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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rare Earth Nanoprobes for Functional Biomolecular Imaging and Theranostics</title><author><name sortKey="Naczynski, Dominik J" sort="Naczynski, Dominik J" uniqKey="Naczynski D" first="Dominik J." last="Naczynski">Dominik J. Naczynski</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Stanford University School of Medicine, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Department of Chemical & Biochemical Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Tan, Mei Chee" sort="Tan, Mei Chee" uniqKey="Tan M" first="Mei Chee" last="Tan">Mei Chee Tan</name><affiliation><nlm:aff id="A2">Engineering Product Development, Singapore University of Technology and Design, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Materials Science and Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Riman, Richard E" sort="Riman, Richard E" uniqKey="Riman R" first="Richard E." last="Riman">Richard E. Riman</name><affiliation><nlm:aff id="A3">Department of Materials Science and Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Moghe, Prabhas V" sort="Moghe, Prabhas V" uniqKey="Moghe P" first="Prabhas V." last="Moghe">Prabhas V. Moghe</name><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Department of Chemical & Biochemical Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24921049</idno><idno type="pmc">4048749</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048749</idno><idno type="RBID">PMC:4048749</idno><idno type="doi">10.1039/C4TB00094C</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000319</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000319</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rare Earth Nanoprobes for Functional Biomolecular Imaging and Theranostics</title><author><name sortKey="Naczynski, Dominik J" sort="Naczynski, Dominik J" uniqKey="Naczynski D" first="Dominik J." last="Naczynski">Dominik J. Naczynski</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Stanford University School of Medicine, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Department of Chemical & Biochemical Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Tan, Mei Chee" sort="Tan, Mei Chee" uniqKey="Tan M" first="Mei Chee" last="Tan">Mei Chee Tan</name><affiliation><nlm:aff id="A2">Engineering Product Development, Singapore University of Technology and Design, Singapore</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Materials Science and Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Riman, Richard E" sort="Riman, Richard E" uniqKey="Riman R" first="Richard E." last="Riman">Richard E. Riman</name><affiliation><nlm:aff id="A3">Department of Materials Science and Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Moghe, Prabhas V" sort="Moghe, Prabhas V" uniqKey="Moghe P" first="Prabhas V." last="Moghe">Prabhas V. Moghe</name><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Department of Chemical & Biochemical Engineering, Rutgers University, New Jersey, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of materials chemistry. B, Materials for biology and medicine</title><idno type="ISSN">2050-750X</idno><idno type="eISSN">2050-7518</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Contrast agents designed to visualize the molecular mechanisms underlying cancer pathogenesis and progression have deepened our understanding of disease complexity and accelerated the development of enhanced drug strategies targeted to specific biochemical pathways. For the next generation probes and imaging systems to be viable, they must exhibit enhanced sensitivity and robust quantitation of morphologic and contrast features, while offering the ability to resolve the disease-specific molecular signatures that may be critical to reconstitute a more comprehensive portrait of pathobiology. This feature article provides an overview on the design and advancements of emerging biomedical optical probes in general and evaluates the promise of rare earth nanoprobes, in particular, for molecular imaging and theranostics. Combined with new breakthroughs in nanoscale probe configurations, and improved dopant compositions, and multimodal infrared optical imaging, rare-earth nanoprobes can be used to address a wide variety of biomedical challenges, including deep tissue imaging, real-time drug delivery tracking and multispectral molecular profiling.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101598493</journal-id><journal-id journal-id-type="pubmed-jr-id">40936</journal-id><journal-id journal-id-type="nlm-ta">J Mater Chem B Mater Biol Med</journal-id><journal-id journal-id-type="iso-abbrev">J Mater Chem B Mater Biol Med</journal-id><journal-title-group><journal-title>Journal of materials chemistry. B, Materials for biology and medicine</journal-title></journal-title-group><issn pub-type="ppub">2050-750X</issn><issn pub-type="epub">2050-7518</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24921049</article-id><article-id pub-id-type="pmc">4048749</article-id><article-id pub-id-type="doi">10.1039/C4TB00094C</article-id><article-id pub-id-type="manuscript">NIHMS581884</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Rare Earth Nanoprobes for Functional Biomolecular Imaging and Theranostics</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Naczynski</surname><given-names>Dominik J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Mei Chee</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Riman</surname><given-names>Richard E.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Moghe</surname><given-names>Prabhas V.</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Radiation Oncology, Stanford University School of Medicine, California, USA</aff><aff id="A2"><label>2</label>Engineering Product Development, Singapore University of Technology and Design, Singapore</aff><aff id="A3"><label>3</label>Department of Materials Science and Engineering, Rutgers University, New Jersey, USA</aff><aff id="A4"><label>4</label>Department of Biomedical Engineering, Department of Chemical & Biochemical Engineering, Rutgers University, New Jersey, USA</aff><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed. Prabhas V. Moghe, Distinguished Professor, Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, <email>moghe@rutgers.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>28</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>5</month><year>2015</year></pub-date><volume>2</volume><issue>20</issue><fpage>2958</fpage><lpage>2973</lpage><pmc-comment>elocation-id from pubmed: 10.1039/C4TB00094C</pmc-comment>
<abstract><p id="P1">Contrast agents designed to visualize the molecular mechanisms underlying cancer pathogenesis and progression have deepened our understanding of disease complexity and accelerated the development of enhanced drug strategies targeted to specific biochemical pathways. For the next generation probes and imaging systems to be viable, they must exhibit enhanced sensitivity and robust quantitation of morphologic and contrast features, while offering the ability to resolve the disease-specific molecular signatures that may be critical to reconstitute a more comprehensive portrait of pathobiology. This feature article provides an overview on the design and advancements of emerging biomedical optical probes in general and evaluates the promise of rare earth nanoprobes, in particular, for molecular imaging and theranostics. Combined with new breakthroughs in nanoscale probe configurations, and improved dopant compositions, and multimodal infrared optical imaging, rare-earth nanoprobes can be used to address a wide variety of biomedical challenges, including deep tissue imaging, real-time drug delivery tracking and multispectral molecular profiling.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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