Infrared neural stimulation of human spinal nerve roots in vivo
Identifieur interne : 000A21 ( Ncbi/Curation ); précédent : 000A20; suivant : 000A22Infrared neural stimulation of human spinal nerve roots in vivo
Auteurs : Jonathan M. Cayce [États-Unis] ; Jonathon D. Wells [États-Unis] ; Jonathan D. Malphrus [États-Unis] ; Chris Kao [États-Unis] ; Sharon Thomsen [États-Unis] ; Noel B. Tulipan [États-Unis] ; Peter E. Konrad [États-Unis] ; E. Duco Jansen [États-Unis] ; Anita Mahadevan-Jansen [États-Unis]Source :
- Neurophotonics [ 2329-423X ] ; 2015.
Abstract
Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans
Url:
DOI: 10.1117/1.NPh.2.1.015007
PubMed: 26157986
PubMed Central: 4478764
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<author><name sortKey="Malphrus, Jonathan D" sort="Malphrus, Jonathan D" uniqKey="Malphrus J" first="Jonathan D." last="Malphrus">Jonathan D. Malphrus</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>University of Texas</institution>
, Department of Biomedical Engineering, Austin, Texas, and 500 Discovery View Drive, Sequim, Washington 98382,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Tulipan, Noel B" sort="Tulipan, Noel B" uniqKey="Tulipan N" first="Noel B." last="Tulipan">Noel B. Tulipan</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Vanderbilt University</institution>
, Department of Neurological Surgery, 1161 21st Avenue, Nashville, Tennessee 37232-2380,<country>United States</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Konrad, Peter E" sort="Konrad, Peter E" uniqKey="Konrad P" first="Peter E." last="Konrad">Peter E. Konrad</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vanderbilt University</institution>
, Department of Biomedical Engineering, 5824 Stevenson Center, Station B, Box 351631 Nashville, Tennessee 37235-1631,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Vanderbilt University</institution>
, Department of Neurological Surgery, 1161 21st Avenue, Nashville, Tennessee 37232-2380,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E. Duco" last="Jansen">E. Duco Jansen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vanderbilt University</institution>
, Department of Biomedical Engineering, 5824 Stevenson Center, Station B, Box 351631 Nashville, Tennessee 37235-1631,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Vanderbilt University</institution>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mahadevan Jansen, Anita" sort="Mahadevan Jansen, Anita" uniqKey="Mahadevan Jansen A" first="Anita" last="Mahadevan-Jansen">Anita Mahadevan-Jansen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vanderbilt University</institution>
, Department of Biomedical Engineering, 5824 Stevenson Center, Station B, Box 351631 Nashville, Tennessee 37235-1631,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Department of Neurological Surgery, 1161 21st Avenue, Nashville, Tennessee 37232-2380,<country>United States</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Neurophotonics</title>
<idno type="ISSN">2329-423X</idno>
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<front><div type="abstract" xml:lang="en"><title>Abstract.</title>
<p>Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans <italic>in vivo</italic>
. The feasibility of INS in humans was assessed in patients (<inline-formula><mml:math id="M1"><mml:mrow><mml:mi>n</mml:mi>
<mml:mo>=</mml:mo>
<mml:mn>7</mml:mn>
</mml:mrow>
</mml:math>
</inline-formula>
) undergoing selective dorsal root rhizotomy, where hyperactive dorsal roots, identified for transection, were stimulated <italic>in vivo</italic>
with INS on two to three sites per nerve with electromyogram recordings acquired throughout the stimulation. The stimulated dorsal root was removed and histology was performed to determine thermal damage thresholds of INS. Threshold activation of human dorsal rootlets occurred in 63% of nerves for radiant exposures between 0.53 and <inline-formula><mml:math id="M2"><mml:mrow><mml:mn>1.23</mml:mn>
<mml:mtext> </mml:mtext>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="normal">J</mml:mi>
<mml:mo stretchy="false">/</mml:mo>
<mml:msup><mml:mrow><mml:mi>cm</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>2</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:math>
</inline-formula>
. In all cases, only one or two monitored muscle groups were activated from INS stimulation of a hyperactive spinal root identified by electrical stimulation. Thermal damage was first noted at <inline-formula><mml:math id="M3"><mml:mrow><mml:mn>1.09</mml:mn>
<mml:mtext> </mml:mtext>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="normal">J</mml:mi>
<mml:mo stretchy="false">/</mml:mo>
<mml:msup><mml:mrow><mml:mi>cm</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>2</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
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</inline-formula>
and a <inline-formula><mml:math id="M4"><mml:mrow><mml:mn>2</mml:mn>
<mml:mo>∶</mml:mo>
<mml:mn>1</mml:mn>
</mml:mrow>
</mml:math>
</inline-formula>
safety ratio was identified. These findings demonstrate the success of INS as a fresh approach for activating human nerves <italic>in vivo</italic>
and providing the necessary safety data needed to pursue clinically driven therapeutic and diagnostic applications of INS in humans.</p>
</div>
</front>
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