Fibroblast Response to Lanthanoid Metal Ion Stimulation: Potential Contribution to Fibrotic Tissue Injury
Identifieur interne : 000248 ( Pmc/Corpus ); précédent : 000247; suivant : 000249Fibroblast Response to Lanthanoid Metal Ion Stimulation: Potential Contribution to Fibrotic Tissue Injury
Auteurs : William Jenkins ; Patricia Perone ; Kyle Walker ; Narasimharao Bhagavathula ; Muhammad Nadeem Aslam ; Marissa Dasilva ; Michael K. Dame ; James VaraniSource :
- Biological trace element research [ 0163-4984 ] ; 2011.
Abstract
The purpose of this study was to compare each of the 14 naturally occurring lanthanoid metal ions for ability to stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed to individual lanthanoids over the concentration range of 1–100 μM, increased proliferation was observed with each of the agents as compared with control cells that were already proliferating rapidly in a growth factor-enriched culture medium. Dose-response differences were observed among the individual metal ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 levels were also increased in response to lanthanoid exposure but type I procollagen production was not. A dose–response relationship between induction of proliferation and increased MMP-1 was observed. Non-lanthanoid transition metal ions (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, and zinc) were examined in the same assays; there was little stimulation with any of these metals. When epidermal keratinocytes were examined in place of dermal fibroblasts, there was no growth stimulation with any of the lanthanoids. Several of the lanthanoid metals inhibited keratinocyte proliferation at higher concentrations (50–100 μM).
Url:
DOI: 10.1007/s12011-011-9041-x
PubMed: 21484406
PubMed Central: 3214234
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PMC:3214234Le document en format XML
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<author><name sortKey="Jenkins, William" sort="Jenkins, William" uniqKey="Jenkins W" first="William" last="Jenkins">William Jenkins</name>
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<author><name sortKey="Perone, Patricia" sort="Perone, Patricia" uniqKey="Perone P" first="Patricia" last="Perone">Patricia Perone</name>
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<author><name sortKey="Walker, Kyle" sort="Walker, Kyle" uniqKey="Walker K" first="Kyle" last="Walker">Kyle Walker</name>
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<author><name sortKey="Bhagavathula, Narasimharao" sort="Bhagavathula, Narasimharao" uniqKey="Bhagavathula N" first="Narasimharao" last="Bhagavathula">Narasimharao Bhagavathula</name>
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<author><name sortKey="Aslam, Muhammad Nadeem" sort="Aslam, Muhammad Nadeem" uniqKey="Aslam M" first="Muhammad Nadeem" last="Aslam">Muhammad Nadeem Aslam</name>
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<author><name sortKey="Aslam, Muhammad Nadeem" sort="Aslam, Muhammad Nadeem" uniqKey="Aslam M" first="Muhammad Nadeem" last="Aslam">Muhammad Nadeem Aslam</name>
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<series><title level="j">Biological trace element research</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">The purpose of this study was to compare each of the 14 naturally occurring lanthanoid metal ions for ability to stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed to individual lanthanoids over the concentration range of 1–100 μM, increased proliferation was observed with each of the agents as compared with control cells that were already proliferating rapidly in a growth factor-enriched culture medium. Dose-response differences were observed among the individual metal ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 levels were also increased in response to lanthanoid exposure but type I procollagen production was not. A dose–response relationship between induction of proliferation and increased MMP-1 was observed. Non-lanthanoid transition metal ions (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, and zinc) were examined in the same assays; there was little stimulation with any of these metals. When epidermal keratinocytes were examined in place of dermal fibroblasts, there was no growth stimulation with any of the lanthanoids. Several of the lanthanoid metals inhibited keratinocyte proliferation at higher concentrations (50–100 μM).</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7911509</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1735</journal-id>
<journal-id journal-id-type="nlm-ta">Biol Trace Elem Res</journal-id>
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<title-group><article-title>Fibroblast Response to Lanthanoid Metal Ion Stimulation: Potential Contribution to Fibrotic Tissue Injury</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Jenkins</surname>
<given-names>William</given-names>
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<contrib contrib-type="author"><name><surname>Perone</surname>
<given-names>Patricia</given-names>
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<contrib contrib-type="author"><name><surname>Walker</surname>
<given-names>Kyle</given-names>
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<contrib contrib-type="author"><name><surname>Bhagavathula</surname>
<given-names>Narasimharao</given-names>
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<contrib contrib-type="author"><name><surname>Aslam</surname>
<given-names>Muhammad Nadeem</given-names>
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<contrib contrib-type="author"><name><surname>DaSilva</surname>
<given-names>Marissa</given-names>
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<contrib contrib-type="author"><name><surname>Dame</surname>
<given-names>Michael K.</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Varani</surname>
<given-names>James</given-names>
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<aff id="A1">The Department of Pathology, The University of Michigan Medical School, 1301 Catherine St., SPC 5602, Ann Arbor, MI 48109, USA</aff>
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<author-notes><corresp id="CR1"><email>varani@umich.edu</email>
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<pub-date pub-type="nihms-submitted"><day>1</day>
<month>8</month>
<year>2011</year>
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<pub-date pub-type="epub"><day>12</day>
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<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2012</year>
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<volume>144</volume>
<issue>1-3</issue>
<fpage>621</fpage>
<lpage>635</lpage>
<permissions><copyright-statement>© Springer Science+Business Media, LLC 2011</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">The purpose of this study was to compare each of the 14 naturally occurring lanthanoid metal ions for ability to stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed to individual lanthanoids over the concentration range of 1–100 μM, increased proliferation was observed with each of the agents as compared with control cells that were already proliferating rapidly in a growth factor-enriched culture medium. Dose-response differences were observed among the individual metal ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 levels were also increased in response to lanthanoid exposure but type I procollagen production was not. A dose–response relationship between induction of proliferation and increased MMP-1 was observed. Non-lanthanoid transition metal ions (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, and zinc) were examined in the same assays; there was little stimulation with any of these metals. When epidermal keratinocytes were examined in place of dermal fibroblasts, there was no growth stimulation with any of the lanthanoids. Several of the lanthanoid metals inhibited keratinocyte proliferation at higher concentrations (50–100 μM).</p>
</abstract>
<kwd-group><kwd>Fibroblast</kwd>
<kwd>Lanthanoidmetalions</kwd>
<kwd>Nephrogenicsystemic fibrosis (NSF)</kwd>
<kwd>Matrix metalloproteinase-1 (MMP-1)</kwd>
<kwd>Tissue inhibitor of metalloproteinase-1 (TIMP-1)</kwd>
<kwd>Type I procollagen</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R21 CA140760-02 || CA</award-id>
</award-group>
</funding-group>
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