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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modified natural nanoparticles as contrast agents for medical imaging</title><author><name sortKey="Cormode, David P" sort="Cormode, David P" uniqKey="Cormode D" first="David P." last="Cormode">David P. Cormode</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author><author><name sortKey="Jarzyna, Peter A" sort="Jarzyna, Peter A" uniqKey="Jarzyna P" first="Peter A." last="Jarzyna">Peter A. Jarzyna</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author><author><name sortKey="Mulder, Willem J M" sort="Mulder, Willem J M" uniqKey="Mulder W" first="Willem J. M." last="Mulder">Willem J. M. Mulder</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author><author><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A." last="Fayad">Zahi A. Fayad</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19900496</idno><idno type="pmc">2827667</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827667</idno><idno type="RBID">PMC:2827667</idno><idno type="doi">10.1016/j.addr.2009.11.005</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000231</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000231</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Modified natural nanoparticles as contrast agents for medical imaging</title><author><name sortKey="Cormode, David P" sort="Cormode, David P" uniqKey="Cormode D" first="David P." last="Cormode">David P. Cormode</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author><author><name sortKey="Jarzyna, Peter A" sort="Jarzyna, Peter A" uniqKey="Jarzyna P" first="Peter A." last="Jarzyna">Peter A. Jarzyna</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author><author><name sortKey="Mulder, Willem J M" sort="Mulder, Willem J M" uniqKey="Mulder W" first="Willem J. M." last="Mulder">Willem J. M. Mulder</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author><author><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A." last="Fayad">Zahi A. Fayad</name><affiliation><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff></affiliation></author></analytic><series><title level="j">Advanced drug delivery reviews</title><idno type="ISSN">0169-409X</idno><idno type="eISSN">1872-8294</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The development of novel and effective contrast agents is one of the drivers of the ongoing improvement in medical imaging. Many of the new agents reported are nanoparticle-based. There are a variety of natural nanoparticles known, e.g. lipoproteins, viruses or ferritin. Natural nanoparticles have advantages as delivery platforms such as biodegradability. In addition, our understanding of natural nanoparticles is quite advanced, allowing their adaptation as contrast agents. They can be labeled with small molecules or ions such as Gd<sup>3+</sup> to act as contrast agents for magnetic resonance imaging, <sup>18</sup>F to act as positron emission tomography contrast agents or fluorophores to act as contrast agents for fluorescence techniques. Additionally, inorganic nanoparticles such as iron oxide, gold nanoparticles or quantum dots can be incorporated to add further contrast functionality. Furthermore, these natural nanoparticle contrast agents can be rerouted from their natural targets via the attachment of targeting molecules. In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8710523</journal-id><journal-id journal-id-type="pubmed-jr-id">21484</journal-id><journal-id journal-id-type="nlm-ta">Adv Drug Deliv Rev</journal-id><journal-title>Advanced drug delivery reviews</journal-title><issn pub-type="ppub">0169-409X</issn><issn pub-type="epub">1872-8294</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19900496</article-id><article-id pub-id-type="pmc">2827667</article-id><article-id pub-id-type="doi">10.1016/j.addr.2009.11.005</article-id><article-id pub-id-type="manuscript">NIHMS158170</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Modified natural nanoparticles as contrast agents for medical imaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cormode</surname><given-names>David P.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Jarzyna</surname><given-names>Peter A.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Mulder</surname><given-names>Willem J. M.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Fayad</surname><given-names>Zahi A.</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Tel: 212-241-6858, Fax: 240-368-8096, <email>Zahi.Fayad@mssm.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>6</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>8</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>8</day><month>3</month><year>2011</year></pub-date><volume>62</volume><issue>3</issue><fpage>329</fpage><lpage>338</lpage><abstract><p id="P2">The development of novel and effective contrast agents is one of the drivers of the ongoing improvement in medical imaging. Many of the new agents reported are nanoparticle-based. There are a variety of natural nanoparticles known, e.g. lipoproteins, viruses or ferritin. Natural nanoparticles have advantages as delivery platforms such as biodegradability. In addition, our understanding of natural nanoparticles is quite advanced, allowing their adaptation as contrast agents. They can be labeled with small molecules or ions such as Gd<sup>3+</sup> to act as contrast agents for magnetic resonance imaging, <sup>18</sup>F to act as positron emission tomography contrast agents or fluorophores to act as contrast agents for fluorescence techniques. Additionally, inorganic nanoparticles such as iron oxide, gold nanoparticles or quantum dots can be incorporated to add further contrast functionality. Furthermore, these natural nanoparticle contrast agents can be rerouted from their natural targets via the attachment of targeting molecules. In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents.</p></abstract><kwd-group><kwd>Nanoparticles</kwd><kwd>contrast agents</kwd><kwd>medical imaging</kwd><kwd>lipoproteins</kwd><kwd>viruses</kwd><kwd>MRI</kwd></kwd-group><contract-num rid="HL1">R01 HL078667-04S1
||HL</contract-num><contract-num rid="HL1">R01 HL071021-07
||HL</contract-num><contract-num rid="EB1">R01 EB009638-05A2
||EB</contract-num><contract-sponsor id="HL1">National Heart, Lung, and Blood Institute : NHLBI</contract-sponsor><contract-sponsor id="EB1">National Institute of Biomedical Imaging and Bioengineering : NIBIB</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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