Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.
Identifieur interne : 000012 ( PubMed/Corpus ); précédent : 000011; suivant : 000013Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.
Auteurs : Shuki Maruyama ; Junpei Ueda ; Atsuomi Kimura ; Kenya MuraseSource :
- Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine [ 1880-2206 ] ; 2016.
Abstract
To develop a novel probe for chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) based on thermosensitive liposomes (lipoCEST) for theranostics, in which diagnostics and therapy are integrated into a single platform.
DOI: 10.2463/mrms.mp.2015-0039
PubMed: 26841852
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.</title><author><name sortKey="Maruyama, Shuki" sort="Maruyama, Shuki" uniqKey="Maruyama S" first="Shuki" last="Maruyama">Shuki Maruyama</name><affiliation><nlm:affiliation>Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.</nlm:affiliation></affiliation></author><author><name sortKey="Ueda, Junpei" sort="Ueda, Junpei" uniqKey="Ueda J" first="Junpei" last="Ueda">Junpei Ueda</name></author><author><name sortKey="Kimura, Atsuomi" sort="Kimura, Atsuomi" uniqKey="Kimura A" first="Atsuomi" last="Kimura">Atsuomi Kimura</name></author><author><name sortKey="Murase, Kenya" sort="Murase, Kenya" uniqKey="Murase K" first="Kenya" last="Murase">Kenya Murase</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.2463/mrms.mp.2015-0039</idno><idno type="RBID">pubmed:26841852</idno><idno type="pmid">26841852</idno><idno type="wicri:Area/PubMed/Corpus">000012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000012</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.</title><author><name sortKey="Maruyama, Shuki" sort="Maruyama, Shuki" uniqKey="Maruyama S" first="Shuki" last="Maruyama">Shuki Maruyama</name><affiliation><nlm:affiliation>Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.</nlm:affiliation></affiliation></author><author><name sortKey="Ueda, Junpei" sort="Ueda, Junpei" uniqKey="Ueda J" first="Junpei" last="Ueda">Junpei Ueda</name></author><author><name sortKey="Kimura, Atsuomi" sort="Kimura, Atsuomi" uniqKey="Kimura A" first="Atsuomi" last="Kimura">Atsuomi Kimura</name></author><author><name sortKey="Murase, Kenya" sort="Murase, Kenya" uniqKey="Murase K" first="Kenya" last="Murase">Kenya Murase</name></author></analytic><series><title level="j">Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine</title><idno type="eISSN">1880-2206</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To develop a novel probe for chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) based on thermosensitive liposomes (lipoCEST) for theranostics, in which diagnostics and therapy are integrated into a single platform.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26841852</PMID><DateCreated><Year>2016</Year><Month>2</Month><Day>4</Day></DateCreated><DateRevised><Year>2016</Year><Month>2</Month><Day>6</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1880-2206</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year><Month>Feb</Month><Day>3</Day></PubDate></JournalIssue><Title>Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine</Title><ISOAbbreviation>Magn Reson Med Sci</ISOAbbreviation></Journal><ArticleTitle>Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To develop a novel probe for chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) based on thermosensitive liposomes (lipoCEST) for theranostics, in which diagnostics and therapy are integrated into a single platform.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We developed two kinds of lipoCEST agents. The first kind encapsulated dysprosium (Dy)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-Na·3NaCl, terbium-DOTA-Na·3NaCl, or thulium-DOTA-Na·3NaCl into the inner cavity of thermosensitive liposomes, while the second kind encapsulated Dy-DOTA-Na and incorporated amphiphilic metal complex [thulium-diethylenetriamine pentaacetic acid-bis (stearylamide) (Tm-DTPA-BSA)] as a membrane constituent. The nuclear magnetic resonance (NMR)- and Z-spectra of these lipoCEST agents were acquired at various temperatures on a 9.4T MRI scanner. To investigate their applicability to the drug release induced by hyperthermia, we also encapsulated a fluorescent dye (calcein) into the inner cavity of liposomes and measured calcein release after warming them.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The intra- and extraliposomal water signals could be differentiated in all agents from their NMR- and Z-spectra. The agent incorporating Tm-DTPA-BSA showed the largest chemical shift (approximately 15 ppm) derived from the intraliposomal water protons. The calcein retained in this agent was successfully released at 44°C. The agent incorporating 30 mol% of Tm-DTPA-BSA in its membrane released more calcein at 42-44ºC than that of the agent incorporating 10 mol%.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We developed novel thermosensitive lipoCEST agents and characterized them. Our preliminary results suggest that they are useful and can be applied to theranostics.</AbstractText></Abstract><AuthorList><Author><LastName>Maruyama</LastName><ForeName>Shuki</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University.</Affiliation></AffiliationInfo></Author><Author><LastName>Ueda</LastName><ForeName>Junpei</ForeName><Initials>J</Initials></Author><Author><LastName>Kimura</LastName><ForeName>Atsuomi</ForeName><Initials>A</Initials></Author><Author><LastName>Murase</LastName><ForeName>Kenya</ForeName><Initials>K</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>2</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Magn Reson Med Sci</MedlineTA><NlmUniqueID>101153368</NlmUniqueID><ISSNLinking>1347-3182</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.2463/mrms.mp.2015-0039</ArticleId><ArticleId IdType="pubmed">26841852</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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