Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes
Identifieur interne : 000220 ( Pmc/Corpus ); précédent : 000219; suivant : 000221Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes
Auteurs : Jason M. Zhao ; Yah-El Har-El ; Michael T. Mcmahon ; Jinyuan Zhou ; A. Dean Sherry ; George Sgouros ; Jeff W. M. Bulte ; Peter C. M. Van ZijlSource :
- Journal of the American Chemical Society [ 0002-7863 ] ; 2008.
Abstract
Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 ± 0.14 μm/s for the specific lipid composition at 22 °C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.
Url:
DOI: 10.1021/ja710159q
PubMed: 18361490
PubMed Central: 2759111
Links to Exploration step
PMC:2759111Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes</title><author><name sortKey="Zhao, Jason M" sort="Zhao, Jason M" uniqKey="Zhao J" first="Jason M." last="Zhao">Jason M. Zhao</name></author><author><name sortKey="Har El, Yah El" sort="Har El, Yah El" uniqKey="Har El Y" first="Yah-El" last="Har-El">Yah-El Har-El</name></author><author><name sortKey="Mcmahon, Michael T" sort="Mcmahon, Michael T" uniqKey="Mcmahon M" first="Michael T." last="Mcmahon">Michael T. Mcmahon</name></author><author><name sortKey="Zhou, Jinyuan" sort="Zhou, Jinyuan" uniqKey="Zhou J" first="Jinyuan" last="Zhou">Jinyuan Zhou</name></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name></author><author><name sortKey="Sgouros, George" sort="Sgouros, George" uniqKey="Sgouros G" first="George" last="Sgouros">George Sgouros</name></author><author><name sortKey="Bulte, Jeff W M" sort="Bulte, Jeff W M" uniqKey="Bulte J" first="Jeff W. M." last="Bulte">Jeff W. M. Bulte</name></author><author><name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18361490</idno><idno type="pmc">2759111</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759111</idno><idno type="RBID">PMC:2759111</idno><idno type="doi">10.1021/ja710159q</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000220</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000220</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes</title><author><name sortKey="Zhao, Jason M" sort="Zhao, Jason M" uniqKey="Zhao J" first="Jason M." last="Zhao">Jason M. Zhao</name></author><author><name sortKey="Har El, Yah El" sort="Har El, Yah El" uniqKey="Har El Y" first="Yah-El" last="Har-El">Yah-El Har-El</name></author><author><name sortKey="Mcmahon, Michael T" sort="Mcmahon, Michael T" uniqKey="Mcmahon M" first="Michael T." last="Mcmahon">Michael T. Mcmahon</name></author><author><name sortKey="Zhou, Jinyuan" sort="Zhou, Jinyuan" uniqKey="Zhou J" first="Jinyuan" last="Zhou">Jinyuan Zhou</name></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name></author><author><name sortKey="Sgouros, George" sort="Sgouros, George" uniqKey="Sgouros G" first="George" last="Sgouros">George Sgouros</name></author><author><name sortKey="Bulte, Jeff W M" sort="Bulte, Jeff W M" uniqKey="Bulte J" first="Jeff W. M." last="Bulte">Jeff W. M. Bulte</name></author><author><name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name></author></analytic><series><title level="j">Journal of the American Chemical Society</title><idno type="ISSN">0002-7863</idno><idno type="eISSN">1520-5126</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P6">Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 ± 0.14 μm/s for the specific lipid composition at 22 °C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7503056</journal-id><journal-id journal-id-type="pubmed-jr-id">4435</journal-id><journal-id journal-id-type="nlm-ta">J Am Chem Soc</journal-id><journal-title>Journal of the American Chemical Society</journal-title><issn pub-type="ppub">0002-7863</issn><issn pub-type="epub">1520-5126</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18361490</article-id><article-id pub-id-type="pmc">2759111</article-id><article-id pub-id-type="doi">10.1021/ja710159q</article-id><article-id pub-id-type="manuscript">NIHMS108540</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Jason M.</given-names></name><xref ref-type="corresp" rid="CR1">*</xref><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="author-notes" rid="FN2">§</xref></contrib><contrib contrib-type="author"><name><surname>Har-el</surname><given-names>Yah-el</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref></contrib><contrib contrib-type="author"><name><surname>McMahon</surname><given-names>Michael T.</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="author-notes" rid="FN2">§</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Jinyuan</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="author-notes" rid="FN2">§</xref></contrib><contrib contrib-type="author"><name><surname>Sherry</surname><given-names>A. Dean</given-names></name><xref ref-type="author-notes" rid="FN4">‡</xref></contrib><contrib contrib-type="author"><name><surname>Sgouros</surname><given-names>George</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Bulte</surname><given-names>Jeff W. M.</given-names></name><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="author-notes" rid="FN3">&</xref><xref ref-type="author-notes" rid="FN5">#</xref></contrib><contrib contrib-type="author"><name><surname>van Zijl</surname><given-names>Peter C. M.</given-names></name><xref ref-type="corresp" rid="CR1">*</xref><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="author-notes" rid="FN2">§</xref></contrib><aff id="A1">Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390</aff></contrib-group><author-notes><fn id="FN1"><label>†</label><p id="P1">Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine.</p></fn><fn id="FN2"><label>§</label><p id="P2">Kennedy Krieger Institute.</p></fn><fn id="FN3"><label>&</label><p id="P3">Johns Hopkins University Whiting School of Engineering.</p></fn><fn id="FN4"><label>‡</label><p id="P4">University of Texas Southwestern Medical Center.</p></fn><fn id="FN5"><label>#</label><p id="P5">Institute for Cell Engineering, Johns Hopkins University School of Medicine.</p></fn><corresp id="CR1">E-mail: <email>jmzhao@mri.jhu.edu</email>; <email>pvanzijl@jhu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>4</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>25</day><month>3</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>16</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>8</day><month>10</month><year>2009</year></pub-date><volume>130</volume><issue>15</issue><fpage>5178</fpage><lpage>5184</lpage><permissions><copyright-statement>© 2008 American Chemical Society</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p id="P6">Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 ± 0.14 μm/s for the specific lipid composition at 22 °C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.</p></abstract><contract-num rid="EB1">R21 EB005252-02</contract-num><contract-num rid="CA1">R01 CA115531-03</contract-num><contract-num rid="RR1">P41 RR002584-216312</contract-num><contract-num rid="DK1">P01 DK058398-070006</contract-num><contract-num rid="EB1">K01 EB006394-02</contract-num><contract-sponsor id="EB1">National Institute of Biomedical Imaging and Bioengineering : NIBIB</contract-sponsor><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor><contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor><contract-sponsor id="DK1">National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000220 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000220 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:2759111
|texte= Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:18361490" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ThuliumV1
| This area was generated with Dilib version V0.6.21. |  |