Thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) as a 23Na shift reagent for the in vivo rat liver
Identifieur interne : 001820 ( Pascal/Checkpoint ); précédent : 001819; suivant : 001821Thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) as a 23Na shift reagent for the in vivo rat liver
Auteurs : N. Bansal [États-Unis] ; M. J. Germann [États-Unis] ; V. Seshan [États-Unis] ; G. T. Iii Shires ; C. R. Malloy [États-Unis] ; A. D. Sherry [États-Unis]Source :
- Biochemistry : (Easton) [ 0006-2960 ] ; 1993.
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Abstract
The use of thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate (TmDOTP5-) as an in vivo 23Na NMR shift reagent for rat liver was evaluated by collecting interleaved 23Na and 31P spectra. Infusion of 80 mM TmDOTP5- without added Ca2+ produced baseline-resolved peaks from intra- and extracellular sodium without producing any changes in phosphate metabolite resonances or intracellular pH. Several key physiological parameters measured in parallel groups of animals confirmed that liver physiology is largely unaffected by this shift reagent
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) as a <sup>23</sup>Na shift reagent for the in vivo rat liver</title><author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N." last="Bansal">N. Bansal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Germann, M J" sort="Germann, M J" uniqKey="Germann M" first="M. J." last="Germann">M. J. Germann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Seshan, V" sort="Seshan, V" uniqKey="Seshan V" first="V." last="Seshan">V. Seshan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Shires, G T Iii" sort="Shires, G T Iii" uniqKey="Shires G" first="G. T. Iii" last="Shires">G. T. Iii Shires</name></author><author><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C. R." last="Malloy">C. R. Malloy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A. D." last="Sherry">A. D. Sherry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">93-0581015</idno><date when="1993">1993</date><idno type="stanalyst">PASCAL 93-0581015 INIST</idno><idno type="RBID">Pascal:93-0581015</idno><idno type="wicri:Area/Pascal/Corpus">001893</idno><idno type="wicri:Area/Pascal/Curation">001893</idno><idno type="wicri:Area/Pascal/Checkpoint">001820</idno><idno type="wicri:explorRef" wicri:stream="Pascal" wicri:step="Checkpoint">001820</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) as a <sup>23</sup>Na shift reagent for the in vivo rat liver</title><author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N." last="Bansal">N. Bansal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Germann, M J" sort="Germann, M J" uniqKey="Germann M" first="M. J." last="Germann">M. J. Germann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Seshan, V" sort="Seshan, V" uniqKey="Seshan V" first="V." last="Seshan">V. Seshan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Shires, G T Iii" sort="Shires, G T Iii" uniqKey="Shires G" first="G. T. Iii" last="Shires">G. T. Iii Shires</name></author><author><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C. R." last="Malloy">C. R. Malloy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A. D." last="Sherry">A. D. Sherry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas TX 75235-9085</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Biochemistry : (Easton)</title><title level="j" type="abbreviated">Biochemistry : (Easton)</title><idno type="ISSN">0006-2960</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Biochemistry : (Easton)</title><title level="j" type="abbreviated">Biochemistry : (Easton)</title><idno type="ISSN">0006-2960</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gradient</term><term>In vivo</term><term>Liver</term><term>NMR spectrometry</term><term>Rat</term><term>Relaxation time</term><term>Shift reagent</term><term>Sodium Ions</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Réactif déplacement</term><term>Spectrométrie RMN</term><term>Sodium Ion</term><term>Gradient</term><term>Temps relaxation</term><term>Foie</term><term>Rat</term><term>In vivo</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The use of thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate (TmDOTP<sup>5-</sup>) as an in vivo <sup>23</sup>Na NMR shift reagent for rat liver was evaluated by collecting interleaved <sup>23</sup>Na and <sup>31</sup>P spectra. Infusion of 80 mM TmDOTP<sup>5-</sup> without added Ca<sup>2+</sup> produced baseline-resolved peaks from intra- and extracellular sodium without producing any changes in phosphate metabolite resonances or intracellular pH. Several key physiological parameters measured in parallel groups of animals confirmed that liver physiology is largely unaffected by this shift reagent</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-2960</s0></fA01><fA03 i2="1"><s0>Biochemistry : (Easton)</s0></fA03><fA05><s2>32</s2></fA05><fA06><s2>21</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) as a <sup>23</sup>Na shift reagent for the in vivo rat liver</s1></fA08><fA11 i1="01" i2="1"><s1>BANSAL (N.)</s1></fA11><fA11 i1="02" i2="1"><s1>GERMANN (M. J.)</s1></fA11><fA11 i1="03" i2="1"><s1>SESHAN (V.)</s1></fA11><fA11 i1="04" i2="1"><s1>SHIRES (G. T. III)</s1></fA11><fA11 i1="05" i2="1"><s1>MALLOY (C. R.)</s1></fA11><fA11 i1="06" i2="1"><s1>SHERRY (A. D.)</s1></fA11><fA14 i1="01"><s1>Univ. Texas Southwestern medical cent., Mary Nell Ralph B. Rogers magnetic resonance cent., dep. radiology</s1><s2>Dallas TX 75235-9085</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>5638-5643</s1></fA20><fA21><s1>1993</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>9758</s2><s5>354000033981470200</s5></fA43><fA44><s0>0000</s0></fA44><fA45><s0>35 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>93-0581015</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i2="1"><s0>Biochemistry : (Easton)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The use of thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate (TmDOTP<sup>5-</sup>) as an in vivo <sup>23</sup>Na NMR shift reagent for rat liver was evaluated by collecting interleaved <sup>23</sup>Na and <sup>31</sup>P spectra. Infusion of 80 mM TmDOTP<sup>5-</sup> without added Ca<sup>2+</sup> produced baseline-resolved peaks from intra- and extracellular sodium without producing any changes in phosphate metabolite resonances or intracellular pH. Several key physiological parameters measured in parallel groups of animals confirmed that liver physiology is largely unaffected by this shift reagent</s0></fC01><fC02 i1="01" i2="X"><s0>002A04B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Réactif déplacement</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Shift reagent</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Reactivo desplazamiento</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Spectrométrie RMN</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>NMR spectrometry</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Espectrometría RMN</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Sodium Ion</s0><s2>NC</s2><s2>NA</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Sodium Ions</s0><s2>NC</s2><s2>NA</s2><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sodio Ión</s0><s2>NC</s2><s2>NA</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Gradient</s0><s5>13</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Gradient</s0><s5>13</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Gradiente</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Temps relaxation</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Relaxation time</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Tiempo relajación</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Foie</s0><s5>21</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Liver</s0><s5>21</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Hígado</s0><s5>21</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Rat</s0><s5>43</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Rat</s0><s5>43</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Rata</s0><s5>43</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>In vivo</s0><s5>46</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>In vivo</s0><s5>46</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>In vivo</s0><s5>46</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>272</s1></fN21></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Shires, G T Iii" sort="Shires, G T Iii" uniqKey="Shires G" first="G. T. Iii" last="Shires">G. T. Iii Shires</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N." last="Bansal">N. Bansal</name></noRegion><name sortKey="Germann, M J" sort="Germann, M J" uniqKey="Germann M" first="M. J." last="Germann">M. J. Germann</name><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C. R." last="Malloy">C. R. Malloy</name><name sortKey="Seshan, V" sort="Seshan, V" uniqKey="Seshan V" first="V." last="Seshan">V. Seshan</name><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A. D." last="Sherry">A. D. Sherry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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