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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Undecaprenyl Pyrophosphate Involvement in Susceptibility of <named-content content-type="genus-species">Bacillus subtilis</named-content> to Rare Earth Elements</title><author><name sortKey="Inaoka, Takashi" sort="Inaoka, Takashi" uniqKey="Inaoka T" first="Takashi" last="Inaoka">Takashi Inaoka</name><affiliation><nlm:aff id="aff1">National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki, Japan</nlm:aff></affiliation></author><author><name sortKey="Ochi, Kozo" sort="Ochi, Kozo" uniqKey="Ochi K" first="Kozo" last="Ochi">Kozo Ochi</name><affiliation><nlm:aff id="aff2">Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima, Japan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22904278</idno><idno type="pmc">3458658</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458658</idno><idno type="RBID">PMC:3458658</idno><idno type="doi">10.1128/JB.01147-12</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Undecaprenyl Pyrophosphate Involvement in Susceptibility of <named-content content-type="genus-species">Bacillus subtilis</named-content> to Rare Earth Elements</title><author><name sortKey="Inaoka, Takashi" sort="Inaoka, Takashi" uniqKey="Inaoka T" first="Takashi" last="Inaoka">Takashi Inaoka</name><affiliation><nlm:aff id="aff1">National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki, Japan</nlm:aff></affiliation></author><author><name sortKey="Ochi, Kozo" sort="Ochi, Kozo" uniqKey="Ochi K" first="Kozo" last="Ochi">Kozo Ochi</name><affiliation><nlm:aff id="aff2">Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima, Japan</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Bacteriology</title><idno type="ISSN">0021-9193</idno><idno type="eISSN">1098-5530</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The rare earth element scandium has weak antibacterial potency. We identified a mutation responsible for a scandium-resistant phenotype in <named-content content-type="genus-species">Bacillus subtilis</named-content>. This mutation was found within the <italic>uppS</italic> gene, which encodes undecaprenyl pyrophosphate synthase, and designated <italic>uppS86</italic> (for the Thr-to-Ile amino acid substitution at residue 86 of undecaprenyl pyrophosphate synthase). The <italic>uppS86</italic> mutation also gave rise to increased resistance to bacitracin, which prevents cell wall synthesis by inhibiting the dephosphorylation of undecaprenyl pyrophosphate, in addition to enhanced amylase production. Conversely, overexpression of the wild-type <italic>uppS</italic> gene resulted in increased susceptibilities to both scandium and bacitracin. Moreover, the mutant lacking undecaprenyl pyrophosphate phosphatase (BcrC) showed increased susceptibility to all rare earth elements tested. These results suggest that the accumulation of undecaprenyl pyrophosphate renders cells more susceptible to rare earth elements. The availability of undecaprenyl pyrophosphate may be an important determinant for susceptibility to rare earth elements, such as scandium.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Bacteriol</journal-id><journal-id journal-id-type="iso-abbrev">J. Bacteriol</journal-id><journal-id journal-id-type="hwp">jb</journal-id><journal-id journal-id-type="pmc">jb</journal-id><journal-id journal-id-type="publisher-id">JB</journal-id><journal-title-group><journal-title>Journal of Bacteriology</journal-title></journal-title-group><issn pub-type="ppub">0021-9193</issn><issn pub-type="epub">1098-5530</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22904278</article-id><article-id pub-id-type="pmc">3458658</article-id><article-id pub-id-type="publisher-id">01147-12</article-id><article-id pub-id-type="doi">10.1128/JB.01147-12</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Undecaprenyl Pyrophosphate Involvement in Susceptibility of <named-content content-type="genus-species">Bacillus subtilis</named-content> to Rare Earth Elements</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Inaoka</surname><given-names>Takashi</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ochi</surname><given-names>Kozo</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><aff id="aff1"><label>a</label>National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki, Japan</aff><aff id="aff2"><label>b</label>Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima, Japan</aff></contrib-group><author-notes><corresp>Address correspondence to Takashi Inaoka, <email>tina2672@affrc.go.jp</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2012</year></pub-date><volume>194</volume><issue>20</issue><fpage>5632</fpage><lpage>5637</lpage><history><date date-type="received"><day>27</day><month>6</month><year>2012</year></date><date date-type="accepted"><day>8</day><month>8</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjb02012005632.pdf"></self-uri><abstract><p>The rare earth element scandium has weak antibacterial potency. We identified a mutation responsible for a scandium-resistant phenotype in <named-content content-type="genus-species">Bacillus subtilis</named-content>. This mutation was found within the <italic>uppS</italic> gene, which encodes undecaprenyl pyrophosphate synthase, and designated <italic>uppS86</italic> (for the Thr-to-Ile amino acid substitution at residue 86 of undecaprenyl pyrophosphate synthase). The <italic>uppS86</italic> mutation also gave rise to increased resistance to bacitracin, which prevents cell wall synthesis by inhibiting the dephosphorylation of undecaprenyl pyrophosphate, in addition to enhanced amylase production. Conversely, overexpression of the wild-type <italic>uppS</italic> gene resulted in increased susceptibilities to both scandium and bacitracin. Moreover, the mutant lacking undecaprenyl pyrophosphate phosphatase (BcrC) showed increased susceptibility to all rare earth elements tested. These results suggest that the accumulation of undecaprenyl pyrophosphate renders cells more susceptible to rare earth elements. The availability of undecaprenyl pyrophosphate may be an important determinant for susceptibility to rare earth elements, such as scandium.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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