MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.
Identifieur interne : 000594 ( PubMed/Checkpoint ); précédent : 000593; suivant : 000595MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.
Auteurs : Elena Vinogradov [États-Unis] ; Huamei He ; Angelo Lubag ; James A. Balschi ; A Dean Sherry ; Robert E. LenkinskiSource :
- Magnetic resonance in medicine [ 0740-3194 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- anatomie et histologie : Rein.
- Animaux, Composés organométalliques, Femelle, Imagerie par résonance magnétique, Mâle, Souris.
English descriptors
- KwdEn :
- MESH :
- chemical : Organometallic Compounds.
- anatomy & histology : Kidney.
- Animals, Female, Magnetic Resonance Imaging, Male, Mice.
Abstract
In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC(-) in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC(-), 200 microL of a 2-mM stock solution (corresponds to approximately 0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.
DOI: 10.1002/mrm.21393
PubMed: 17899603
Affiliations:
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pubmed:17899603Le document en format XML
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<front><div type="abstract" xml:lang="en">In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC(-) in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC(-), 200 microL of a 2-mM stock solution (corresponds to approximately 0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.</div>
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