Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.
Identifieur interne : 000B10 ( Ncbi/Merge ); précédent : 000B09; suivant : 000B11Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.
Auteurs : Shuki Maruyama ; Junpei Ueda ; Atsuomi Kimura ; Kenya MuraseSource :
- Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine [ 1880-2206 ] ; 2016.
Abstract
To develop a novel probe for chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) based on thermosensitive liposomes (lipoCEST) for theranostics, in which diagnostics and therapy are integrated into a single platform.
DOI: 10.2463/mrms.mp.2015-0039
PubMed: 26841852
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<author><name sortKey="Maruyama, Shuki" sort="Maruyama, Shuki" uniqKey="Maruyama S" first="Shuki" last="Maruyama">Shuki Maruyama</name>
<affiliation><nlm:affiliation>Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.</nlm:affiliation>
<wicri:noCountry code="subField">Osaka University</wicri:noCountry>
</affiliation>
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<author><name sortKey="Ueda, Junpei" sort="Ueda, Junpei" uniqKey="Ueda J" first="Junpei" last="Ueda">Junpei Ueda</name>
</author>
<author><name sortKey="Kimura, Atsuomi" sort="Kimura, Atsuomi" uniqKey="Kimura A" first="Atsuomi" last="Kimura">Atsuomi Kimura</name>
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<author><name sortKey="Murase, Kenya" sort="Murase, Kenya" uniqKey="Murase K" first="Kenya" last="Murase">Kenya Murase</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.</title>
<author><name sortKey="Maruyama, Shuki" sort="Maruyama, Shuki" uniqKey="Maruyama S" first="Shuki" last="Maruyama">Shuki Maruyama</name>
<affiliation><nlm:affiliation>Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.</nlm:affiliation>
<wicri:noCountry code="subField">Osaka University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ueda, Junpei" sort="Ueda, Junpei" uniqKey="Ueda J" first="Junpei" last="Ueda">Junpei Ueda</name>
</author>
<author><name sortKey="Kimura, Atsuomi" sort="Kimura, Atsuomi" uniqKey="Kimura A" first="Atsuomi" last="Kimura">Atsuomi Kimura</name>
</author>
<author><name sortKey="Murase, Kenya" sort="Murase, Kenya" uniqKey="Murase K" first="Kenya" last="Murase">Kenya Murase</name>
</author>
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<series><title level="j">Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine</title>
<idno type="eISSN">1880-2206</idno>
<imprint><date when="2016" type="published">2016</date>
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<front><div type="abstract" xml:lang="en">To develop a novel probe for chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) based on thermosensitive liposomes (lipoCEST) for theranostics, in which diagnostics and therapy are integrated into a single platform.</div>
</front>
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<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26841852</PMID>
<DateCreated><Year>2016</Year>
<Month>2</Month>
<Day>4</Day>
</DateCreated>
<DateRevised><Year>2016</Year>
<Month>2</Month>
<Day>6</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1880-2206</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year>
<Month>Feb</Month>
<Day>3</Day>
</PubDate>
</JournalIssue>
<Title>Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine</Title>
<ISOAbbreviation>Magn Reson Med Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.</ArticleTitle>
<Pagination><MedlinePgn></MedlinePgn>
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<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To develop a novel probe for chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) based on thermosensitive liposomes (lipoCEST) for theranostics, in which diagnostics and therapy are integrated into a single platform.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We developed two kinds of lipoCEST agents. The first kind encapsulated dysprosium (Dy)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-Na·3NaCl, terbium-DOTA-Na·3NaCl, or thulium-DOTA-Na·3NaCl into the inner cavity of thermosensitive liposomes, while the second kind encapsulated Dy-DOTA-Na and incorporated amphiphilic metal complex [thulium-diethylenetriamine pentaacetic acid-bis (stearylamide) (Tm-DTPA-BSA)] as a membrane constituent. The nuclear magnetic resonance (NMR)- and Z-spectra of these lipoCEST agents were acquired at various temperatures on a 9.4T MRI scanner. To investigate their applicability to the drug release induced by hyperthermia, we also encapsulated a fluorescent dye (calcein) into the inner cavity of liposomes and measured calcein release after warming them.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The intra- and extraliposomal water signals could be differentiated in all agents from their NMR- and Z-spectra. The agent incorporating Tm-DTPA-BSA showed the largest chemical shift (approximately 15 ppm) derived from the intraliposomal water protons. The calcein retained in this agent was successfully released at 44°C. The agent incorporating 30 mol% of Tm-DTPA-BSA in its membrane released more calcein at 42-44ºC than that of the agent incorporating 10 mol%.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We developed novel thermosensitive lipoCEST agents and characterized them. Our preliminary results suggest that they are useful and can be applied to theranostics.</AbstractText>
</Abstract>
<AuthorList><Author><LastName>Maruyama</LastName>
<ForeName>Shuki</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Ueda</LastName>
<ForeName>Junpei</ForeName>
<Initials>J</Initials>
</Author>
<Author><LastName>Kimura</LastName>
<ForeName>Atsuomi</ForeName>
<Initials>A</Initials>
</Author>
<Author><LastName>Murase</LastName>
<ForeName>Kenya</ForeName>
<Initials>K</Initials>
</Author>
</AuthorList>
<Language>ENG</Language>
<PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>2</Month>
<Day>03</Day>
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<MedlineJournalInfo><MedlineTA>Magn Reson Med Sci</MedlineTA>
<NlmUniqueID>101153368</NlmUniqueID>
<ISSNLinking>1347-3182</ISSNLinking>
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<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year>
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<PublicationStatus>aheadofprint</PublicationStatus>
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<tree><noCountry><name sortKey="Kimura, Atsuomi" sort="Kimura, Atsuomi" uniqKey="Kimura A" first="Atsuomi" last="Kimura">Atsuomi Kimura</name>
<name sortKey="Maruyama, Shuki" sort="Maruyama, Shuki" uniqKey="Maruyama S" first="Shuki" last="Maruyama">Shuki Maruyama</name>
<name sortKey="Murase, Kenya" sort="Murase, Kenya" uniqKey="Murase K" first="Kenya" last="Murase">Kenya Murase</name>
<name sortKey="Ueda, Junpei" sort="Ueda, Junpei" uniqKey="Ueda J" first="Junpei" last="Ueda">Junpei Ueda</name>
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