></author></analytic><series><title level="j">Biomaterials</title><idno type="eISSN">1878-5905</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Caenorhabditis elegans (ultrastructure)</term><term>Cell Survival</term><term>Fluorides (analysis)</term><term>Fluorides (chemistry)</term><term>Fluorides (toxicity)</term><term>HeLa Cells</term><term>Humans</term><term>Luminescent Agents (analysis)</term><term>Luminescent Agents (chemistry)</term><term>Luminescent Agents (toxicity)</term><term>Nanoparticles (analysis)</term><term>Nanoparticles (chemistry)</term><term>Nanoparticles (toxicity)</term><term>Nanoparticles (ultrastructure)</term><term>Spectroscopy, Near-Infrared (methods)</term><term>Thulium (analysis)</term><term>Thulium (chemistry)</term><term>Thulium (toxicity)</term><term>Ytterbium (analysis)</term><term>Ytterbium (chemistry)</term><term>Ytterbium (toxicity)</term><term>Yttrium (analysis)</term><term>Yttrium (chemistry)</term><term>Yttrium (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fluorides</term><term>Luminescent Agents</term><term>Thulium</term><term>Ytterbium</term><term>Yttrium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorides</term><term>Luminescent Agents</term><term>Thulium</term><term>Ytterbium</term><term>Yttrium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Fluorides</term><term>Luminescent Agents</term><term>Thulium</term><term>Ytterbium</term><term>Yttrium</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Spectroscopy, Near-Infrared</term></keywords><keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Caenorhabditis elegans</term><term>Nanoparticles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Survival</term><term>HeLa Cells</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vitro or in vivo bioimaging utilizing the upconversion (UC) luminescence of rare earth fluoride nanocrystals (NCs) has attracted much attention, especially for Yb(3+)/Tm(3+) doped NCs with a near-infrared (NIR) UC emission at 800 nm. Herein, water-soluble NaYF(4):Yb,Tm NCs with strong NIR UC emission were synthesized with a solvothermal method. In vitro and in vivo bioimaging and toxicity assessments were carried out with HeLa cell and Caenorhabditis elegans (C. elegans) cases, respectively. NaYF(4):Yb,Tm NCs afforded an efficient NIR image of the HeLa cells with an incubation concentration of 10 μg mL(-1), and CCK-8 assay revealed a low cytotoxicity. Fed with Escherichia coli (E. coli) and NCs together, the C. elegans showed a NIR image in the gut from the pharynx to the anus. Further, these NCs could be excreted out when those worms were then fed with only E. coli. Toxicity studies were further addressed with protein expression, life span, egg production, egg viability, and growth rate of the worms in comparison with those of the intact ones. The feeding of rare earth fluoride NCs with a dose of 100 μg does not arise obvious toxicity effect from the growth to procreation. The in vitro and in vivo studies confirm that NaYF(4):Yb,Tm NCs could be served as an excellent NIR emission bioprobe with low toxicity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21880365</PMID><DateCreated><Year>2011</Year><Month>09</Month><Day>29</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5905</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>34</Issue><PubDate><Year>2011</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Biomaterials</Title><ISOAbbreviation>Biomaterials</ISOAbbreviation></Journal><ArticleTitle>Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals.</ArticleTitle><Pagination><MedlinePgn>9059-67</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biomaterials.2011.08.038</ELocationID><Abstract><AbstractText>In vitro or in vivo bioimaging utilizing the upconversion (UC) luminescence of rare earth fluoride nanocrystals (NCs) has attracted much attention, especially for Yb(3+)/Tm(3+) doped NCs with a near-infrared (NIR) UC emission at 800 nm. Herein, water-soluble NaYF(4):Yb,Tm NCs with strong NIR UC emission were synthesized with a solvothermal method. In vitro and in vivo bioimaging and toxicity assessments were carried out with HeLa cell and Caenorhabditis elegans (C. elegans) cases, respectively. NaYF(4):Yb,Tm NCs afforded an efficient NIR image of the HeLa cells with an incubation concentration of 10 μg mL(-1), and CCK-8 assay revealed a low cytotoxicity. Fed with Escherichia coli (E. coli) and NCs together, the C. elegans showed a NIR image in the gut from the pharynx to the anus. Further, these NCs could be excreted out when those worms were then fed with only E. coli. Toxicity studies were further addressed with protein expression, life span, egg production, egg viability, and growth rate of the worms in comparison with those of the intact ones. The feeding of rare earth fluoride NCs with a dose of 100 μg does not arise obvious toxicity effect from the growth to procreation. The in vitro and in vivo studies confirm that NaYF(4):Yb,Tm NCs could be served as an excellent NIR emission bioprobe with low toxicity.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jia-Cai</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Zheng-Lin</ForeName><Initials>ZL</Initials></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ruo-Jin</ForeName><Initials>RJ</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Ling-Dong</ForeName><Initials>LD</Initials></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Chun-Hua</ForeName><Initials>CH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biomaterials</MedlineTA><NlmUniqueID>8100316</NlmUniqueID><ISSNLinking>0142-9612</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D049408">Luminescent Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>58784XQC3Y</RegistryNumber><NameOfSubstance UI="D015019">Yttrium</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance 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MajorTopicYN="N" UI="Q000633">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>8</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>8</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0142-9612(11)00965-3</ArticleId><ArticleId 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