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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcatheter aortic valve replacement: transapical resection of the aortic valve <italic>in vivo</italic>
</title>
<author><name sortKey="Bombien Quaden, Rene" sort="Bombien Quaden, Rene" uniqKey="Bombien Quaden R" first="René" last="Bombien Quaden">René Bombien Quaden</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Surgery—Vascular and Endovascular Surgery</addr-line>
,<institution>University of Munich—Grosshadern</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2"><addr-line>Department of Cardiovascular Surgery</addr-line>
,<institution>University Hospital Schleswig-Holstein</institution>
,<addr-line>Campus Kiel, Kiel</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leester Schaedel, Monika" sort="Leester Schaedel, Monika" uniqKey="Leester Schaedel M" first="Monika" last="Leester-Schaedel">Monika Leester-Schaedel</name>
<affiliation><nlm:aff id="af3"><institution>Institute for Microtechnology</institution>
,<institution>University of Braunschweig</institution>
,<addr-line>Braunschweig</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lozonschi, Lucian" sort="Lozonschi, Lucian" uniqKey="Lozonschi L" first="Lucian" last="Lozonschi">Lucian Lozonschi</name>
<affiliation><nlm:aff id="af4"><addr-line>Divison of Cardiothoracic Surgery</addr-line>
,<institution>University of Wisconsin School of Medicine</institution>
,<addr-line>Madison, WI</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lutter, Georg" sort="Lutter, Georg" uniqKey="Lutter G" first="Georg" last="Lutter">Georg Lutter</name>
<affiliation><nlm:aff id="af2"><addr-line>Department of Cardiovascular Surgery</addr-line>
,<institution>University Hospital Schleswig-Holstein</institution>
,<addr-line>Campus Kiel, Kiel</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22707518</idno>
<idno type="pmc">3422953</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422953</idno>
<idno type="RBID">PMC:3422953</idno>
<idno type="doi">10.1093/icvts/ivs246</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000274</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000274</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Transcatheter aortic valve replacement: transapical resection of the aortic valve <italic>in vivo</italic>
</title>
<author><name sortKey="Bombien Quaden, Rene" sort="Bombien Quaden, Rene" uniqKey="Bombien Quaden R" first="René" last="Bombien Quaden">René Bombien Quaden</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Surgery—Vascular and Endovascular Surgery</addr-line>
,<institution>University of Munich—Grosshadern</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2"><addr-line>Department of Cardiovascular Surgery</addr-line>
,<institution>University Hospital Schleswig-Holstein</institution>
,<addr-line>Campus Kiel, Kiel</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leester Schaedel, Monika" sort="Leester Schaedel, Monika" uniqKey="Leester Schaedel M" first="Monika" last="Leester-Schaedel">Monika Leester-Schaedel</name>
<affiliation><nlm:aff id="af3"><institution>Institute for Microtechnology</institution>
,<institution>University of Braunschweig</institution>
,<addr-line>Braunschweig</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lozonschi, Lucian" sort="Lozonschi, Lucian" uniqKey="Lozonschi L" first="Lucian" last="Lozonschi">Lucian Lozonschi</name>
<affiliation><nlm:aff id="af4"><addr-line>Divison of Cardiothoracic Surgery</addr-line>
,<institution>University of Wisconsin School of Medicine</institution>
,<addr-line>Madison, WI</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lutter, Georg" sort="Lutter, Georg" uniqKey="Lutter G" first="Georg" last="Lutter">Georg Lutter</name>
<affiliation><nlm:aff id="af2"><addr-line>Department of Cardiovascular Surgery</addr-line>
,<institution>University Hospital Schleswig-Holstein</institution>
,<addr-line>Campus Kiel, Kiel</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Interactive Cardiovascular and Thoracic Surgery</title>
<idno type="ISSN">1569-9293</idno>
<idno type="eISSN">1569-9285</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The resection of pulmonary valves has already been demonstrated in an experimental beating-heart model. The aim of this study was to analyse the transapical laser-assisted resection of aortic valves in an <italic>in vivo</italic>
porcine model in a non-beating heart. The resection was performed in a porcine model (<italic>n</italic>
= 10) using a Thullium:YAG laser. After establishing a standard extracorporeal circulatory support, the aortic valve isolation chamber (AVIC) system was inserted transapically. The resection of the aortic leaflets was carried out step-by-step in the arrested heart. The AVIC implantation, the resection process, and the gross anatomy of intracardiac lesions were analysed. The procedure for installing the AVIC took 5.8 ± 1.5 min. A sealed chamber was achieved in 9/10 cases. The resection of the valves was performed in 8/10 and completed in 7/10 cases. The resection took, on average, 7.4 ± 2.7 min/cusp. In 9/10 cases, the sealing was sufficient. Gross anatomy and histological analysis demonstrated only superficial damage to the surrounding tissue. In this study, the <italic>in vivo</italic>
on-pump isolation of the left ventricular outflow tract and the laser resection of the native aortic valve could be demonstrated successfully. Nevertheless, this model is the next step towards a beating-heart resection of the aortic valve using the isolation chamber.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Interact Cardiovasc Thorac Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Interact Cardiovasc Thorac Surg</journal-id>
<journal-id journal-id-type="publisher-id">icvtsurg</journal-id>
<journal-id journal-id-type="hwp">icvtsurg</journal-id>
<journal-title-group><journal-title>Interactive Cardiovascular and Thoracic Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">1569-9293</issn>
<issn pub-type="epub">1569-9285</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22707518</article-id>
<article-id pub-id-type="pmc">3422953</article-id>
<article-id pub-id-type="doi">10.1093/icvts/ivs246</article-id>
<article-id pub-id-type="publisher-id">ivs246</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>New Ideas</subject>
<subj-group subj-group-type="heading"><subject>Adult Cardiac</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Transcatheter aortic valve replacement: transapical resection of the aortic valve <italic>in vivo</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bombien Quaden</surname>
<given-names>René</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leester-Schaedel</surname>
<given-names>Monika</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lozonschi</surname>
<given-names>Lucian</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lutter</surname>
<given-names>Georg</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Department of Surgery—Vascular and Endovascular Surgery</addr-line>
,<institution>University of Munich—Grosshadern</institution>
,<addr-line>Munich</addr-line>
,<country>Germany</country>
</aff>
<aff id="af2"><label>2</label>
<addr-line>Department of Cardiovascular Surgery</addr-line>
,<institution>University Hospital Schleswig-Holstein</institution>
,<addr-line>Campus Kiel, Kiel</addr-line>
,<country>Germany</country>
</aff>
<aff id="af3"><label>3</label>
<institution>Institute for Microtechnology</institution>
,<institution>University of Braunschweig</institution>
,<addr-line>Braunschweig</addr-line>
,<country>Germany</country>
</aff>
<aff id="af4"><label>4</label>
<addr-line>Divison of Cardiothoracic Surgery</addr-line>
,<institution>University of Wisconsin School of Medicine</institution>
,<addr-line>Madison, WI</addr-line>
,<country>USA</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author: Department of Surgery—Vascular and Endovascular Surgery, University of Munich—Grosshadern, Munich, Germany. Tel: +<phone>49-89-70955059</phone>
; fax: +<fax>49-89-70958873</fax>
; e-mail: <email>rbombien@quabo.de</email>
(R. Bombien Quaden).</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>6</month>
<year>2012</year>
</pub-date>
<volume>15</volume>
<issue>3</issue>
<fpage>348</fpage>
<lpage>351</lpage>
<history><date date-type="received"><day>13</day>
<month>11</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><day>29</day>
<month>2</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>12</day>
<month>3</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2012. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="ivs246.pdf"></self-uri>
<abstract><p>The resection of pulmonary valves has already been demonstrated in an experimental beating-heart model. The aim of this study was to analyse the transapical laser-assisted resection of aortic valves in an <italic>in vivo</italic>
porcine model in a non-beating heart. The resection was performed in a porcine model (<italic>n</italic>
= 10) using a Thullium:YAG laser. After establishing a standard extracorporeal circulatory support, the aortic valve isolation chamber (AVIC) system was inserted transapically. The resection of the aortic leaflets was carried out step-by-step in the arrested heart. The AVIC implantation, the resection process, and the gross anatomy of intracardiac lesions were analysed. The procedure for installing the AVIC took 5.8 ± 1.5 min. A sealed chamber was achieved in 9/10 cases. The resection of the valves was performed in 8/10 and completed in 7/10 cases. The resection took, on average, 7.4 ± 2.7 min/cusp. In 9/10 cases, the sealing was sufficient. Gross anatomy and histological analysis demonstrated only superficial damage to the surrounding tissue. In this study, the <italic>in vivo</italic>
on-pump isolation of the left ventricular outflow tract and the laser resection of the native aortic valve could be demonstrated successfully. Nevertheless, this model is the next step towards a beating-heart resection of the aortic valve using the isolation chamber.</p>
</abstract>
<kwd-group><kwd>Resection</kwd>
<kwd>Transapical</kwd>
<kwd>Aortic valve</kwd>
<kwd>Endovascular</kwd>
<kwd><italic>In vivo</italic>
</kwd>
</kwd-group>
<counts><page-count count="4"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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