MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.
Identifieur interne : 000614 ( PubMed/Corpus ); précédent : 000613; suivant : 000615MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.
Auteurs : Elena Vinogradov ; Huamei He ; Angelo Lubag ; James A. Balschi ; A Dean Sherry ; Robert E. LenkinskiSource :
- Magnetic resonance in medicine [ 0740-3194 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical : Organometallic Compounds.
- anatomy & histology : Kidney.
- Animals, Female, Magnetic Resonance Imaging, Male, Mice.
Abstract
In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC(-) in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC(-), 200 microL of a 2-mM stock solution (corresponds to approximately 0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.
DOI: 10.1002/mrm.21393
PubMed: 17899603
Links to Exploration step
pubmed:17899603Le document en format XML
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Balschi</name></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A Dean" last="Sherry">A Dean Sherry</name></author><author><name sortKey="Lenkinski, Robert E" sort="Lenkinski, Robert E" uniqKey="Lenkinski R" first="Robert E" last="Lenkinski">Robert E. Lenkinski</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mrm.21393</idno><idno type="RBID">pubmed:17899603</idno><idno type="pmid">17899603</idno><idno type="wicri:Area/PubMed/Corpus">000614</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000614</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.</title><author><name sortKey="Vinogradov, Elena" sort="Vinogradov, Elena" uniqKey="Vinogradov E" first="Elena" last="Vinogradov">Elena Vinogradov</name><affiliation><nlm:affiliation>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. evinogra@bidmc.harvard.edu</nlm:affiliation></affiliation></author><author><name sortKey="He, Huamei" sort="He, Huamei" uniqKey="He H" first="Huamei" last="He">Huamei He</name></author><author><name sortKey="Lubag, Angelo" sort="Lubag, Angelo" uniqKey="Lubag A" first="Angelo" last="Lubag">Angelo Lubag</name></author><author><name sortKey="Balschi, James A" sort="Balschi, James A" uniqKey="Balschi J" first="James A" last="Balschi">James A. Balschi</name></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A Dean" last="Sherry">A Dean Sherry</name></author><author><name sortKey="Lenkinski, Robert E" sort="Lenkinski, Robert E" uniqKey="Lenkinski R" first="Robert E" last="Lenkinski">Robert E. Lenkinski</name></author></analytic><series><title level="j">Magnetic resonance in medicine</title><idno type="ISSN">0740-3194</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Female</term><term>Kidney (anatomy & histology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mice</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC(-) in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC(-), 200 microL of a 2-mM stock solution (corresponds to approximately 0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17899603</PMID><DateCreated><Year>2007</Year><Month>10</Month><Day>02</Day></DateCreated><DateCompleted><Year>2008</Year><Month>02</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0740-3194</ISSN><JournalIssue CitedMedium="Print"><Volume>58</Volume><Issue>4</Issue><PubDate><Year>2007</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Magnetic resonance in medicine</Title><ISOAbbreviation>Magn Reson Med</ISOAbbreviation></Journal><ArticleTitle>MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.</ArticleTitle><Pagination><MedlinePgn>650-5</MedlinePgn></Pagination><Abstract><AbstractText>In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC(-) in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC(-), 200 microL of a 2-mM stock solution (corresponds to approximately 0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vinogradov</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. evinogra@bidmc.harvard.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Huamei</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Lubag</LastName><ForeName>Angelo</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Balschi</LastName><ForeName>James A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Sherry</LastName><ForeName>A Dean</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Lenkinski</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA115531</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB004582</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL 78634</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR02584</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Magn Reson Med</MedlineTA><NlmUniqueID>8505245</NlmUniqueID><ISSNLinking>0740-3194</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C463281">thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007668">Kidney</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000033">anatomy & histology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009942">Organometallic Compounds</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>9</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>2</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>9</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mrm.21393</ArticleId><ArticleId IdType="pubmed">17899603</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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